Abstracts

Poster
Oral

Presenter	Institution	Abstract
Akkoyunlu Mustafa	US Food and Drug Administration	Unique features of IL-6 mediated germinal center responses to vaccines in neonatal mice
Alberts Ellie	King's College London	The role of lymph node germinal centers and the B cell response in triple-negative breast cancer
Asaf Lihee	Weizmann Institute of Science	Isolation and characterization of antibodies from non-small cell lung cancer (NSCLC)
Bandyopadhyay Arnab	Helmholtz center for Infection Research	Modeling the germinal center reaction and the production of memory B and plasma cells
Beccaria Cristian	OSPEDALE SAN RAFFAELE SRL	Deciphering the Hepatitis B virus specific B cell-mediated immune responses in a mouse model of HBV pathogenesis
Ben-Shalom Noam	Tel Aviv University	Immunization Under Stress: Limits B Cell Clonal Expansion and Promotes Selection of Higher Affinity Antibody Variants
Bessell Emily	Queen Mary University of London	Mesenteric lymph node remodelling requires lymphotoxin beta signaling during helminth infection
Beyou Alicia	INSERM Centre d'Immunologie de Marseille Luminy	Single cell characterization of Follicular Lymphoma B cell heterogeneity governing disease progression and recurrence
Calderon Lesly	Research Institute of Molecular Pathology	On the way to a CRISPR/Cas9 in vivo screen for new regulators of antibody-secreting cells
Chen Zhian	The University of Queensland Diamantina Institute	The sulfation of heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal centre B cell selection and differentiation
Cornelis Rebecca	German Rheumatism Research Center	Long-lived plasma cells require stromal cell-dependent activation of PI3K signaling and APRIL to prevent caspase-dependent cell death
Crespi Marta	Barts Cancer Institute-Queen Mary University of London	Autophagy regulates somatic mutagenesis via Lamin B1-dependent mechanism
Dale Gordon	Ragon Institute	Somatic mutations encoding germline-like motifs in germinal center B cells are associated with clonal expansion and differentiation into memory compartments
Dalit Lennard	Walter and Eliza Hall Institute of Medical Research	Core and pathogen-specific transcriptional networks of T follicular helper cells
Deimel Lachlan	University of Oxford	Overcoming the Glycan Blind Spot: Raising antibodies against immunorecessive carbohydrate-based antigens
Enterina Jhon	University of Alberta	Glycan remodeling regulates germinal centre B cell response through CD22
Eyran Tsuf	wiezman	Longitudinal kinetics of RBD+ antibodies in COVID-19 recovered patients over 14 months
Foster William	Babraham Institute	T follicular helper cells and the germinal centre are required for memory B cell formation and humoral immunity after ChAdOx1 nCoV-19 vaccination.
Gaspar Pedro	iMM-JLA: Instituto de Medicina Molecular Jo?o Lobo Antunes	Immunoregulation and Autoantibody Production in Primary Thrombotic Antiphospholipid Syndrome
Gaspar Pedro	iMM-JLA: Instituto de Medicina Molecular - Jo?o Lobo Antunes	Immunoregulation and Autoantibody Production in Primary Thrombotic Antiphospholipid Syndrome
Huang Xiaobo	University of Helsinki	Significance of MAITs and B cells in SARS-CoV-2 Infection
Kagan Ben Tikva Sharon	Weizmann Institute of Science	Defining a new B cell selection niche in germinal centers
Kealy Liam	Monash University	The Role of DOT1L in the Regulation of the GC Reaction
Laakso Sini	University of Helsinki	Alterations in plasmablasts in the cerebrospinal fluid of patients with multiple sclerosis support a relation to Epstein Barr virus
Lee Jeonghyun	Kangwon National University	IL-21 regulates c-Myc and mTORC1 activity in Germinal Center B cells
Mittal Soumya	Indian Institute of Science	Trade-off between antiviral and vaccinal effects of passive immunization
NOWLAN KIRSTEN	University of Helsinki	The Characterisation of Ectopic Germinal Centres in MG
Nathan Nachi	Weizmann Institute of Science	Tumor-draining lymph nodes in ovarian carcinoma patients are dysfunctional
Neuman Hadas	Bar-Ilan University	IgTreeZ: A toolkit for immunoglobulin gene lineage tree analysis
Obara Maureen	Hannover Medical School	Somatic hypermutation increases antibody binding and enhances coverage of emerging SARS-CoV-2 variants
Obraztcova Anna	German Cancer Research Center	Antigen valency controls the susceptibility of B cell activation to antibody feedback
Payne Kathryn	Medical center University of Freiburg	DISSECTING GERMINAL CENTER B CELL RESPONSES IN COMMON VARIABLE IMMUNODEFICIENCY
Petersone Lina	University College London	Pinpointing the role of IL-21 in directing B cell fate within germinal centers
Phad Ganesh E.	Institute for Research in Biomedicine (IRB)	Clonal structure, stability and dynamics of human memory B cells and circulating plasmablasts
Pritchard Gretchen	University of Washington	Rapidly responsive CD73+CD80+ memory B cells are BCL6-dependent but can form outside a germinal center response
Quast Isaak	Monash University	IL-21 acts beyond the immunological synapse to establish and sustain germinal center dynamics.
Rauschmeier Rene	IMP - Research Institute of Molecular Pathology	Bhlhe40 function in activated B and T follicular helper cells restrains the GC reaction and prevents lymphomagenesis
Reusch Laura	University of Gothenburg	Effect of pre-existing memory B cells and antibodies on memory responses and reshaping immunodominance patterns to influenza A virus.
Sarkkinen Joona	University of Helsinki	Ectopic germinal centers in the thymus accurately predict prognosis of myasthenia gravis after thymectomy
Sheward Daniel	Karolinska Institutet	Pan-SARS-CoV-2 neutralization by affinity-matured public antibodies
Silva Cayetano Alyssa	Babraham Institute	Spatial dysregulation of T follicular helper cells impairs vaccine responses in ageing
Sprumont Adrien	Weatherall Institute of Molecular Medicine	A snapshot of germinal center plasma cell differentiation during a viral infection
Uhlig Maximilian	The Rockefeller University	Dynamic Regulation of T follicular helper cell selection during the germinal center reaction
V. H. de Carvalho Renan	The Rockefeller University	Clonal replacement sustains long-lived germinal centers primed by respiratory viruses
Westermann Juergen	University of Luebeck	The T cell receptor repertoire of splenic germinal centers and its distribution within and between lymphoid organs
Xu An Qi	Francis Crick Institute	Homeostatic regulation of plasma cell turnover
Yefet Ron	Tel Aviv University	Characterizing the B cell response towards Monkeypox virus in humans
Zehner Matthias	University Hospital of Cologne	Identification of potent HCMV-neutralizing antibodies targeting novel binding sites on the trimeric and pentameric surface complex.
Zhang Lingling	The Francis Crick Institute	The Ca2+ flux of IgG1+ germinal center B cells is actively regulated to favor positive selection
schips marta	Helmholtz Centre for Infection Research	How does T-FR limit autoreactivity despite being outnumbered in the GC?

Presenter	Institution	Abstract
BRUHNS Pierre	Institut Pasteur	Human autoreactive plasma cell characterization in multiple organs
Bach Luisa	University Hospital Bonn	TGF? induces murine CXCR5 and Bcl6 and differentially specifies Tfh versus Th17 cell fates
Bemark Mats	University of Gothenburg	The plasmablast response to COVID-19 in naive individuals is dominated by IgA1 cells cross-reactive to other coronaviruses but memory formation is not
Calado Dinis	The Francis Crick Institute	Impaired germinal center confinement and plasma cell differentiation by MYC activation is critical for Burkitt lymphomagenesis
Casola Stefano	IFOM ETS, The AIRC Institute of Molecular Oncology	Immunoglobulin class-associated BCR silencing in high-grade germinal center B cell lymphomas
Cockburn Ian	Australian National University	Time, not affinity, drives the differentiation of plasmacells from the germinal center
Dominguez-Sola David	Icahn School of Medicine at Mount Sinai	MYC mutations in Burkitt lymphoma uncouple MYC from mTOR to bypass germinal center selection bottlenecks
Dubey Lalit Kumar	Queen Mary University of London	B cell-Stromal Cross Talk Drives Mesenteric Lymph Node Eosinophilia
Garcia-Martinez J. Victor	University of North Carolina at Chapel Hill	Cryptopatches Are Essential for the Development of Human GALT
Graca Luis	iMM-JLA: Instituto de Medicina Molecular - Jo?o Lobo Antunes	Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue
Gurwicz Neta	Weizmann Institute of Science	Dynamics and origin of Tingible body macrophages
Imkeller Katharina	Edinger Institute, Frankfurt Cancer Institute	Computational approach to study human immunogenetic diversity in tumor-immune interactions
Kabrani Eleni	Max Delbrueck Center for Molecular Medicine	RIF1 acts as a cell identity gatekeeper during mature B cell differentiation
Kreslavsky Taras	Karolinska Institutet	Regulation of cell fate decisions in early B cell activation
Liu Jingjing	Weizmann Institute of Science	Cellular dynamic of antibody-mediated immune response during nasal vaccination
Nowosad Carla	NYU Grossman School of Medicine	Tunable dynamics of B cell selection in gut-draining germinal centers
Pinschewer Daniel	University of Basel, Department of Biomedicine	Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection
Rosser Elizabeth	1Centre for Rheumatology Research, Division of Medicine, University College London, London, UK; 2Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCLH and GOSH	Interaction of GPR183 with its ligand 7a25-dihydroxycholesterol drives pathogenic extrafollicular B cell responses in systemic lupus erythematosus
Roulland Sandrine	INSERM	Emergence of B cell state heterogeneity and early immune microenvironment changes during Kmt2d-driven B cell lymphomagenesis
Stoler-Barak Liat	Weizmann Institute of Science	B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation
Yu Di	The University of Queensland	Ferroptosis regulates follicular helper T cell function

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