Conventionally therapeutic antibodies are obtained by exposing the immune system to recombinant target protein from another species. However, to exert therapeutic properties usually an antibody has to recognize and block only certain epitopes in the functional part of the target. Thus, obtaining a suitable immunoglobulin is a challenging process, since the whole target protein presents many different epitopes. Combining skills in the field of organic synthesis with those in peptide chemistry and cell biology we synthesize molecules, which mimic specific native proteins surfaces. We intend to use these organopeptidic adducts to raise antibodies against specific epitopes.
