Structures

3D Macromolecular Structures Determined by the Sussman/Silman Group
Weizmann Institute of Science, Rehovot 76100 ISRAEL

Click on any structure and you'll see details of it in Proteopedia.

Proteopedia
QUATERNARY LIGAND BINDING TO AROMATIC RESIDUES IN THE ACTIVE-SITE GORGE OF ACETYLCHOLINESTERASE

1ACJ
 QUATERNARY LIGAND BINDING TO AROMATIC RESIDUES IN THE ACTIVE-SITE GORGE OF ACETYLCHOLINESTERASE

1ACL
 TRANSITION STATE ANALOG: ACETYLCHOLINESTERASE COMPLEXED WITH M-(N,N,N-TRIMETHYLAMMONIO)TRIFLUOROACETOPHENONE

1AMN
 ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, LAUE DATA

1AX9
 HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH FASCICULIN-II, GLYCOSYLATED PROTEIN

1B41
 METHYLPHOSPHONYLATED ACETYLCHOLINESTERASE (AGED) OBTAINED BY REACTION WITH O-ISOPROPYLMETHYLPHOSPHONOFLUORIDATE (GB, SARIN)

1CFJ
 CRYSTAL STRUCTURE OF DEMETALLIZED CONCANAVALIN A. THE METAL-BINDING REGION

1CN1
 THE THREE-DIMENSIONAL STRUCTURES OF BULGE-CONTAINING DNA FRAGMENTS

1D31
2FE-2S FERREDOXIN FROM HALOARCULA MARISMORTUI

1DOI
 ACHE FROM DROSOPHILA MELANOGASTER COMPLEX WITH TACRINE DERIVATIVE 9-(3-PHENYLMETHYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE

1DX4
 STRUCTURE OF ACETYLCHOLINESTERASE COMPLEXED WITH (-)-GALANTHAMINE AT 2.3A RESOLUTION

1DX6
 TORPEDO CALIFORNICA ACETYLCHOLINESTERASE COMPLEXED WITH BW284C51

1E3Q
 STRUCTURE OF ACETYLCHOLINESTERASE COMPLEXED WITH (-)-HUPRINE X AT 2.1A RESOLUTION

1E66
 NATIVE ACETYLCHOLINESTERASE (E.C. 3.1.1.7) FROM TORPEDO CALIFORNICA AT 1.8A RESOLUTION

1EA5
 Acetylcholinesterase

1EEA
 THREE DIMENSIONAL STRUCTURE OF THE ANTI-ALZHEIMER DRUG, E2020 (ARICEPT), COMPLEXED WITH ITS TARGET ACETYLCHOLINESTERASE

1EVE
CRYSTAL STRUCTURE OF MUTANT E202Q OF HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH GREEN MAMBA VENOM PEPTIDE FASCICULIN-II

1F8U
 ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH FASCICULIN-II

1FSS
 REFINED CRYSTAL STRUCTURE OF'AGED

1GCD
 REFINED CRYSTAL STRUCTURE OF'AGED

1GMH
 STRUCTURE OF ACETYLCHOLINESTERASE COMPLEX WITH (+)-HUPERZINE A AT 2.1A RESOLUTION

1GPK
 STRUCTURE OF ACETYLCHOLINESTERASE COMPLEXED WITH HUPERZINE B AT 2.35A RESOLUTION

1GPN
 ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH RIVASTIGMINE

1GQR
 ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH NAP

1GQS
STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH (S,S)-(-)-BIS(10)-HUPYRIDONE AT 2.15A RESOLUTION

1H22
 STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH (S,S)-(-)-BIS(12)-HUPYRIDONE AT 2.15A RESOLUTION

1H23
 X-RAY CRYSTAL STRUCTURE OF COMPLEX BETWEEN TORPEDO CALIFORNICA ACHE AND A REVERSIBLE INHIBITOR, 4-AMINO-5-FLUO RO-2-METHYL-3-(3-TRIFLUOROACETYLBENZYLTHIOMETHYL)QUINOLINE

1HBJ
 A-BUNGAROTOXIN COMPLEXED WITH HIGH AFFINITY PEPTIDE

1HC9
 STRUCTURAL FEATURES STABILIZING HALOPHILIC MALATE DEHYDROGENASE FROM AN ARCHAEBACTERIUM

1HLP
 A neutral molecule in cation-binding site: Specific binding of PEG-SH to Acetylcholinesterase from Torpedo californica

1JJB
 COMPARISON OF THE CRYSTAL STRUCTURES OF GENETICALLY ENGINEERED HUMAN MANGANESE SUPEROXIDE DISMUTASE AND MANGANESE SUPEROXIDE DISMUTASE FROM THERMUS THERMOPHILUS. DIFFERENCES IN DIMER-DIMER INTERACTIONS.

