Disulfide Bonding in Mucin Assembly
Using cryo-electron microscopy, X-ray crystallography, and biochemistry, we have shed light on the mechanisms by which mucins form disulfide-linked polymers.
Overview
Redox Regulation of the Golgi Apparatus
The QSOX1 enzyme regulates glycan modification in the Golgi by introducing activating disulfides into glycosyltransferases.
Antibody Inhibition of Disulfide Catalyst QSOX1
We have developed a monoclonal antibody that binds and inhibits human QSOX1 with an inhibition constant of about 1 nM.
