Events
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Date:18
Tuesday
March 2025
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Proteome-wide prediction of protein-protein interaction networks and protein compound interactions and their integration for biological discoveryadd event Proteome-wide prediction of protein-protein interaction networks and protein compound interactions and their integration for biological discovery to your calendarlecture
Prof. Barry Honig,
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Date:31
Monday
March 2025
Hour: 11:00 - 12:15,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Decoding the molecular mechanism of histone modificationadd event Decoding the molecular mechanism of histone modification to your calendarcolloquium
Prof. Cynthia Wolberger, Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University
<p>Post-translational modifications of histones play a central role in regulating all cellular processes requiring access to DNA. Monoubiquitinated histone H2B-K120 is a hallmark of actively transcribed genes that plays multiple roles in activating transcription, while monoubiquitinated histone H2A-K119 is abundant in heterochromatin, which is transcriptionally silent. Our structural studies have revealed how histone H2B is specifically ubiquitinated and deubiquitinated, and ubiquitinated H2B stimulates histone methylation. We have also shown how ubiquitin can regulate access to the nucleosome acidic patch, a hotspot for interactions with other chromatin-modifying enzymes. I will also discuss recent studies of a histone kinase that has an unusual mode of binding nucleosomes.</p>
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Date:23
Monday
June 2025
Hour: 11:00 - 12:15,Location: Gerhard M.J. Schmidt Lecture HallEvent name: title tbdadd event title tbd to your calendarcolloquium
Prof. Danna Freedman, Chemistry, MIT