1MSD
 "STRUCTURE

1ODC
HUMAN ACID-BETA-GLUCOSIDASE

1OGS
 SPECIFIC CHEMICAL AND STRUCTURAL DAMAGE AT NINE TIME POINTS (POINT A) CAUSED BY INTENSE SYNCHROTRON RADIATION TO TORPEDO CALIFORNICA ACETYLCHOLINESTERASE

1QID
 SPECIFIC CHEMICAL AND STRUCTURAL DAMAGE AT NINE TIME POINTS (POINT B) CAUSED BY INTENSE SYNCHROTRON RADIATION TO TORPEDO CALIFORNICA ACETYLCHOLINESTERASE

1QIE
 SPECIFIC CHEMICAL AND STRUCTURAL DAMAGE AT NINE TIME POINTS (POINT C) CAUSED BY INTENSE SYNCHROTRON RADIATION TO TORPEDO CALIFORNICA ACETYLCHOLINESTERASE

1QIF
 SPECIFIC CHEMICAL AND STRUCTURAL DAMAGE AT NINE TIME POINTS (POINT D) CAUSED BY INTENSE SYNCHROTRON RADIATION TO TORPEDO CALIFORNICA ACETYLCHOLINESTERASE

1QIG
 SPECIFIC CHEMICAL AND STRUCTURAL DAMAGE AT NINE TIME POINTS (POINT E) CAUSED BY INTENSE SYNCHROTRON RADIATION TO TORPEDO CALIFORNICA ACETYLCHOLINESTERASE

1QIH
 SPECIFIC CHEMICAL AND STRUCTURAL DAMAGE AT NINE TIME POINTS (POINT F) CAUSED BY INTENSE SYNCHROTRON RADIATION TO TORPEDO CALIFORNICA ACETYLCHOLINESTERASE

1QII
 SPECIFIC CHEMICAL AND STRUCTURAL DAMAGE AT NINE TIME POINTS (POINT G) CAUSED BY INTENSE SYNCHROTRON RADIATION TO TORPEDO CALIFORNICA ACETYLCHOLINESTERASE

1QIJ
SPECIFIC CHEMICAL AND STRUCTURAL DAMAGE AT NINE TIME POINTS (POINT H) CAUSED BY INTENSE SYNCHROTRON RADIATION TO TORPEDO CALIFORNICA ACETYLCHOLINESTERASE

1QIK
 SPECIFIC CHEMICAL AND STRUCTURAL DAMAGE AT NINE TIME POINTS (POINT I) CAUSED BY INTENSE SYNCHROTRON RADIATION TO TORPEDO CALIFORNICA ACETYLCHOLINESTERASE

1QIM
 SPECIFIC CHEMICAL AND STRUCTURAL DAMAGE CAUSED BY INTENSE SYNCHROTRON RADIATION TO HEN EGG WHITE LYSOZYME

1QIO
 NATIVE ACETYLCHOLINESTERASE FROM DROSOPHILA MELANOGASTER

1QO9
 ACHE FROM DROSOPHILA MELANOGASTER COMPLEX WITH TACRINE DERIVATIVE 9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE

1QON
 TORPEDO CALIFORNICA ACETYLCHOLINESTERASE INHIBITED BY NERVE AGENT GD (SOMAN).

1SOM
 Ache W. CPT-11

1U65
 STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH N-9-(1',2',3',4'-TETRAHYDROACRIDINYL)-1,8-DIAMINOOCTANE AT 2.4 ANGSTROMS RESOLUTION.

1UT6
SERUM PARAOXONASE BY DIRECTED EVOLUTION

1V04
 ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH HUPERZINE A

1VOT
 METHYLPHOSPHONYLATED ACETYLCHOLINESTERASE (AGED) OBTAINED BY REACTION WITH O-ETHYL-S-[2-[BIS(1-METHYLETHYL)AMINO]ETHYL] METHYLPHOSPHONOTHIOATE (VX)

1VXO
 O-ETHYLMETHYLPHOSPHONYLATED ACETYLCHOLINESTERASE OBTAINED BY REACTION WITH O-ETHYL-S-[2-[BIS(1-METHYLETHYL)AMINO]ETHYL] METHYLPHOSPHONOTHIOATE (VX)

1VXR
 STRUCTURE OF THE TETRAMERIZATION DOMAIN OF ACETYLCHOLINESTERASE: FOUR-FOLD INTERACTION OF A WWW MOTIF WITH A LEFT-HANDED POLYPROLINE HELIX

1VZJ
 COMPLEX OF TCACHE WITH BIS-ACTING GALANTHAMINE DERIVATIVE

1W4L
 COMPLEX OF TCACHE WITH GALANTHAMINE DERIVATIVE

1W6R
 NATIVE ORTHORHOMBIC FORM OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE (ACHE)

1W75
ORTHORHOMBIC FORM OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE (ACHE) COMPLEXED WITH BIS-ACTING GALANTHAMINE DERIVATIVE

1W76
 X-ray structure of human acid-beta-glucosidase covalently bound to conduritol B epoxide

1Y7V
 Crystal structure of a halotolerant carbonic anhydrase from Dunaliella salina

1Y7W
 Crystal Structure of Torpedo Californica Acetylcholinesterase in Complex With an (R)-Tacrine(10)-Hupyridone Inhibitor.

