9:00 Opening remarks Session 1: Evolution (Chair - Ilan Samish) 9:05 Nick V. Grishin. Dramatic Evolutionary Changes in Protein Structures. (Invited Presentation) 9:35 Sandra Maguid, Gustavo Parisi, Sebastian Fernandez-Alberti, Julian Echave. Sequence-structure-flexibility relationship in protein evolution. (more) 9:55 Maria S. Fornasari, Gustavo Parisi. Protein Structure Diversity and Sequence Divergence in Evolution. (more) 10:15 Diana K Ekman, Åsa K Björklund, Arne Elofsson. Evolutionary History of Multi-Domain Proteins. (more) 10:35 Coffee Break 11:05 Christopher Dupont, Song Yang, Brian Palenik, Philip E. Bourne. Modern Proteomes Contain Imprints of Ancient Shifts in Environmental Chemistry. (invited presentation) Session 2: Homology Modeling (Chair - Nick Grishin) 11:35 Francisco Melo, Alejandro Panjkovich, Andrej Sali, Marc A. Marti-Renom. Structure Specific Statistical Potentials for Protein Structure Prediction. (more) 11:55 Iris Antes, Thomas Lengauer. DynaDock: Inhibitor based Refinement of Homology Modeled Protein Structures for Molecular Docking. (more) 12:15 Lunch and Laptop Session 1 15:00 Discussion 1: The roles of Evolution, physics and informatics (Chair - Phil Bourne). Session 3: Ligand Binding (Chair - Phil Bourne) 15:45 Rafael J. Najmanovich, Richard J. Morris, Janet M. Thornton. Single-Family Analysis of Binding Site Structural Similarities. (more) 16:05 Thomas Funkhouser, Roman Laskowski, Janet Thornton. Matching Volumetric Models of Protein Active Sites. (more) 16:25 Melissa R. Landon, Spencer C. Thiel, David R. Lancia Jr., Sandor Vajda. Identification of Druggabable "Hot Spots" in Ligand Binding Pockets by Computational Solvent Mapping of Proteins. (more) 16:45 Coffee Break Session 4: Model Quality (Chair - John Moult) 17:15 Michal J. Gajda, Marta Kaczor, Janusz M. Bujnicki, Anastasia Bakulina, Andrzej Kasperski, Alan M. Friedman, Chris Bailey-Kellogg. FILTREST3D: a Simple Method for Discrimination of Multiple Structural Models Against Spatial Restraints. (more) 17:35 Marcin Pawlowski, Janusz Bujnicki, Ryszard Matlak. Meta-MQAP: an SVM-based meta-server for the quality assessment of protein models. (more) 17:55 Wah Chiu, Matthew L Baker. Modeling Protein Components of Biological Nano-Machines in Subnanometer Resolution CryoEM Density Maps. (invited presentation) 18:25 Break: Busses to evening session 20:00 Get-together Dinner at main headquarters hotel (Oasis Atlantic Hotel). 21:00 John Moult. CASP: Progress, Bottlenecks, Prognosis, and Messages for Computational Biology. 23:00 Lights out... Top Day 2