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Positions

Positions | Msc Students
Scientist	Description
\| 2 Years Phone:+972-8-934- Homepage	<p>Size matters, especially in neurons. Differentiated cells in higher eukaryotes exhibit a wide variety of shapes and sizes, while maintaining defined size ranges within cell subtypes. How do they do that? Genome expression must be matched to different cell sizes, with rapidly growing cells likely requiring higher transcriptional and translational output than cells in slow growth or maintenance phase.
Dr. Nir Fluman \| 18 Months Phone:+972-8-934-6456 nir.fluman@weizmann.ac.il Homepage	Membrane proteins make up a quarter of the proteome of every living organism and participate in nearly every biological process. We are interested in the fascinating process of how these proteins get produced, fold, and assemble in cells. The questions we address are: How do proteins fold in the membranes of living cells? How do the dynamic features of unfolded proteins assist in this process? How do cellular factors recognize membrane proteins that failed to fold and need to be cleared? The lab combines biochemical, cell biology, genetic and computational tools.
Prof. Neta Regev-Rudzki \| 18 Months Phone:+972-8-934-3160 neta.regev-rudzki@weizmann.ac.il Homepage	<p>The projects center on different fascinating aspects of the cellular biology of the malaria parasite.</p> <p>Applicants with a strong background at the interfaces of molecular biology and/or biophysics are encouraged to apply. The chosen applicant will peruse wide spread of molecular biology technics, tissue-culture, microscopy, bioinformatics and more.</p> <p>Candidate should send a cover letter and CV (includes a publication list) to Dr. Neta Regev-Rudzki.</p>
Prof. Eitan Reuveny \| 2 Years Phone:+972-8-934-3243 e.reuveny@weizmann.ac.il Homepage	<p>G protein-coupled receptors (GPCRs) are the largest gene family in the human genome. Their role is to translate chemical information into cellular responses, like olfactory processing, neuronal activity modulation, and hormone actions or regulating blood pressure among many. Their cellular effectors can range from various enzymes to ion channels. Interestingly, nature has designed the GPCR as a major target for many natural compounds and the pharmaceutical industry has focused its attention on designing various agonists and antagonists to treat various illnesses.

Positions | PhD Students
Scientist	Description
Prof. Gad Asher \| 4 Years Phone:+972-8-934-6949 gad.asher@weizmann.ac.il Homepage	<p>Circadian clocks are key regulators of daily physiology and metabolism in mammals. Our understanding of the role of the circadian clock and specific clock proteins in controlling exercise capacity is rudimentary. Consequently, there is growing interest in exercise biology in general, specifically in its interaction with other processes that govern whole-body physiology and metabolism.
Prof. Gad Asher \| 4 Years Phone:+972-8-934-6949 gad.asher@weizmann.ac.il Homepage	<p>We demonstrated that low-amplitude oxygen cycles, which mimic the daily physiological cycles in oxygen levels observed in rodents, can reset the clock in a HIF-1a-dependent manner (<a href="https://www.weizmann.ac.il/Biomolecular_Sciences/Asher/publications" style="color: rgb(30, 121, 159); text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: "Proxima Nova"; font-size: 15px; font-style: normal; font-weight: 400; word-spacing: 0px; white-space: normal; orphans: 2; widows: 2; font-variant-ligatures: normal; font-variant-caps: n
Prof. Gad Asher \| 4 Years Phone:+972-8-934-6949 gad.asher@weizmann.ac.il Homepage	<p>Our lab has a longstanding interest in circadian clock resetting. We previously have identified and characterized novel resetting cues such as hypoxia and CO2. Recently, we have developed a new method to study resetting agents in vitro in an efficient and high-throughput manner, dubbed <a href="https://www.nature.com/articles/s41467-021-26210-1">Circa-SCOPE</a>. The method allows screening of multiple drugs in parallel to identify which affects the clock and how.
\| 5 Years Phone:+972-8-934- Homepage	<p>Size matters, especially in neurons. Differentiated cells in higher eukaryotes exhibit a wide variety of shapes and sizes, while maintaining defined size ranges within cell subtypes. How do they do that? Genome expression must be matched to different cell sizes, with rapidly growing cells likely requiring higher transcriptional and translational output than cells in slow growth or maintenance phase.
Dr. Nir Fluman \| 4.5 Years Phone:+972-8-934-6456 nir.fluman@weizmann.ac.il Homepage	Membrane proteins make up a quarter of the proteome of every living organism and participate in nearly every biological process. We are interested in the fascinating process of how these proteins get produced, fold, and assemble in cells. The questions we address are: How do proteins fold in the membranes of living cells? How do the dynamic features of unfolded proteins assist in this process? How do cellular factors recognize membrane proteins that failed to fold and need to be cleared? The lab combines biochemical, cell biology, genetic and computational tools.
