Can we modulate metabolism for cancer therapy?

The liver plays a central role in regulating nutrient availability, drug metabolism, and inflammatory signaling, and its dysfunction can profoundly limit therapeutic efficacy. Our work focuses on strategies to preserve and restore hepatic metabolic programs while selectively intervening in tumor-driven systemic cues, such as inflammatory cytokines, nutrient stress signals, and cachexia-associated pathways. By stabilizing liver metabolism and reshaping the systemic metabolic milieu, we aim to reduce treatment toxicity, prevent maladaptive host responses, and create a physiological environment that improves the patients' wellbeing while constraining tumor growth and enhancing therapeutic response.