Classical Dendritic cells (cDC) are migratory myeloid cells with an unrivalled potential to stimulate naïve T cells. Adoptive transfer experiments have established that cDC are derived from dedicated DC precursors which differentiate in tissue context into distinct DC subsets, including XCR1+ (CD8a+) cDC and CD11b+ DC. Functional differences between these subsets remain incompletely understood, as is their relation to monocyte-derived DC that complement the cDC compartment during inflammation.
Past and present Jung lab members involved in these studies:
Tal Birnberg, Liat Bar-On, Anita Sapoznikov, Alexander Mildner, Cateria Curato, Shira Tabachnik (shared with Ami Navon)
Publications:
Sapoznikov et al. JExMed 2007
Birnberg et al, Immunity 2008
Plaks V, Birnberg T et al. JCI 2008
Sapoznikov et al. Nat. Immunology 2009
Bar-On et al, PNAS 2011
Bar-On et al EJI 2012
Mildner et al, BLOOD 2013
Jaitin et al, Science 2014 (collaboration with Amit and Tanay labs)
Mildner and Jung, Immunity 2014 (review)
Zupancic et al., JContrRel 2017 (collaboration with Florindo lab, Lisbon University)
Curato et al Frontiers in Immunology 2019
Past and Present funding:
ISF, MINERVA, BSF