Prof. Ofer Yizhar

Our lab studies the neural circuits that mediate goal-directed behavior. Animals learn to avoid risks and obtain rewards in a constantly changing environment. Many of these behaviors are mediated by circuits linking the prefrontal cortex (PFC) with subcortical brain regions. Studying these complex circuits presents a significant challenge. We combine optogenetics, behavioral, electrophysiological, and imaging-based readouts, to monitor and perturb the activity of neural circuits with the goal of better understanding their contribution to behavior. The lab develops innovative optogenetic approaches, and projects in the lab span a wide range, from molecular tool development, through detailed single-neuron analysis to macroscopic recordings and behavioral tasks in mice. Rotation students are typically mentored one-on-one by an experienced PhD student or postdoc, and are focused on a specific hypothesis or question to be addressed during the rotation. If you're interested in working with us, please visit our lab website, and email Ofer with your CV to schedule a meeting.