Lecture on Alon Ohel and Other Hostages

Type: Lecture
Date: Nov 20 2024

Time11:00 - 12:00

LocationDolfi and Lola Ebner Auditorium

Contact sandra.britton@weizmann.ac.il

Seminar for PhD thesis defense

Type: Lecture
Date: Nov 05 2024

Time11:30 - 11:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerTslil Braun

Contact sandra.britton@weizmann.ac.il

Seminar for PhD thesis defense

Type: Lecture
Date: Oct 08 2024

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNaama Zung

Contact evi.ben-ami@weizmnn.ac.il

Biologically Inspired Engineering for Probing, Programming and Recoding Organisms

Type: Lecture
Date: Sep 18 2024

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Farren J. Isaacs

Contact esther.weindling@weizmann.ac.il

Abstract
A defining challenge in synthetic biology is the development of high-throughput and automated methodologies for precise design and engineering of cells. To address these challenges, we develop multiplex genome engineering technologies for versatile genome modification and evolution of bacterial and eukaryotic cells. We use these technologies to create genetic variants to reveal a causal understanding of complex phenotypes as well as engineer pathways and recode genomes. These Genomically Recoded Organisms (GROs) contain alternative genetic codes, in which codons have been eliminated from the genome of E. coli. GROs exhibit improved properties for incorporation of nonstandard amino acids that expand the chemical diversity of proteins or polymers, establish genetic isolation and multi-virus resistance, and enable the engineering of GROs to depend on synthetic amino acids for robust biocontainment strategies. We have also developed new computational-experimental technologies – computer aided design of synthetic genetic elements (CAD-SGE) – that permits the redesign, expression, and mobilization of biosynthetic pathways in diverse organisms for the discovery of new metabolites. This work increases the toolbox for genomic and cellular engineering with broad applications for new classes of enzymes, materials, and therapeutics.

Seminar for MSc thesis defense

Type: Lecture
Date: Jul 11 2024

Time15:00 - 15:00

LecturerShani Ravid

Contact evi.ben-ami@weizmnn.ac.il

Seminar for PhD thesis defense

Type: Lecture
Date: Apr 30 2024

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRan Shachar

Contact sandra.britton@weizmann.ac.il

Friction and Time Measurement: How the Invention of the Pendulum Made Clocks Much More Accurate

Type: Lecture
Date: Apr 11 2024

Time14:00 - 15:00

LocationGerhard M.J. Schmidt Lecture Hall

LecturerPro. Michael Nosonovsky

Contact esther.weindling@weizmann.ac.il

Special Guest Seminar with Prof. Eugene V. Koonin

Type: Lecture
Date: Mar 21 2024

Time11:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eugene V. Koonin

Contact evi.ben-ami@weizmnn.ac.il

Abstract
Viruses and virus-like mobile genetic elements are ubiquitous parasites (and sometime symbionts) of all cellular life forms and the most abundant biological entities on earth. The recent, unprecedented advances of comparative genomics and metagenomics have led to the discovery of diverse novel groups of viruses and a rapid expansion of the chartered region of the virosphere. These discoveries provide for a vastly improved understanding of the evolutionary relationships within the virosphere. Arguably, we are approaching the point when the global architecture of the virus world can be outlined in its entirety, and the key evolutionary events in each of its domains can be reconstructed. I will present such an outline of the global organization of the virosphere and the corresponding megataxonomy, including 6 distinct virus realms, that has been recently approved by the International Committee on Taxonomy of Viruses, as well as some new candidates. The expansion of the prokaryotic virosphere that is being shown to include many groups of viruses, particularly, those with RNA genomes, previously thought to be eukaryote-specific, will be emphasized. I will further discuss the position of viruses within the wider space of replicators and the recent dramatic expansion of the “alternative virosphere” that includes viroids and diverse viroid-like viruses that seem to have evolved on multiple, independent occasions.

Seminar for PhD thesis defense

Type: Lecture
Date: Mar 12 2024

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerGabriela Lobinska

Contact evi.ben-ami@weizmnn.ac.il

Seminar for PhD thesis defense

Type: Lecture
Date: Feb 25 2024

Time10:00 - 11:00

LocationThe David Lopatie Hall of Graduate Studies

LecturerAlejandro Aguilera Castrejon

Contact sandra.britton@weizmann.ac.il

Seminar for PhD thesis defense

Type: Lecture
Date: Feb 22 2024

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYehuda-Matan Danino

Contact evi.ben-ami@weizmnn.ac.il

Seminar thesis defense

Type: Lecture
Date: Jan 21 2024

Time10:00 - 11:00

LecturerJacob Hanna lab,Max Rose

Contact sandra.britton@weizmann.ac.il

Special Guest Seminar with Prof. Ziv Bar-Joseph

Type: Lecture
Date: Jan 18 2024

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ziv Bar-Joseph

Contact evi.ben-ami@weizmnn.ac.il

Abstract
Abstract: While research institutions including Weizmann are leading the way in cutting edge work in omics data analysis and modeling, biotechs and pharma are very advanced, and in some cases leading, in areas related to molecular design and clinical data analysis. I have been leading the AI / ML work for R&D at one of the largest pharma companies for almost two years and will share some of the methods we have been developing and using to address computational challenges across all stages of the drug discovery and development process. I Will also try to share some of the lessons I have learned over this period.

Special Guest Seminar with Prof. Yegor Bazykin

Type: Lecture
Date: Jan 04 2024

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Yegor Bazykin

Contact evi.ben-ami@weizmnn.ac.il

Seminar for PhD thesis defense

Type: Lecture
Date: Dec 06 2023

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerSarit Meril

Contact evi.ben-ami@weizmnn.ac.il

Seminar for PhD thesis defense

Type: Lecture
Date: Nov 23 2023

Time11:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAvigail Stokar Avihail

Contact evi.ben-ami@weizmnn.ac.il

Special Guest Seminar with Prof. Judith Frydman

Type: Lecture
Date: Aug 29 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Judith Frydman

Contact evi.ben-ami@weizmnn.ac.il

Special Guest seminar with Dr. Raul Andino

Type: Lecture
Date: Aug 28 2023

Time14:30 - 15:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Raul Andino

Contact sandra.britton@weizmann.ac.il

Seminar for PhD thesis defense

Type: Lecture
Date: Aug 08 2023

Time16:00 - 17:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOffir Lupo

Contact evi.ben-ami@weizmnn.ac.il

Systems Biology Seminar 2022-2023

Type: Lecture
Date: Jul 24 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact esther.weindling@weizmann.ac.il

Special guest Seminar

Type: Lecture
Date: Jul 16 2023

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Anton Zilman

Contact evi.ben-ami@weizmnn.ac.il

Systems Biology Seminar 2022-2023

Type: Lecture
Date: Jul 10 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact esther.weindling@weizmann.ac.il

Systems Biology Seminar 2022-2023

Type: Lecture
Date: Jun 26 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact esther.weindling@weizmann.ac.il

Special guest seminar with Nadav Ahituv

Type: Lecture
Date: Jun 13 2023

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Nadav Ahituv,Sandi Britton

Contact sandra.britton@weizmann.ac.il

Systems Biology Seminar 2022-2023

Type: Lecture
Date: Jun 12 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact esther.weindling@weizmann.ac.il

Systems Biology Seminar 2022-2023

Type: Lecture
Date: May 29 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact esther.weindling@weizmann.ac.il

Special Guest Seminar

Type: Lecture
Date: May 16 2023

Time15:00 - 16:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Alexander Meissner & Prof. Paul Tesar

Contact evi.ben-ami@weizmnn.ac.il

Special Guest Seminar

Type: Lecture
Date: May 16 2023

Time15:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Alexander Meissner & Prof. Paul Tesar

Contact evi.ben-ami@weizmnn.ac.il

Systems Biology Seminar 2022-2023

Type: Lecture
Date: May 15 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact esther.weindling@weizmann.ac.il

Systems Biology Seminar

Type: Lecture
Date: May 01 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact esther.weindling@weizmann.ac.il

Systems Biology Seminar 2022-2023

Type: Lecture
Date: May 01 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact esther.weindling@weizmann.ac.il

MSc Thesis Defense

Type: Lecture
Date: Apr 02 2023

Time14:00 - 14:00

LecturerElisheva Berent-Barzel

Contact evi.ben-ami@weizmnn.ac.il

Systems Biology Seminar 2022-2023

Type: Lecture
Date: Mar 27 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact esther.weindling@weizmann.ac.il

Special Guest Seminar

Type: Lecture
Date: Mar 14 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Leonid Chernomordik

Contact evi.ben-ami@weizmnn.ac.il

Systems Biology Seminar 2022-2023

Type: Lecture
Date: Mar 13 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact esther.weindling@weizmann.ac.il

Special Guest Seminar

Type: Lecture
Date: Mar 09 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Danielle Grotjahn

Contact evi.ben-ami@weizmnn.ac.il

Special Guest Seminar

Type: Lecture
Date: Feb 16 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Jennifer Lippincott-Schwartz

Contact evi.ben-ami@weizmnn.ac.il

Seminar for PhD Thesis Defense

Type: Lecture
Date: Feb 09 2023

Time09:30 - 09:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYaara Finkel

Contact evi.ben-ami@weizmnn.ac.il

Seminar for thesis defense with Yaara Finkel

Type: Lecture
Date: Feb 09 2023

Time09:30 - 10:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerSandi Britton,Yaara Finkel

Contact sandra.britton@weizmann.ac.il

Seminar for MSc thesis defense

Type: Lecture
Date: Jan 22 2023

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerSivan Arad

Contact evi.ben-ami@weizmnn.ac.il

Special Guest Seminar

Type: Lecture
Date: Jan 19 2023

Time15:30 - 16:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ritsuko K. Pooh

Contact evi.ben-ami@weizmnn.ac.il

Systems Biology Seminar 2022-2023

Type: Lecture
Date: Jan 16 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact esther.weindling@weizmann.ac.il

Seminar for MSc Thesis Defense

Type: Lecture
Date: Jan 16 2023

Time15:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLior Peer

Contact evi.ben-ami@weizmnn.ac.il

Seminar for Thesis Defense with Raman Singh

Type: Lecture
Date: Jan 16 2023

Time09:00 - 10:00

LocationNella and Leon Benoziyo Building for Biological Sciences

LecturerRaman Singh,Sandi Britton

Contact sandra.britton@weizmann.ac.il

Seminar for Thesis Defense with Svetlana Markman

Type: Lecture
Date: Jan 15 2023

Time14:30 - 15:30

LocationGerhard M.J. Schmidt Lecture Hall

LecturerDr. Svetlana Markman,Sandi Britton

Contact sandra.britton@weizmann.ac.il

Systems Biology Seminar 2022-2023

Type: Lecture
Date: Jan 02 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact esther.weindling@weizmann.ac.il

Special Guest Seminar

Type: Lecture
Date: Jan 01 2023

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Yaron Orenstein

Contact evi.ben-ami@weizmnn.ac.il

Seminar for Thesis defense

Type: Lecture
Date: Dec 12 2022

Time15:30 - 16:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNoa Aharon-Hefetz

Contact evi.ben-ami@weizmnn.ac.il

Special Guest Seminar

Type: Lecture
Date: Nov 24 2022

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Florian Wilfling

Contact evi.ben-ami@weizmnn.ac.il

Special guest seminar, Dr Harry Burgess

Type: Lecture
Date: Aug 15 2022

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Harry Burgess

Contact sandra.britton@weizmann.ac.il

Seminar for Thesis Defense of Adi Millman

Type: Lecture
Date: Jul 24 2022

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAdi Millman

Contact sandra.britton@weizmann.ac.il

Guest seminar with Prof. Utpal Banerjee

Type: Lecture
Date: Jul 20 2022

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Utpal Banerjee

Contact sandra.britton@weizmann.ac.il

Special guest semianr with Dr. Asaf Zviran

Type: Lecture
Date: Jul 17 2022

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Asaf Zviran

Contact sandra.britton@weizmann.ac.il

Abstract
Early detection of recurrence and monitoring of Molecular Residual Disease (MRD) post-surgery is critical for clinical decision-making to tailor personalized treatments across solid cancers. C2i Genomics has developed an ultra-sensitive whole-genome ctDNA test, allowing extremely accurate and sensitive monitoring of patients with solid tumors. Here we present results from applying whole-genome sequencing (WGS) and identification of ctDNA across a variety of adult and pediatric solid tumors. We integrate a genome-wide mutation and copy number monitoring approach coupled with advanced signal processing and Artificial Intelligence (AI) for measuring the tumor load from low-input blood samples (~1mL of plasma) with ultra-sensitive detection. The increased sensitivity allowed clinical detection of tumor fraction down to 5*10-5 and recurrence detection sensitivity achieving >65% at the first two months after definitive treatment, enabling earlier clinical intervention for high-risk patients.

Seminar for PhD thesis defense

Type: Lecture
Date: Jul 12 2022

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNir Cohen

Contact evi.ben-ami@weizmnn.ac.il

Special Guest Seminar

Type: Lecture
Date: Jul 11 2022

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. David Reich

Contact evi.ben-ami@weizmnn.ac.il

Seminar for PhD thesis defense

Type: Lecture
Date: May 25 2022

Time15:00 - 16:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerGal Chaim Nuta

Contact evi.ben-ami@weizmnn.ac.il

Special guest semianr with Prof. Jin Billy Li

Type: Lecture
Date: May 25 2022

Time13:15 - 13:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerJin Billy Li

Contact sandra.britton@weizmann.ac.il

Special Guest Seminar with Prof. Hervé Le Hir

Type: Lecture
Date: May 15 2022

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact sandra.britton@weizmann.ac.il

Transcription Drive Development Minisymposium

Type: Lecture
Date: May 11 2022

Time10:30 - 15:00

LocationDolfi and Lola Ebner Auditorium

Contact sandra.britton@weizmann.ac.il

Seminar for Thesis Defense

Type: Lecture
Date: May 11 2022

Time14:00 - 15:00

LecturerDr. Karin Broennimann

Contact evi.ben-ami@weizmnn.ac.il

Molecular Genteics departmental retreat

Type: Lecture
Date: May 09 2022 - May 10 2022

Molecular Genetics Departmental seminar

Type: Lecture
Date: May 08 2022

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYehuda Danino & Tslil Braun

Contact Sandra.britton@weizmann.ac.il

Special guest seminar with Prof. Kent Søe

Type: Lecture
Date: Apr 07 2022

Time13:30 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact sandra.britton@weizmann.ac.il

Seminar for PhD thesis defense

Type: Lecture
Date: Mar 10 2022

Time12:00 - 13:00

LecturerMira Rosenthal

Contact evi.ben-ami@weizmnn.ac.il

Department of Molecular Genetics departmental seminar

Type: Lecture
Date: Feb 20 2022

Time13:00 - 14:00

LocationDolfi and Lola Ebner Auditorium

LecturerAssaf Biran

Contact sandra.britton@weizmann.ac.il

Special Guest Seminar

Type: Lecture
Date: Feb 15 2022

Time13:00 - 14:00

LecturerDr. Lilach Sheiner

Contact evi.ben-ami@weizmnn.ac.il

Department of Molecular Genetics departmental seminar

Type: Lecture
Date: Feb 06 2022

Time13:00 - 14:00

LecturerYury Bykov and Oldak Bernardo

Contact sandra.britton@weizmann.ac.il

Azrieli Institute for Systems Biology, guest seminar with Ahmed H. Badran

Type: Lecture
Date: Jan 18 2022

Time17:00 - 18:00

LecturerAhmed H. Badran, PhD,The Scripps Research Institute,USA

Contact sandra.britton@weizmann.ac.il

Seminar for PhD thesis defense

Type: Lecture
Date: Jan 17 2022

Time13:30 - 13:30

LecturerSivan Kaminski Strauss

Contact evi.ben-ami@weizmnn.ac.il

Seminar for PhD thesis defense

Type: Lecture
Date: Jan 05 2022

Time11:00 - 11:00

Contact evi.ben-ami@weizmnn.ac.il

Guest seminar with Vered Shacham-Silverberg

Type: Lecture
Date: Dec 26 2021

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Vered Shacham-Silverberg

Contact sandra.britton@weizmann.ac.il

Seminar for PhD thesis defense

Type: Lecture
Date: Dec 12 2021

Time13:15 - 13:15

LecturerTom Shani

Contact evi.ben-ami@weizmnn.ac.il

Molecular Genetics departmental seminar

Type: Lecture
Date: Nov 28 2021

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAmit Kahana (lancet lab) Gabriela Lobinska (Pilpel lab)

