Anti cancer treatment modality
Rosenbach-Belkin, V., L.
Chen, L. Fiedor, F. Tregub, F. Pavlotsky, V. Brumfeld, Y. Salomon and
A. Scherz (1996) Serine conjugates of chlorophyll and
bacteriochlorophyll: phototoxicity in-vitro and tissue distribution in
mice bearing melanoma tumors. Photochem. Photobiol. 64, 174-181.
Zilberstein, J.,
Bromberg, A., Franz, A.,Rosenbach-Belkin, V., Kritzmann, A.,
Pefferman, R., Salomon, Y. and Scherz, A. (1997) Light dependent
oxygen consumption in bacteriochlorophyll-serine treated melanoma
tumors: on-line determination using a tissue-inserted oxygen
microsensor Photochem Photobiol. 65, 1012-1019.
Gross, S., Brandis, A.,
Chen, L., Rosenbach-Belkin, V., Roehrs, S. Scherz A. and Salomon,
Y. (1997) Protein A mediated targeting of Bacteriochlorophyll-IgG to
Staphylococcus aureus: a model for site-specific
photocytotoxicity.Photochem. Photobiol. 66, 872-878.
Eichwurzel, I., Stiel, H., Teuchner,
K.,. Leupold, D., Scheer, H., Salomon Y. and A. Scherz (2000)
Photophysical consequences of coupling of bacteriochlorophyll a with
serine and resulting solubility in water Photochem Photobiol. 72,
204-9.
Zilberstein, J.,
Schreiber, S., Bloemers, M.C.W.M., Bendel, P., Neeman, M., Schechtman,
E., Kohen, F., Scherz, A., Salomon Y. (2001) Anti vascular treatment of
solid melanoma tumors with bacteriochlorophyll-serine-based
photodynamic therapy, Photochem. Photobiol. 73 257-263.
Chen, Q., Huang ,
Z., Luck, D., Beckers, J., Brun, PH., Wilson, BC., Scherz, A., Salomon,
Y., & Fred W. Hetzel (2002) Preclinical studies in normal
canine prostate of a novel palladium- bacteriopheophorbide
photosensitizer (Tookad: WST09) for photodynamic therapy of prostate
cancer Photochem.Photobiol. 76, 88-95.
Q. Chen, Z. Huang,
D. Luck, J. Beckers, P. Brun, B. Wilson, A. Scherz, Y. Salomon and F.
Hetzel. "WST09 (TOOKAD) mediated photodynamic therapy as an alternative
modality in the treatment of prostate cancer" Proceedings of SPIE Vol
4612, 29-39, 2002.
Schreiber S., Gross
S.,, Brandis A., Harmelin A., Rosenbach-Belkin, V., Scherz A.,
and Salomon Y. (2002) Local Photodynamic Therapy (PDT) of rat C6
glioma xenografts with Pd-Bacteriopheophorbide Leads to Decreased
Metastases and Increased Animal Cure Compared to Surgery. IntÕ
J. Of Cancer, 99, 279-285.
Kelleher, D. K. Thews,
O. Scherz, A. Salomon Y. and Vaupel P. (2003) Combined hyperthermia and
chlorophyll-based photodynamic therapy: Tumour growth and metabolic
microenvironment British J. of Cancer , 89, 2333-2339.
Preise, D., Mazor,
O., Koudinova, N., Liscovitch, M., Scherz, A., and Salomon, Y., (2003),
Bypass Of Tumor Drug Resistance By Antivascular Therapy, Neopliasia, 5,
475-480.
Gross. S, Gilead
A. Scherz A. Neeman M. and Salomon Y.(2003) Monitoring Photodynamic
Therapy of Solid Tumors Online by BOLD Contrast MRI, Nature Medicine,
9, 1327-1331.
Koudinova, N,
Pinthus, J.H. , Brandis, A., Brenner, O., Bendel, P., Ramon J., Eshhar,
Z., Scherz, A, Salomon, Y. (2003). Photodynamic therapy with
Pd-bacteropheophorbid (TOOKAD): successful In vivo treatment of human
prostatic small cell carcinoma xenograft. Intl. J. cancer Res 104,
782-789.
Z. Huang,
Q. Chen, D. Luck, J. Beckers, P. Brun, B. C. Wilson, A. Scherz, Y.
Salomon and F. W. Hetzel (2002) "Studies of Novel Photosensitizer
TOOKAD for Treatment of Prostate Cancer" Proceedings of SPIE Vol 4952,
104-114.
Z. Huang, Q.
Chen, P. Brun, B. C. Wilson, A. Scherz, Y. Salomon, D. Luck, J. Beckers
and F. W. Hetzel (2003) "Studies of a novel photosensitizer
Pd-bacteriopheophorbide (Tookad) for the prostate cancer PDT in canine
model" Proceedings of SPIE Vol 5254, 83-90.
Kelleher DK,
Thews O, Scherz A, Salomon Y., Vaupel P. (2004) Perfusion, oxygenation
status and growth of experimental tumors upon photodynamic therapy with
Pd-bacteriopheophorbide Int J Oncol. 24,1505-11.
Plaks, V.,
Koudinova, N., Nevo, U., Pinthus, J.H., Kanety, H., Eshhar, Z., Ramon,
J., Scherz, A., Neeman M. and Salomon, Y. (2004) Photodynamic
Therapy of Established Prostatic Adenocarcinoma with TOOKAD: A Biphasic
Apparent Diffusion Coefficient Change as Potential Early MRI Response
Marker Neoplasia 6, 224-233.
Plaks, V., Posen,
Y., Mazor, O., Brandis, A., Scherz, A., and Salomon Y. (2004)
Homologous adaptation to oxidative stress Induced by the
photosensitized Pd-bacteriochlorophyll derivative (WST11) in cultured
endothelial cells J. Biol. Chem. 44, 45713-45720.
Mazor O, Brandis A, Plaks V, Neumark E, Rosenbach-Belkin V, Salomon Y,
Scherz A. (2005), WST11, A Novel Water-Soluble Bacteriochlorophyll
Derivative; Cellular uptake, Pharmacokinetics, Biodistribution, and
Vascular Targeted Photodynamic Activity Against Melanoma
tumors.Photochem Photobiol.81(2):342-51.
Vilensky, J.,
Koudinova, N.V., Harmelin, A., Scherz, A. and Salomon Y. (2005)
Vascular-Targeted PhotodynamicTherapy (VTP) of a Canine Transmissible
Venereal Tumor in a Murine Model with Pd-bacteriopheophorbide (WST09).
Vet. Comp. Oncol. Veterinary and Comparative Oncology 4, (3) 182-193.
Brandis A, Mazor O,
Neumark E, Rosenbach-Belkin V, Salomon Y, Scherz A. (2005) Novel
water-soluble bacteriochlorophyll derivatives for vascular-targeted
photodynamic therapy: synthesis, solubility, phototoxicity, and the
effect of serum proteins.Photochem Photobiol. 81, 983-993.
Fleshker, S., Preise,
D., Kalchenko A., Scherz, A., and Salomon, Y., (2007). Prompt
Assessment Of Wst11-Vtp Outcome Using Luciferase Transfected Tumors
Enables Second Treatment And Increase In Overall Therapeutic Rate.
Photochem. Photobiol. (in press).
Preise, D., Oren, R.,
Glinert, I., Kalchenko, V., Jung, S., Scherz A., and Salomon. Y.
(2008). Systemic antitumor protection by vascular-targeted photodynamic
therapy (VTP) involves cellular and humoral immunity. Cancer Immunology
and immunotherapy. (In press).