Lecturer Prof. Gil Ast

Contact tamar.cohen@weizmann.ac.il

Abstract Alternative splicing (AS) is a mechanism that increases transcriptomic and proteomic diversity by allowing the generation of multiple mRNA products from a single gene. A strong connection was established between AS and carcinogenesis. We recently developed a method that integrates all known physical interaction (protein-DNA, protein-RNA, protein-protein), gene expression and AS data to construct the largest map of transcriptomic and proteomic interactions leading to cancerous splicing aberrations defined to date and identify driver pathways therein. The method was already applied to colon adenocarcinoma and non-small-cell lung carcinoma. I will also talk about the link between chromatin organization and epigenetics markers and how they are related to the appearance of warm-blooded organisms and exon selection.