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Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3' and 5'-phosphotyrosyl bonds, involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI
Localization:
Intensity:
Fold change:
Significance:
  • C’ GFP library in SD
    YBR223C
    below threshold
    14.6
  • N' NOP1pr-GFP in SD
    YBR223C
    punctate,nucleus
    64.7321
  • N' TEF2pr-mCherry in SD
    YBR223C
    nucleus
    74.2195
  • N' NATIVEpr-GFP in SD
    YBR223C
    ambiguous,ER
    20.6684
  • N' TEF2pr-VC and Cyto-VN in SD
    YBR223C
    nucleus
    28.615
  • C’ GFP library in SD+DTT 
    YBR223C
    cytosol
    19.48
    1.33
    No
  • C’ GFP library in SD+H2O2
    YBR223C
    cytosol
    14.26
    0.97
    No
  • C’ GFP library in Starvation Media
    YBR223C
    cytosol
    18.26
    1.24
    No
  • C’ GFP library on the background of Pup2-DaMP
    noimage.png
    below threshold
  • C’ GFP library on the background of CCT mutant
    noimage.png
    below threshold
    17.2874
    1.18317
    No