Lecturer Prof. Tamar Geiger

Contact tamar.cohen@weizmann.ac.il

Abstract For more information and assistance with Accessibility issues, please contact Rina Tzoref, Seminars Coordinator: li.tzoref@weizmann.ac.il Batya Greenman: batya.greenman@weizmann.ac.il Host Prof. Yosef Yarden 08 934 4015 yosef.yarden@weizmann.ac.il Breast cancer is a heterogeneous group of diseases, traditionally distinguished based on the expression levels of three key receptors: Estrogen receptor, progesterone receptor and Her2. However extensive mRNA expression studies, and genomic studies show higher complexity of classification and can further subdivide the tumors. In our work, we apply mass spectrometry-based proteomics analysis and challenge the existing classification. Furthermore, we analyze the internal tumor heterogeneity by dividing the tumors according to their histopathological parameters, and identify the diversity of proteomic profiles within single tumors. Altogether, the proteomic approach was able to unravel hidden layers within this complex disease.

Details Department of Human Molecular Genetics and Biochemistry Sackler Faculty of Medicine Tel Aviv University