1ZGB
 Crystal Structure of Torpedo Californica Acetylcholinesterase in Complex With an (RS)-Tacrine(10)-Hupyridone Inhibitor.

1ZGC
 NATIVE ACETYLCHOLINESTERASE (E.C. 3.1.1.7) FROM TORPEDO CALIFORNICA

2ACE
 ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, MONOCHROMATIC DATA

2ACK
 THREE-DIMENSIONAL STRUCTURES OF AVIDIN AND THE AVIDIN-BIOTIN COMPLEX

2AVI
TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH 500MM ACETYLTHIOCHOLINE

2C4H
 TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A NON HYDROLYSABLE SUBSTRATE ANALOGUE, 4-OXO-N,N,N-TRIMETHYLPENTANAMINIUM

2C5F
 TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH 20MM THIOCHOLINE

2C5G
 TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH 20MM ACETYLTHIOCHOLINE

2C58
 TORPEDO CALIFORNICA ACETYLCHOLINESTERASE COMPLEXED WITH ALKYLENE-LINKED BIS-TACRINE DIMER (7 CARBON LINKER)

2CKM
 TORPEDO CALIFORNICA ACETYLCHOLINESTERASE COMPLEXED WITH ALKYLENE-LINKED BIS-TACRINE DIMER (5 CARBON LINKER)

2CMF
 X-RAY STRUCTURE OF AGED DI-ISOPROPYL-PHOSPHORO-FLUORIDATE (DFP) BOUND TO ACETYLCHOLINESTERASE

2DFP
 PARTIALLY DEGLYCOSYLATED GLUCOCERAMIDASE

2J25
NATIVE MONOCLINIC FORM OF TORPEDO ACETYLCHOLINESTERASE

2J3D
 TORPEDO ACETYLCHOLINESTERASE COMPLEXED WITH FLUOROPHORE THIOFLAVIN T

2J3Q
 TORPEDO ACETYLCHOLINESTERASE- HG HEAVY-ATOM DERIVATIVE

2J4F
 ACID-BETA-GLUCOSIDASE WITH N-BUTYL-DEOXYNOJIRIMYCIN

2V3D
 ACID-BETA-GLUCOSIDASE WITH N-NONYL-DEOXYNOJIRIMYCIN

2V3E
 ACID-BETA-GLUCOSIDASE PRODUCED IN CARROT

2V3F
 CRYSTAL STRUCTURE OF YEAST PHENYLALANINE T-RNA. I.CRYSTALLOGRAPHIC REFINEMENT

6TNA
 PROTEIN MODEL BUILDING BY THE USE OF A CONSTRAINED-RESTRAINED LEAST-SQUARES PROCEDURE

7LYZ
GAMMA-CHYMOTRYPSIN IS A COMPLEX OF ALPHA-CHYMOTRYPSIN WITH ITS OWN AUTOLYSIS PRODUCTS

8GCH
 REFINED CRYSTAL STRUCTURE OF DOGFISH M4 APO-LACTATE DEHYDROGENASE

8LDH

Abbreviations

Abbreviations
AChE  acetylcholinesterase 
BChE  butyrylcholinesterase 
Tc Torpedo californica
Ee Electrophorus electricus
Dm Drosophila melanogaster
Bf Bungarus fasciatus
h human 
m mouse 
r recombinant 

    For more detailed information about the PDB, refer to the OCA-3DB browser (WIS).

     

    Nucleic Acids

    Nucleic Acids
    • 1TNA:
    		 tRNA-Phe (OCA) (coordinates)
    • 1DNN:
    		 Theoretical model of smoothly bent DNA (OCA) (coordinates)
    • 1D31:
    		 Bulged DNA d(CGCAGAATTCGCG) (OCA) (coordinates)

       

      Acetylcholinesterase (AChE)