Contact sandra.britton@weizmann.ac.il

Special Guest seminar

Type: Lecture
Date: Nov 24 2021

Time11:00 - 11:00

LecturerProf. Gianni Liti

Contact evi.ben-ami@weizmnn.ac.il

“Computational Methods for Super-resolution Single Molecule Localization Microscopy”

Type: Lecture
Date: Nov 21 2021

Time11:30 - 12:30

LecturerDr. Ismail M. Khater

Contact evi.ben-ami@weizmnn.ac.il

Special Guest Seminar

Type: Lecture
Date: Nov 02 2021

Time10:00 - 11:00

LecturerDr. Eyal Karzbrun

Contact sandra.britton@weizmann.ac.il

Seminar for Thesis Defense,

Type: Lecture
Date: Oct 19 2021

Time09:00 - 10:00

LecturerLia Heinemann Yerushalmi

Contact sandra.britton@weizmann.ac.il

Seminar for PhD thesis defense

Type: Lecture
Date: Oct 17 2021

Time10:00 - 10:00

LecturerHagai Marmor - Kollet

Contact evi.ben-ami@weizmann.ac.il

Special seminar with Dr. Yaara Oren

Type: Lecture
Date: Aug 16 2021

Time15:00 - 16:00

LecturerDr. Yaara Oren

Contact sandra.britton@weizmann.ac.il

Abstract
Despite favorable initial response to therapy, a third of cancer patients will develop recurrent disease and succumb to it within five years of diagnosis. While there has been much progress in characterizing the pathways that contribute to stable genetic drug resistance, the mechanisms underlying early reversible resistance, also known as persisters-driven resistance, remain largely unknown. It has long been believed that persisters represent a subset of cells that happen to be non-proliferating at the time of treatment, and therefore can survive drugs that preferentially kill rapidly proliferating cells. However, in my talk I will describe a rare persister population which, despite not harboring any resistance-conferring mutation, can maintain proliferative capacity in the presence of drug. To study this rare, transiently-resistant, cycling persister population, we developed Watermelon, a high-complexity expressed barcode lentiviral library for simultaneous tracing of each cell’s clonal origin and proliferative and transcriptional states. We combine single cell transcriptomics with imaging and metabolomics to show that cycling and non-cycling persisters arise from different cell lineages with distinct transcriptional and metabolic programs. Finally, I will describe how by studying persister cells we can gain critical insights on cellular memory, fate, and evolution, which can guide the development of better anti-cancer treatments.

Special guest seminar with Dr. Inna Ricardo-Lax

Type: Lecture
Date: Jul 20 2021

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Inna Ricardo-Lax

Contact sandra.britton@weizmann.ac.il

Molecular Genetics departmental seminar with Omri Gilhar

Type: Lecture
Date: Jun 27 2021

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOmri Gilhar

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental seminar with Nancy Yacovzada

Type: Lecture
Date: Jun 20 2021

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNancy Yacovzada

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental seminar with Daoud Sheiban

Type: Lecture
Date: Jun 13 2021

Time13:00 - 13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDaoud Sheiban

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental seminar with Yotam David

Type: Lecture
Date: Jun 06 2021

Time13:00 - 13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYotam David

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental seminar with Sveta Markman

Type: Lecture
Date: May 30 2021

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Svetlana Markman

Contact sandra.britton@weizmann.ac.il

Departmental seminar with Michal Schwartz

Type: Lecture
Date: May 23 2021

Time13:00 - 13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Michal Schwartz

Contact sandra.britton@weizmann.ac.il

Seminar for PhD thesis defense - Aya Shkedy

Type: Lecture
Date: May 13 2021

Time12:00 - 13:00

LecturerAya Shkedy

Contact Evi.ben-ami@weizmann.ac.il

Departmental Seminar with Lena Sapoznikov

Type: Lecture
Date: May 09 2021

Time13:00 - 13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLena Sapoznikov

Contact sandra.britton@weizmann.ac.il

Seminar for Thesis defense of Gat Krieger

Type: Lecture
Date: Apr 25 2021

Time13:30 - 14:30

LecturerGat Krieger

Contact sandra.britton@weizmann.ac.il

ILASOL 2021 Conference

Type: Lecture
Date: Apr 20 2021

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact amit.kahana@weizmann.ac.il

Seminar for PhD thesis defense - Moran Shalev

Type: Lecture
Date: Apr 18 2021

Time11:00 - 11:00

LecturerMoran Shalev

Contact Evi.ben-ami@weizmann.ac.il

Molecular Genetics Departmental Seminar

Type: Lecture
Date: Apr 11 2021

Time13:00 - 13:30

LecturerNadav Goldberg

Contact sandra.britton@weizmann.ac.il

Seminar for PhD thesis defense

Type: Lecture
Date: Apr 11 2021

Time15:00 - 16:00

LecturerGal Ofir

Contact Evi.ben-ami@weizmann.ac.il

Molecular Genetics Departmental Seminar

Type: Lecture
Date: Apr 04 2021

Time13:00 - 13:30

LecturerSivan Kaminski

Contact sandra.britton@weizmann.ac.il

Seminar for MSc thesis defense - Nadav Goldberg

Type: Lecture
Date: Mar 22 2021

Time10:00 - 11:00

LecturerNadav Goldberg

Contact Evi.ben-ami@weizmann.ac.il

Department of Molecular Genetics departmental seminar

Type: Lecture
Date: Mar 21 2021

Time13:00 - 13:30

LecturerNir Cohen

Contact sandra.britton@weizmann.ac.il

Department of Molecular Genetics departmental seminar

Type: Lecture
Date: Mar 14 2021

Time13:00 - 13:30

LecturerSarah Rubin

Contact sandra.britton@weizmann.ac.il

Department of Molecular Genetics department seminar

Type: Lecture
Date: Mar 07 2021

Time13:00 - 13:30

LecturerJohannes Auth

Contact sandra.britton@weizmann.ac.il

Seminar for PhD thesis defense - Lior Lasman

Type: Lecture
Date: Feb 24 2021

Time10:00 - 11:00

LecturerLior Lasman

Contact Evi.ben-ami@weizmann.ac.il

Molecular Genetics Departmental Seminar

Type: Lecture
Date: Feb 14 2021

Time13:00 - 13:00

LecturerTamar Gera

Contact sandra.britton@weizmann.ac.il

Seminar for PhD thesis defense - Revital Ravid

Type: Lecture
Date: Feb 07 2021

Time10:00 - 10:00

LecturerRevital Ravid

Contact Evi.ben-ami@weizmann.ac.il

PhD Thesis defense - Orel Mizrahi

Type: Lecture
Date: Jan 24 2021

Time11:00 - 12:00

LecturerOrel Mizrahi

Contact Evi.ben-ami@weizmann.ac.il

Departmental seminar with Anna Uzonyi

Type: Lecture
Date: Jan 17 2021

Departmental seminar with Nelly Frenkel

Type: Lecture
Date: Jan 10 2021

Special zoom joint guest seminar

Type: Lecture
Date: Jan 07 2021

Time11:00 - 12:00

LecturerDr. Anat Florentin

Contact Evi.ben-ami@weizmann.ac.il

Special Guest Seminar - David Gokhman

Type: Lecture
Date: Dec 27 2020

Time10:00 - 10:00

LecturerDr. David Gokhman

Contact Evi.ben-ami@weizmann.ac.il

Molecular Genetics Departmental Seminar with Yaara Finkel

Type: Lecture
Date: Dec 06 2020

Time13:00 - 13:00

LecturerYaara Finkel

Contact sandra.britton@weizmann.ac.il

Seminar for thesis definse of Dvir Schirman

Type: Lecture
Date: Dec 03 2020

Time11:00 - 11:00

LecturerDvir Schirman

Contact sandra.britton@weizmann.ac.il

Seminar for thesis defense, Moria Weiss

Type: Lecture
Date: Dec 02 2020

Time10:00 - 11:00

LecturerMoria Weiss

Contact sandra.britton@weizmann.ac.il

Seminar for thesis defense - Shiri Kult

Type: Lecture
Date: Dec 01 2020

Time16:00 - 16:00

LecturerShiri Kult

Contact Evi.ben-ami@weizmann.ac.il

Molecular Genetics departmental seminar with Sharon Ben-Hur

Type: Lecture
Date: Nov 29 2020

Time13:00 - 13:00

LocationDolfi and Lola Ebner Auditorium

LecturerSharon Ben-Hur

Contact sandra.britton@weizmann.ac.il

Molecular Genetics departmental seminar with Orel Mizrahi

Type: Lecture
Date: Nov 22 2020

Time13:00 - 13:00

LocationDolfi and Lola Ebner Auditorium

LecturerOrel Mizrahi

Contact sandra.britton@weizmann.ac.il

Seminar for thesis defense

Type: Lecture
Date: Nov 18 2020

Time13:00 - 14:00

LecturerNelly Frenkel

Contact Evi.ben-ami@weizmann.ac.il

seminar for thesis defense with Jonathan Bayerl

Type: Lecture
Date: Nov 17 2020

Time13:00 - 13:00

LecturerJonathan Bayerl

Contact sandra.britton@weizmann.ac.il

Special guest seminar with Dr. Yosef Kaplan Dor

Type: Lecture
Date: Nov 16 2020

Time16:00 - 16:00

LecturerDr. Yosef Dor Kaplan

Contact sandra.britton@weizmann.ac.il

Abstract
Sleep is ubiquitous in the animal kingdom, but its function has been a mystery. Besides its importance for the brain, sleep appears to play an essential physiological role, emphasized by the fact that severe sleep loss can be lethal. The cause of this lethality was unknown. We found that extreme sleep deprivation results in high levels of reactive oxygen species (ROS) that trigger oxidative stress specifically in the gut of flies and mice. Using flies, we show that neutralization of intestinal ROS prevents premature death of sleep-deprived animals, suggesting a causal link between ROS accumulation in the gut and lethality upon sleep loss. What may explain the observed phenomena? Could it teach us about the normal, daily function of sleep? In the second part of my talk, I will present our current attempts and preliminary data aiming at answering these questions.

Seminar for thesis defense with Unnikannan CP

Type: Lecture
Date: Nov 16 2020

Time10:00 - 10:00

LecturerUnnikannan CP

Contact sandra.britton@weizmann.ac.il

Molecular Genetics departmental seminar

Type: Lecture
Date: Nov 15 2020

Time13:00 - 13:00

LecturerNaama Zung

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental seminar

Type: Lecture
Date: Nov 08 2020

Time13:00 - 13:00

LecturerHagai Marmor

Contact sandra.britton@weizmann.ac.il

Department seminar with Batsheva Rozman

Type: Lecture
Date: Oct 25 2020

Time13:00 - 14:00

LecturerBatsheva Rozman

Contact sandra.britton@weizmann.ac.il

Braginsky Center for the Interface between Science and the Humanities zoom lecture with Prof. Mario Livio

Type: Lecture
Date: Oct 19 2020

Time16:00 - 17:00

LecturerProf. Mario Livio

Contact sandra.britton@weizmann.ac.il

Abstract
A fresh biography of Galileo Galilei which puts his scientific discoveries in context. Disturbed by rampant science denial in America—and around the world—that has only intensified in recent years, I began researching the life, ideas, and actions of this brilliant man who encountered similar pressures centuries ago. The result is a biography filled with lessons relevant for today—whether with respect to trusting the advice given by scientists in relation to COVID-19, the reality of climate change, the efficacy of vaccines, or the teaching of creationist theories in schools. I will discuss these topics in this talk.

Special zoom Seminar with Dr. Dvir Gur

Type: Lecture
Date: Oct 14 2020

Time10:00 - 11:00

LecturerDr. Dvir Gur

Contact Evi.ben-ami@weizmann.ac.il

Special zoom seminar with Dr. Dan Landau

Type: Lecture
Date: Sep 30 2020

Time16:00 - 17:00

LecturerDr. Dan Landau

Contact sandra.britton@weizmann.ac.il

Departmental Seminar by Mira Rosenthal & Lia Yerushalmi

Type: Lecture
Date: Jul 05 2020

Time13:00 - 14:00

Contact Evi.ben-ami@weizmann.ac.il

Departmental seminar by Miri Shnayder

Type: Lecture
Date: Jun 28 2020

Time13:00 - 13:45

Contact Evi.ben-ami@weizmann.ac.il

Developmental Club Series 2019-20-cancelled

Type: Lecture
Date: Jun 24 2020

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ori Avinoam

Contact sandra.britton@weizmann.ac.il

Departmental Seminar by Romano Strobelt

Type: Lecture
Date: Jun 21 2020

Time13:00 - 13:45

Contact Evi.ben-ami@weizmann.ac.il

Departmental Seminar by Aya Shkedy

Type: Lecture
Date: Jun 14 2020

Time13:00 - 14:00

Contact Evi.ben-ami@weizmann.ac.il

Developmental Club Series 2019-20 - cancelled

Type: Lecture
Date: Jun 10 2020

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eli Arama

Contact sandra.britton@weizmann.ac.il

Departmental Seminar by Kamalesh Kumari

Type: Lecture
Date: Jun 07 2020

Time13:00 - 13:45

Contact Evi.ben-ami@weizmann.ac.il

Departmental seminar by Aude Bernheim

Type: Lecture
Date: May 31 2020

Time13:00 - 13:45

Contact Evi.ben-ami@weizmann.ac.il

Developmental Club Series 2019-20

Type: Lecture
Date: May 27 2020

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Gil Levkowitz

Contact sandra.britton@weizmann.ac.il

POSTPONED: Braginsky Center for the interface between the Science and the Humanities

Type: Lecture
Date: May 25 2020

Time14:00 - 15:00

LocationDolfi and Lola Ebner Auditorium

LecturerProf. Menachem Fisch

Contact sandra.britton@weizmann.ac.il

Departmental Seminar by Daria Amiad-Pavlov

Type: Lecture
Date: May 24 2020

Time13:00 - 14:00

Contact Evi.ben-ami@weizmann.ac.il

Developmental Club Series 2019-20

Type: Lecture
Date: May 20 2020

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Yonatan Stelzer

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2019-20

Type: Lecture
Date: May 13 2020

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Efrat Shema

Contact sandra.britton@weizmann.ac.il

Developmental Club Series

Type: Lecture
Date: May 06 2020

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Amir Sapir

Contact sandra.britton@weizmann.ac.il

Departmental Seminar by Lihi Ben Reuven & Miri Shnayder

Type: Lecture
Date: May 03 2020

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact Evi.ben-ami@weizmann.ac.il

Developmental Club Series 2019-20

Type: Lecture
Date: Apr 22 2020

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eran Hornstein

Contact sandra.britton@weizmann.ac.il

Departmental Seminar by Nir Cohen & TBD

Type: Lecture
Date: Apr 19 2020

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact Evi.ben-ami@weizmann.ac.il

Decoding transcriptional regulation in Drosophila

Type: Lecture
Date: Apr 07 2020

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Alexander Stark

Contact igor.ulitsky@weizmann.ac.il

TBA - cancelled

Type: Lecture
Date: Apr 01 2020

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRuth Sperling

Contact Evi.ben-ami@weizmann.ac.il

POSTPONED: Departmental Seminar by Daria Amiad-Pavlov & Lia Yerushalmi

Type: Lecture
Date: Mar 29 2020

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact Evi.ben-ami@weizmann.ac.il

POSTPONED: Developmental Club Series with Elazar Zelzer

Type: Lecture
Date: Mar 25 2020

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Elazar Zelzer

Contact sandra.britton@weizmann.ac.il

Seminar for Thesis Defense- Roni Winkler

Type: Lecture
Date: Mar 19 2020

Time11:30 - 12:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRoni Winkler

Contact sandra.britton@weizmann.ac.il

Departmental Seminar by Gat Krieger & Kamalesh Kumari

Type: Lecture
Date: Mar 15 2020

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact Evi.ben-ami@weizmann.ac.il

Azrieli Institute for Systems Biology

Type: Lecture
Date: Mar 04 2020

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Dieter Ebert

Contact sandra.britton@weizmann.ac.il

Departmental Seminar by Rami Tshuva & Dvir Schirman

Type: Lecture
Date: Mar 01 2020

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact Evi.ben-ami@weizmann.ac.il

Molecular Genetics special guest seminar

Type: Lecture
Date: Feb 27 2020

Time11:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Gilad Barnea

Contact sandra.britton@weizmann.ac.il

Abstract
I will present trans-Tango, a new technique for anterograde transsynaptic circuit tracing and manipulation that we have established in fruit flies. At the core of trans-Tango is a synthetic signaling pathway that is introduced into all neurons in the animal. This pathway converts receptor activation at the cell-surface into reporter expression through site-specific proteolysis. Specific labeling is achieved by presenting a tethered ligand at the synapses of genetically defined neurons, thereby activating the pathway in their postsynaptic partners. Activation of the pathway culminates in expression of a reporter that can be visualized. Because our system is modular, it can be easily adapted to experiments in which the properties of specific circuits are modified and the functional consequences are analyzed. We first validated trans-Tango in the Drosophila olfactory system and then implemented it in the gustatory system, where projections beyond the firstorder receptor neurons are not well characterized. We identified second-order neurons within the sweet and bitter circuits and revealed that they target brain areas involved in neuromodulation with similar but distinct projection patterns. I will also present experiments in which we use trans-Tango in functional analysis of the gustatory circuits. Using our studies in flies as proof of concept, we are currently establishing an equivalent technique for labeling circuits in vertebrate models, such as mice and zebrafish. These experiments establish trans-Tango as a flexible platform for comprehensive transsynaptic analysis of neural circuits.

