Molecular and Physiological Mechanisms Ion Channels Function

Prof. Eitan Reuveny

Biomolecular Sciences
Field
How neurons and cells regulate their electrical activities and calcium levels, from molecular insights to behavior
Research Focus
We are interested in deciphering questions spanning from molecular to behavioral levels

Ion flow through protein channels is one of the fundamental mechanisms of transmembrane signaling. Ion channels are involved in processes as diverse as development, hormone secretion, salt balance, and memory. Abnormalities in channel function underlie a wide range of neural, muscular, cardiovascular, and renal diseases. In order to understand the roles of ion channels under normal and pathological conditions, it is necessary to know how they regulate the flow of specific ions across the membrane and how other proteins affect their function. We address these questions by combining state-of-the-art electrophysiological, molecular, and imaging techniques, both in cultured cells and in native tissues. We also utilize natural animal neurotoxins as probes to study the biophysical properties of ion channels.

https://www.weizmann.ac.il/Biomolecular_Sciences/prof-eitan-reuveny

https://www.weizmann.ac.il/molneuro/eitan-reuveny

Field
How neurons and cells regulate their electrical activities and calcium levels, from molecular insights to behavior
Research Focus
We are interested in deciphering questions spanning from molecular to behavioral levels
Model Organism