Targeting and sensing cell surface proteins

Cell surface proteins (CSPs) are an important class of disease biomarkers and represent a key category of drug targets. Building on our previous work in developing turn-on probes for protein detection, we are advancing novel CSP-targeting probes for both diagnostic and therapeutic applications. For instance, we have created probes that detect changes in bacterial CSP expression levels and designed turn-on probes to sense CSP-ligand interactions, which we are using in high-throughput screening (HTS) assays to find novel agonists or antagonists. Furthermore, this ongoing research has led to the development of new methods for delivering DNA or enzyme-based therapeutics into cancer cells.

Selected relevant publications

1. Chem. Commun. 2021, 57 ,1875.
2. Molecules. 2021, 26, 2828.
3. Chem. Eur. J. 2015, 21, 1598.
4. Chem. Sci. 2015, 6, 5419.