To understand the function of subpopulations identified in clinical samples we leverage patient-derived models as well as a collection of cell lines that we analyzed at single cell resolution (Nature Genetics 2020). We then use selected models to isolate particular subpopulations that resemble those found in patients and study their function, including their invasion and drug responses. Finally, genomics and CRISPR-Cas9 technologies are used to reconstruct the regulation of tumor subpopulations and develop novel treatments that would either eradicate those cells or alter their states (differentiation therapy, Cancer Cell 2024).
Tumor systems biology