Developmental Club Series 2019-20

Type: Lecture
Date: Feb 26 2020

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Talila Volk

Contact sandra.britton@weizmann.ac.il

Departmental Seminar by Sagie Brodsky & Noa Novershtern

Type: Lecture
Date: Feb 16 2020

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact Evi.ben-ami@weizmann.ac.il

Seminar for thesis defense - Karen Fridman Talmon

Type: Lecture
Date: Feb 13 2020

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerKaren Fridman Talmon

Contact Evi.ben-ami@weizmann.ac.il

Developmental Club Series 2019-20

Type: Lecture
Date: Feb 12 2020

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Takashi Kawashima

Contact sandra.britton@weizmann.ac.il

Special Guest Seminar with Prof. Detlef Wiegel

Type: Lecture
Date: Feb 12 2020

Time11:30 - 12:30

LocationNella and Leon Benoziyo Building for Biological Sciences

LecturerProf. Detlef Wiegel

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2019-20

Type: Lecture
Date: Feb 05 2020

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Meital Oren

Contact sandra.britton@weizmann.ac.il

Departmental Seminar - Molecular Genetics Dept.

Type: Lecture
Date: Feb 02 2020

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact Evi.ben-ami@weizmann.ac.il

Developmental Club Series 2019-20

Type: Lecture
Date: Jan 29 2020

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Oren Schuldiner

Contact sandra.britton@weizmann.ac.il

Department of Molecular Genetics Special guest seminar

Type: Lecture
Date: Jan 28 2020

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Francesca Bartolini

Contact sandra.britton@weizmann.ac.il

Braginsky Center for the Interface between the Sciences and the Humanities

Type: Lecture
Date: Jan 27 2020

Time11:00 - 11:00

LocationDolfi and Lola Ebner Auditorium

LecturerProf. Oren Harman

Contact sandra.britton@weizmann.ac.il

Departmental Seminar - Molecular Genetics Dept.

Type: Lecture
Date: Jan 19 2020

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact Evi.ben-ami@weizmann.ac.il

Special Guest Seminar with Dr, Michael E. Ward

Type: Lecture
Date: Jan 16 2020

Time11:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Michael E. Ward

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2019-20

Type: Lecture
Date: Jan 15 2020

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ido Amit

Contact sandra.britton@weizmann.ac.il

Departmental Seminar - Molecular Genetics Dept.

Type: Lecture
Date: Jan 05 2020

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact Evi.ben-ami@weizmann.ac.il

Special Guest Seminar with Dr. Arbel Harpak

Type: Lecture
Date: Jan 02 2020

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Arbel Harpak

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2019-20

Type: Lecture
Date: Jan 01 2020

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Amnon Sharir, DVM, PhD.

Contact sandra.britton@weizmann.ac.il

Special Guest Seminar with Dr. Onn Brandman

Type: Lecture
Date: Dec 30 2019

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Onn Brandman

Contact sandra.britton@weizmann.ac.il

The Braginsky Center for the Interface between the Sciences and the Humanities

Type: Lecture
Date: Dec 30 2019

Time11:00 - 11:00

LocationGerhard M.J. Schmidt Lecture Hall

LecturerProf. Reviel Netz

Contact sandra.britton@weizmann.ac.il

Seminar for thesis defense, Nofar Mor

Type: Lecture
Date: Dec 29 2019

Time15:00 - 16:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNofar Mor

Contact Evi.ben-ami@weizmann.ac.il

Special guest seminar with Moran Dvela-Levitt

Type: Lecture
Date: Dec 22 2019

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMoran Dvela-Levitt

Contact sandra.britton@weizmann.ac.il

Abstract
Protein homeostasis is critical for cellular function and survival. Dysregulation of the cellular protein homeostasis can lead to a build-up of misfolded proteins and facilitate the manifestation of a variety of pathological disorders including neurodegeneration, cancer and inflammation. Where and how the misfolded proteins accumulate, however, has remained a mystery. In studying MUC1 kidney disease (a rare kidney disorder), we have found that some of these pathologies may share a single, previously unrecognized cellular mechanism: a jam at a specific step in the secretory pathway involving a cargo receptor called TMED9. A small molecule called BRD4780 can break the jam and restore cells to normal function, providing a promising potential for therapeutic developments.

Seminar for thesis defense, Maya Voichek

Type: Lecture
Date: Dec 19 2019

Time15:00 - 16:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMaya Voichek

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2019-20

Type: Lecture
Date: Dec 18 2019

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yaron Antebi

Contact sandra.britton@weizmann.ac.il

Special Guest Seminar

Type: Lecture
Date: Dec 18 2019

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Orly Laufman

Contact Evi.ben-ami@weizmann.ac.il

Departmental Seminar - Molecular Genetics Dept.

Type: Lecture
Date: Dec 15 2019

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact Evi.ben-ami@weizmann.ac.il

Developmental Club Series 2019-20

Type: Lecture
Date: Dec 11 2019

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Avraham Yaron

Contact sandra.britton@weizmann.ac.il

Seminar for thesis Defense - Zohar Erez

Type: Lecture
Date: Dec 08 2019

Time15:30 - 15:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerZohar Erez

Contact Evi.ben-ami@weizmann.ac.il

Special Guest Seminar

Type: Lecture
Date: Dec 02 2019

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNevan Krogan

Contact Evi.ben-ami@weizmann.ac.il

Departmental Seminar - Molecular Genetics Dept.

Type: Lecture
Date: Dec 01 2019

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact Evi.ben-ami@weizmann.ac.il

Braginsky Center for the Interface between the Sciences and the Humanities, special guest lecture with Daniel Matt

Type: Lecture
Date: Dec 01 2019

Time16:00 - 17:00

LocationGerhard M.J. Schmidt Lecture Hall

LecturerProf. Daniel Matt

Contact Evi.ben-ami@weizmann.ac.il

Seminar for thesis defense Naama Dekel

Type: Lecture
Date: Oct 30 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNaama Dekel

Contact sandra.britton@weizmann.ac.il

Special Guest Seminar

Type: Lecture
Date: Oct 27 2019

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Peter Tsvetkov

Contact Evi.ben-ami@weizmann.ac.il

Special Guest Seminar with Anat Zimmer

Type: Lecture
Date: Oct 03 2019

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAnat Zimmer

Contact sandra.britton@weizmann.ac.il

Abstract
It is a challenge to answer questions like: why some people develop a disease, react to a specific treatment and/or develop severe side-effects while others don’t. In order to explain these occurrences, one has to take a holistic approach and study the body physiology from a systems level perspective. Longitudinal multi-omics measurements together with genetics, on a large population, can serve such a purpose and help in predicting, reasoning, and preventing diseases. In partnership with Arivale Inc., we have developed infrastructure to collect longitudinal Personalized Dense Dynamic Data clouds (PD3 clouds) on thousands of individuals, which include genetics and longitudinal measurements of clinical labs, microbiome, metabolome, proteome, and self-reported data. The value of these extremely high-dimensional data clouds is clear; however, it also comprises a challenge in data analysis and interpretation. One way to reduce data dimensionality is called Pareto Task Inference (PARTI, Hart et al. 2015). We used this method to analyze the clinical labs and found that the data falls on a significant tetrahedron. The 4 vertices are archetypes that specialize in a certain task. Using all other datatypes, we identified enriched traits next to every archetype and revealed the underline tradeoffs that shape the data. This distinctive analysis uncovers unexpected relationships between datasets such as metabolomics, proteomics and clinical labs, and helps in interconnecting the different datatypes to characterize different states of human health.

Special Guest Seminar with Dr. Johnathan Cooper-Knock

Type: Lecture
Date: Sep 05 2019

Time11:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Johnathan Cooper-Knock

Contact sandra.britton@weizmann.ac.il

Special Guest Seminar with Ophir Shalem

Type: Lecture
Date: Aug 22 2019

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOphir Shalem,Ph.D

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: Jul 31 2019

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ori Avinoam

Contact evi.ben-ami@weizmann.ac.il

Special Guest Seminar

Type: Lecture
Date: Jul 21 2019

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerClaire Thomas

Contact Evi.ben-ami@weizmann.ac.il

Shoulder Injury Seminar Department of Molecular Genetics

Type: Lecture
Date: Jul 18 2019

Time09:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerPh.D,Prof. Louis J. Soslowsky

Contact sandra.britton@weizmann.ac.il

Special Guest Seminar

Type: Lecture
Date: Jul 16 2019

Time11:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yael Weiss

Contact evi.ben-ami@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: Jul 03 2019

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Amrutha Swaminathan

Contact Evi.ben-ami@weizmann.ac.il

Departmental Seminar

Type: Lecture
Date: Jun 30 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRuth Barshir

Contact Evi.ben-ami@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: Jun 26 2019

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Nadav Ahituv

Contact evi.ben-ami@weizmann.ac.il

Developmental Club

Type: Lecture
Date: Jun 19 2019

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eran Hornstein

Contact Evi.ben-ami@weizmann.ac.il

Departmental Seminar

Type: Lecture
Date: Jun 16 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAldema Sas Chen

Contact Evi.ben-ami@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: Jun 12 2019

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Efrat Shema

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: Jun 12 2019

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Efrat Shema

Contact Evi.ben-ami@weizmann.ac.il

Departmental Seminar

Type: Lecture
Date: Jun 02 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerHarsh Maan

Contact Evi.ben-ami@weizmann.ac.il

Developmental Club

Type: Lecture
Date: May 29 2019

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Shalev Itzkovitz

Contact evi.ben-ami@weizmann.ac.il

Departmental Seminar

Type: Lecture
Date: May 26 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYaara Finkel

Contact evi@weizmann.ac.il

Departmental Seminar

Type: Lecture
Date: May 19 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerQihui Hou

Contact evi@weizmann.ac.il

Polymerizing the Fiber Between Bacterial Biofilms and Human Amyloids

Type: Lecture
Date: May 16 2019

Time10:00 - 11:00

LocationNella and Leon Benoziyo Building for Biological Sciences

LecturerProf. Matthew Chapman

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental Retreat

Type: Lecture
Date: May 14 2019 - May 16 2019

Cross regulation between the apoptotic cascade and the unfolded protein response

Type: Lecture
Date: May 13 2019

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAvi Ashkenazi

Contact sandra.britton@weizmann.ac.il

Departmental Seminar

Type: Lecture
Date: May 12 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerHagai Marmor

Contact evi@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: May 07 2019

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOphir Klein

Contact sandra.britton@weizmann.ac.il

Seminar for thesis defense

Type: Lecture
Date: May 05 2019

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNeta Felsenthal

Contact evi@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: May 01 2019

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Benny Shilo

Contact evi@weizmann.ac.il

Departmental Seminar

Type: Lecture
Date: Apr 28 2019

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerInes Castro

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: Apr 17 2019

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Yonatan Stelzer

Contact sandra.britton@weizmann.ac.il

Special Guest Seminar with Dr. Markus Mund

Type: Lecture
Date: Apr 16 2019

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Markus Mund

Contact sandra.britton@weizmann.ac.il

Special Guest Seminar with prof. Johannes Herrmann

Type: Lecture
Date: Apr 11 2019

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Dr. Johannes Herrmann

Contact sandra.britton@weizmann.ac.il

Special guest seminar

Type: Lecture
Date: Apr 04 2019

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Andrea Pauli

Contact Ingrid.lehrer@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: Apr 03 2019

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Andrea Pauli

Contact sandra.britton@weizmann.ac.il

Department of Molecular Genetics seminar for thesis defense

Type: Lecture
Date: Mar 26 2019

Time13:00 - 13:00

LecturerYael Cohen Sharir

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: Mar 20 2019

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eran Hornstein

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: Mar 20 2019

Time10:00 - 11:00

LocationCamelia Botnar Building

LecturerHannes Buelow

Contact sandra.britton@weizmann.ac.il

Department of Molecular Genetics seminar for thesis defense

Type: Lecture
Date: Mar 19 2019

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEyal Metzl Raz

Contact sandra.britton@weizmann.ac.il

Department of Molecular Genetics seminar for thesis defense

Type: Lecture
Date: Mar 17 2019

Time09:00 - 10:00

LecturerMarianna Riutin

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: Mar 13 2019

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Talila Volk

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: Mar 06 2019

Time09:30 - 09:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMeital Oren

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Feb 24 2019

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEden Yifrach

Contact sandra.britton@weizmann.ac.il

Seminar for thesis defense

Type: Lecture
Date: Feb 20 2019

Time14:30 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerTzahi Noiman

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: Feb 06 2019

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Oren Schuldiner

Contact sandra.britton@weizmann.ac.il

"Mechanisms of asymmetric cell division"

Type: Lecture
Date: Jan 28 2019

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Yves Barral

Contact ilona.kalderon@weizmann.ac.il

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Jan 27 2019

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMaayan Barnea

Contact sandra.britton@weizmann.ac.il

Special Guest Seminar with Prof. Meytal Landau

Type: Lecture
Date: Jan 22 2019

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Meytal Landau

Contact sandra.britton@weizmann.ac.il

Special Guest Seminar with Ariel Schwartz

Type: Lecture
Date: Jan 17 2019

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ariel Schwartz

Contact sandra.britton@weizmann.ac.il

Abstract
Computational assignment of function to proteins with no known homologs is still an unsolved problem. We have created a novel, function-based approach to protein annotation and discovery called D-SPACE (Deep Semantic Protein Annotation Classification and Exploration), comprised of a multi-task, multi-label deep neural network trained on over 70 million proteins. Distinct from homology and motif-based methods, D-SPACE encodes proteins in high-dimensional representations (embeddings), allowing the accurate assignment of over 180,000 labels for 13 distinct tasks. The embedding representation enables fast searches for functionally related proteins, including homologs undetectable by traditional approaches. D-SPACE annotates all 109 million proteins in UniProt in under 35 hours on a single computer and searches the entirety of these in seconds. D-SPACE further quantifies the relative functional effect of mutations, facilitating rapid in-silico mutagenesis for protein engineering applications. D-SPACE incorporates protein annotation, search, and other exploratory efforts into a single cohesive model. We have recently extended this work from protein to DNA, enabling assignment of function to whole genomes and metagenomic contigs in seconds. Conserved genomic motifs as well as the functional impact of mutations in coding as well as non-coding genomic regions can be predicted directly from raw DNA sequence without the use of traditional comparative genomics approaches for motif detection, such as multiple sequence alignments, PSSMs, and profile HMMs.

