Our lab focus is on deciphering the dynamics of cellular metabolism at different disease states. In particular, we are interested in understanding the contribution of the urea cycle enzyme’s and intermediates to the metabolic changes that accompany disease pathogenesis. Outside the liver, the urea cycle components serve as metabolic nexus for multiple cellular pathways integrating amino acid/nitrogen and glucose/oxidative stress metabolism. Hence, urea cycle components may directly regulate the differential flux of its metabolites between these pathways. In addition to basic molecular methods, we are using a setup for metabolic characterization which includes GC/MS and specific HPLC instruments for detection of metabolic changes both in vitro and in vivo.
Wholly Metaboly
