INVITED SPEAKERS

David Clemmer Indiana University Bloomington Professor Clemmer’s work at Indiana University has focused on developing Ion Mobility-Mass... Read more About David Clemmer David Clemmer Indiana University Bloomington Professor Clemmer’s work at Indiana University has focused on developing Ion Mobility-Mass Spectrometry techniques for studying the structures of biomolecules. These techniques are valuable as a means of understanding complex mixtures, such as those that are encountered in the emerging areas of proteomics and glycomics. Currently, Clemmer’s group is developing these measurements of the conformations of gaseous ions as a means of determining thermodynamic information about populations of states that exist in solution.	Arie Admon Technion Arie Admon’s research focuses on molecular immunology, with a special interest on the analysis of... Read more About Arie Admon Arie Admon Technion Arie Admon’s research focuses on molecular immunology, with a special interest on the analysis of the repertoires of peptides bound and presented at the cell surface to the immune system, by the Human leukocyte antigens (HLA). Large-scale LC-MS-MS analyses of these HLA peptidomes (the immunopeptidomes) aims to characterize the full repertoires of HLA peptides presented on the surface of the different types of human cells and by any of the ~5000 allomorphs HLAs in the human population. We also attempt to better understand the molecular and cellular pathway leading to the processing of these peptides, and to identify peptides that can serve as useful candidates for development of immunotherapeutics for cancer (cancer vaccines).
Asaph Aharoni Weizmann Institute of science Read more About Asaph Aharoni Asaph Aharoni Weizmann Institute of science	Tamar Avin Wittenberg Max Planck Institute of Molecular Plant Physiology & The Hebrew University of Jerusalem Plants constantly modulate their metabolic content in order to cope with changing environmental... Read more About Tamar Avin Wittenberg Tamar Avin Wittenberg Max Planck Institute of Molecular Plant Physiology & The Hebrew University of Jerusalem Plants constantly modulate their metabolic content in order to cope with changing environmental conditions. Our group studies primary metabolism in plants, focusing on nutrient allocation during stress response. Specifically, we focus on autophagy, an eukaryotic degradation mechanism for nutrient recycling and its effect on plant metabolism
Perdita Barran The University of Manchester We develop mass spectrometry based methods and instruments to allow us to look at conformation,... Read more About Perdita Barran Perdita Barran The University of Manchester We develop mass spectrometry based methods and instruments to allow us to look at conformation, conformational change and aggregation. Methods that allow us to preserve non-colvalent protein complexes are also applied to inorganic supramolecular biomimetic systems. We also generate IM-MS data from standard small molecules and proteins that can be used to calibrate TW IM-MS instrumentation. Our principal areas of research interest are in understanding pre-fibrillar aggregation, intrinsically disordered proteins and how to tame disorder, probing the stability of protein complexes and of model peptide systems.	Tami Geiger Tel-Aviv University In our lab we use high resolution mass spectrometry to profile the proteomes of tumor tissues and... Read more About Tami Geiger Tami Geiger Tel-Aviv University In our lab we use high resolution mass spectrometry to profile the proteomes of tumor tissues and body fluids. MS technology in combination with advanced computational analyses enable elucidation of disease mechanisms as well as identification of potential cancer biomarkers and drug targets.
Jules Griffin University of Oxford The aim of the Griffin group, in conjunction with the Lipid Profiling and Signalling group at MRC... Read more About Jules Griffin Jules Griffin University of Oxford The aim of the Griffin group, in conjunction with the Lipid Profiling and Signalling group at MRC Human Nutrition Research, is to understand the regulation of lipid metabolism and its interplay with health and diseases of over nutrition. To address this, we have developed analytical chemistry techniques, including methods using mass spectrometry and high resolution NMR spectroscopy, to analyze a wide range of metabolites in cells, tissue or biofluids as part of a metabolomic approach to defining disease processes	Kathryn Lilley University of Cambridge Intracellular proteins exist in controlled micro-environments where they fulfil different roles... Read more About Kathryn Lilley Kathryn Lilley University of Cambridge Intracellular proteins exist in controlled micro-environments where they fulfil different roles dependent on their local environment. To gain a complete functional analysis of the proteome, the possible sub-cellular niches in which a protein may reside must be determined. Moreover, the ability to map changes in location in response to perturbation such as drug treatment is of paramount importance to our understanding of cellular mechanisms. We have created hyperLOPIT, which couples quantitative mass spectrometry methods with advanced machine-learning tools. This method enables the simultaneous assignment of the steady-state location of thousands of proteins to multiple subcellular compartments to create a high resolution map of a cell. HyperLOPIT maps have revealed sub-organellar detail and the location of hundreds of protein complexes. The method can be used in a comparative manner, where the intracellular maps of cells in two or more conditions can be assessed. Moreover, HyperLOPIT workflows can be used to determine the effect of post transcriptional and post translational modification upon localization. HyperLOPIT allows interrogation of the dynamic subcellular proteome on an unprecedented scale, and is complementary to other high throughput spatial methods such as immunocytochemistry and proximity labelling.
Shabaz Mohammed University of Oxford Ben-Gurion University of the Negev The proteome is a highly complex dynamic entity that challenges... Read more About Shabaz Mohammed Shabaz Mohammed University of Oxford Ben-Gurion University of the Negev The proteome is a highly complex dynamic entity that challenges all aspects of every methodology used to interrogate it. In this contribution I will describe our work in PTM and protein identification as well as quantitation. I will specifically focus on the improvements we have made towards allowing facile comprehensive quantitative proteomics experiments.	Arie Moussaieff Hebrew University of Jerusalem Read more About Arie Moussaieff Arie Moussaieff Hebrew University of Jerusalem
Chen Sagiv Sagiv Tech MALDI-imaging offers a rich source of information for analysis and research. As advancement in... Read more About Chen Sagiv Chen Sagiv Sagiv Tech MALDI-imaging offers a rich source of information for analysis and research. As advancement in acquisition methods provides more information, and analysis algorithms become more sophisticated, it is obvious that fast computation methods are critical. 3D-MASSOMICS is a EU funded project that aimed at developing new methodologies for data collection, data analysis and computational methods. In this talk we will present the work done on GPU implementation of machine learning algorithms that run on MALDI data and state of the art research on the application of Deep Learning methodologies to MALDI imaging.	Carla Schmidt University of Oxford Combining native mass spectrometry and chemical cross-linking to study large protein assemblies... Read more About Carla Schmidt Carla Schmidt University of Oxford Combining native mass spectrometry and chemical cross-linking to study large protein assemblies Mass spectrometry is playing an increasing role in structural biology and a multitude of techniques has evolved to address different questions in the structure elucidation of protein-ligand assemblies. We apply the available mass spectrometric techniques and develop new methods and strategies to study the structures and function of protein assemblies which are hard to tackle by conventional structural techniques. This includes particularly the protein-ligand assemblies embedded in biological membranes.
Zoltan Takats Imperial College London The research topic is development of ambient mass spectrometric ionization methods for... Read more About Zoltan Takats Zoltan Takats Imperial College London The research topic is development of ambient mass spectrometric ionization methods for characterizing biological tissues and the clinical translation of these methods to the level of everyday medical diagnostics