Prof. Neta Regev-Rudzki \| 5 Years Phone:+972-8-934-3160 neta.regev-rudzki@weizmann.ac.il Homepage	<p><strong>Applicants with a strong research background at the intersection of molecular biology, biochemistry, imaging and/or biophysics are encouraged to apply.
Prof. Eitan Reuveny \| 5 Years Phone:+972-8-934-3243 e.reuveny@weizmann.ac.il Homepage	<p>G protein-coupled receptors (GPCRs) are the largest gene family in the human genome. Their role is to translate chemical information into cellular responses, like olfactory processing, neuronal activity modulation, and hormone actions or regulating blood pressure among many. Their cellular effectors can range from various enzymes to ion channels. Interestingly, nature has designed the GPCR as a major target for many natural compounds and the pharmaceutical industry has focused its attention on designing various agonists and antagonists to treat various illnesses.

Positions | PostDocs
Scientist	Description
Prof. Gad Asher \| 2 Years Phone:+972-8-934-6949 gad.asher@weizmann.ac.il Homepage	<p>The relevant projects address the influence of circadian clocks on exercise performance, and training efficiency, as well as the effect of chronotype, feeding, and hypoxia on exercise capacity.</p> <p>Circadian clocks are key regulators of daily physiology and metabolism in mammals. Our understanding of the role of the circadian clock and specific clock proteins in controlling exercise capacity is rudimentary.
Prof. Gad Asher \| 2 Years Phone:+972-8-934-6949 gad.asher@weizmann.ac.il Homepage	<ul> <li><strong>Clocks resetting \|</strong><em> </em>Recently, we have developed a new method to study resetting agents in vitro in an efficient and high-throughput manner, dubbed Circa-SCOPE (<a href="https://www.weizmann.ac.il/Biomolecular_Sciences/Asher/publications">Man... al</em>., <em>Nature Communication</em> 2021)</a>. This methodology opens the door to a wide range of applications, in both basic and translational research.
\| 5 Years Phone:+972-8-934- Homepage	<p>Size matters, especially in neurons. Differentiated cells in higher eukaryotes exhibit a wide variety of shapes and sizes, while maintaining defined size ranges within cell subtypes. How do they do that? Genome expression must be matched to different cell sizes, with rapidly growing cells likely requiring higher transcriptional and translational output than cells in slow growth or maintenance phase.
Dr. Nir Fluman \| 2 Years Phone:+972-8-934-6456 nir.fluman@weizmann.ac.il Homepage	Membrane proteins make up a quarter of the proteome of every living organism and participate in nearly every biological process. We are interested in the fascinating process of how these proteins get produced, fold, and assemble in cells. The questions we address are: How do proteins fold in the membranes of living cells? How do the dynamic features of unfolded proteins assist in this process? How do cellular factors recognize membrane proteins that failed to fold and need to be cleared? The lab combines biochemical, cell biology, genetic and computational tools.
Prof. Neta Regev-Rudzki \| 3 Years Phone:+972-8-934-3160 neta.regev-rudzki@weizmann.ac.il Homepage	<p>Applicants with a strong research background at the intersection of molecular biology, biochemistry, imaging and/or biophysics are encouraged to apply. Experience in microbiology, molecular genetics (including CRISPR/Cas9), advanced imaging platforms (including image analysis) or advanced protein chemistry is advantageous. This is a full-time position available from October 2023 for a period of two years with a possibility of a further extension subject to funding availability. Candidate should send a cover letter and CV (includes a publication list) to Dr. Neta Regev-Rudzki.
Prof. Neta Regev-Rudzki \| 3 Years Phone:+972-8-934-3160 neta.regev-rudzki@weizmann.ac.il Homepage	<p>Applicants with a strong research background at the intersection of molecular biology, biochemistry, imaging and/or biophysics are encouraged to apply. Experience in microbiology, molecular genetics (including CRISPR/Cas9), advanced imaging platforms or advanced protein chemistry is advantageous. This is a full-time position available for a period of three years with a possibility of a further extension subject to funding availability. Candidate should send a cover letter and CV (includes a publication list) to Prof. Neta Regev-Rudzki.
Prof. Eitan Reuveny \| 4 Years Phone:+972-8-934-3243 e.reuveny@weizmann.ac.il Homepage	<p>G protein-coupled receptors (GPCRs) are the largest gene family in the human genome. Their role is to translate chemical information into cellular responses, like olfactory processing, neuronal activity modulation, and hormone actions or regulating blood pressure among many. Their cellular effectors can range from various enzymes to ion channels. Interestingly, nature has designed the GPCR as a major target for many natural compounds and the pharmaceutical industry has focused its attention on designing various agonists and antagonists to treat various illnesses.
