lecture
Biomolecular Sciences

Genomic and functional approaches to modeling and targeting cancer aneuploidy announced

Prof. Uri Ben-David,Prof. Uri Ben-David
January 30, 2025
15:00 - 16:00

Aneuploidy, an imbalanced number of chromosomes or chromosome arms, is a genetic hallmark of cancer cells, yet aneuploidy remains a biological enigma and a missed opportunity for cancer therapy. My lab applies experimental and computational approaches to dissect the basic biology underlying cancer aneuploidy and to study its cellular consequences. In this seminar, I will focus on an unpublished study in which we discovered an important role for a recurrent aneuploidy in driving brain metastasis, revealed the underlying molecular mechanism, and identified a therapeutically-relevant cellular vulnerability that is associated with this common aneuploidy.