YBR221C PDB1 / SGDID:S000000425
SGD CSV
Disease Associated
Homo Sapiens
Mus Musculus
Danio Rerio
Drosophila Melanogaster
Caenorhabditis Elegans
Arabidopsis Thaliana
Escherichia Coli
Yeast Systematic Name Yeast Symbol SGDID Analog Name Analog Description EC Organism Disease Structure Uniprot Human ID Human Symbol HHsearch Probability HHsearch E_value HHsearch P_value HHsearch Score Flag Disease related Flag Homo sapiens Flag Mus musculus Flag Danio rerio Flag Drosophila melanogaster Flag Caenorhabditis elegans Flag Arabidopsis thaliana Flag Escherichia coli
YBR221C PDB1 SGDID:S000000425
tkt Cj1645
tkt Cj1645
 2.2.1.1 Campylobacter jejuni
3l84_a Q0P7Y3 99.80 2.30E-25 1.50E-29 213.80 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
kgd sucA MSMEG_5049 MSMEI_4922
Multifunctional 2-oxoglutarate metabolism enzyme (2-hydroxy-3-oxoadipate synthase) (HOA synthase) (HOAS) (EC 2.2.1.5) (2-oxoglutarate carboxy-lyase) (2-oxoglutarate decarboxylase) (Alpha-ketoglutarate decarboxylase) (KG decarboxylase) (KGD) (EC 4.1.1.71) (Alpha-ketoglutarate-glyoxylate carboligase) [Includes: 2-oxoglutarate dehydrogenase E1 component (ODH E1 component) (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase E1 component) (KDH E1 component); Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex E2 component) (ODH E2 component) (OGDC-E2) (Dihydrolipoamide succinyltransferase)]
 1.2.4.2,2.2.1.5,2.3.1.61,4.1.1.71, Mycolicibacterium smegmatis
2y0p_c A0R2B1 99.70 1.30E-21 8.50E-26 192.80 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
TKTC
Transketolase, chloroplastic (TK) (EC 2.2.1.1)
 2.2.1.1 Zea mays
1itz_b Q7SIC9 99.90 3.20E-27 2.10E-31 228.00 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
PDHB PHE1B
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)
 1.2.4.1 Homo sapiens
Pyruvate Dehydrogenase Phosphatase Deficiency,Marshall-Smith Syndrome,Lactic Acidosis,Pyruvate Dehydrogenase E1-Beta Deficiency,Pyruvate Dehydrogenase E1-Alpha Deficiency,Leigh Syndrome
 2ozl_d P11177 ENSG00000168291 PDHB 100.00 1.70E-37 1.10E-41 276.80 1 1 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
dxs yajP b0420 JW0410
1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS)
 2.2.1.7 Escherichia coli
2o1s_a P77488 99.90 1.10E-27 7.10E-32 229.90 0 0 0 0 0 0 0 1
YBR221C PDB1 SGDID:S000000425
TTHA0108
TTHA0108
 2.2.1.1 Thermus thermophilus
2e6k_a Q5SM35 99.90 3.00E-27 2.00E-31 227.70 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
sucA b0726 JW0715
2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase)
 1.2.4.2 Escherichia coli
2jgd_a P0AFG3 99.80 1.20E-23 8.00E-28 208.40 0 0 0 0 0 0 0 1
YBR221C PDB1 SGDID:S000000425
TKT
Transketolase (TK) (EC 2.2.1.1)
 2.2.1.1 Homo sapiens
Short Stature, Developmental Delay, And Congenital Heart Defects,Pfeiffer Syndrome,Lung Cancer Susceptibility 3,Leukemia, Chronic Myeloid,Cerebral Angioma,Colon Adenocarcinoma,Wernicke Encephalopathy,Cataract,Megaloblastic Anemia,Ovarian Cancer,Patent Foramen Ovale,Malignant Astrocytoma,Beriberi,Colorectal Cancer,Human Immunodeficiency Virus Type 1,Wernicke-Korsakoff Syndrome,Transaldolase Deficiency,Nasopharyngeal Carcinoma,Leukemia, Chronic Lymphocytic,Thiamine Deficiency Disease,Wet Beriberi,Dry Beriberi,Lung Cancer,3-Methylglutaconic Aciduria, Type Iii
 3mos_a P29401 ENSG00000163931 TKT 99.90 8.20E-30 5.40E-34 244.20 1 1 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
tktA FTT_1369c
tktA FTT_1369c
 2.2.1.1 Francisella tularensis
3kom_a Q5NF74 99.80 1.30E-25 8.90E-30 216.50 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
xfp
xfp
 4.1.2.- Bifidobacterium breve
3ahc_a D6PAH1 99.70 1.10E-22 7.10E-27 199.20 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
TKL1 YPR074C YP9499.29C
Transketolase 1 (TK 1) (EC 2.2.1.1)
