| Yeast Systematic Name | Yeast Symbol | SGDID | Analog Name | Analog Description | EC | Organism | Disease | Structure | Uniprot | Human ID | Human Symbol | HHsearch Probability | HHsearch E_value | HHsearch P_value | HHsearch Score | Flag Disease related | Flag Homo sapiens | Flag Mus musculus | Flag Danio rerio | Flag Drosophila melanogaster | Flag Caenorhabditis elegans | Flag Arabidopsis thaliana | Flag Escherichia coli |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| YCR038C | BUD5 | SGDID:S000000634 | Rapgef4 Cgef2 Epac2 |
Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) |
Mus musculus | 4f7z_a | Q9EQZ6 | 99.90 | 1.10E-33 | 1.00E-37 | 334.00 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | ||||
| YCR038C | BUD5 | SGDID:S000000634 | SOS1 |
Son of sevenless homolog 1 (SOS-1) |
Homo sapiens | Heart Septal Defect,Heart Disease,Lung Cancer Susceptibility 3,Pulmonary Valve Stenosis,Atrial Heart Septal Defect,Neurofibromatosis-Noonan Syndrome,Neuroma,Hypertrophic Cardiomyopathy,Rasopathy,Noonan Syndrome-Like Disorder With Loose Anagen Hair,Keratosis Pilaris Atrophicans Faciei,Costello Syndrome,Joubert Syndrome 3,Neurofibromatosis, Type I,Villonodular Synovitis,Pilocytic Astrocytoma,Fibromatosis,Cryptorchidism, Unilateral Or Bilateral,Skin Granular Cell Tumor,Pseudo-Turner Syndrome,Noonan Syndrome 1,Noonan Syndrome And Noonan-Related Syndrome,Dilated Cardiomyopathy,Aortic Valve Disease 1,Gingival Hypertrophy,Noonan Syndrome-Like Disorder With Loose Anagen Hair 2,Adenocarcinoma,Neurofibromatosis,Breast Cancer,Patent Foramen Ovale,Colorectal Cancer,Gingival Overgrowth,Pulmonary Valve Disease,Hepatocellular Carcinoma,Cardiofaciocutaneous Syndrome 1,Embryonal Rhabdomyosarcoma,Rhabdomyosarcoma,Noonan Syndrome With Multiple Lentigines,Noonan Syndrome 3,Gingival Disease,Prostate Cancer,Keratosis Pilaris Atrophicans,Noonan Syndrome 4,Prostate Transitional Cell Carcinoma,Fibromatosis, Gingival, 1,Tetralogy Of Fallot,Epilepsy, Familial Temporal Lobe, 8,Patent Ductus Arteriosus 1,Ptosis,Juvenile Myelomonocytic Leukemia,Gingival Fibromatosis,Lung Cancer,Pulmonic Stenosis |
1nvu_s | Q07889 | 100.00 | 6.00E-45 | 5.20E-49 | 401.70 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YCR038C | BUD5 | SGDID:S000000634 | SH2D3C NSP3 UNQ272/PRO309/PRO34088 |
SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) |
Homo sapiens | Coronavirus Infectious Disease,Rasopathy,Noonan Syndrome 1,Eastern Equine Encephalitis,Western Equine Encephalitis,Blue Toe Syndrome,Noonan Syndrome 3,Noonan Syndrome 2,Sennetsu Fever,Zika Fever |
3t6g_a | Q8N5H7 | ENSG00000095370 | SH2D3C | 99.90 | 2.80E-27 | 2.60E-31 | 246.10 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| YCR038C | BUD5 | SGDID:S000000634 | Rgl2 Rab2l Rlf |
Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) |
Mus musculus | 4jgw_a | Q61193 | 100.00 | 2.40E-36 | 2.20E-40 | 331.30 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | ||||
| YCR038C | BUD5 | SGDID:S000000634 | SOS1 |
Son of sevenless homolog 1 (SOS-1) |
