Pathogens secrete factors to manipulate their hosts by diverting host pathways to facilitate infection. Malaria parasites are masters of their own survival, capable of drastic changes during their lifecycle. While it is clear that sophisticated strategies of malaria sensing and manipulation of their hosts exist; their nature and activity remains largely unknown. Our results demonstrate that malaria parasites, while residing within the host red blood cells, produce “armed EVs” to deliver molecules harboring potential signals for modulating host target cells. Malaria-derived EVs are implicated in host immune manipulation and induction of gametocytogenesis, both of which play an important role in malaria pathogenesis. Furthermore, our results show that EVs are capable of modulating the mechanical properties of naïve host red blood cells, thus priming them for efficient parasitic invasion. In our laboratory we begin to unravel the complex mutual interactions between Plasmodium falciparum and their hosts. We use imaging, molecular genetics, biochemistry and cell biology approaches to investigate different host responses.