 2.2.1.1 Saccharomyces cerevisiae
1tka_a P23254 99.80 3.60E-26 2.40E-30 221.00 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
LL1502 L138230
Probable phosphoketolase (EC 4.1.2.-)
 4.1.2.- Lactococcus lactis
6gua_a Q9CFH4 99.90 3.00E-27 2.00E-31 232.10 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
tktA LSL_1946
tktA LSL_1946
 2.2.1.1 Lactobacillus salivarius
4c7v_a Q1WQU8 99.90 4.30E-27 2.80E-31 227.40 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
TRK1 CHLRE_02g080200v5 CHLREDRAFT_141319
TRK1 CHLRE_02g080200v5 CHLREDRAFT_141319
 2.2.1.1 Chlamydomonas reinhardtii
5nd6_b A8IAN1 99.90 4.00E-27 2.60E-31 227.80 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
pdhB
Pyruvate dehydrogenase E1 component subunit beta (EC 1.2.4.1)
 1.2.4.1 Geobacillus stearothermophilus
1w85_b P21874 100.00 6.50E-35 4.30E-39 258.40 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
TKT
TKT
 2.2.1.1 Leishmania mexicana
1r9j_a Q8MPM3 99.90 1.80E-28 1.20E-32 237.00 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
tkt Rv1449c MTCY493.05
Transketolase (TK) (EC 2.2.1.1)
 2.2.1.1 Mycobacterium tuberculosis
3rim_d P9WG25 99.80 4.30E-24 2.80E-28 207.20 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
xfp
xfp
 4.1.2.22 Bifidobacterium longum
3ai7_f Q6R2Q7 99.80 2.10E-23 1.40E-27 204.60 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
aceE b0114 JW0110
Pyruvate dehydrogenase E1 component (PDH E1 component) (EC 1.2.4.1)
 1.2.4.1 Escherichia coli
2qtc_b P0AFG8 99.80 2.50E-23 1.60E-27 202.90 0 0 0 0 0 0 0 1
YBR221C PDB1 SGDID:S000000425
TKT TKT1 PICST_67105
Transketolase (TK) (EC 2.2.1.1)
 2.2.1.1 Scheffersomyces stipitis
5xvt_a P34736 99.90 1.00E-26 6.60E-31 225.30 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
TTHA0230
2-oxoisovalerate dehydrogenase subunit beta (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDH E1-beta)
 1.2.4.4 Thermus thermophilus
1um9_d Q5SLR3 100.00 1.50E-34 1.00E-38 256.10 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
bkdA2
2-oxoisovalerate dehydrogenase subunit beta (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDH E1-beta)
 1.2.4.4 Pseudomonas putida
1qs0_b P09061 99.90 9.00E-34 6.00E-38 252.60 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
tktA tkt b2935 JW5478
Transketolase 1 (TK 1) (EC 2.2.1.1)
 2.2.1.1 Escherichia coli
1qgd_b P27302 99.80 3.70E-26 2.40E-30 220.50 0 0 0 0 0 0 0 1
YBR221C PDB1 SGDID:S000000425
dxs DR_1475
1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS)
 2.2.1.7 Deinococcus radiodurans
2o1x_b Q9RUB5 99.90 2.80E-29 1.80E-33 241.00 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
tkt BTH_I1195
tkt BTH_I1195
 2.2.1.1 Burkholderia thailandensis
3uk1_b Q2SZA7 99.80 4.90E-26 3.20E-30 220.70 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
NGK_0759
NGK_0759
 2.2.1.1 Neisseria gonorrhoeae
5vrb_b B4RKU9 99.80 2.40E-26 1.60E-30 221.80 0 0 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
BCKDHB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDE1B) (BCKDH E1-beta)
 1.2.4.4 Homo sapiens
Citrullinemia, Classic,Amino Acid Metabolic Disorder,Urea Cycle Disorder,Branched-Chain Keto Acid Dehydrogenase Kinase Deficiency,Mitochondrial Complex Iii Deficiency, Nuclear Type 2,Intermediate Maple Syrup Urine Disease,Methylmalonic Acidemia,Glycine Encephalopathy,Propionic Acidemia,Isovaleric Acidemia,Nephrolithiasis/Osteoporosis, Hypophosphatemic, 2,Dihydrolipoamide Dehydrogenase Deficiency,Maple Syrup Urine Disease,Organic Acidemia,Ornithine Transcarbamylase Deficiency, Hyperammonemia Due To
 1olu_b P21953 ENSG00000083123 BCKDHB 100.00 8.80E-35 5.80E-39 259.30 1 1 0 0 0 0 0 0
YBR221C PDB1 SGDID:S000000425
PAE2646
PAE2646
 1.2.7.11 Pyrobaculum aerophilum
1ik6_a Q8ZUR7 100.00 3.60E-34 2.40E-38 257.30 0 0 0 0 0 0 0 0