YDL042C SIR2 / SGDID:S000002200
SGD CSV
Disease Associated
Homo Sapiens
Mus Musculus
Danio Rerio
Drosophila Melanogaster
Caenorhabditis Elegans
Arabidopsis Thaliana
Escherichia Coli
Yeast Systematic Name Yeast Symbol SGDID Analog Name Analog Description EC Organism Disease Structure Uniprot Human ID Human Symbol HHsearch Probability HHsearch E_value HHsearch P_value HHsearch Score Flag Disease related Flag Homo sapiens Flag Mus musculus Flag Danio rerio Flag Drosophila melanogaster Flag Caenorhabditis elegans Flag Arabidopsis thaliana Flag Escherichia coli
YDL042C SIR2 SGDID:S000002200
SIRT2 SIR2L SIR2L2
NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2)
 2.3.1.286 Homo sapiens
Monckeberg Arteriosclerosis,Wallerian Degeneration,Anoxia,Mood Disorder,Hutchinson-Gilford Progeria Syndrome,Disease Of Mental Health,Body Mass Index Quantitative Trait Locus 11,Type 2 Diabetes Mellitus
 1j8f_a Q8IXJ6 100.00 1.20E-53 9.10E-58 439.40 1 1 0 0 0 0 0 0
YDL042C SIR2 SGDID:S000002200
SIRT2 SIR2L SIR2L2
NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2)
 2.3.1.286 Homo sapiens
Monckeberg Arteriosclerosis,Wallerian Degeneration,Anoxia,Mood Disorder,Hutchinson-Gilford Progeria Syndrome,Disease Of Mental Health,Body Mass Index Quantitative Trait Locus 11,Type 2 Diabetes Mellitus
 4rmh_a Q8IXJ6 ENSG00000068903 SIRT2 100.00 1.00E-42 8.90E-47 355.50 1 1 0 0 0 0 0 0
YDL042C SIR2 SGDID:S000002200
SIR2RP1 LINF_260007100 LINJ_26_0200
SIR2RP1 LINF_260007100 LINJ_26_0200
 2.3.1.286 Leishmania infantum
5ol0_a Q8I6E4 100.00 8.20E-44 7.00E-48 367.30 0 0 0 0 0 0 0 0
YDL042C SIR2 SGDID:S000002200
cobB sir2 TM_0490
NAD-dependent protein deacetylase (EC 2.3.1.286) (Regulatory protein SIR2 homolog) (Sir2Tm)
 2.3.1.286 Thermotoga maritima
1yc5_a Q9WYW0 100.00 5.20E-40 4.70E-44 324.30 0 0 0 0 0 0 0 0
YDL042C SIR2 SGDID:S000002200
SIR2 MAR1 YDL042C D2714
NAD-dependent histone deacetylase SIR2 (EC 2.3.1.286) (Regulatory protein SIR2) (Silent information regulator 2)
 2.3.1.286 Saccharomyces cerevisiae
2hjh_b P06700 100.00 9.80E-58 8.30E-62 477.70 0 0 0 0 0 0 0 0
YDL042C SIR2 SGDID:S000002200
SIRT3 SIR2L3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (hSIRT3) (EC 2.3.1.286) (Regulatory protein SIR2 homolog 3) (SIR2-like protein 3)
 2.3.1.286 Homo sapiens
Non-Alcoholic Fatty Liver Disease,Diabetes Mellitus,Monckeberg Arteriosclerosis,Skin Amelanotic Melanoma,Optic Atrophy 1,Disease Of Mental Health,Body Mass Index Quantitative Trait Locus 11,Hypertension, Essential,Mitochondrial Complex I Deficiency, Nuclear Type 1,Aging,Lung Cancer
 4bn4_a Q9NTG7 ENSG00000142082 SIRT3 100.00 2.10E-41 1.80E-45 341.70 1 1 0 0 0 0 0 0
YDL042C SIR2 SGDID:S000002200
cobB1 AF_1676
NAD-dependent protein deacylase 1 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 1) (SIR2-Af1)
 2.3.1.286 Archaeoglobus fulgidus
