Department of Molecular Cell Biology

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Dr. Leeat Yankielowicz-Keren
Systems tissue pathology

Prof. Ravid Straussman
The study of resistance to anti-cancer therapy

Prof. Yonatan Stelzer
Epigenetics in development and disease

Prof. Gil Levkowitz
Linking genes, development and function of the zebrafish hypothalamus

Prof. Uri Alon
Systems biology and physics of behavior

Prof. Varda Rotter
The role of p53 in maintaining genomic plasticity

Prof. Eldad Tzahor
Cardiomyocyte cell-cycle control and dedifferentiation

Prof. Moshe Oren
Molecular and cellular biology of cancer

Prof. Elior Peles
Development of myelinated nerves

Prof. Yehiel Zick
Cross talk between insulin resistance, animal lectins and bone remodeling

Prof. Itay Tirosh
Tumor Systems Biology

Prof. Shalev Itzkovitz
Systems Biology of Mammalian Tissues

Prof. Sima Lev
Cell Signaling in Cancer Development and Metastasis

Prof. Eran Segal
Developing Computational Models for Personalized Medicine

Prof. Oren Schuldiner
Mechanisms of neuronal remodeling

Prof. Valery Krizhanovsky
Cellular senescence in tissue damage cancer and aging

Prof. Yardena Samuels
Melanoma Functional Genomics

Research in our department centers around molecular mechanisms that control different aspects of cell biology during development and disease states. Large part of the research focuses on cancer heterogeneity at both genomics, proteomics, and the cancer microbiome. We bring unique and innovative research approaches that shed light on organ function in vivo, such as heart, liver, pancreas, gut, and the nervous system. Studies at the department explore diverse cell biology topics including cell-cell communication, cytoskeletal organization; intracellular signaling; senescence, differentiation; physiology and metabolism.

Latest PUBLICATIONS

Sex-specific dietary habits and their association with weight change in healthy adults

Rein M., Elkan M., Godneva A., Dolev N. C. & Segal E. (2024), BMC Medicine. 22, 512

A Necessary Role for Cyclin D2 Induction During Colon Cancer Progression Mediated by L1

Saha A., Gavert N., Brabletz T. & Ben-Zeev A. (2024), Cells. 13, 21, 1810

Identification of gut microbiome features associated with host metabolic health in a large population-based cohort

Keshet A. & Segal E. (2024), Nature Communications. 15, 9358

The oncogenic axis YAP/MYC/EZH2 impairs PTEN tumor suppression activity enhancing lung tumorigenicity

Lo Sardo F., Turco C., Messina B., Sacconi A., Auciello F. R., Pulito C., Strano S., Lev S. & Blandino G. (2024), Cell Death Discovery. 10, 1, 452

TRIM46 Is Required for Microtubule Fasciculation In Vivo But Not Axon Specification or Axon Initial Segment Formation

Melton A. J., Palfini V. L., Ogawa Y., Oses Prieto J. A., Vainshtein A., Burlingame A. L., Peles E. & Rasband M. N. (2024), Journal of Neuroscience. 44, 42, e097624202

All publications

Events

Lecture / Seminar

Date: Sunday, November 24th, 2024

Hour: 9:00-10:00

Location: Wolfson Building for Biological Research

Lecture: Location matters - a spatial view of cellular interactions

Dr. Michal Polonsky

California Institute of Technology (Caltech)

Add the event Lecture / Seminar to calendar Shar the event Lecture / Seminar with Email
Lecture / Seminar

Date: Sunday, November 24th, 2024

Hour: 9:00-10:00

Location: Wolfson Building for Biological Research

Lecture: Location matters - a spatial view of cellular interactions

Dr. Michal Polonsky

California Institute of Technology (Caltech)

Add the event Lecture / Seminar to calendar Shar the event Lecture / Seminar with Email

See all events

news

Date: June 16, 2024

Congratulations to Prof. Yardena Samuels

President of EACR
Date: June 16, 2024

Congratulations to Dr. Osnat Bartok

Maxine Singer Prize for Outstanding Staff Scientists
Date: June 16, 2024

Congratulations to Prof. Itay Tirosh

Scientific Council Prize for Life Sciences