We study in vivo functions of specific innate immune cells in health and pathology using state of the art mouse models, gene manipulation and advanced transcriptome, translatome and epigenome profiling technologies.

With background in fluid dynamics and biogeochemistry, we study the properties of kidney stones and urine, as well as the function of ureteral stents, and implications for clinical diagnoses and treatments.

From Single cells to Microbial Collectives

Systematic analysis of combinatorial signals during cellular fate determination processes

We study how antibodies are generated in response to invading pathogens in mouse models, infected subjects and cancer patients. We use this information to produce novel antibodies for immunotherapy.

Proprioception and the the musculoskeletal system in development and disease

Our studies proceed along three major lines: (1) Microbial population dynamics under stress, (2) Understanding drought resistance and engineering drought-resistant nutritious plants (3) The plant microbiome and its dynamics

We are interested to learn basic principles dictating specificity of proteinprotein interactions and how this relates to cell signaling

We study interactions between peripheral circadian clocks and exercise physiology, hypoxia signaling and metabolic pathways

The synaptic basis for sexual dimorphism in the nervous system

Functional genomics and systematic screens to uncover new protein functions

Mechanisms of leukocyte migration across distinct blood vessels during infections using genetically manipulated immune competent mice and state of the art imaging approaches. Imaging cancer cell crossing of blood vessels during metastatic processes.

Drug resistance in cancer, effects that intra-tumor bacteria on cancer biology and drug resistance, ex vivo organ culture for the prediction of drug response

Mechanisms of axon growth, destruction and refinement during developmental neuronal remodeling

Studying cell-cell communication mechanisms of malaria parasites within a population and with their hosts

We study how osteoclasts, the only cells in our body that can degrade bone, are formed and how they function, both in health and in disease

Neurobiology of sexual dimorphism in social and reproductive behavior

Deciphering the intrinsic and extrinsic mechanisms of neuronal wiring

Death without caspases and caspases without death in development

How human RNA viruses interact with their host cells and transform them into viral factories

We study bacterial ecological interactions, diversity, stability and stress in communities from pre-Cambrian oceans

A quantitative, structural, and evolutionary understanding of cells and their proteome

Combine molecular biology, biochemical and advanced microscopy techniques to study myelinating glial cells

cryo-electron tomography

Serotonergic control of learning, Development of learning abilities

Investigating how adaptive variation arises (as opposed to being selected) and testing predictions of a theory of individual-specific adaptation that complements natural selection by explaining adaptation on every timescale and level of organization

We use advanced electron microscopy to understand the cellular processes of mineral morphogenesis

Genomic & state-dependent regulation of neural circuit plasticity

Characterization of the functions and mechanisms of long noncoding RNAs and of nuclear RNA export

Intracellular and intercellular trafficking of mRNA and its role in protein localization and cell physiology