1m2h_a O28597 100.00 1.10E-37 1.00E-41 307.70 0 0 0 0 0 0 0 0
YDL042C SIR2 SGDID:S000002200
SIRT6 SIR2L6
NAD-dependent protein deacetylase sirtuin-6 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 6) (SIR2-like protein 6)
 2.3.1.286 Homo sapiens
Lethal Brain And Heart Developmental Defects,Monckeberg Arteriosclerosis,Osteoporosis,Premature Menopause,Mood Disorder,Hutchinson-Gilford Progeria Syndrome,Disease Of Mental Health,Body Mass Index Quantitative Trait Locus 11,Type 2 Diabetes Mellitus,Aging
 3zg6_a Q8N6T7 ENSG00000077463 SIRT6 100.00 5.70E-39 4.90E-43 327.00 1 1 0 0 0 0 0 0
YDL042C SIR2 SGDID:S000002200
Sir2A Sir2 PF13_0152
NAD-dependent protein deacylase Sir2A (EC 2.3.1.-) (Regulatory protein SIR2 homolog A)
 2.3.1.- Plasmodium falciparum
3jwp_a Q8IE47 100.00 1.50E-37 1.40E-41 309.80 0 0 0 0 0 0 0 0
YDL042C SIR2 SGDID:S000002200
sirt4 TGas015j14.1-001
sirt4 TGas015j14.1-001
 2.3.1.-,2.3.1.286, Xenopus tropicalis
5oj7_a Q28CB4 100.00 9.40E-37 8.30E-41 307.50 0 0 0 0 0 0 0 0
YDL042C SIR2 SGDID:S000002200
SIRT5 SIR2L5
NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 2.3.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)
 2.3.1.- Homo sapiens
Monckeberg Arteriosclerosis,Disease Of Mental Health,Body Mass Index Quantitative Trait Locus 11
 4g1c_b Q9NXA8 ENSG00000124523 SIRT5 100.00 5.60E-38 5.10E-42 312.10 1 1 0 0 0 0 0 0
YDL042C SIR2 SGDID:S000002200
cobB2 Sir2Af2 AF_0112
NAD-dependent protein deacylase 2 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 2) (SIR2-Af2)
 2.3.1.286 Archaeoglobus fulgidus
1s7g_c O30124 100.00 1.40E-38 1.30E-42 314.10 0 0 0 0 0 0 0 0
YDL042C SIR2 SGDID:S000002200
SIRT1 SIR2L1
NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
 2.3.1.286 Homo sapiens
Glucose Metabolism Disease,Retinitis Pigmentosa,Non-Alcoholic Fatty Liver Disease,Overnutrition,Inherited Metabolic Disorder,Diabetes Mellitus,Non-Alcoholic Steatohepatitis,Lipid Storage Disease,Alzheimer Disease,Myocardial Infarction,Osteonecrosis Of The Jaw,Major Depressive Disorder,Stroke, Ischemic,Amyotrophic Lateral Sclerosis 1,Primary Biliary Cholangitis,Leukemia, Acute Myeloid,Periapical Periodontitis,Cataract,Optic Atrophy 1,Osteoporosis,Cockayne Syndrome,Aplastic Anemia,Burkitt Lymphoma,Breast Cancer,Colorectal Cancer,Peripheral Nervous System Disease,Age-Related Hearing Loss,Lipomatosis,Mood Disorder,Hutchinson-Gilford Progeria Syndrome,Prostate Cancer,Disease Of Mental Health,Body Mass Index Quantitative Trait Locus 11,Type 2 Diabetes Mellitus,Hyperphosphatemia,Renal Fibrosis,Huntington Disease,Hypertension, Essential,Acquired Metabolic Disease,Nijmegen Breakage Syndrome,Systemic Lupus Erythematosus,Inguinal Hernia,Medulloblastoma,Aging,Progesterone Resistance
 4kxq_a Q96EB6 ENSG00000096717 SIRT1 100.00 2.10E-38 1.80E-42 318.90 1 1 0 0 0 0 0 0