The Shulman Lab

Antibody-Mediated Immune Responses

Research

The origins and functions of antibodies

Our research group delves into the fundamental molecular and cellular processes underlying the development of protective antibodies and the establishment of enduring immunity. Employing a combination of mouse models and human-derived tissues, along with advanced imaging techniques and next-generation genomics, we unveil the regulatory mechanisms governing antibody-mediated immunity in the context of vaccination, pathogen invasion, and cancer.

Research page

Selected Publications

SMARCA5-mediated chromatin remodeling is required for germinal center formation

Stoler-Barak L., Schmiedel D., Sarusi-Portuguez A., Rogel A., Blecher-Gonen R., Haimon Z., Stopka T. & Shulman Z. (2024) Journal of Experimental Medicine. 221, 11, e20240433.

Turbinate-homing IgA-secreting cells originate in the nasal lymphoid tissues

Liu J., Stoler-Barak L., Hezroni-Bravyi H., Biram A., Lebon S., Davidzohn N., Kedmi M., Chemla M., Pilzer D., Cohen M., Brenner O., Biton M. & Shulman Z. (2024) Nature. 632, 8025, p. 637-646

The tumor-driven antibody-mediated immune response in cancer

Paparoditis P. & Shulman Z. (2024) Current Opinion in Immunology. 88, 102431.
All Publications