Professor Ruth Arnon The Paul Ehrlich Professor of Immunology

 Short List of Publications:

• A DNA Aptamer prevents influenza infection by blocking the Receptor binding region of the viral haemagglutinin.
  Sung Ho Jeon, Basak Kayhan, Tamar Ben-Yedidia, Ruth Arnon.
  J. Biol. Chem. 279:No.46: 48410-48419 (2004).
• Mechanism of action of glatiramer acetate in multiple sclerosis and its potential for the development of new applications.
  Ruth Arnon, Rina Aharoni.
  PNAS 101: (Supplement) 14593-14598 (2004).
• Oral Glatiramer Acetate in Experimental Autoimmune Encephalomyelitis. Clinical and Immunological Studies.
  Dvora Teitelbaum, Rina Aharoni, Ety Klinger, Rivka Kreitman, Emanual Raymond, Arthur Malley, Rona Shofti, Michael Sela, Ruth Arnon.
  Ann. N.Y. Acad. Sci. 1029: 239-249 (2004).
• Combined treatment of Glatiramer Acetate and low doses of immunosuppressive drugs is effective in the prevention of graft rejection.
  Rina Aharoni, Alexander Yussim, Michael Sela, Ruth Arnon
  International Immunopharm. 5: 23-32 (2005) .
• Towards an epitope-based human vaccine for influenza.
  Tamar Ben-Yedidia, Ruth Arnon.
  Human Vaccines. 1:3, 95-101 (2005) .
• Therapeutic effect of the immunomodulator glatiramer acetate on trinitrobenzene sulfonic acid-induced experimental colitis.
  Rina Aharoni, Basak Kayhan, Ruth Arnon.
  Inflam. Bowel Disease 11: 106-115 (2005).
• Neurogenesis and Neuroprotection induced by peripheral immunodulatory treatment of experimental autoimmune encephalomyelitis.
  Rina Aharoni, Raya Eilam, Ruth Arnon.
  J. of Neuroscience 25(36): 8217-8228 (2005).
• Case History of Copaxone® - From the Bench to Bedside.
  Dvora Teitelbaum*, Ruth Arnon, Michael Sela.
  Comprehensive Medicinal Chemistry II Vol. 8: 172-185 (2005).
• Ecto- and Exo-Protein kinases in Schistosoma mansoni: Regulation of surface phosphorylation by acetylcholine and identification of the alpha subunit of CKII as a major secreted protein kinase.
  Rebeca Tarrab-Hazdai, Tamar Hanoch, Sung Ho Jeon, Henya Pauli, Daniel Gold, Ruth Arnon, Rony Seger.
  J. of Parasitol. 91(4): 756-763 (2005).
• The immunomodulator glatiramer acetate augements the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis mice.
  Rina Aharoni, Raya Eilam, Hagit Domev, Galya Labunskay, Michael Sela, Ruth Arnon.
  PNAS 102(52): 19045-19050 (2005).
• Immunomodulatory Therapeutic Effect of Glatiramer Acetate on Several Murine Models of Inflammatory Bowel Disease.
  Rina Aharoni, Basak Kayhan, Ori Brenner, Hagit Domev, Galya Labunskay, Ruth Arnon.
  J. of Pharmacology and Experimental Therapeutics 318(1): 68-78 (2006).
• Flagella as a Platform for Epitope-Based Vaccines.
  Tamar Ben-Yedidya, Ruth Arnon.
  IMAJ. 8: 316-317 (2006).
• Does glatiramer acetate indice neurogenesis in experimental autoimmune encephalomyelitis?
  Ruth Arnon.
  J. Neurol. 254: 41-46 (2007). Supp.1, Barcelona.
• Copaxone.
  D. Teitelbaum, R. Arnon, M. Sela.
  Comprehensive Medicinal Chemistry II (Editors-in-Chief John. B. Taylor and David J. Triggle). 8: 173 -185 (2007).
• Epitope-based vaccine against influenza.
  T. Ben-Yedidia, R. Arnon.
  "Expert Review of Vaccines" (ERV) 6(6): 939-948 (2007).
• The therapeutic effect of glatiramer acetate in a murine model of inflammatory bowel disease is mediated by anti-inflammatory T-cells.
  Rina Aharoni, Hagar Sonego, Ori Brenner, Raya Eilam, Ruth Arnon.
  Immun. Letts. 112(2): 110-119 (2007).
• Demyelination arrest and remyelination induced by Glatiramer acetate treatment.
  Rina Aharoni, Avia Herschkovitz, Raya Eilam, Michal Bloomberg, Michael Sela, Wolfgang Bruck, Ruth Arnon.
  PNAS 105(32): 11358-11363 (2008).
• A Universal epitope-based influenza vaccine and its efficacy against H5N1.
  Adar Y, Singer Y, Levi R, Tzehoval E, Perk S, Banet-Noach C, Nagar S, Arnon R, Ben-Yedidia T.
  Vaccine, 2099-2107 (2009).
• The therapeutic effect of TV-5010 in a murine model of inflammatory bowel disease - dextran induced colitis.
  Rina Aharoni, Ori Brenner, Adva Cohen, Ruth Arnon.
  International Immunopharmacology 8: 1578-1588 (2008).
• Preclinical efficacy of virus-like particl -based vaccine against avian influenza H5N1.
  Ruth Arnon, Tamar Ben-Yedidia.
  Future Microbiol. 4(5): 503 (2009).
• Transplanted myogenic progenitor cells express neuronal markers in the CNS and ameliorate disease in the mouse model of multiple sclerosis.
  Rina Aharoni, Elizabeta Aizman, Ora Fuchs, Ruth Arnon, David Yaffe, Rachel Sarig.
  J. of Neuroimmunology 30: 73-83 (2009).
• Glatiramer acetate reduces Th-17 inflammation and induces regulatory T-cells in the CNS of mice with relapsing-remitting or chronic EAE.
  Rina Aharoni, Raya Eilam, Ariel Stock, Ania Vainshtein, Elias Shezen, Hilah Gal, Nir Friedman, Ruth Arnon.
  J. of Neuroimmunology 225: 100-111 (2010).
• Glatiramer Acetate (GA, Copolymer-1) an hypothetical treatment option for Rett syndrome.
  B.Ben-Zeev, Rina Aharoni, A. Nissenkorn, Ruth Arnon.
  Submitted (2010).
• The beneficial effect of glatiramer acetate treatment on syndecan-1 expression in dextran sodium sulfate colitis.
  Doron Yablecovitch, Maytal Shabat�Simon, Rina Aharoni, Raya Eilam, Ori Brenner, Ruth Arnon.
  J. Pharmacol. Exp. Ther. 337(2): 391-399 (2011).
• Distinct pathological patterns in relapsing-remitting and chronic models of experimental autoimmune encephalomyelitis and the neuroprotective effect of glatiramer acetate.
  Rina Aharoni, Anya Vainshtein, Raya Eilam, Ariel Stock, Renana From, Vera Shinder, Ruth Arnon.
  Journal of Autoimmunity Submitted (2011).

 Books Published:

• Copolymer 1 and related peptides as immunomodulsting agents.
  Ruth Arnon.
  Chapter in Martin & Kastin (eds.) Handbook of Biologically Active Peptides, 2006.
• Peptides and Polypeptides as Immunomodulators and their Consequential Therapeutic Effect in Multiple Sclerosis and Other Autoimmune Diseases. (Ed. Santos)
  Ruth Arnon, Michael Sela, Rina Aharoni.
  In press.