Research

Malaria-derived extracellular vesicles

Our research focuses on elucidating the intricate mechanisms of cell-cell communication, and its role in the development of the malaria disease. We investigate the role of extracellular vesicles (EVs), in mediating intercellular signaling and delivery of bioactive components. By employing advanced nano approaches, our laboratory aims to unravel how these EVs are loaded with cargo, released, and function within both the extracellular milieu and recipient target cells. Our findings not only contribute to a deeper understanding of parasite biology but also hold promise for advancing the broader field of EVs research..

Parasite to host communication

Our research investigates how malaria parasites manipulate host cells through the release of specialized EVs. These "armed EVs" modulate host immune responses and promote factors crucial for malaria's pathogenesis. Additionally, we've found that these EVs alter the mechanical properties of host red blood cells, facilitating parasitic invasion. Utilizing diverse techniques including imaging and molecular genetics, our laboratory aims to unravel the complex interactions between Plasmodium falciparum and its hosts, offering insights for combating malaria.

Parasite to parasite networking

In our lab, we study how malaria parasites communicate and exchange molecular signals. By combining cell-communication methods with molecular biology, we aim to unravel this parasite's mysteries. With malaria causing up to half a million deaths annually, especially among children, understanding parasite survival and transmission is vital. Given the lack of effective vaccines and rising drug resistance, discovering new treatment and prevention methods is urgent.