Events
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Date:23
Monday
June 2025
Hour: 11:00 - 12:15,Location: Gerhard M.J. Schmidt Lecture HallEvent name: title tbdProf. Danna Freedman, Chemistry, MIT
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Date:31
Monday
March 2025
Hour: 11:00 - 12:15,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Decoding the molecular mechanism of histone modificationProf. Cynthia Wolberger, Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University
<p>Post-translational modifications of histones play a central role in regulating all cellular processes requiring access to DNA. Monoubiquitinated histone H2B-K120 is a hallmark of actively transcribed genes that plays multiple roles in activating transcription, while monoubiquitinated histone H2A-K119 is abundant in heterochromatin, which is transcriptionally silent. Our structural studies have revealed how histone H2B is specifically ubiquitinated and deubiquitinated, and ubiquitinated H2B stimulates histone methylation. We have also shown how ubiquitin can regulate access to the nucleosome acidic patch, a hotspot for interactions with other chromatin-modifying enzymes. I will also discuss recent studies of a histone kinase that has an unusual mode of binding nucleosomes.</p>
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Date:18
Tuesday
March 2025
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: Proteome-wide prediction of protein-protein interaction networks and protein compound interactions and their integration for biological discoveryProf. Barry Honig,
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Date:04
Tuesday
March 2025
Hour: 14:00 - 15:00,Location: Gerhard M.J. Schmidt Lecture HallEvent name: "Cut it Out" – Lytic Cell Death and Inflammation Mediated by the “NINJA” Protein – NINJ1Dr. Liron David,