Special Guest Seminar with Dan Bracha

Type: Lecture
Date: Jan 17 2019

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDan Bracha

Contact sandra.britton@weizmann.ac.il

Special Guest Seminar with Dr. Shai Carmi

Type: Lecture
Date: Jan 16 2019

Time11:30 - 11:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Shai Carmi

Contact ilona.kalderon@weizmann.ac.il

Abstract
In this talk, I will review recent work by myself and others on Jewish population and medical genetics, focusing on Ashkenazi Jews (AJ). I will describe the mixture events of AJ in Europe, the founder event they have experienced in the late Middle Ages, and their connections to ancient populations of the Levant. I will then describe large-scale genomic databases that we have recently generated for AJ, and the opportunities they open in medical genetics given the unique AJ demographic history. I will describe a few medical genetics projects including carrier screening, genome-wide association studies of microbiome composition and other traits, and preimplantation genetic diagnosis.

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Jan 13 2019

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerJulie Tai

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: Jan 09 2019

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerBruno Lemaitre

Contact sandra.britton@weizmann.ac.il

“The Foreign within: Drosophilia-Spiroplasma interaction as a model of insect endosymbiosis”

Type: Lecture
Date: Jan 09 2019

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerBruno Lemaitre

Contact ilona.kalderon@weizmann.ac.il

Large-scale genomic investigations of psychiatric and neurodevelopmental disorders and their connection to somatic disease in the Danish population

Type: Lecture
Date: Jan 07 2019

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRon Nudel

Contact Simon.Fishilevich@weizmann.ac.il

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Jan 06 2019

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAdi Millman

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Jan 06 2019

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAdi Millman

Contact sandra.britton@weizmann.ac.il

Smaller is better

Type: Lecture
Date: Jan 03 2019

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Klaus Herick

Contact Moran.Shalev@weizmann.ac.il

Developmental Club Series 2018-19

Type: Lecture
Date: Dec 26 2018

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eldad Tzahor

Contact ilona.kalderon@weizmann.ac.il

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Dec 16 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerInna Averbukh

Contact sandra.britton@weizmann.ac.il

Joint mini-symposium

Type: Lecture
Date: Dec 13 2018

Time11:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Joel Richter

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2018-19

Type: Lecture
Date: Dec 12 2018

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Elazar Zelzer

Contact ilona.kalderon@weizmann.ac.il

Developmental Club Series 2018-2019, special guest seminar

Type: Lecture
Date: Dec 05 2018

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Naihe Jing

Contact sandra.britton@weizmann.ac.il

Abstract
During postimplantation development of the mouse embryo, descendants of the inner cell mass cells in the early epiblast transit from the naïve pluripotent state to the primed pluripotent state. Concurrent with the transition of the pluripotency states is the specification of cell lineages and formation of germ layers in the embryos that serves as the blueprint for embryogenesis. Fate mapping and lineage analysis studies have revealed that cells in different regions of the germ layers acquire location-specific cell fates during gastrulation. The regionalization of cell fates heralding the formation of the basic body plan is conserved in vertebrate embryos at a common phylotypic stage of development. Knowledge of the molecular regulation that underpins the lineage specification and tissue patterning is instrumental for understanding embryonic programming and stem cell-based translational study. However, a genome-wide molecular annotation of lineage segregation and tissue architecture of post-implantation embryo has yet to be undertaken. Here, we reported a spatially resolved transcriptome of cell populations at defined positions in the germ layers over the period of pre- to late gastrulation development. This spatio-temporal transcriptome provides high resolution digitized in situ gene expression profiles and defines the molecular attribute of the genealogy of lineages and continuum of pluripotency states in time and space. The transcriptome further identifies the networks of molecular determinants that drive lineage specification and tissue patterning in the early postimplantation mouse embryo.

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Dec 02 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerTzahi Gabzi

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: Nov 28 2018

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Nathan Lawson

Contact sandra.britton@weizmann.ac.il

Department of Molecular Genetics seminar for thesis defense

Type: Lecture
Date: Nov 26 2018

Time13:30 - 13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRivi Halimi

Contact sandra.britton@weizmann.ac.il

Nuclear Genome Nanostructure Imaging at Single Molecule Resolution

Type: Lecture
Date: Nov 20 2018

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Christoph Cremer

Contact Ingrid.lehrer@weizmann.ac.il

Abstract
Super-resolution fluorescence microscopy allows quantitative studies of nuclear genome organization on the nanoscale1. Here we report on results obtained by single molecule localization microscopy (SMLM). SMLM has made possible to explore chromatin nanostructure down to the imaging of single histones, of short oligosequences, or single DNA sites; presently, an intranuclear optical resolution down to the 5 nm range has been achieved. Applying a novel SMLM technique (fBALM)2, the DNA distribution across entire nuclei at nanoscale resolution was quantitatively determined, localizing in individual nuclear optical sections up to ~4 million individual DNA bound single fluorophore molecule positions, corresponding to about one position per nucleosome. Intensity profile analyses of the intranuclear DNA distributions indicated sharp transitions between high-density domains and low-density compartments, with differences up to almost two orders of magnitude; compacted regions had a minimum diameter down to ca. 50 nm diameter. In contrast to these results, conventional resolution imaging of the same nuclear sites indicated only small differences in the compaction of different regions, combined with very smooth density transitions. Taken together, the quantitative compaction estimates support models of a nuclear organization based on highly compartmentalized chromatin nanostructures3.

Special Guest Seminar

Type: Lecture
Date: Nov 19 2018

Time10:00 - 10:00

LocationNella and Leon Benoziyo Building for Biological Sciences

LecturerDr. Nadav Sharon

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Nov 18 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental Seminars 2018-2019

Type: Lecture
Date: Nov 18 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact sandra.britton@weizmann.ac.il

Special Guest Seminar

Type: Lecture
Date: Nov 08 2018

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eugene Rosenberg

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2018-2019

Type: Lecture
Date: Oct 31 2018

Time10:00 - 10:00

LocationCamelia Botnar Building

LecturerProf. Karina Yaniv

Contact sandra.britton@weizmann.ac.il

Seminar for thesis defense

Type: Lecture
Date: Oct 11 2018

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerUri Weill

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2017-2018

Type: Lecture
Date: Jul 18 2018

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eli Arama

Contact sandra.britton@weizmann.ac.il

Department of Molecular Genetics seminar for thesis defense

Type: Lecture
Date: Jul 04 2018

Time15:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDoreen Ben-Zvi

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Jul 01 2018

Time13:15 - 13:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Karin Broennimann

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Jun 24 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLihi Ben-Reuven

Contact sandra.britton@weizmann.ac.il

Special Guest Seminar

Type: Lecture
Date: Jun 20 2018

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNava Segev

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2017-2018

Type: Lecture
Date: Jun 20 2018

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ori Avinoam

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Jun 17 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRonit Suissa

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2017-2018

Type: Lecture
Date: Jun 06 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerCarmine Settembre, PhD

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Jun 03 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNoa Dahan

Contact sandra.britton@weizmann.ac.il

Contrary to Dogma: Tau is not a stabilizer of microtubules in the axon

Type: Lecture
Date: May 29 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Peter W. Baas

Contact Ingrid.lehrer@weizmann.ac.il

Building the pathway for motion vision

Type: Lecture
Date: May 27 2018

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Claude Desplan

Contact Ingrid.lehrer@weizmann.ac.il

Developmental Club Series 2017-2018

Type: Lecture
Date: May 23 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Shalev Itzkovitz

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2017-2018

Type: Lecture
Date: May 16 2018

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Jerome Gros

Contact ingrid.lehrer@weizmann.ac.il

Accelerating bio discovery with machine learning

Type: Lecture
Date: May 15 2018

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerPhilip Nelson

Contact Ingrid.lehrer@weizmann.ac.il

Abstract
Google Accelerated Sciences is a translational research team that brings Google's technological expertise to the scientific community. Recent advances in machine learning have delivered incredible results in consumer applications (e.g. photo recognition, language translation), and is now beginning to play an important role in life sciences. Taking examples from active collaborations in the biochemical, biological, and biomedical fields, I will focus on how our team transforms science problems into data problems and applies Google's scaled computation, data-driven engineering, and machine learning to accelerate discovery.

Leica Biosystems

Type: Lecture
Date: May 15 2018

Time10:00 - 11:30

LocationRaoul and Graziella de Picciotto Building for Scientific and Technical Support

LecturerDr. Dorothee Lasrich

Contact sandra.britton@weizmann.ac.il

Cyagen technologies

Type: Lecture
Date: May 14 2018

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Matthew Wheeler

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: May 13 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRoni Winkler

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2017-2018

Type: Lecture
Date: May 09 2018

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. James Sharpe

Contact sandra.britton@weizmann.ac.il

Abstract
The vertebrate limb bud is a classical model system for developmental biology – with the advantage of having been studied for many decades. Despite this, and despite its relatively simple shape, a consensus model of its physical morphogenesis has not been reached. I will introduce our own hypothesis on limb bud morphogenesis – convergent-extension coupled with tissue growth – and contrast it to previous ideas. I will introduce a 3D dynamical model which captures this hypothesis (a Cellular Potts Model) and also discuss our ongoing improvements to these simulations.

Atlases of structure-function relationships in small motifs: the limits of modularity

Type: Lecture
Date: May 08 2018

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. James Sharpe

Contact Ingrid.lehrer@weizmann.ac.il

Abstract
Abstract: I will discuss our work on visualizing “topology atlases” which act as a map of possible circuit designs for small 3-node regulatory motifs. These can help in understanding the relationship between a circuit's structure and its function, but how is this relationship affected if the circuit must perform multiple distinct functions within the same organism? In particular, to what extent do multi‐functional circuits contain modules which reflect the different functions? We computationally surveyed a range of bi‐functional circuits which show no simple structural modularity: They can switch between two qualitatively distinct functions, while both functions depend on all genes of the circuit. Our analysis revealed two distinct classes: hybrid circuits which overlay two simpler mono‐functional sub‐circuits within their circuitry, and emergent circuits, which do not. In this second class, the bi‐functionality emerges from more complex designs which are not fully decomposable into distinct modules and are consequently less intuitive to predict or understand. These non‐intuitive emergent circuits are just as robust as their hybrid counterparts, and we therefore suggest that the common bias toward studying modular systems may hinder our understanding of real biological circuits. Relevant papers: 1. A spectrum of modularity in multi-functional gene circuits. Jiménez A, Cotterell J, Munteanu A, Sharpe J. (2017) Mol Syst Biol 13(4):925. doi: 10.15252/msb.20167347 http://msb.embopress.org/content/13/4/925 2. An atlas of gene regulatory networks reveals multiple three-gene mechanisms for interpreting morphogen gradients. Cotterell J, Sharpe J. (2010) Mol Syst Biol 6:425. doi: 10.1038/msb.2010.74 http://msb.embopress.org/content/6/1/425 Bio: James Sharpe was originally captivated by computer programming, but upon learning about the digital nature of the genetic code, chose to study Biology for his undergraduate degree at Oxford University (1988-1991). He then did his PhD on the genetic control of embryo development at NIMR, London (1992-1997) and in parallel started writing computer simulations of multicellular development. During his post-doc in Edinburgh, he began modelling the dynamics of limb development, and also invented a new optical imaging technology called Optical Projection Tomography (OPT), which is dedicated to imaging specimens too large for microscopy - tissues and organs. In 2006 he moved to Barcelona, becoming a senior group leader at the Centre for Genomic Regulation, and focusing on a systems biology approach to modelling limb development – combining experimentation with computer modelling. In this way the group demonstrated that the signalling proteins which pattern the fingers during embryogenesis, act as a Turing reaction-diffusion system. In 2011 he became the coordinator of the Systems Biology Program, and in 2017 was recruited to EMBL as Head of the new Barcelona outstation on Tissue Biology and Disease Modelling.

Molecular Genetics Departmental Seminar

Type: Lecture
Date: Apr 29 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAvigail Stokar

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2017-2018

Type: Lecture
Date: Apr 25 2018

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ben-Zion Shilo

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2017-2018

Type: Lecture
Date: Apr 25 2018

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerBenny Shilo

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Apr 22 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAlona keren-Paz

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Apr 15 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRivi Halimi

Contact sandra.britton@weizmann.ac.il

Special Guest Seminar

Type: Lecture
Date: Apr 11 2018

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAvi Ashkenazi, PhD

Contact sandra.britton@weizmann.ac.il

Abstract
Precise protein folding by the endoplasmic reticulum (ER) supports homeostasis, while cumulative protein misfolding causes ER stress and promotes disease. The kinases PERK and IRE1 help orchestrate the unfolded protein response (UPR) to alleviate ER stress; however, if stress persists, the UPR activates apoptosis to eliminate the damaged cell. We have previously shown that PERK drives cell death via transcriptional up-regulation of the pro-apoptotic death receptor DR5; we further showed that IRE1—which harbors both kinase and RNase modules—blocks apoptosis through regulated IRE1-dependent mRNA decay (RIDD) of DR5 (Lu et al, Science 2014). Recently, we turned to investigate the paradoxical observation that under irresolvable ER stress PERK activity persists, while IRE1 function attenuates. We discovered that PERK governs the attenuation of IRE1, through a phosphatase called RNA polymerase II-associated protein 2 (RPAP2). RPAP2 reverses IRE1 phosphorylation, inhibiting IRE1 RNase activation. This disrupts IRE1-dependent generation of the cytoprotective transcription factor XBP1s and dampens ER-associated degradation of misfolded proteins. Furthermore, it inhibits RIDD, thereby licensing DR5-mediated caspase activation and apoptotic cell death. Thus, under excessive ER stress, PERK attenuates IRE1 via RPAP2 to abort failed adaptation and trigger an apoptotic cell fate.

Special Guest Seminar

Type: Lecture
Date: Apr 11 2018

Time11:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Avi Ashkenazi

Contact sandra.britton@weizmann.ac.il

Abstract
Precise protein folding by the endoplasmic reticulum (ER) supports homeostasis, while cumulative protein misfolding causes ER stress and promotes disease. The kinases PERK and IRE1 help orchestrate the unfolded protein response (UPR) to alleviate ER stress; however, if stress persists, the UPR activates apoptosis to eliminate the damaged cell. We have previously shown that PERK drives cell death via transcriptional up-regulation of the pro-apoptotic death receptor DR5; we further showed that IRE1—which harbors both kinase and RNase modules—blocks apoptosis through regulated IRE1-dependent mRNA decay (RIDD) of DR5 (Lu et al, Science 2014). Recently, we turned to investigate the paradoxical observation that under irresolvable ER stress PERK activity persists, while IRE1 function attenuates. We discovered that PERK governs the attenuation of IRE1, through a phosphatase called RNA polymerase II-associated protein 2 (RPAP2). RPAP2 reverses IRE1 phosphorylation, inhibiting IRE1 RNase activation. This disrupts IRE1-dependent generation of the cytoprotective transcription factor XBP1s and dampens ER-associated degradation of misfolded proteins. Furthermore, it inhibits RIDD, thereby licensing DR5-mediated caspase activation and apoptotic cell death. Thus, under excessive ER stress, PERK attenuates IRE1 via RPAP2 to abort failed adaptation and trigger an apoptotic cell fate.