Prof. David Wallach \| 4 Years Phone:+972-8-934-3941 d.wallach@weizmann.ac.il Homepage	<p>Motivated and creative students with background in molecular biology are invited to join our studies of the mechanisms by which signaling by the TNF family contributes to immune defense, to chronic inflammatory and autoimmune diseases and to cancer, and our attempts to derive from this knowledge new ways of therapy. See our website and list of publications for the range of research subjects that we are exploring and for the range of experimental approaches that we are applying. (https://www.weizmann.ac.il/Biomolecular_Sciences/Wallach/home)</p>

Positions | Master's Rotation
Scientist	Description
Prof. Gad Asher \| Rotation: 1st, 2nd, 3rd Phone:+972-8-934-6949 gad.asher@weizmann.ac.il Homepage	<p>The relationship between hypoxia and the core circadian clock</p>
Prof. Gad Asher \| Rotation: 1st, 2nd, 3rd Phone:+972-8-934-6949 gad.asher@weizmann.ac.il Homepage	<p>Biochemical identification of metabolic sensors</p>
Prof. Gad Asher \| Rotation: 1st, 2nd, 3rd Phone:+972-8-934-6949 gad.asher@weizmann.ac.il Homepage	<p>The interplay between circadian clocks and exercise performance</p>
Prof. Gad Asher \| Rotation: 1st, 2nd, 3rd Phone:+972-8-934-6949 gad.asher@weizmann.ac.il Homepage	<p>Computational analyses of rhythmic outputs (e.g. metabolites, gases)</p>
Prof. Rivka Dikstein \| Rotation: 1st, 2nd, 3rd Phone:+972-8-934-2117 rivka.dikstein@weizmann.ac.il Homepage	<p>Regulation of gene expression at the transcriptional and translational levels is fundamental to all biological activities and is frequently altered in disease states. Our broad research interests are (i) to elucidate how the transcription and translation processes control the cellular response to enviromental stimuli; (ii) to reveal the connections between the transcription and translation processes and (iii) to develop tools to manipulate these processes for potential treatment of cancer, chronic inflammation and neurodegenrative diseases.</p>
\| Rotation: 1st,2nd,3rd Phone:+972-8-934- Homepage	<p>Size matters, especially in neurons. Differentiated cells in higher eukaryotes exhibit a wide variety of shapes and sizes, while maintaining defined size ranges within cell subtypes. How do they do that? Genome expression must be matched to different cell sizes, with rapidly growing cells likely requiring higher transcriptional and translational output than cells in slow growth or maintenance phase.
Dr. Nir Fluman \| Rotation: 3rd Phone:+972-8-934-6456 nir.fluman@weizmann.ac.il Homepage	Membrane proteins make up a quarter of the proteome of every living organism and participate in nearly every biological process. We are interested in the fascinating process of how these proteins get produced, fold, and assemble in cells. The questions we address are: How do proteins fold in the membranes of living cells? How do the dynamic features of unfolded proteins assist in this process? How do cellular factors recognize membrane proteins that failed to fold and need to be cleared? The lab combines biochemical, cell biology, genetic and computational tools.
Prof. Neta Regev-Rudzki \| Rotation: 1st,2nd,3rd Phone:+972-8-934-3160 neta.regev-rudzki@weizmann.ac.il Homepage	<p>We are seeking for highly motivated, committed and curious students to join our team as rotation students. The projects center on different fascinating aspects of the cellular biology of the malaria parasite.</p> <p>The chosen applicant will peruse wide spread of molecular biology technics, tissue-culture, microscopy, bioinformatics and more.</p> <p>Candidate should send a cover letter and CV to Prof.
Prof. Neta Regev-Rudzki \| Rotation: 1st,2nd,3rd Phone:+972-8-934-3160 neta.regev-rudzki@weizmann.ac.il Homepage	<p><strong>Our research combines molecular biology, microbiology, genetics (including CRISPR/Cas9), biochemistry, advanced imaging platforms, omics and biophysics.</strong></p> <p><strong>Anyone interested or having questions, please email Professor Neta Regev-Rudzki: </strong></p> <p><strong><a href="mailto:neta.regev-rudzki@weizmann.ac.il">neta.regev-rudzki@weizmann.ac.il</a></strong></p> <p> </p&gt
Prof. Gideon Schreiber \| Rotation: 1st,2nd,3rd Phone:+972-8-934-3249 gideon.schreiber@weizmann.ac.il Homepage	<p>Our research group is interested in investigating all aspects of protein-protein interactions, from their biophysical nature to their role in signaling within the cell. As our cellular model system we are investigating the multiple activities of type I interferons. </p>
Prof. David Wallach \| Rotation: 1st, 2nd, 3rd Phone:+972-8-934-3941 d.wallach@weizmann.ac.il Homepage	<p>Caspase-8, a cysteine protease discovered in our laboratory, is the main proximal signaling enzyme in the activation of the extrinsic cell-death pathway by receptors of the TNF/NGF family. In certain cells it also participates in the regulation of cell growth, differentiation and survival. A number of different human tumors, including small cell lung carcinoma, neuroblastoma, hepatocellular carcinoma, and others, are frequently deficient of caspase-8.