Homo sapiens | Heart Septal Defect,Heart Disease,Lung Cancer Susceptibility 3,Pulmonary Valve Stenosis,Atrial Heart Septal Defect,Neurofibromatosis-Noonan Syndrome,Neuroma,Hypertrophic Cardiomyopathy,Rasopathy,Noonan Syndrome-Like Disorder With Loose Anagen Hair,Keratosis Pilaris Atrophicans Faciei,Costello Syndrome,Joubert Syndrome 3,Neurofibromatosis, Type I,Villonodular Synovitis,Pilocytic Astrocytoma,Fibromatosis,Cryptorchidism, Unilateral Or Bilateral,Skin Granular Cell Tumor,Pseudo-Turner Syndrome,Noonan Syndrome 1,Noonan Syndrome And Noonan-Related Syndrome,Dilated Cardiomyopathy,Aortic Valve Disease 1,Gingival Hypertrophy,Noonan Syndrome-Like Disorder With Loose Anagen Hair 2,Adenocarcinoma,Neurofibromatosis,Breast Cancer,Patent Foramen Ovale,Colorectal Cancer,Gingival Overgrowth,Pulmonary Valve Disease,Hepatocellular Carcinoma,Cardiofaciocutaneous Syndrome 1,Embryonal Rhabdomyosarcoma,Rhabdomyosarcoma,Noonan Syndrome With Multiple Lentigines,Noonan Syndrome 3,Gingival Disease,Prostate Cancer,Keratosis Pilaris Atrophicans,Noonan Syndrome 4,Prostate Transitional Cell Carcinoma,Fibromatosis, Gingival, 1,Tetralogy Of Fallot,Epilepsy, Familial Temporal Lobe, 8,Patent Ductus Arteriosus 1,Ptosis,Juvenile Myelomonocytic Leukemia,Gingival Fibromatosis,Lung Cancer,Pulmonic Stenosis |
4nyi_s | Q07889 | ENSG00000115904 | SOS1 | 100.00 | 2.40E-38 | 2.20E-42 | 347.50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| YCR038C | BUD5 | SGDID:S000000634 | RASGRP1 RASGRP |
RAS guanyl-releasing protein 1 (Calcium and DAG-regulated guanine nucleotide exchange factor II) (CalDAG-GEFII) (Ras guanyl-releasing protein) |
Homo sapiens | Leukocyte Adhesion Deficiency, Type Iii,Combined Immunodeficiency,Autoimmune Lymphoproliferative Syndrome,Fibrosclerosis Of Breast,Lupus Erythematosus,Leukocyte Adhesion Deficiency, Type I,Bleeding Disorder, Platelet-Type, 18,Immunodeficiency 64,Systemic Lupus Erythematosus,Lymphoproliferative Syndrome |
4l9m_a | O95267 | ENSG00000172575 | RASGRP1 | 100.00 | 3.40E-41 | 3.10E-45 | 375.40 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| YCR038C | BUD5 | SGDID:S000000634 | RASGRP4 |
RAS guanyl-releasing protein 4 |
Homo sapiens | Mast-Cell Leukemia,Mastocytosis,Bleeding Disorder, Platelet-Type, 18,Asthma |
6axg_a | Q8TDF6 | ENSG00000171777 | RASGRP4 | 100.00 | 3.40E-41 | 3.00E-45 | 364.30 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| YCR038C | BUD5 | SGDID:S000000634 | RASGRP2 CDC25L MCG7 |
RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) (Cdc25-like protein) (hCDC25L) (F25B3.3 kinase-like protein) |
Homo sapiens | Leukocyte Adhesion Deficiency, Type Iii,Hemorrhagic Disease,Combined Immunodeficiency,Glanzmann Thrombasthenia,Leukocyte Adhesion Deficiency, Type I,Thrombocytopenia,Bleeding Disorder, Platelet-Type, 18,Stormorken Syndrome |
6axf_g | Q7LDG7 | ENSG00000068831 | RASGRP2 | 100.00 | 2.40E-39 | 2.20E-43 | 346.20 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| YCR038C | BUD5 | SGDID:S000000634 | RALGPS1 KIAA0351 RALGEF2 |
Ras-specific guanine nucleotide-releasing factor RalGPS1 (Ral GEF with PH domain and SH3-binding motif 1) (Ral guanine nucleotide exchange factor 2) (RalGEF 2) (RalA exchange factor RalGPS1) |
Homo sapiens | Developmental And Epileptic Encephalopathy 4 |
3qxl_a | Q5JS13 | ENSG00000136828 | RALGPS1 | 99.90 | 9.20E-32 | 8.30E-36 | 273.40 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| YCR038C | BUD5 | SGDID:S000000634 | Rasgrf1 Cdc25 Grf1 |
Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (CDC25Mm) (Guanine nucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchange factor CDC25) |
Mus musculus | 2ije_s | P27671 | 99.90 | 9.10E-32 | 8.40E-36 | 267.20 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |