Prof. Ada E. Yonath Group

Ribosome structure and function,
human genetic diseases linked to mutated ribosomes,
next generation antibiotics & origin of life

 Department of Structural Biology
 

The Martin S. and Helen Kimmel Professor of Structural Biology
Director, The Helen and Milton A. Kimmelman Center for Biomolecular Structure and Assembly

NOBEL PRIZE IN CHEMISTRY 2009

Tel: (972) 8 934 3028/2541;
Fax: (972) 8 934 4154/4136

ada.yonath@weizmann.ac.il

Ribosome Group led by Prof Ada Yonath:
Chemical and Structural Biology Department, Weizmann Institute of Science, Rehovot, Israel

Members of the group: 
Admon Roni*, Dr. Agmon Ilana*, Assis Nofar*, Dr. Auerbach-Nevo Tamar*, Dr. Baram David*, Dr. Bashan Anat, Dr. Belousoff Matthew*, Dr. Bose Tanaya, Dr. Breiner Elinor*, Dr. Cimicata Giuseppe, Dr. Davidovich Chen*, Dr. Eyal Zohar*, Fedorenko Aliza, Dr. Fridkin Gil, Gaivoronskii Filipp, Dr. Halfon Yehuda*, Hiregange Disha-Gajanan, Dr. Pyetan Erez*, Kaczmarczyk Igor*, Dr. Kessler Maggie, Dr. Krupkin Miri*, Laschever Miriam*, Dr. Matzov Donna*, Melenitzki Tal, Metz Markus*, Dr. Mruwat Rufayda*, Dr. Peretz Moshe, Rivalta Andre', Rosenfield Liat, Dr. Rozenberg Haim, Samiya Sarit*, Dr. Shalev-Benami Moran*, Dr. Shanmugha Rajan K, Shapira Tal*, Dr. Sun Liping*, Tel-Or Shoshi, Dr. Wekselman Itai*, Dr. Zarivach Raz*, Dr. Zimmerman Ella

* Previous Members

Scientific Activities and explanation to the below Figures
Publications
Ada E.Yonath Curriculum Vitae
Ada E.Yonath Curriculum Vitae (Heb)

 

Schluenzen et al., Cell, 102, 615-23 (2000)

Figure A:

The Small Ribosomal Subunit

Schluenzen et al., Cell, 102, 615-23 (2000)
Harms et al., Cell, 107, 679-88 (2001)

Figure B:

The Large Ribosomal Subunit

 

Harms et al., Cell, 107, 679-88 (2001)

 

Agmon etal., Eur J Biochem, 270, 2543-56(2003); Bashan et al., Mol Cell, 11,91-102 (2003); Yonath, ChemBioChem 4, 1008-17 (2003); Yonath, Biol Chem 384, 1411-9 (2003)

*Figure C:

tRNA A-site --->P site

 

Agmon et al., 2003; Bashan et al., 2003

*For details go to "Scientific Activities" (Figure 5)
Agmon et al., Eur J Biochem, 270, 2543-56 (2003); Bashan et al., Mol Cell, 11,91-102 (2003)

*Figure D:

tRNA A-site--->P passage

Agmon et al., 2003; 2005

 

 

*For details go to "Scientific Activities" (Figure 5)

 

View into the Tunnel
Figure E:

View into the Tunnel

Schluenzen et al., Nature, 413, 814-21 (2001)

Wekselman et al., Structure 25, 1233-1241 (2017)

 

Schluenzen et al., Nature, 413, 814-21 (2001)
Figure F:

Antibiotic Agents Blocking the Ribosmal Exit Tunnel

 

Schluenzen et al., Nature, 413, 814-21 (2001)

 

NEXT GENERATION ENVIRONMENTAL FRIENDLY ANTIBIOTICS

Figure G:
Next Generation Environmental Friendly Antibiotics

Matzov et al 2017, Auerbach-Nevo 2016

 

 

 

Ribosome Movies:
Ribosome in action (Eng):
http://www.youtube.com/watch?v=Jml8CFBWcDs
Ribosome in action (Chinese):
 http://v.youku.com/v_show/id_XNzMxNzEwNjg0.html
Antibiotics targeting ribosomes (Eng):
http://www.youtube.com/watch?v=RedO6rLNQ2o
Antibiotics targeting ribosomes (Chinese):
 http://v.youku.com/v_show/id_XNzMyNDU4Mzgw.html

 

 

Scientific Activities and explanation to the below Figures
Publications
Ada E.Yonath Curriculum Vitae
Ada E.Yonath Curriculum Vitae (Heb)


Weizmann Institute of Science, Rehovot, 76100 Israel
Tel: (972) 8 934 3028/2541   Fax: (972) 8 934 4154/4136;
Email: ada.yonath@weizmann.ac.il