| Yeast Systematic Name | Yeast Symbol | SGDID | Analog Name | Analog Description | EC | Organism | Disease | Structure | Uniprot | Human ID | Human Symbol | HHsearch Probability | HHsearch E_value | HHsearch P_value | HHsearch Score | Flag Disease related | Flag Homo sapiens | Flag Mus musculus | Flag Danio rerio | Flag Drosophila melanogaster | Flag Caenorhabditis elegans | Flag Arabidopsis thaliana | Flag Escherichia coli |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| YHR079C | IRE1 | SGDID:S000001121 | CAMK2D CAMKD |
Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) |
2.7.11.17 | Homo sapiens | Dilated Cardiomyopathy,Cardiomyopathy, Dilated, 1dd |
2wel_a | Q13557 | ENSG00000145349 | CAMK2D | 99.60 | 2.30E-20 | 3.10E-24 | 180.30 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YHR079C | IRE1 | SGDID:S000001121 | TTK MPS1 MPS1L1 |
Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) |
2.7.12.1 | Homo sapiens | Polyposis Syndrome, Hereditary Mixed, 1,Hereditary Mixed Polyposis Syndrome,Osteogenesis Imperfecta, Type Xvii,Lung Cancer,Mosaic Variegated Aneuploidy Syndrome 1,Pancreatic Cancer |
4js8_a | P33981 | ENSG00000112742 | TTK | 99.70 | 1.20E-21 | 1.70E-25 | 178.30 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YHR079C | IRE1 | SGDID:S000001121 | MAP4K4 HGK KIAA0687 NIK |
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase) |
2.7.11.1 | Homo sapiens | Arteriovenous Malformations Of The Brain,Autosomal Recessive Distal Hereditary Motor Neuronopathy,Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1,Theileriasis |
4zp5_b | O95819 | ENSG00000071054 | MAP4K4 | 99.60 | 1.60E-20 | 2.30E-24 | 176.60 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YHR079C | IRE1 | SGDID:S000001121 | MAP4K1 HPK1 |
Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) |
2.7.11.1 | Homo sapiens | 6cqd_b | Q92918 | ENSG00000104814 | MAP4K1 | 99.60 | 1.90E-20 | 2.60E-24 | 176.40 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| YHR079C | IRE1 | SGDID:S000001121 | CHEK1 CHK1 |
Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1) |
2.7.11.1 | Homo sapiens | Tongue Carcinoma,Neuroblastoma,Leukemia, Acute Myeloid,Sporadic Breast Cancer,Cerebellar Disease,Ovarian Cancer,Breast Cancer,Colorectal Cancer,Microcephaly,Xeroderma Pigmentosum, Variant Type,Fanconi Anemia, Complementation Group A,Retinoblastoma,Esophageal Cancer,Seckel Syndrome,Mantle Cell Lymphoma,Pigmentary Disorder, Reticulate, With Systemic Manifestations, X-Linked,Ovarian Clear Cell Carcinoma,Autosomal Recessive Cerebellar Ataxia,Li-Fraumeni Syndrome,Ataxia-Telangiectasia,Medulloblastoma,Primary Autosomal Recessive Microcephaly,Lung Cancer |
2e9v_b | O14757 | ENSG00000149554 | CHEK1 | 99.60 | 1.20E-20 | 1.70E-24 | 172.30 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YHR079C | IRE1 | SGDID:S000001121 | RPS6KA1 MAPKAPK1A RSK1 |
Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) |
2.7.11.1 | Homo sapiens | Tuberous Sclerosis 2,Tuberous Sclerosis,Cardiomyopathy, Familial Hypertrophic, 4,Disease Of Mental Health,Adrenal Cortical Adenocarcinoma,Dyskeratosis Congenita, Autosomal Dominant 3,Tuberous Sclerosis 1,Coffin-Lowry Syndrome,Polycystic Kidney Disease 3 With Or Without Polycystic Liver Disease |
4nif_d | Q15418 | ENSG00000117676 | RPS6KA1 | 99.60 | 1.50E-20 | 2.00E-24 | 183.80 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YHR079C | IRE1 | SGDID:S000001121 | Camk1 |
Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) |
2.7.11.17 | Rattus norvegicus | 1a06_a | Q63450 | 99.90 | 1.80E-27 | 2.00E-31 | 243.10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YHR079C | IRE1 | SGDID:S000001121 | RNASEL RNS4 |
2-5A-dependent ribonuclease (2-5A-dependent RNase) (EC 3.1.26.-) (Ribonuclease 4) (Ribonuclease L) (RNase L) |
3.1.26.- | Homo sapiens | Viral Infectious Disease,Myalgic Encephalomyelitis/Chronic Fatigue Syndrome,Rasopathy,Dengue Disease,Prostate Cancer, Hereditary, 1,West Nile Encephalitis,West Nile Fever,Noonan Syndrome 1,Chronic Fatigue Syndrome,Herpes Simplex,West Nile Virus Infection,Vaccinia,Prostate Cancer,Lynch Syndrome,La Crosse Encephalitis,Noonan Syndrome 2,Paralytic Poliomyelitis,Aicardi-Goutieres Syndrome,Immune Deficiency Disease,Microphthalmia With Limb Anomalies |
4oau_c | Q05823 | ENSG00000135828 | RNASEL | 99.90 | 2.40E-27 | 3.20E-31 | 252.80 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YHR079C | IRE1 | SGDID:S000001121 | IRE1 ERN1 YHR079C |
Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] |
2.7.11.1 | Saccharomyces cerevisiae | 2be1_a | P32361 | 99.90 | 2.40E-29 | 2.90E-33 | 252.50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YHR079C | IRE1 | SGDID:S000001121 | yopO ypkA ERS008652_04012 |
yopO ypkA ERS008652_04012 |
2.7.11.1 | Yersinia enterocolitica | 5ce3_d | Q93KQ6 | 99.80 | 3.20E-24 | 3.30E-28 | 241.30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YHR079C | IRE1 | SGDID:S000001121 | ERN1 IRE1 |
Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] |
2.7.11.1 | Homo sapiens | Retinitis Pigmentosa,Non-Alcoholic Fatty Liver Disease,Prion Disease,Alzheimer Disease,Ovarian Cancer,Wolfram Syndrome,Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus,Huntington Disease |
6hx1_a | O75460 | ENSG00000178607 | ERN1 | 100.00 | 1.80E-35 | 2.30E-39 | 300.90 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YHR079C | IRE1 | SGDID:S000001121 | DYRK2 |
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) |
2.7.12.1 | Homo sapiens | 4azf_a | Q92630 | ENSG00000127334 | DYRK2 | 99.60 | 2.70E-20 | 3.40E-24 | 189.40 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| YHR079C | IRE1 | SGDID:S000001121 | STT7 MICPUN_107392 |
STT7 MICPUN_107392 |
Micromonas commoda | 4ix3_b | C1EBN1 | 99.60 | 2.00E-20 | 2.90E-24 | 175.30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |