Professor Avraham Ben-Nun The Eugene & Marcia Applebaum Professor

 List of Publications (last 3 years):

Mendel, I., Katz, A., Kozak, N., Ben-Nun, A. and Revel, M. (1998) Interleukin-6 functions in autoimmune encephalomyelitis: a study in gene-targeted mice. Eur. J. Immunol. 28: 1727-1737.

Mendel, I., Gur, H., Kerlero de Rosbo, N. and Ben-Nun, A. (1998) Experimental autoimmune encephalomyelitis induced in B6.C-H-2bm12 mice by myelin oligodendrocyte glycoprotein: Effect of MHC class II mutation on immunodominant epitope selection and fine epitope specificity of encephalitogenic T cells. J. Neuroimmunol. 96: 9-20.

Yoshizawa, I., Bronson, R., Ben-Nun, A., Richert, J.R. and Abromson-Leeman, S. (1998) Differential recognition of MBP epitopes in BALB/c mice determines the site of inflammatory disease induction. J. Neuroimmunol. 89: 73-82.

Kerlero de Rosbo, N. and Ben-Nun, A. (1998) T cell responses to myelin antigens in multiple sclerosis: relevance of the predominant autoimmune reactivity to myelin oligodendrocyte glycoprotein. J. Autoimmun. 11: 287-299.

Kerlero de Rosbo, N. and Ben-Nun, A. Experimental autoimmune encephalomyelitis induced by various antigens of the central nervous system. Overview and relevance to multiple sclerosis. In "The decade of autoimmunity 1987-1997" (Y. Shoenfeld, ed.), Elsevier Science, Amsterdam. pp.169-177.

Karni, A., Bakimer-Kleiner, R., Abramsky, O. and Ben-Nun, A. (1999) Elevated levels of antibody to myelin oligodendrocyte glycoprotein is not specific for patients with multiple sclerosis. Arch. Neurol. 56: 311-315.

Barda-Saad, m., Rozenszajn, L. A., Ashush, H., Shav-Tal, Y., Ben-Nun, A., and Zipori, D. (1999) Adhesion molecules involved in the interactions between early T cells and mesenchymal bone marrow stromal cells. Exp. Hematol. 27: 834-844.

Brenner, T., Steinberger, I., Soffer, D., Beraud, E., Ben-Nun, A. and Loberboum-Galski, H. (1999) A novel antigen-toxin chimeric protein: myelin basic protein-pseudomonas exotoxin (MBP-PE 40) for treatment of experimental autoimmune encephalomyelitis. Immunol. Lett. 68: 403-410.

Gur, H., Mendel, I., Kerlero de Rosbo, N. and Ben-Nun, A. (1999) Effect of the bm12 class II mutation on proliferative and cytokine responses of encephalitogenic T cells in myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis. J. Autoimmun. 13: 3-10.

Kaye, J., Kerlero de Rosbo, N., Mendel, I., Flechter, S., Hoffman, M., Yust, I. and Ben-Nun, A. (1999) The central nervous system-specific myelin oligodendrocytic basic protein (MOBP) is encephalitogenic and a potential target antigen in multiple sclerosis. J. Neuroimmunol. 102: 189-198.

Zhong, M.-C., Cohen, L., Meshorer, A., Kerlero de Rosbo, N. and Ben-Nun, A. (2000) T-cells specific for soluble recombinant oligodendrocyte-specific protein induce severe clinical experimental autoimmune encephalomyelitis in H-2b and H-2s mice. J. Neuroimmunol. 105: 39-45.

Mancardi, G, 't Hart, B. A., Capello, E., Brok, H. P. M., Ben-Nun, A., Roccatagliata, L., Giunti, D., Gazzola, P., Dono, M., Kerlero de Rosbo, N., Colombo, M. and Uccelli, A. (2000) Restricted immune responses lead to CNS demyelination and axonal damage. J. Neuroimmunol. 107: 178-183.

Brok, H. P. M., Ucelli, A., Kerlero de Rosbo, N., Roccatagliata, L., de Groot, N. G., Capello, E., Bontrop, R. E., Nicolay, K., Mancardi, L., Ben-Nun, A. and 't Hart, B. A. (2000) Myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis in the common marmoset: Presentation of the immunodominant T cell epitope by the monomorphic MHC class II molecule Caja-DRB*W1201. J. Immunol. 165: 1093-1101.

Kerlero de Rosbo, N., Brok, H. P. M., Bauer, J., Kaye, J. F., 't Hart, B. A. and Ben-Nun, A. (2000) Rhesus monkeys are highly susceptible to experimental autoimmune encephalomyelitis induced with myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. Characterization of immunodominant T- and B-cell epitopes. J. Neuroimmunol. 110: 83-96.

Fisher, J., Levkovitch-Verbin, H., Schori, H., Yoles, E., Butovsky, O., Kaye, J. F., Ben-Nun, A., and Schwartz, M. (2001) Vaccination for neuroprotection in the mouse optic nerve: implications for optic neuropathies. J. Neurosci. 21: 136-42.

Latif, R., Kerlero de Rosbo, N., Amarant, T., Rappuoli, R., Sappler, G. and Ben-Nun, A. (2001) Reversal of the CD4+/CD8+ T-cell ratio in lymph node cells upon in vitro mitogenic stimulation by highly purified, water-soluble S3-S4 dimer of pertussis toxin. Infect. Immun. 69: 3073-3081.

Kerlero de Rosbo, N. and Ben-Nun, A. (2001) Humoral immune response and antibody-mediated brain injury. In "Brain diseases: Therapeutic strategies and repair" (O. Abramsky, A. Compston, A. Miller and G. Said, eds.), Martin Dunitz Ltd, London. Chapter 4.