The interplay between viruses and their hosts

Proteomic analysis of cancer heterogeneity to elucidate disease progression mechanisms and resistance to therapy

Our lab is a major driver in developing and applying cutting edge single-cell genomics technologies and advanced computational approaches. We apply these novel tools in animal models and human patients to uncover immune regulatory mechanisms and pathways

Developing experimental and computational approaches for multiplexed imaging of clinical specimens to uncover tumor-immune interactions

Molecular pathogenesis of neurodegenerative diseases

Systematic analysis of combinatorial signals during cellular fate determination processes

Spatial transcriptomics of mammalian tissues

intra-tumor heterogeneity in glioma and in head and neck cancer

We study the functional roles of epigenetics during cell-fate decisions

Biological circuits: design, function and evolution • Regulatory genome: transcription, replication and the chromatin as a communication platform • Developmental patterning: morphogen gradients, scaling, robustness