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Apr 08 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMichal Chapal

Contact sandra.britton@weizmann.ac.il

Barcoding evolution

Type: Lecture
Date: Mar 27 2018

Time13:00 - 13:00

LocationCamelia Botnar Building

LecturerProf. Dmitri Petrov

Contact Ingrid.lehrer@weizmann.ac.il

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Mar 25 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRon Weiss

Contact sandra.britton@weizmann.ac.il

Department of Molecular Genetics seminar for thesis defense

Type: Lecture
Date: Mar 25 2018

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLiraz Keidar

Contact sandra.britton@weizmann.ac.il

Mini-Symposium on Genome, Transcriptome and Proteome

Type: Lecture
Date: Mar 11 2018

Time14:30 - 16:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact Ingrid.lehrer@weizmann.ac.il

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Mar 11 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEyal Metzl-Raz

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Mar 11 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Daoud Sheban

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2017-2018

Type: Lecture
Date: Mar 07 2018

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Orly Reiner

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2017-2018

Type: Lecture
Date: Mar 07 2018

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Orly Reiner

Contact sandra.britton@weizmann.ac.il

Predator-prey interactions of nematophagous fungi and C. elegans

Type: Lecture
Date: Mar 01 2018

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yen-Ping Hsueh

Contact Ingrid.lehrer@weizmann.ac.il

Optimizations and trade-offs in cellular growth and survial

Type: Conference
Date: Feb 25 2018 - Feb 27 2018

Time08:00 - 08:00

LocationThe David Lopatie Conference Centre

Website http://www.weizmann.ac.il/conferences/OTCGS2018/

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Feb 25 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLia Yerushalmi

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2017-2018

Type: Lecture
Date: Feb 07 2018

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eran Hornstein

Contact sandra.britton@weizmann.ac.il

Noncoding RNA in Health and Disease

Type: Lecture
Date: Jan 30 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Nikolaus Rajewsky

Contact ingrid.lehrer@weizmann.ac.il

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Jan 28 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShiran Maskit

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2017-2018

Type: Lecture
Date: Jan 24 2018

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Gil Levkowitz

Contact sandra.britton@weizmann.ac.il

Functions and regulation of 3D genome organisation in development and disease

Type: Lecture
Date: Jan 23 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Francois Spitz

Contact ingrid.lehrer@weizmann.ac.il

Abstract
The complex hierarchy of three-dimensional patterns that characterize the 3D folding of mammalian chromosomes appears as an important element in controlling gene expression. At the megabase scale, chromosomes are partitioned into domains that define two main compartments, corresponding to transcriptionally active and inactive regions, respectively. Each compartment domain is itself composed of distinct domains characterized by increased self-interactions called topological domains (TADs). Recent high-resolution Hi-C approaches revealed a finer-scale organisation of the genome in smaller “contact domains”, often associated with loops linking specific points. At these different scales, the spatial organisation of the genome shows tight correlation with its chromatin structure and its transcriptional activity. However, while steady progress is being made in describing the 3D folding of the genome at increased resolution, the mechanisms that determine this folding, its dynamic properties and the functional implications of these emerging features are still poorly understood. We use advanced genome tagging and engineering strategies, as well as targeted inactivation of factors involved in chromosomal folding to unravel the elements and mechanisms that drive the folding of large loci in specific yet dynamic conformations and their influence on gene expression. Our recent results show that the complex patterns of vertebrate HiC maps result from the superimposition of two distinct mechanisms: 1) a cohesin-independent mechanism which brings together regions of similar chromatin states 2) a cohesin-dependent folding that associate different small compartments into TADs. Within TADS, we show as well that enhancers are not acting in a homogeneous manner, but that their influence is distributed in complex patterns, partially guided by the underlying structure. I will discuss the different implications of these findings for our views of genome organisation.

Molecular Genetics Special Guest Seminar

Type: Lecture
Date: Jan 21 2018

Time10:00 - 11:00

LecturerDr. Nicolas Plachta

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental Seminar

Type: Lecture
Date: Jan 21 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEran Yanowski

Contact sandra.britton@weizmann.ac.il

Frontiers in Systems Biology: Prof. Anshule Kundaje

Type: Lecture
Date: Jan 16 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Anshule Kundaje

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Jan 14 2018

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerIdan Frumkin

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2017-2018

Type: Lecture
Date: Jan 10 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Talila Volk

Contact sandra.britton@weizmann.ac.il

Molecular Genetics Special Guest Seminar

Type: Lecture
Date: Jan 10 2018

Time14:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yoav Ram

Contact sandra.britton@weizmann.ac.il

Single cell analysis of rare events in cancer

Type: Lecture
Date: Jan 09 2018

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Arjun Raj

Contact ingrid.lehrer@weizmann.ac.il

Perception and computation in cellular signaling pathways

Type: Lecture
Date: Jan 09 2018

Time13:30 - 13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yaron Antebi

Contact Ingrid.lehrer@weizmann.ac.il

Molecular Genetics Departmental Seminar

Type: Lecture
Date: Jan 07 2018

Time13:15 - 13:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Dana Lorber

Contact sandra.britton@weizmann.ac.il

Special Guest Seminar

Type: Lecture
Date: Dec 28 2017

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRavit Boger, MD

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2017-2018

Type: Lecture
Date: Dec 27 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerElla Preger-Ben Noon

Contact sandra.britton@weizmann.ac.il

Revealing the structural basis for membrane transport and GPCR signaling through atomic-level simulation

Type: Lecture
Date: Dec 26 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ron Dror

Contact ingrid.lehrer@weizmann.ac.il

Departmental Seminar

Type: Lecture
Date: Dec 24 2017

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerGal Nuta

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2017-2018

Type: Lecture
Date: Dec 20 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Gil Levkowitz

Contact sandra.britton@weizmann.ac.il

Frontiers in Systems Biology

Type: Lecture
Date: Dec 19 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Mihaela Zavolan

Contact sandra.britton@weizmann.ac.il

Abstract
In yeast, the knock out of individual ribosomal protein (RP) genes leads to a wide range of life span phenotypes, some mutants having significantly increased, other significantly decreased life span. In this talk I would like to present our efforts in characterizing the regulation of mRNA translation in relation to cellular states, from yeast to man. I will describe our work on inferring determinants of protein synthesis rates in yeast, where we found that the Gcn4 transcription factor, which is induced in many conditions that enhance yeast lifespan (RP gene knockout, calorie restriction, mTOR inhibition) not only activates transcription of amino acid biosynthesis genes, but also represses protein biosynthesis. How much variation in RP expression is expected in human tissues has been largely unknown, but RP gene mutations have been described in association with hematological disorders. Through a comprehensive analysis of human RP mRNAs expression pattern across 28 tissues, over 300 primary cells and 16 tumor types, we identified many RPs which exhibit tissue-specific expression. In the hematopoietic system, a small number of RP genes, possible regulated by transcription factors with tissue-specific expression, unequivocally discriminate cells of distinct lineages and developmental stages. Different cancer types also show dysregulated expression of individual RPs, some RPs having a relative increase and other decrease in expression. Finally, I will discuss our efforts in mapping sites of snoRNA-guided RNA modifications.

Unexpected Adventures with Human Endogenous Retroviruses and Centromeres

Type: Lecture
Date: Dec 18 2017

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. David Markovitz

Contact Ingrid.lehrer@weizmann.ac.il

Accessing the genome: transcription factors as sensors and modifiers of chromatin

Type: Lecture
Date: Dec 12 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Dirk Schubeler

Contact ingrid.lehrer@weizmann.ac.il

(Re)Constructing the Vertebrate Neural Tube

Type: Lecture
Date: Dec 07 2017

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. James Briscoe

Contact Ingrid.lehrer@weizmann.ac.il

Developmental Club Series 2017-2018

Type: Lecture
Date: Dec 06 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr.Meital Oren

Contact sandra.britton@weizmann.ac.il

Frontiers in Systems Biology: Prof. Jörg Vogel

Type: Lecture
Date: Dec 05 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact ingrid.lehrer@weizmann.ac.il

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Dec 03 2017

Time13:15 - 13:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNofar Mor

Contact sandra.britton@weizmann.ac.il

Population as Distributed Memory System

Type: Lecture
Date: Nov 29 2017

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ehud Lamm

Contact Ingrid.lehrer@weizmann.ac.il

Abstract
We show how the distribution of skills or phenotypes in a population acts as collective memory or "distributed information store" serving individual so that individuals with varying innate abilities are able to attain the mature fully skilled phenotype. We show how information moves "in" and "out" of genomes, relative to this memory system, elucidating how evolution determines where best to store information. This question applies to understanding diverse biological systems in which individuals acquire capacities from the population, including immunity, the microbiome, and social learning. Using Agent Based Modeling we investigate how properties of the population and social aspects of the acquisition process affect the behavior of the system. We show that the genetic properties of the population react predictably to changes in population properties that affect selection pressures, without any group level selective processes. Specifically, parameter changes that make acquisition slower lead to skills becoming increasingly innate while changes in parameters that improve the results of acquisition (e.g., making acquisition reliant on abundant left-over tools) lead to an increased reliance on acquisition, all while the average phenotype remains constant. The dynamics we study contribute to understanding how individuals can evolve to become more or less reliant on social learning and cultural information, how this depends on population properties (e.g., group size), and how this manifests demographically. The more information stored externally, the stronger the selection pressure on traits that support acquisition. Finally, we contrast our model and the Baldwin Effect and relate out results to the study of the evolution of human social learning.

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Nov 26 2017

Time13:15 - 13:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerModi Safra

Contact sandra.britton@weizmann.ac.il

Identification of Druggable and Redox vulnerabilities in a genetically defined cancer

Type: Lecture
Date: Nov 26 2017

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Liron Bar-Peled

Contact Ingrid.lehrer@weizmann.ac.il

When enhancers drive the wrong genes: Mechanisms and role in tumorigenesis

Type: Lecture
Date: Nov 22 2017

Time09:00 - 09:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yotam Drier

Contact Ingrid.lehrer@weizmann.ac.il

"Coordination of microbial metabolism through metabolite-protein interactions”

Type: Lecture
Date: Nov 21 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Uwe Sauer

Contact ingrid.lehrer@weizmann.ac.il

Molecular Genetics Departmental Seminars 2017-2018

Type: Lecture
Date: Nov 19 2017

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDagan Segal

Contact sandra.britton@weizmann.ac.il

Epistasis, pleiotropy, the ruggedness of fitness landscape, and the Predictability of RNA virus evolution

Type: Lecture
Date: Nov 14 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Santiago Elena

Contact ingrid.lehrer@weizmann.ac.il

Developmental Club Series 2017-2018

Type: Lecture
Date: Nov 08 2017

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Efrat Shema

Contact sandra.britton@weizmann.ac.il

You say tomato, I say potato. Evolution of the genetic code in yeasts

Type: Lecture
Date: Nov 07 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ken Wolfe

Contact sandra.britton@weizmann.ac.il

Specificity and evolution of bacterial signaling proteins

Type: Lecture
Date: Oct 31 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Michael Laub

Contact ingrid.lehrer@weizmann.ac.il

Abstract
Protein-protein interactions are critical to the operation and functions of all cells. The specificity of these interactions is often dictated at the level of molecular recognition, meaning proteins have an intrinsic ability to discriminate cognate from non-cognate partners. Understanding precisely how this discrimination is accomplished remains a major problem, particularly for paralogous protein families in which the individual members share high sequence and structural similarity. Our work tackles this problem primarily in the context of two-component signal transduction systems, the predominant form of signaling in bacteria, and more recently with toxin-antitoxin systems, also found throughout the bacterial kingdom. I will describe our work using analyses of amino acid coevolution to pinpoint the molecular basis of specificity in these proteins. This work has enabled the rational rewiring of protein-protein interactions and signal transduction pathways. Additionally, these studies have driven efforts to systematically map sequence spaces and probe the selective pressures and constraints that govern the evolution of protein-protein interactions.

"A stress-Induced Hidden Secret of the Genetic Code"

Type: Lecture
Date: Oct 22 2017

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Hanna Engelberg-Kulka

Contact sandra.britton@weizmann.ac.il

Systems Biology innovative awards

Type: Lecture
Date: Sep 19 2017

Time09:00 - 09:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact ingrid.lehrer@weizmann.ac.il

Imaging how cells decide their fate, shape and position in the early mouse embryo

Type: Lecture
Date: Sep 17 2017

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Nicolas Plachta

Contact Ingrid.lehrer@weizmann.ac.il

Abstract
ABSTRACT During development, each cell must resolve its fate, shape and position. Revealing how these decisions are made is critical to understand how embryos form, yet their real time control in mammals is unknown. Because fixed specimens cannot capture in vivo cell dynamics, we use imaging technologies to study single cells directly in live mouse embryos. We recently combined fluorescence correlation spectroscopy and photoactivation to show how the transcription factors Oct4 and Sox2 bind to DNA to determine the first cell fates of the embryo. We also designed methods to study how cells regulate their mechanical properties, and how they reorganize their actin and microtubule cytoskeletons to establish the first forms of tissue architecture. We discovered a new class of filopodia which helps cells to polarize and achieve embryo compaction, a role for cortical tension in driving the formation of the pluripotent inner mass, and a new type of non-centrosomal microtubule organizing center (MTOC) directing intracellular transport and differentiation in the embryo.

The surprising expansion of the epigenetic regulatory repertoire in mammals

Type: Lecture
Date: Sep 10 2017

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Andrew Xiao, PhD

Contact sandra.britton@weizmann.ac.il

Studying human evolution using DNA methylation maps of Neanderthals

Type: Lecture
Date: Sep 05 2017

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. David Gokhman

Contact ingrid.lehrer@weizmann.ac.il

Virology Club speacial guest seminar

Type: Lecture
Date: Jul 13 2017

Time12:15 - 12:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Osnat Tirosh

Contact sandra.britton@weizmann.ac.il

Developmental Club Series 2016-2017

Type: Lecture
Date: Jul 12 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAlon Greenbaum

Contact sandra.britton@weizmann.ac.il

To be announced

Type: Lecture
Date: Jul 02 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerTzahi Noiman

Contact cherill.banks@weizmann.ac.il

Microbial Ecology Student's Club

Type: Lecture
Date: Jun 27 2017

Time13:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerArik Ogran; Lianet Noda-Garcia

Contact ingrid.lehrer@weizmann.ac.il

To be announced

Type: Lecture
Date: Jun 25 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAditya Kshirsagar

Contact cherill.banks@weizmann.ac.il

Developmental Club Series 2016-2017

Type: Lecture
Date: Jun 21 2017

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerBenny Shilo

Contact sandra.britton@weizmann.ac.il

Rapid DNA Re-Identification for Cell Line Authentication and Forensics

Type: Lecture
Date: Jun 20 2017

Time09:30 - 09:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Sophie Zaaijer

Contact ingrid.lehrer@weizmann.ac.il

To be announced

Type: Lecture
Date: Jun 18 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerTBD

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Jun 11 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEran Yanowski

Contact cherill.banks@weizmann.ac.il

Developmental Club Series 2016-2017

Type: Lecture
Date: Jun 07 2017

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Shalev Itzkovitz

Contact sandra.britton@weizmann.ac.il

To be announced

Type: Lecture
Date: Jun 04 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerInna Averbukh

Contact cherill.banks@weizmann.ac.il

Through the looking glass: The red queens race and other tales of immunovirology

Type: Lecture
Date: Jun 01 2017

Time11:15 - 11:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Leslie Lobel

Contact ingrid.lehrer@weizmann.ac.il

To be announced

Type: Lecture
Date: May 28 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Alina Kolpakova

Contact cherill.banks@weizmann.ac.il

Mitochondrial DNA transcription regulation - not as simple as once thought

Type: Lecture
Date: May 22 2017

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDan Mishmar, PhD

Contact ingrid.lehrer@weizmann.ac.il

Understanding HCMV latency by looking at transcription at the single cell level

Type: Lecture
Date: May 21 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMiri Shnayder

Contact cherill.banks@weizmann.ac.il

The Relation Between Cell Fusion and Aneuploidy

Type: Lecture
Date: May 16 2017

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Alan Tartakoff

Contact ingrid.lehrer@weizmann.ac.il

Directed evolution of high-performance reprogramming factors

Type: Lecture
Date: May 14 2017

Time10:00 - 10:00

LocationCamelia Botnar Building

LecturerRalf Jauch

Contact sandra.britton@weizmann.ac.il

Molecular Genetics retreat

Type: Lecture
Date: May 09 2017 - May 11 2017

System level study of the cell death signature in melanoma: a vision towards precision cancer therapy

Type: Lecture
Date: Apr 30 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNaama Dekel

Contact cherill.banks@weizmann.ac.il

Seminar

Type: Lecture
Date: Apr 27 2017

Time10:00 - 11:00

LocationCamelia Botnar Building

LecturerJoanne Kamens, Ph.D.