      Acetylcholinesterase
      • 1ACE:
      		 obsolete native TcAChE structure
      • 2ACE:
      		 TcAChE - native structure (OCA) (coordinates) (structure factors)
      • 1EA5:
      		 TcAChE - native structure 1.8A resolution (OCA) (coordinates) (structure factors)
      • 1ACJ:
      		 TcAChE - tacrine complex (OCA) (coordinates)
      • 1ACK:
      		 TcAChE - edrophonium complex (OCA) (coordinates)
      • 1ACL:
      		 TcAChE - decamethonium complex (OCA) (coordinates)
      • 1AMN:
      		 TcAChE - TMTFA complex (OCA) (coordinates) (structure factors)
      • 1B41:
      		 hrAChE - fasciculin-complex (OCA) (coordinates)
      • 1F8U:
      		 hrAChE - fasiculin-complex - Mutant E202Q (OCA) (coordinates)
      • 1CFJ:
      		 TcAChE - aged sarin complex (OCA) (coordinates)
      • 2CLJ:
      		 homology model of hAChE (OCA) (coordinates)
      • 1DX4:
      		 DmAChE - with a derivative of tacrine (OCA) (coordinates) (structure factors)
      • 1DX6:
      		 TcAChE - with Galanthamine derivatives (OCA) (coordinates) (structure factors)
      • 1EEA:
      		 EeAChE - tetramer (OCA) (coordinates) (structure factors)
      • 1EVE:
      		 EeAChE - E2020 complex (OCA) (coordinates) (structure factors)
      • 1E3Q:
      		 TcAChE - BW complex (OCA) (coordinates) (structure factors)
      • 1QO9:
      		 DmAChE - native (OCA) (coordinates) (structure factors)
      • 1QON:
      		 DmAChE - with an iodo derivative of tacrine (OCA) (coordinates) (structure factors)
      • 1QID:
      		 TcAChE - Radiation Damage at 100K, point A (OCA) (coordinates) (structure factors)
      • 1QIE:
      		 TcAChE - Radiation Damage at 100K, point B (OCA) (coordinates) (structure factors)
      • 1QIG:
      		 TcAChE - Radiation Damage at 100K, point D (OCA) (coordinates) (structure factors)
      • 1QIH:
      		 TcAChE - Radiation Damage at 100K, point E (OCA) (coordinates) (structure factors)
      • 1QII:
      		 TcAChE - Radiation Damage at 100K, point F (OCA) (coordinates) (structure factors)
      • 1QIJ:
      		 TcAChE - Radiation Damage at 100K, point G (OCA) (coordinates) (structure factors)
      • 1QIK:
      		 TcAChE - Radiation Damage at 100K, point H (OCA) (coordinates) (structure factors)
      • 1SOM:
      		 TcAChE - soman complex (OCA) (coordinates) (structure factors)
      • 1VOT:
      		 TcAChE - huperzine A complex (OCA) (coordinates) (structure factors)
      • 1VXO:
      		 TcAChE - VX-complex (Aged) (OCA) (coordinates)
      • 1VXR:
      		 TcAChE - VX-complex (OCA) (coordinates)
      • 2ACK:
      		 TcAChE - edrophonium complex (OCA) (coordinates) (structure factors)
      • 2DFP:
      		 TcAChE - DFP complex (OCA) (coordinates) (structure factors)
      • 1E66:
      		 TcAChE - HuprineX complex (OCA) (coordinates) (structure factors)
      • 1HBJ:
      		 TcAChE - Reversible Inhibitor, 4-Amino-5-Fluoro-2-Methyl-3-
      (3-Trifluoroacetylbenzylthiomethyl)Quinoline complex      		 (OCA) (coordinates) (structure factors)
      • 1GQR:
      		 TcAChE - complexed with rivastigmine (OCA) (coordinates) (structure factors)
      • 1GQS:
      		 TcAChE - complexed with NAP (OCA) (coordinates) (structure factors)
      • 1JJB:
      		 TcAChE - complexed with PEG-Sh (OCA) (coordinates) (structure factors)

         

        Other Proteins

        Other Proteins
        • 7LYZ:
        		 Lysozyme Triclinic Form (7lyz) (coordinates)
        • 1QIO:
        		 hen egg white lysozyme - radiation damage (7lyz) (coordinates)
        • 1CN1:
        		 Concanavalin A (demetalized) (OCA) (coordinates)
        • 8GCH:
        		 Gamma-Chymotrypsin (OCA) (coordinates)
        • 1GCD:
        		 Organophosphoryl-complex: Gamma-Chymotrypsin complexed with
        Diethyl Phosphory        		 (OCA) (coordinates
        • 1GMH:
        		 Organophosphoryl-complex: Gamma-Chymotrypsin complexed with Diisopropylphosphorofluoridate (OCA) (coordinates)
        • 1MSD:
        		 Manganese Superoxide Dismutase (OCA) (coordinates)
        • 2AVI:
        		 Avidin Complex with Biotin (OCA) (coordinates)
        • 1HLP:
        		 Halophilic Malate Dehydrogenase (OCA) (coordinates)
        • 1DOI:
        		 2Fe-2S Ferredoxin from Haloarcula marismortui (OCA) (coordinates) (structure factors)
        • 1HC9:
        		 alpha-Bungarotoxin Complexed With High Affinity Peptide (OCA) (coordinates) (structure factors)