| Yeast Systematic Name | Yeast Symbol | SGDID | Analog Name | Analog Description | EC | Organism | Disease | Structure | Uniprot | Human ID | Human Symbol | HHsearch Probability | HHsearch E_value | HHsearch P_value | HHsearch Score | Flag Disease related | Flag Homo sapiens | Flag Mus musculus | Flag Danio rerio | Flag Drosophila melanogaster | Flag Caenorhabditis elegans | Flag Arabidopsis thaliana | Flag Escherichia coli |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| YJR036C | HUL4 | SGDID:S000003797 | UBE3A E6AP EPVE6AP HPVE6A |
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54) |
2.3.2.26 | Homo sapiens | Chromosomal Disease,Seizure Disorder,Epilepsy,Angelman Syndrome Due To A Point Mutation,Angelman Syndrome Due To Imprinting Defect In 15q11-Q13,Kleefstra Syndrome,Vaginal Cancer,Gene Duplication Disease,Angelman Syndrome,Chromosome 15q11-Q13 Duplication Syndrome,Congenital Nervous System Abnormality,Angelman Syndrome Due To Paternal Uniparental Disomy Of Chromosome 15,Angelman Syndrome Due To Maternal 15q11q13 Deletion,Rectal Disease,Papilloma,Oropharynx Cancer,Penis Squamous Cell Carcinoma,Childhood Disintegrative Disease,Anus Disease,Herpangina,Microcephaly,Anus Cancer,Epidermodysplasia Verruciformis 1,Sotos Syndrome 1,Alacrima, Achalasia, And Mental Retardation Syndrome,Anogenital Venereal Wart,Prader-Willi Syndrome,Disease Of Mental Health,Lubs X-Linked Mental Retardation Syndrome,Cervical Cancer,Penile Disease,Fragile X Syndrome,Combined Oxidative Phosphorylation Deficiency 20,Pitt-Hopkins Syndrome,Mowat-Wilson Syndrome,Beckwith-Wiedemann Syndrome,Chromosome 15q13.3 Deletion Syndrome,Phelan-Mcdermid Syndrome,Early Infantile Epileptic Encephalopathy,Huntington Disease,Specific Developmental Disorder,Pervasive Developmental Disorder,Autism Spectrum Disorder,Rett Syndrome,Autism,Christianson Syndrome |
1c4z_c | Q05086 | ENSG00000114062 | UBE3A | 100.00 | 1.50E-57 | 1.60E-61 | 489.20 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YJR036C | HUL4 | SGDID:S000003797 | RSP5 MDP1 NPI1 YER125W SYGP-ORF41 |
E3 ubiquitin-protein ligase RSP5 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase RSP5) (Reverses SPT-phenotype protein 5) |
2.3.2.26 | Saccharomyces cerevisiae | 5hpl_a | P39940 | 100.00 | 3.80E-58 | 3.90E-62 | 500.70 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YJR036C | HUL4 | SGDID:S000003797 | SMURF2 |
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2) |
2.3.2.26 | Homo sapiens | 1zvd_a | Q9HAU4 | ENSG00000108854 | SMURF2 | 100.00 | 3.80E-58 | 3.90E-62 | 500.00 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| YJR036C | HUL4 | SGDID:S000003797 | UBE3A E6AP EPVE6AP HPVE6A |
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54) |
2.3.2.26 | Homo sapiens | Chromosomal Disease,Seizure Disorder,Epilepsy,Angelman Syndrome Due To A Point Mutation,Angelman Syndrome Due To Imprinting Defect In 15q11-Q13,Kleefstra Syndrome,Vaginal Cancer,Gene Duplication Disease,Angelman Syndrome,Chromosome 15q11-Q13 Duplication Syndrome,Congenital Nervous System Abnormality,Angelman Syndrome Due To Paternal Uniparental Disomy Of Chromosome 15,Angelman Syndrome Due To Maternal 15q11q13 Deletion,Rectal Disease,Papilloma,Oropharynx Cancer,Penis Squamous Cell Carcinoma,Childhood Disintegrative Disease,Anus Disease,Herpangina,Microcephaly,Anus Cancer,Epidermodysplasia Verruciformis 1,Sotos Syndrome 1,Alacrima, Achalasia, And Mental Retardation Syndrome,Anogenital Venereal Wart,Prader-Willi Syndrome,Disease Of Mental Health,Lubs X-Linked Mental Retardation Syndrome,Cervical Cancer,Penile Disease,Fragile X Syndrome,Combined Oxidative Phosphorylation Deficiency 20,Pitt-Hopkins Syndrome,Mowat-Wilson Syndrome,Beckwith-Wiedemann Syndrome,Chromosome 15q13.3 Deletion Syndrome,Phelan-Mcdermid Syndrome,Early Infantile Epileptic Encephalopathy,Huntington Disease,Specific Developmental Disorder,Pervasive Developmental Disorder,Autism Spectrum Disorder,Rett Syndrome,Autism,Christianson Syndrome |
1c4z_a | Q05086 | 100.00 | 7.90E-66 | 7.40E-70 | 563.50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| YJR036C | HUL4 | SGDID:S000003797 | NEDD4L KIAA0439 NEDL3 |
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) |
2.3.2.26 | Homo sapiens | Dyslexia,Renal Tubular Transport Disease,Periventricular Nodular Heterotopia 7,Long Qt Syndrome,Disease Of Mental Health,Liddle Syndrome 1,Brugada Syndrome,Periventricular Nodular Heterotopia,Hypertension, Essential,Photosensitive Epilepsy,Pseudohypoaldosteronism, Type I, Autosomal Recessive |
2oni_a | Q96PU5 | ENSG00000049759 | NEDD4L | 100.00 | 2.20E-58 | 2.20E-62 | 506.50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YJR036C | HUL4 | SGDID:S000003797 | HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272 |
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) |
2.3.2.26 | Homo sapiens | Angelman Syndrome,Blepharophimosis,Trigonocephaly-Broad Thumbs Syndrome,X-Linked Intellectual Disability, Turner Type,Microcephaly,Alacrima, Achalasia, And Mental Retardation Syndrome,Disease Of Mental Health,Mental Retardation, X-Linked, Syndromic, Turner Type,Syndromic X-Linked Intellectual Disability,Trigonocephaly With Short Stature And Developmental Delay,Syndromic X-Linked Intellectual Disability Turner Type |
3g1n_a | Q7Z6Z7 | ENSG00000086758 | HUWE1 | 100.00 | 5.40E-60 | 5.50E-64 | 518.00 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YJR036C | HUL4 | SGDID:S000003797 | NEDD4 KIAA0093 NEDD4-1 PIG53 |
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4) |
2.3.2.26 | Homo sapiens | Charcot-Marie-Tooth Disease, Demyelinating, Type 1c,Gastric Cardia Carcinoma,Gastric Cardia Adenocarcinoma,Cowden Syndrome,Cowden Syndrome 1,Renal Tubular Transport Disease,Lassa Fever,Pseudohypoaldosteronism,Cockayne Syndrome,Charcot-Marie-Tooth Disease,Parkinson Disease, Late-Onset,Parkinson Disease 1, Autosomal Dominant,Spinocerebellar Ataxia 30,Spinocerebellar Ataxia 31,Proteus Syndrome,Liddle Syndrome 1,Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive,Hypertension, Essential,Keloid Formation |
5c91_a | P46934 | ENSG00000069869 | NEDD4 | 100.00 | 7.60E-59 | 7.70E-63 | 505.40 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YJR036C | HUL4 | SGDID:S000003797 | WWP2 |
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2) |
2.3.2.26 | Homo sapiens | Cowden Syndrome,Spondyloepiphyseal Dysplasia, Nishimura Type |
5tj7_d | O00308 | ENSG00000198373 | WWP2 | 100.00 | 6.80E-61 | 6.90E-65 | 532.50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YJR036C | HUL4 | SGDID:S000003797 | WWP1 |
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1) |
2.3.2.26 | Homo sapiens | Spastic Paraplegia 20, Autosomal Recessive,Liddle Syndrome 1,Breast Mucinous Carcinoma |
5hps_a | Q9H0M0 | ENSG00000123124 | WWP1 | 100.00 | 4.50E-58 | 4.50E-62 | 500.60 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YJR036C | HUL4 | SGDID:S000003797 | ITCH |
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1) |
2.3.2.26 | Homo sapiens | Autoimmune Disease,Influenza,Itch E3 Ubiquitin Ligase Deficiency,Spastic Paraplegia 20, Autosomal Recessive,Autoimmune Disease, Multisystem, With Facial Dysmorphism |
5c7m_a | Q96J02 | ENSG00000078747 | ITCH | 100.00 | 3.10E-59 | 3.10E-63 | 513.60 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |