| Yeast Systematic Name | Yeast Symbol | SGDID | Analog Name | Analog Description | EC | Organism | Disease | Structure | Uniprot | Human ID | Human Symbol | HHsearch Probability | HHsearch E_value | HHsearch P_value | HHsearch Score | Flag Disease related | Flag Homo sapiens | Flag Mus musculus | Flag Danio rerio | Flag Drosophila melanogaster | Flag Caenorhabditis elegans | Flag Arabidopsis thaliana | Flag Escherichia coli |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| YKR080W | MTD1 | SGDID:S000001788 | MTHFD1 MTHFC MTHFD |
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] |
1.5.1.5,3.5.4.9,6.3.4.3 | Homo sapiens | Heart Disease,Physical Disorder,Spina Bifida Occulta,Childhood Acute Lymphocytic Leukemia,Placental Choriocarcinoma,Placental Abruption,Neural Tube Defects, Folate-Sensitive,Combined Immunodeficiency,Choline Deficiency Disease,Megaloblastic Anemia,Upper Thoracic Spina Bifida Cystica,Cervicothoracic Spina Bifida Cystica,Cervical Spina Bifida Cystica,Lumbosacral Spina Bifida Cystica,Thoracolumbosacral Spina Bifida Cystica,Total Spina Bifida Cystica,Upper Thoracic Spina Bifida Aperta,Thoracolumbosacral Spina Bifida Aperta,Lumbosacral Spina Bifida Aperta,Cervical Spina Bifida Aperta,Cervicothoracic Spina Bifida Aperta,Total Spina Bifida Aperta,Colorectal Cancer,Tethered Spinal Cord Syndrome,Combined Immunodeficiency And Megaloblastic Anemia With Or Without Hyperhomocysteinemia,Cleft Palate, Isolated,Cutis Laxa, Autosomal Dominant 1,Neural Tube Defects,Orofacial Cleft,Cutis Laxa, Autosomal Dominant 2,Frank-Ter Haar Syndrome,Cutis Laxa, Autosomal Dominant 3,Anencephaly,Myelomeningocele,Omphalocele |
1a4i_a | P11586 | ENSG00000100714 | MTHFD1 | 100.00 | 1.20E-38 | 8.20E-43 | 270.50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YKR080W | MTD1 | SGDID:S000001788 | LMJF_26_0320 |
LMJF_26_0320 |
3.5.4.9 | Leishmania major | 4a26_a | Q4Q9F9 | 100.00 | 3.80E-39 | 2.50E-43 | 273.70 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YKR080W | MTD1 | SGDID:S000001788 | folD HMPREF0010_02058 |
folD HMPREF0010_02058 |
1.5.1.5,3.5.4.9, | Acinetobacter baumannii | 4b4u_a | D0CBC8 | 100.00 | 9.00E-40 | 5.90E-44 | 276.80 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YKR080W | MTD1 | SGDID:S000001788 | folD Ta0898 |
Bifunctional protein FolD [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] |
1.5.1.5,3.5.4.9, | Thermoplasma acidophilum | 3ngx_a | Q05213 | 100.00 | 5.30E-36 | 3.50E-40 | 251.20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YKR080W | MTD1 | SGDID:S000001788 | folD Rv3356c |
Bifunctional protein FolD [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] |
1.5.1.5,3.5.4.9, | Mycobacterium tuberculosis | 2c2x_b | P9WG81 | 100.00 | 2.10E-38 | 1.40E-42 | 266.60 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YKR080W | MTD1 | SGDID:S000001788 | MTHFD2 NMDMC |
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] |
1.5.1.15,3.5.4.9, | Homo sapiens | Cutis Laxa, Autosomal Dominant 1,Neural Tube Defects,Cutis Laxa, Autosomal Dominant 2,Cutis Laxa, Autosomal Dominant 3,Mitochondrial Complex I Deficiency, Nuclear Type 1 |
5tc4_a | P13995 | ENSG00000065911 | MTHFD2 | 100.00 | 1.30E-39 | 8.80E-44 | 277.80 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YKR080W | MTD1 | SGDID:S000001788 | Tb927.7.1600 |
Tb927.7.1600 |
1.5.1.5 | Trypanosoma brucei | 4cjx_b | Q57WP0 | 100.00 | 1.50E-39 | 9.60E-44 | 277.90 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YKR080W | MTD1 | SGDID:S000001788 | folD XALc_1581 |
folD XALc_1581 |
1.5.1.5,3.5.4.9, | Xanthomonas albilineans | 5nhs_a | D2UAL4 | 100.00 | 1.10E-38 | 7.20E-43 | 270.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YKR080W | MTD1 | SGDID:S000001788 | folD Cj0855 |
Bifunctional protein FolD [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] |
1.5.1.5,3.5.4.9, | Campylobacter jejuni | 3p2o_a | Q0PA35 | 100.00 | 3.10E-35 | 2.10E-39 | 248.20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YKR080W | MTD1 | SGDID:S000001788 | folD HPG27_536 |
folD HPG27_536 |
1.5.1.5,3.5.4.9, | Helicobacter pylori | 6ape_a | B5Z6U8 | 100.00 | 4.70E-38 | 3.10E-42 | 266.30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YKR080W | MTD1 | SGDID:S000001788 | MTD1 YKR080W YKR400 |
Methylenetetrahydrofolate dehydrogenase [NAD(+)] (EC 1.5.1.15) |
1.5.1.15 | Saccharomyces cerevisiae | 1edz_a | Q02046 | 100.00 | 6.20E-45 | 4.10E-49 | 312.40 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YKR080W | MTD1 | SGDID:S000001788 | folD ads b0529 JW0518 |
Bifunctional protein FolD [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] |
1.5.1.5,3.5.4.9, | Escherichia coli | 1b0a_a | P24186 | 100.00 | 6.00E-39 | 4.00E-43 | 270.60 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | |||
| YKR080W | MTD1 | SGDID:S000001788 | folD FTT_0892 |
Bifunctional protein FolD [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] |
1.5.1.5,3.5.4.9, | Francisella tularensis | 3l07_b | Q5NGF3 | 100.00 | 4.10E-38 | 2.70E-42 | 265.40 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |