March 28, 1994 - March 28, 2027

  • Date:25TuesdaySeptember 2018

    “From “Crowdoxidation” to Organoselenide C-E Bond Cleavage: Enlisting the help of Chalcogens in Analysis of Biological Systems Trough Novel Probe Design”

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    Time
    11:00 - 12:00
    Location
    Helen and Milton A. Kimmelman Building
    Dov Elad Room
    Lecturer
    Prof. David G. Churchill
    Department of Chemistry, KAIST
    Organizer
    Department of Molecular Chemistry and Materials Science
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    AbstractShow full text abstract about Our laboratory is studying small molecule selenium-containin...»
    Our laboratory is studying small molecule selenium-containing organic and organometallic systems for their potential selective fluorescence imaging properties; our goal is to eventually probing aspects of neurodegenerative disease and disease models in a more precise way based on the present state of the art. Like some transition metals, heavier chalcogens also have capacity for redox with common changes in their valence state from 2 to 4 and from 4 to 6 being possible. Also, reduced heavier chalcogenide centers such as selenium have the ability for metal chelation. The optical characteristics are sometimes profoundly changed by an additional 2+ oxidation state at e.g. a selenium atom when the Se is in an aromatic ring or as a direct aryl substituent to a fluorogenic framework. While the atom which can become chemically oxidized may be contained within an aromatic ring, or present as a substituent, there is also the possibility for C-E bond rupture; C-Se bond c! leavage was studied with selective biothiol detection in mind and therefore, the extent of Se-C rupture possible is a design parameter in these small fluorogenic molecules and its study is ongoing. Sulfur chemistry in biology is dynamic and diverse; therefore, we are hereby exploring the extent of versatility available for selenium in small synthetic molecules in the context of biology, and specifically, towards better understanding and addressing aging and neurodegenerative disease research.
    Lecture