Contact sandra.britton@weizmann.ac.il

Abstract
Title; ‘Sharing Speeds Science: Intro to Addgene's Nonprofit Science Model Info; addgene is a nonprofit organization founded to help scientists share materials and useful data across borders around the world. Addgene has distributed over 750,000 plasmids to scientists in 85 countries. This movement of samples has influenced fields from Stem Cells to CRISPR and almost everything in between. Addgene's Executive Director, Joanne Kamens will present on this unique compnay model, what's new with Addgene and about what it is like to be an Addgenie. Dr. Kamens is the Executive Director of Addgene, a mission driven, nonprofit dedicated to helping scientists around the world share useful research reagents and data. Dr. Kamens received her PhD in Genetics from Harvard Medical School then spent 15 years as a researcher and manager in Pharma at BASF/Abbott working on both small molecule and antibody therapies for immune disease. In 2007 she joined RXi Pharmaceuticals as Senior Director of Research Collaborations. Dr. Kamens founded the current Boston chapter of the Association for Women in Science. She has helped start and supports many scientist mentoring programs with training and best practices. In 2010, Dr. Kamens received the Catalyst Award from the Science Club for Girls for longstanding dedication to empowering women in the fields of science, technology, engineering and mathematics and in 2013, she was named one of PharmaVoice's 100 Most Inspiring Commanders & Chiefs. She serves on a number of other non-profit boards and speaks widely on career development and workplace diversity topics in person and via Webinar.

Mini Symposium on Immune Response to Viral Infections

Type: Lecture
Date: Apr 25 2017

Time09:00 - 13:30

LocationCamelia Botnar Building

Contact sandra.britton@weizmann.ac.il

PTPROt in chronic lymphocytic leukemia: a tumor suppressor or promotor?

Type: Lecture
Date: Apr 23 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerJean Wakim

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Apr 09 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAnna Gorelick Ashkenazi

Contact cherill.banks@weizmann.ac.il

"The LINC between nuclear anchoring and coordinated DNA replication in syncytial muscle cells"

Type: Lecture
Date: Apr 02 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShuoshuo Wang

Contact cherill.banks@weizmann.ac.il

Microbial Ecology Student's Club

Type: Lecture
Date: Mar 28 2017

Time13:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact ingrid.lehrer@weizmann.ac.il

Lissencephaly and Rett syndrome; two disorders, one story

Type: Lecture
Date: Mar 26 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLiraz Keidar

Contact cherill.banks@weizmann.ac.il

Molecular determinants of a lipid droplet subpopulation at the nucleus vacuole junction

Type: Lecture
Date: Mar 19 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Maria Bohnert

Contact cherill.banks@weizmann.ac.il

Science and Clinical Orthopedics

Type: Lecture
Date: Mar 05 2017

Time08:30 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerKeynote speaker,Prof. Benjamin Alman

Contact ingrid.lehrer@weizmann.ac.il

The Impact of Ploidy on Adaptation

Type: Lecture
Date: Mar 02 2017

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Anna Selmecki

Contact ingrid.lehrer@weizmann.ac.il

RNA Editing in bacteria Recodes Multiple Proteins and Regulates a Toxin-Antitoxin System

Type: Lecture
Date: Feb 26 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDan Bar-Yaacov

Contact cherill.banks@weizmann.ac.il

Growth Plate Anatomy through the lens of cellular architecture

Type: Lecture
Date: Feb 12 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerSarah Rubin

Contact cherill.banks@weizmann.ac.il

The role of FABP4 in ER stress-triggered cell death

Type: Lecture
Date: Feb 05 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRinat Livne

Contact cherill.banks@weizmann.ac.il

Differential mRNA decay re-shapes operon structures in bacteria

Type: Lecture
Date: Jan 29 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Daniel Dar

Contact cherill.banks@weizmann.ac.il

Enhanced Human Naïve Pluripotency Growth Conditions That Endow Tolerance for Loss of Epigenetic Repressors

Type: Lecture
Date: Jan 22 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerJonathan Bayerl

Contact cherill.banks@weizmann.ac.il

Muscle Mechanosensors Keep Skeletal Morphology on Track

Type: Lecture
Date: Jan 15 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRonen Blecher

Contact cherill.banks@weizmann.ac.il

GeneHancer: genome-wide integration of enhancers and target genes in GeneCards

Type: Lecture
Date: Jan 08 2017

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Simon Fishilevich

Contact cherill.banks@weizmann.ac.il

New CRISPR-Cas systems from uncultivated microbes

Type: Lecture
Date: Jan 08 2017

Time09:00 - 09:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. David Burstein

Contact ingrid.lehrer@weizmann.ac.il

Engineering Human T Cell Circuitry

Type: Lecture
Date: Dec 29 2016

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Alexander Marson

Contact ingrid.lehrer@weizmann.ac.il

Building tissues to understand how tissues build themselves

Type: Lecture
Date: Dec 28 2016

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Zev Gartner

Contact ingrid.lehrer@weizmann.ac.il

Contact inhibition of locomotion drives the even spreading of ECM during Drosophila embryogenesis

Type: Lecture
Date: Dec 27 2016

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Brian Stramer

Contact cherill.banks@weizmann.ac.il

Working successfully with WIS new institutional review board principles and a practical guide to human research at WIS

Type: Lecture
Date: Dec 22 2016

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eran Hornstein

Contact ingrid.lehrer@weizmann.ac.il

The regulatory role of short structural variants and the implication to neurodegenerative diseases in aging

Type: Lecture
Date: Dec 22 2016

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ornit Chiba-Falek

Contact ingrid.lehrer@weizmann.ac.il

Abstract
In the post genome-wide association studies (GWAS) era we are shifting gears toward translation of genetic disease loci to molecular mechanisms of pathogenesis and pinpointing the causal genetic factors and their functional effects. It has been suggested that changes, even subtle, in the expression levels of wild-type genes in the brain can, over years, lead to neurodegenerative diseases. Moreover, differences in gene expression profiles between brain tissues from neurodegenerative disease patients compared to healthy controls have been reported. Short structural variants (SSVs) are short genomic variants (<50 bp) other than SNPs. Recently, there has been increased support for the idea that SSVs, which are largely ignored in large-scale genetic studies, may be involved in many complex diseases, and may also contribute significantly to variation in gene expression in human. We have been studying the expression regulation of key genes implicated in Alzheimer’s (AD) and Parkinson’s (PD) diseases and a wide-spectrum of related disorders. In particular, we focus on noncoding SSVs and their cis-regulatory effects on gene expression using a comprehensive strategy that combines multiple-level approaches. (1) in silico: we have developed a new bioinformatics tool for prioritizing candidate functional/causal SSVs. The tool is a searchable, annotated database of SSVs, with associated customizable scoring software that is designed to evaluate and prioritize SSVs that are most likely to have significant biological effects and impact on disease risk. (2) in vitro: we have established induced Pluripotent Stem Cell (iPSC)-derived neurons, dopaminergic and cholinergic, from a normal subject and PD patients. We are currently using this model system to determine how cis-variants modulate expression of disease risk genes via their interactions with the trans-acting factors, by applying CRISPR/Cas9 – mediated genome editing. (3) in vivo: we have quantified cell-type specific gene expression in neurons, astrocytes, and microglia by single-cell gene expression assays using cells isolated from frozen human brain samples via LCM. We have implemented this strategy in studies of genomic loci implicated in Lewy body and AD diseases, specifically SNCA gene and the TOMM40-APOE cluster. Collectively, the innovative approaches we developed represent a cohesive strategy for discovering potentially functional and causal variants within candidate risk-genes associated with AD-PD spectrum disorders.

The natural history of the infant gut microbiome in health and disease

Type: Lecture
Date: Dec 20 2016

Time09:00 - 09:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Moran Yassour

Contact ingrid.lehrer@weizmann.ac.il

Genetic media

Type: Lecture
Date: Dec 19 2016

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Yaniv Erlich

Contact cherill.banks@weizmann.ac.il

Abstract
Abstract: In the last decade, the human population has produced zettabytes (10^21) of digital data. This creates immense opportunities and challenges for biology research. In this talk, I will present two research directions of my groups on the intersection between genetics and data, which we dub “genetic media”. First, I will speak about crowd sourcing massive genetic data using social media. We collected over 80 million profiles from the largest social-media website driven by genealogy and constructed a single family tree of 13 million people. Using this data, we analyzed the genetic architecture of longevity. I will also speak about our on-going efforts to crowd source genomes and social media phenotypes to this massive pedigree. In the second part of my talk, I will present using synthetic DNA as a medium for long-term data storage. Previous studies in leading journal have presented this concept but failed to show reliable data retrieval. Here, we report a storage strategy, called DNA Fountain, that is highly robust and approaches the Shannon limit. The success of our strategy relies on careful adaptation of coding theory to the domain-specific constraints of DNA molecules. To demonstrate its power, we stored a full computer operating system, movie, and other files in DNA oligos and perfectly retrieved the information. We explored the limit of our architecture in terms of bytes per molecules and obtained a perfect retrieval from a density of 215Petabyte/gram of DNA, orders of magnitudes higher than previous techniques.

The non-receptor tyrosine kinase c-Abl controls genomic integrity by coordinating the cell cycle with the DNA damage response

Type: Lecture
Date: Dec 18 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerVicky Meltzer

Contact cherill.banks@weizmann.ac.il

Characterization of proteome dynamics in oleate reveals a novel peroxisome targeting receptor

Type: Lecture
Date: Dec 11 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEden Yifrach

Contact cherill.banks@weizmann.ac.il

Recruiting the protein interaction map of cell death for studying human genetic disease

Type: Lecture
Date: Dec 04 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAya Shkedy

Contact cherill.banks@weizmann.ac.il

Working successfully with WIS new institutional review board principles and a practical guide to human research at WIS

Type: Lecture
Date: Dec 01 2016

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eran Hornstein

Contact ingrid.lehrer@weizmann.ac.il

Dysregulation of safeguard mechanisms underlies hybrid vigor

Type: Lecture
Date: Nov 27 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDana Bar-Zvi

Contact cherill.banks@weizmann.ac.il

Information processing and decision making in live cells

Type: Lecture
Date: Nov 22 2016

Time14:00 - 14:00

LocationGerhard M.J. Schmidt Lecture Hall

LecturerProf. Andre Levchenko

Contact ingrid.lehrer@weizmann.ac.il

C/EBPβ LIP augments cell death by inducing a novel tumor suppressor gene osteoglycin

Type: Lecture
Date: Nov 20 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRina Wassermann-Dozorets

Contact cherill.banks@weizmann.ac.il

In vivo veritas – Using CRISPR genome editing to model cancer in mice

Type: Lecture
Date: Nov 17 2016

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Daniel Schramek

Contact ingrid.lehrer@weizmann.ac.il

Abstract
Modern Genetics is revealing virtually all the genetic and epigenetic alterations associated with human malignancies. Mining this information for Precision Medicine is predicated on weeding out ‘bystander’ mutation and identifying the ‘driver’ mutations responsible for tumor initiation, progression and metastasis, as only the latter have diagnostic and therapeutic value. Secondly, we have to elucidate how driver mutations alter the fundamental molecular pathways governing tissue growth and identify actionable nodes within a given cancer gene network that can be exploited therapeutically. The massive quantity of data emerging from cancer genomics therefore demands a corresponding increase in the efficiency and throughput of in vivo models to comprehensively assess all putative cancer genes. We therefore developed a versatile functional genomics toolbox that enables us to generate and analyze thousands of somatic gene knock-out or overexpression clones within a single animal in a matter of weeks. Ultrasound-guided in utero injections allow us to selectively transduce fluorescently-labeled lentiviral CRISPR or ORF libraries into various organs of living mouse embryos. Subsequent mosaic analysis, next-generation sequencing and library barcode deconvolution enables us to identify genes that regulate proliferation, differentiation and survival. Of note, this analysis not only assess the gene function in an physiological and immune-competent microenvironment, but can also be combined with any mouse model and treatment schedule to faithfully model human malignancies. Using this technique, we have completed several proof-of-concept screens and elucidated several novel tumor suppressor genes in Head&Neck. Currently, we are performing several multiplexed in vivo CRISPR screens to uncover context-specific cancer vulnerabilities, novel immune regulators and genes that confer resistance to chemo- or targeted therapies. In this seminar, I will highlight the utility of direct in vivo screening to integrate human cancer genomics and mouse modeling for rapid and systematic discovery of cancer driver mutations and novel cancer vulnerabilities.

Following Single mRNAs in Living Cells

Type: Lecture
Date: Nov 14 2016

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Robert Singer

Contact ingrid.lehrer@weizmann.ac.il

Host-Bacillus subtilis interaction: using polysaccharides to form new and improved biofilms

Type: Lecture
Date: Nov 13 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNatalia Kemper

Contact cherill.banks@weizmann.ac.il

Novel Function for Aire During Early Development and Somatic Cell Reprogramming

Type: Lecture
Date: Nov 06 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerVladik Krupalnik

Contact cherill.banks@weizmann.ac.il

RNA function in germ and stem cell biology

Type: Lecture
Date: Oct 18 2016

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact ingrid.lehrer@weizmann.ac.il

Abstract
The integrity of the genome transmitted to the next generation intrinsically relies on cells of the germ line. Processes that ensure germ cell development, genomic stability, and reproductive lifespan are essential for the long-term success of a species. Dónal O'Carroll is interested in characterizing spermatogonial stem cell (SSC) populations that support fertility as well the regenerative capacity of the testis throughout adult life. In addition, O'Carroll lab tackles fundamental questions regarding the mammalian male germ line and heredity from an RNA perspective. Specifically, their research explores the contribution of non-coding RNA (miRNA, piRNA and lncRNA) and RNA modification pathways within germ cell development as well as testicular homeostasis/regeneration. The research objectives focus on the contribution of these emerging pathways on the underlying circuitry of self-renewal that underpins the SSC, as well as the coordination of the various cellular/differentiation processes of spermatogenesis.

Breaking out of silence- what happens during cellular quiescence and exit from it

Type: Lecture
Date: Sep 26 2016

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Michael Klutstein

Contact ingrid.lehrer@weizmann.ac.il

Unlocking the Combinatorial Epigenetic Code at a Single-Molecule Level

Type: Lecture
Date: Sep 18 2016

Time09:00 - 09:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Efrat Shema

Contact cherill.banks@weizmann.ac.il

Move or Die: The Journey of Primordial Germ Cells to the Gonads

Type: Lecture
Date: Jun 26 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLama Tarayrah

Contact cherill.banks@weizmann.ac.il

Discovery of microRNA genetic variations in human ALS patients

Type: Lecture
Date: Jun 19 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerChen Cepelovich

Contact cherill.banks@weizmann.ac.il

Horizontal gene transfer in halophilic archaea and a potential role for CRISPR-Cas in speciation processes

Type: Lecture
Date: Jun 14 2016

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Uri Gophna

Contact ingrid.lehrer@weizmann.ac.il

Clocks and brakes: evolving budding yeast to predict their future

Type: Lecture
Date: Jun 13 2016

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Andrew Murray

Contact cherill.banks@weizmann.ac.il

A novel regulator determines the extent of contacts between organelles

Type: Lecture
Date: Jun 05 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMichal Eisenberg

Contact cherill.banks@weizmann.ac.il

Intrinsic limits to gene regulation by global crosstalk

Type: Lecture
Date: May 31 2016

Time15:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Gasper Tkacik

Contact cherill.banks@weizmann.ac.il

A systematic view on Influenza induced host shut-off

Type: Lecture
Date: May 29 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerJulie Tai

Contact cherill.banks@weizmann.ac.il

Metabolic approaches to the Microbiome

Type: Lecture
Date: May 25 2016

Time10:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMaayan Levy,Prof. Andrew Gewirtz,Prof. Yitzhak Mizrahi

Contact ingrid.lehrer@weizmann.ac.il

Systems Biology Approach to the Mammalian Cell Cycle

Type: Lecture
Date: May 25 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Itamar Simon

Contact ingrid.lehrer@weizmann.ac.il

Characterizing cell fate regulation during synchronized reprogramming

Type: Lecture
Date: May 22 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAsaf Zviran

Contact cherill.banks@weizmann.ac.il

Motor neurons get excited by a miRNA

Type: Lecture
Date: May 01 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerIrit Reichenstein

Contact cherill.banks@weizmann.ac.il

How patterning of bone superstructures can explain evolutionary variations in long bones morphology

Type: Lecture
Date: Apr 17 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShai Eyal

Contact cherill.banks@weizmann.ac.il

The distinct substrate specificity of Lag1 and Lac1 explains their differential role in ageing

Type: Lecture
Date: Apr 10 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMarton Megyeri

Contact cherill.banks@weizmann.ac.il

A conserved translational control mechanism involving RNA structures within coding sequences of ER membrane proteins

Type: Lecture
Date: Apr 06 2016

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact ingrid.lehrer@weizmann.ac.il

To be announced

Type: Lecture
Date: Apr 03 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerSantosh Kumar

Contact cherill.banks@weizmann.ac.il

The Role of Filopodia in Muscle Cell Fusion

Type: Lecture
Date: Mar 27 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDagan Segal

Contact cherill.banks@weizmann.ac.il

Quantitative morphogenesis of epithelial tissue in Drosophila

Type: Lecture
Date: Mar 24 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Joerg Grosshans

Contact ingrid.lehrer@weizmann.ac.il

Understanding the formation and regulation of contact sites between organelles

Type: Lecture
Date: Mar 20 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNadav Shai

Contact cherill.banks@weizmann.ac.il

In-vivo flux through the mammalian TRC40 (GET) pathway

Type: Lecture
Date: Mar 16 2016

Time15:00 - 15:00

LecturerProf. Blanche Schwappach

Contact ingrid.lehrer@weizmann.ac.il

To be announced

Type: Lecture
Date: Mar 13 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNadav Myers

Contact cherill.banks@weizmann.ac.il

Communication between viruses guides lysis-lysogeny decisions

Type: Lecture
Date: Mar 06 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerZohar Erez

Contact cherill.banks@weizmann.ac.il

Expression homeostasis during DNA replication

Type: Lecture
Date: Feb 28 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRaz Bar-Ziv

Contact cherill.banks@weizmann.ac.il

The Cost of Living: How to Minimize the Cost of Gene Expression?

Type: Lecture
Date: Feb 21 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerIdan Frumkin

Contact cherill.banks@weizmann.ac.il

Regulatory RNAs

Type: Lecture
Date: Feb 18 2016

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Rajewsky Nikolaus

Contact ingrid.lehrer@weizmann.ac.il

Buffering variability of morphogen gradients

Type: Lecture
Date: Feb 14 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNeta Strasser

Contact cherill.banks@weizmann.ac.il

Cap-independent protein translation controls cell fate decisions in Human Embryonic Stem Cells

Type: Lecture
Date: Feb 07 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMaya David

Contact cherill.banks@weizmann.ac.il

the Gli that changed me: tendon-bone attachment development"

Type: Lecture
Date: Jan 31 2016

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNeta Felsenthal

Contact cherill.banks@weizmann.ac.il

Agonizing minds: The Monod-Jacobs explorations of gene regulation

Type: Lecture
Date: Jan 24 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Dan Tawfik

Contact cherill.banks@weizmann.ac.il

The interspecies competition between Bacillus species and its impact on the evolution of biofilms

Type: Lecture
Date: Jan 17 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerGili Rosenberg

Contact cherill.banks@weizmann.ac.il

Of mice and (hairless) dogs: examples of studying the functional and developmental base of bone and tooth morphology

Type: Lecture
Date: Jan 14 2016

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Kornelius Kupczik

Contact cherill.banks@weizmann.ac.il

Gatad2a-Chd4-Mbd3 Axis in the NuRD complex Facilitates Deterministic Induction of Pluripotenc

Type: Lecture
Date: Jan 10 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNofar Mor

Contact cherill.banks@weizmann.ac.il

The Synaptonemal Complex is a Liquid Crystal

Type: Lecture
Date: Jan 06 2016

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ofer Rog

Contact ingrid.lehrer@weizmann.ac.il

On the mechanism of ubiquitin independent proteasomal degradation

Type: Lecture
Date: Jan 03 2016

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAssaf Biran

Contact cherill.banks@weizmann.ac.il

A synthetic, single-cell approach to mammalian signaling, memory, and cell fate transition circuits

Type: Lecture
Date: Dec 31 2015

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Michael Elowitz

Contact cherill.banks@weizmann.ac.il

Systemic spread of antiviral RNAi immunity in insects through extracellular vesicles

Type: Lecture
Date: Dec 29 2015

Time12:15 - 12:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Carla Saleh

Contact ingrid.lehrer@weizmann.ac.il

To be announced

Type: Lecture
Date: Dec 27 2015

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerGal Ofir

Contact cherill.banks@weizmann.ac.il

Post-translational regulation of coordinated activities in the bacterial-proteasome system

Type: Lecture
Date: Dec 23 2015

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Eyal Gur

Contact ingrid.lehrer@weizmann.ac.il

The messenger takes the lead: Does a cis-acting mRNA motif play an active role in protein secretion?

Type: Lecture
Date: Dec 20 2015

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOsnat Cohen Zontag

Contact cherill.banks@weizmann.ac.il

Disturbance of the bacterial cell wall specifically interferes with biofilm formatio

Type: Lecture
Date: Dec 13 2015

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerTabitha Bucher

Contact cherill.banks@weizmann.ac.il

Protein mechanics: the link between structure, function, and evolution

Type: Lecture
Date: Dec 08 2015

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Rama Ranganathan

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Dec 06 2015

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDavid Lerner

Contact cherill.banks@weizmann.ac.il

RNA-mediated regulation of quorum sensing in bacteria

Type: Lecture
Date: Nov 29 2015

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMaya Shamir

Contact cherill.banks@weizmann.ac.il

The metamorphosis of the tendon-bone attachmen

Type: Lecture
Date: Nov 22 2015

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNeta Felsenthal

Contact cherill.banks@weizmann.ac.il

From design-by-evolution to evolution-by-design – the case of CLL

Type: Lecture
Date: Nov 03 2015

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Dan Landau

Contact ingrid.lehrer@weizmann.ac.il

Switching miRNAs on and off on an evolutionary and physiological time scales

Type: Lecture
Date: Nov 01 2015

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYonit Hoffman

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Oct 25 2015

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOsnat Cohen-Zontag

Contact cherill.banks@weizmann.ac.il

New and old roles of ubiquitin in the cell's fight against environmental stress

Type: Lecture
Date: Oct 19 2015

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Christine Vogel

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Oct 18 2015

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNagaraju Dhanyasi

Contact cherill.banks@weizmann.ac.il

Delving into Paternal Mitochondrial Destruction After Fertilization

Type: Lecture
Date: Oct 11 2015

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYoav Politi

Contact cherill.banks@weizmann.ac.il

No nonsense: functional translational readthrough (in humans)

Type: Lecture
Date: Aug 09 2015

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Sven Thoms

Contact cherill.banks@weizmann.ac.il

PacBio SMRT Sequencing overview

Type: Lecture
Date: Jul 29 2015

Time09:30 - 09:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAmos Grundwag,Eisenberg Bros. Ltd.

Contact ingrid.lehrer@weizmann.ac.il

Abstract
Recent advancements in our understanding of biological complexity have propelled the development of new tools. In the field of DNA and RNA sequencing, next-generation sequencers have dramatically increased productivity and provided novel insights into the structure and function of the genome. The PacBio RS II sequencing technology resolves single molecules in real time, allowing observation of structural and cell type variation not accessible with other technologies. These unique capabilities of the PacBio RS II system are ideally suited for a variety of applications, from De Novo assembly and targeted sequencing to detecting base modifications.

A Molecular Switch for Forming an Epithelial Tissue

Type: Lecture
Date: Jun 16 2015

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerKeith Mostov, M.D. Ph.D.

Contact ingrid.lehrer@weizmann.ac.il

Ubiquitin controls autophagy termination

Type: Lecture
Date: Jun 11 2015

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRuey-Hwa Chen

Contact ingrid.lehrer@weizmann.ac.il

Visualizing global transcription at nucleotide resolution

Type: Lecture
Date: Jun 11 2015

Time11:00 - 11:45

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Stirling Churchman

Contact cherill.banks@weizmann.ac.il

Ten ways to use 100 million protein sequences

Type: Lecture
Date: Jun 11 2015

Time11:45 - 12:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Debbie Marks

Contact cherill.banks@weizmann.ac.il

A New Paradigm for Protein Quality Control at the Ribosome

Type: Lecture
Date: Jun 08 2015

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Onn Brandman

Contact cherill.banks@weizmann.ac.il

From yeast mating to Hutchinson-Gilford Progeria Syndrome (HGPS), a premature aging disorder

Type: Lecture
Date: Jun 07 2015

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Susan Michaelis

Contact cherill.banks@weizmann.ac.il

Molecular Genetics Retreat

Type: Lecture
Date: May 17 2015 - May 19 2015

Molecular Mechanisms ofTranscription in the Third Domain &#8211; from molecules to systems

Type: Lecture
Date: May 03 2015

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Finn Werner

Contact cherill.banks@weizmann.ac.il

Abstract
Our laboratory is applying an interdisciplinary and multi scalar approach to characterise the molecular mechanisms of transcription and in particular of multisubunit RNA polymerases (RNAPs). We explore model systems from the third domain of life, the Archaea, not only because they are fascinating organisms in their own right but because their transcription apparatus is a model system for &#8211; and more biochemically tractable than - eukaryotic RNAPII. Today I will present progress in our understanding of (i) the architecture of transcription initiation complexes, (ii) conformational dynamics of RNAP during the transcription cycle, and (iii) the whole genome-distribution of the basal transcription apparatus and transcription start site mapping. This analysis reveals the underlying molecular nature of the spontaneous DNA melting in archaea, which requires ATP hydrolysis in the RNAPII system. Our data furthermore show that the dynamic recruitment and release of basal factors that guide RNAP through the transcription cycle is modulated by the coupling of transcription and translation, of RNAPs and ribosomes.

Mitochondrial membrane proteins in motion - in situ imaging by live cell superresolution microscopy

Type: Lecture
Date: Mar 31 2015

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Dr. Karin Busch

Contact cherill.banks@weizmann.ac.il

Human Papillomavirus and Cancer, Viral Genomics, Evolution and Pathogenesis in Humans

Type: Lecture
Date: Feb 10 2015

Time15:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Robert D. Burk

Contact yosef.shaul@weizmann.ac.il

mechanisms of nuclear positioning during cell migration and muscle formation

Type: Lecture
Date: Feb 10 2015

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Edgar R. Gomes

Contact maya.schuldiner@weizmann.ac.il

Deciphering and reversing the consequences of mitochondrial DNA damage

Type: Lecture
Date: Jan 21 2015

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Cory Dunn

Contact maya.schuldiner@weizmann.ac.il

Abstract
Mitochondrial DNA (mtDNA) encodes several proteins playing key roles in bioenergetics. Pathological mutations of mtDNA can be inherited or may accumulate following treatment for viral infections or cancer. Furthermore, many organisms, including humans, accumulate significant mtDNA damage during their lifespan, and it is therefore possible that mtDNA mutations can promote the aging process. There are no effective treatments for most diseases caused by mtDNA mutation. An understanding of the cellular consequences of mtDNA damage is clearly imperative. Toward this goal, we use the budding yeast Saccharomyces cerevisiae as a cellular model of mitochondrial dysfunction. Genetic manipulation and biochemical study of this organism is easily achieved, and many proteins and processes important for mitochondrial biogenesis were first uncovered and best characterized using this experimental system. Importantly, current evidence suggests that processes required for survival of cells lacking a mitochondrial genome are widely conserved between yeast and other organisms, making likely the application of our findings to human health. I will discuss our most recent work related to the reversal of mitochondrial dysfunction. Specifically, we have found that reducing the acidity of the vacuole, the yeast analog of the mammalian lysosome, provides significant benefits to cells deleted of mtDNA. Moreover, our work demonstrates that perturbation of conserved signaling pathways involved in nutrient sensation can greatly increase the fitness of cells lacking a mitochondrial genome.

Protein Burden in Budding Yeast: The fitness cost of gene transcription and protein translation

Type: Lecture
Date: Jan 18 2015

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Moshe Kafri

Contact cherill.banks@weizmann.ac.il

Regulating a Ubiquitin-Like Pathway In Autophagy

Type: Lecture
Date: Jan 11 2015

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLimor Wigdorovitz

Contact cherill.banks@weizmann.ac.il

Polyamines and cellular differentiation

Type: Lecture
Date: Jan 04 2015

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShirly Brenner

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Dec 28 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Tslil Ast

Contact cherill.banks@weizmann.ac.il

Eradication of rival colonies through a highly coordinated group behavior

Type: Lecture
Date: Dec 14 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEliane Hadas Yardeni

Contact cherill.banks@weizmann.ac.il

Polyamines and cellular differentiation

Type: Lecture
Date: Dec 07 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShirly Brenner

Contact cherill.banks@weizmann.ac.il

Metagenomics approach to study the ecology of coral reef fish larvae in the Red Sea

Type: Lecture
Date: Nov 30 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOmer Zuqert

Contact cherill.banks@weizmann.ac.il

Proteasomes as substrate trappers

Type: Lecture
Date: Nov 23 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAsaf Biran

Contact cherill.banks@weizmann.ac.il

A composite scaffold provides structural integrity to myonuclei in Drosophila

Type: Lecture
Date: Nov 16 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShuoshuo Wang

Contact cherill.banks@weizmann.ac.il

Mechanisms and functions of RNA silencing pathways in animals

Type: Lecture
Date: Nov 13 2014

Time11:00 - 11:00

LocationDolfi and Lola Ebner Auditorium

LecturerProf. Phillip D. Zamore

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Nov 09 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Avishai Gavish

Contact cherill.banks@weizmann.ac.il

A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation

Type: Lecture
Date: Nov 02 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerHila Gingold

Contact cherill.banks@weizmann.ac.il

In vitro Reconstitution of Human Germ Cell Lineage Differentiation from Naive Pluripotent Cells

Type: Lecture
Date: Oct 26 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLeehee Weinberger

Contact cherill.banks@weizmann.ac.il

Intrinsic Cellular Defense to HIV-1 Infection Drives CD4 T-Cell Depletion and Progression to AIDS

Type: Lecture
Date: Oct 26 2014

Time15:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Gilad Doitsh

Contact yosef.shaul@weizmann.ac.il

To be announced

Type: Lecture
Date: Oct 19 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerFrida Belinky

Contact cherill.banks@weizmann.ac.il

The neural circuitry underlying olfactory perception

Type: Lecture
Date: Sep 29 2014

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProfessor Gilad Barnea

Contact shmuel.pietrokovski@weizmann.ac.il

To be announced

Type: Lecture
Date: Jun 29 2014

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNadav Segev

Contact cherill.banks@weizmann.ac.il

Divergent Regulation of Naive Vs. Primed Pluripotency Maintenance

Type: Lecture
Date: Jun 22 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAbed Mansour

Contact cherill.banks@weizmann.ac.il

Microfluidic-based Manufacture of Nanoparticles for Medicine & to Study Gene Function in Primary Cells in vitro & in vivo

Type: Lecture
Date: Jun 19 2014

Time15:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerJames Taylor, Ph.D.

Contact eran.hornstein@weizmann.ac.il

microRNA based therapeutics for cancer

Type: Lecture
Date: Jun 18 2014

Time10:00 - 10:00

LocationDolfi and Lola Ebner Auditorium

LecturerProf. Frank Slack

Contact cherill.banks@weizmann.ac.il

Actin-based Structures of Pancreatic &#946;-cells Constitute Cell-signaling Microdomains

Type: Lecture
Date: Jun 15 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerErez Geron

Contact cherill.banks@weizmann.ac.il

Deciphering the Molecular Role of N6-Methyladenosine mRNA Modification in Development of Mammalian Cells

Type: Lecture
Date: Jun 08 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShay Geula

Contact cherill.banks@weizmann.ac.il

Unique mode of proteasomal degradation of intrinsically disordered proteins (IDPs)

Type: Lecture
Date: May 25 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNadav Myers

Contact cherill.banks@weizmann.ac.il

Feedforward coordination of cell size and division

Type: Lecture
Date: May 11 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerHannah Schmidt-Glenewinkel

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Apr 27 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAnna Gorelick

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Apr 13 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerInna Recardo-Lax

Contact cherill.banks@weizmann.ac.il

Blindfolded out in the wild - how an ER protease refines cellular nutrient sensing

Type: Lecture
Date: Apr 06 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShai Fuchs

Contact cherill.banks@weizmann.ac.il

Vesicle actin coats in secretion: Formation and function

Type: Lecture
Date: Mar 30 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerTal Rousso

Contact cherill.banks@weizmann.ac.il

CD148 and G6b-B: critical regulators of platelet activation and thrombosis

Type: Lecture
Date: Mar 26 2014

Time14:30 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Yotis Senis

Contact ingrid.lehrer@weizmann.ac.il

The ambivalent phosphatase: The role of PTPROt in Chronic Lymphocytic Leukemia

Type: Lecture
Date: Mar 23 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerJean Wakim

Contact cherill.banks@weizmann.ac.il

Plasticity mechanisms in skeletal patterning: The case of patella development

Type: Lecture
Date: Mar 09 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShai Eyal

Contact cherill.banks@weizmann.ac.il

Congenital Smell Deficits: a Role for Neurodevelopment

Type: Lecture
Date: Mar 02 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAnna Alkelai

Contact cherill.banks@weizmann.ac.il

COPI delivers the message to mitochondria: Old dog - new tricks

Type: Lecture
Date: Feb 23 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDmitry Zabezhinsky

Contact cherill.banks@weizmann.ac.il

A new phage resistance system that is widespread in microbial genomes

Type: Lecture
Date: Feb 16 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerTamara Goldfarb

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Feb 02 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRuth Shiloh

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Feb 02 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRuth Shiloh

Contact cherill.banks@weizmann.ac.il

Uncovering the function of a motor neuron specific miRNA in health and disease

Type: Lecture
Date: Jan 26 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerIrit Reichenstein

Contact cherill.banks@weizmann.ac.il

Mapping the embryo for stem cells research; LifeMap Discovery&#8482; as a road map

Type: Lecture
Date: Jan 21 2014

Time14:30 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ronit Shtrichman

Contact cherill.banks@weizmann.ac.il

Abstract
Understanding how cells differentiate during embryonic development is invaluable for the derivation of functional cells from stem cells in vitro and for the development of regenerative medicine applications. Mapping the human embryome is an overwhelming challenge including characterization of all the cell types that make up both the developing and mature human body, including embryonic progenitor cell types in between states. The LifeMap DiscoveryTM database (http://discovery.lifemapsc.com) is taking the lead role towards this effort, providing the research community with viable, scalable, and easy to use data portal describing embryonic development. The data is manually curated from literature, high throughput experiments and large scale datasets. In addition to embryonic development information, the database provides substantial information about stem and progenitor cells, their differentiation protocols and cell therapy applications. The database has been modeled to integrate data from the in vivo and the in vitro, including gene expression and signaling information which, in developing cells, is essential for stem cells identification and classification. Furthermore, this information can be used to match stem cells and their derived cells to similar in vivo cells, and to enable the development of novel differentiation protocols and therapeutic products. GeneAnalyticsTM, the gene analysis tool, supports analysis of multiple genes and applies a novel algorithm to match gene sets to tissues and cells within the database. The value provided by LifeMap Discovery originates from the combined power of this data, which enables identifying, predicting and indicating possible differentiation paths and future regenerative medicine applications. LifeMap Discovery integrates with the more elemental database GeneCards where rich information is available at the gene level, and MalaCards, that provides human disease information.

Regulated transcriptional termination in bacteria revealed via 3p-seq

Type: Lecture
Date: Jan 05 2014

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Daniel Dar

Contact cherill.banks@weizmann.ac.il

Evolving and measuring individuals with Drop Based Microfluidics

Type: Lecture
Date: Jan 02 2014

Time09:30 - 09:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Assaf Rotem

Contact cherill.banks@weizmann.ac.il

Individual Genomes Reveal Deep Population Histories and Uncover the Evolutionary Roles of Non Coding DNA

Type: Lecture
Date: Jan 01 2014

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ilan Gronau

Contact cherill.banks@weizmann.ac.il

Abstract
High throughput DNA sequencing has transformed the landscape of genomic data and is expected to revolutionize our knowledge of evolution and genomic function. These data are expected to be of particular benefit to the study of recent evolutionary processes, due to our ability to sequence multiple individuals from closely related species. While much excitement revolves around these emerging data sets, realizing this potential requires developing powerful and efficient inference methods that are capable of extracting insights on recent evolution from genome-wide sequence data. In this talk, I will be presenting some of my work in this area, which examines what we can learn from complete individual genome sequences on population history and recent natural selection. I will start by describing a study on ancient human population demography in Africa, focusing on one of the deepest population divergence events in human history, dating roughly 130 thousand years ago. I will then present work I did as part of a large-scale collaborative effort to study the early evolution of dogs using the complete genome sequences of two dogs and three gray wolves. I will show how we were able to settle several longstanding debates revolving around the origins of dogs using these genomes and an innovative computational approach. Lastly, I will introduce a line of research I recently initiated, focused on studying the evolutionary roles of non coding regulatory elements in the human genome. I will present recently published work on natural selection on human transcription factor binding sites, and ongoing efforts to extend that approach to all functional non coding elements in the genome. The talk will focus on the main findings in these three studies and how they contribute to our understanding of recent evolution. I will highlight the computational challenges involved, and will conclude with a map of the opportunities and challenges we face in the study of evolution in a world of rapidly evolving genomic data sets.

Real Time Evolution: Adaptation and Robustness in Polioviruses

Type: Lecture
Date: Dec 23 2013

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Adi Stern

Contact ingrid.lehrer@weizmann.ac.il

To be announced

Type: Lecture
Date: Nov 10 2013

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNaama Aviram

Contact cherill.banks@weizmann.ac.il

The mammalian piRNA pathway, from transposon silencing to germ line maintenance

Type: Lecture
Date: Nov 03 2013

Time14:30 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Donal O'Carroll

Contact ingrid.lehrer@weizmann.ac.il

The translation initiation factor DAP5 controls early stages of human embryonic stem cells differentiation

Type: Lecture
Date: Nov 03 2013

Time13:15 - 13:15

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYael Yoffe

Contact cherill.banks@weizmann.ac.il

Bioinformatics of gene expression illuminates old Evo-Devo questions

Type: Lecture
Date: Oct 21 2013

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Marc Robinson-Rechavi

Contact ingrid.lehrer@weizmann.ac.il

Addiction of t(8;21) and inv(16) Acute Myeloid Leukemia to Native RUNX1

Type: Lecture
Date: Oct 13 2013

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOren Ben-Ami

Contact cherill.banks@weizmann.ac.il

Fuzziness: ambiguity and disorder in specific protein complexes

Type: Lecture
Date: Aug 15 2013

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Monika Fuxreiter

Contact cherill.banks@weizmann.ac.il

Determinants of hepatitis C virus interspecies tropism

Type: Lecture
Date: Jul 14 2013

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Alexander Ploss

Contact cherill.banks@weizmann.ac.il

New insights into regulation of the Hippo signaling pathway

Type: Lecture
Date: Jun 25 2013

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Joseph Kissil

Contact cherill.banks@weizmann.ac.il

Deterministic and Synchronized Induction of Pluripotency in Somatic Cells

Type: Lecture
Date: Jun 23 2013

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYoach Reis

Contact cherill.banks@weizmann.ac.il

Lightsheet microscopy- technology and life-sciences applications

Type: Lecture
Date: Jun 13 2013

Time09:30 - 09:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Jacques Paysan

Contact cherill.banks@weizmann.ac.il

Abstract
In light sheet fluorescence microscopy (LSFM), the sample is illuminated by a thin sheet of excitation light which penetrates the specimen perpendicular to the axis of observation. Consequently, the entire plane of focus can be imaged simultaneously. This method to excite fluorescence in an intact 3-dimensional sample is just starting to revolutionize our abilities to observe processes in live samples over an extended period of time (such as multiple hours or days). It allows high speed optical sectioning of whole organisms at subcellular resolution with high sensitivity and minimal phototoxicity. The Carl Zeiss Lightsheet Z.1 microscope is a new commercially available instrument that supports such applications. Our presentation will introduce you to the basic principles of light sheet microscopy and discuss how your research experiments might take advantage of this leading edge technology.

miR-17-92/106b roles in beta cell replication

Type: Lecture
Date: Jun 09 2013

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAmitai Mandelbaum

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: May 26 2013

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYossi Dicken

Contact cherill.banks@weizmann.ac.il

Molecular Genetics Retreat

Type: Lecture
Date: May 21 2013 - May 23 2013

Embryonic Stem Cells - identity, immortality and lineage choice in embryos and in vitro differentiation

Type: Lecture
Date: May 16 2013

Time15:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Joshua Brickman

Contact cherill.banks@weizmann.ac.il

A contact site between mitochondria and vacuoles serves as a bypass for phospholipid transfer

Type: Lecture
Date: May 12 2013

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYael Elbaz

Contact cherill.banks@weizmann.ac.il

Functional interplay between transcription factors and chromatin

Type: Lecture
Date: May 06 2013

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Randall H. Morse

Contact cherill.banks@weizmann.ac.il

The network of antibiotic cross-resistance interactions

Type: Lecture
Date: Apr 22 2013

Time13:30 - 13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Csaba Pal

Contact ingrid.lehrer@weizmann.ac.il

The Skinny on Fat: Mechanisms of Lipid Homeostasis and Storage

Type: Lecture
Date: Apr 11 2013

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerJr.,Prof. Robert V. Farese

Contact cherill.banks@weizmann.ac.il

From the cradle to the grave: protein folding and misfolding in health and disease

Type: Lecture
Date: Apr 08 2013

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Judith Frydman

Contact ingrid.lehrer@weizmann.ac.il

Mutational and fitness landscapes of an RNA virus: implications for adaptation and pathogenesis

Type: Lecture
Date: Apr 08 2013

Time14:30 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Raul Andino

Contact ingrid.lehrer@weizmann.ac.il

Chaperones as polypeptide unfolding enzymes combating toxic misfolded conformers in protein conformational diseases

Type: Lecture
Date: Mar 21 2013

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Pierre Goloubinoff

Contact ingrid.lehrer@weizmann.ac.il

A dead end for germ cell motility and survival

Type: Lecture
Date: Mar 12 2013

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerThorsten Banisch

Contact cherill.banks@weizmann.ac.il

Polyamines and differentiation: The case of adipogenesis

Type: Lecture
Date: Mar 03 2013

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShirly Brenner

Contact cherill.banks@weizmann.ac.il

From cell shape to cell fate determination: insights from skin development

Type: Lecture
Date: Jan 10 2013

Time09:15 - 10:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Chen Luxenburg

Contact Eli.Arama@weizmann.ac.il

Commitment and noise in nutrient homeostasis

Type: Lecture
Date: Dec 30 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNoam Vardi

Contact cherill.banks@weizmann.ac.il

Deletion of a distant-acting enhancer on chr16p13.3 causes recessive Intractable diarrhea of infancy syndrome

Type: Lecture
Date: Dec 23 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDanit Oz Levi

Contact cherill.banks@weizmann.ac.il

The dynamics of genomic sequence evolution in experimental budding yeast populations

Type: Lecture
Date: Dec 10 2012

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Michael Desai

Contact cherill.banks@weizmann.ac.il

The Goldmine in Eukaryotic Genomes

Type: Lecture
Date: Dec 04 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yuval Tabach

Contact cherill.banks@weizmann.ac.il

Abstract
The information that can be retrieved from the genomic data of eukaryotes can reveal genes function and interaction as identify novel genes in pathways and diseases. By classified the conservation or divergence (i.e., phylogenetic profile) of the entire genes set across 86 eukaryotes I will present how one can better understand human diseases, assign function to proteins and identify dozens of new genes in the small RNA pathways (miRNA and siRNA). In my talk I will present how the new phylogenetic approached I developed, followed with extensive RNAi screens, reveal unexpected interaction between the splicing machinery and RNAi pathway. I found that many splicing factors in C. elegans required for RNAi silencing. In addition I will present how phylogenetic profile analysis can be a powerful tool to study human diseases by focusing on "the vampire disease", mitochondrial disorders and melanoma. By applying my method to study a single gene, I will present a new cofactor of the melanoma oncogene MITF that interact with MITF to regulate of transcription of its targets. Finally by apply novel technique to analyzed phylogenetic data my work offer fast, cost-effective and accurate method to study wide range of biological questions.

Lumen formation in Drosophila tubulogenesis - from the glands to the heart

Type: Lecture
Date: Dec 02 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShuoshuo Wang

Contact cherill.banks@weizmann.ac.il

Cancerous processes hijack the translation machinery

Type: Lecture
Date: Nov 25 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerHila Gingold

Contact cherill.banks@weizmann.ac.il

LDL Receptor as an entry route for VSV

Type: Lecture
Date: Nov 18 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDanit Finkelstein-Beker

Contact cherill.banks@weizmann.ac.il

Autotaxin and neuronal progenitors

Type: Lecture
Date: Nov 11 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRaanan Greenman

Contact cherill.banks@weizmann.ac.il

Integrons, SOS response and Horizontal gene transfers: intimate connections

Type: Lecture
Date: Oct 30 2012

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Didier Mazel

Contact cherill.banks@weizmann.ac.il

Abstract
If integrons are mainly known as the genetic agents responsible for the capture and spread of antibiotic resistance determinants among Gram-negative pathogens, they are also are found in the genomes of hundreds of environmental bacterial species. In particular, all Vibrio genomes sequenced so far have been found to carry a sedentary integron platform. We reported a direct link between this gene capture system and the SOS response, a regulatory network induced by DNA damage, which is known to promote genetic variation in time of stress. We showed that LexA controls the expression of most integron integrases and that SOS induction increases the recombination of gene cassettes. We have now found that horizontal gene transfer mechanisms (conjugation and natural transformation) and most antibiotics induce the SOS response in Vibrio cholerae, and certainly in most Vibrio species. This coupling enhances the potential for cassette swapping and capture in cells undergoing stress, while freezing the cassette arrangement in steady environments. We will discuss how these discoveries sponsors integrons as integrated adaptive systems for these bacteria.

Neural tube closure in the mouse embryo

Type: Lecture
Date: Oct 21 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Rada Massarwa

Contact cherill.banks@weizmann.ac.il

Signal amplification and stabilization in the Spindle Assembly Checkpoint

Type: Lecture
Date: Oct 10 2012

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Andrea Ciliberto

Contact cherill.banks@weizmann.ac.il

Epigenetic mechanisms of inducing pluripotency

Type: Lecture
Date: Jul 01 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOhad Gafni

Contact cherill.banks@weizmann.ac.il

Identifying a new player in the regulation of mTOR and autophagy

Type: Lecture
Date: Jun 24 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYaara Ber

Contact cherill.banks@weizmann.ac.il

Feedbacks linking growth and proliferation in human cancer cells: application of Ergodic Rate Analysis

Type: Lecture
Date: Jun 18 2012

Time13:30 - 13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ran Kafri

Contact cherill.banks@weizmann.ac.il

When cells are inactive in DNA synthesis, viruses R2

Type: Lecture
Date: Jun 17 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerInna Ricardo-Lax

Contact cherill.banks@weizmann.ac.il

Exocrine secretion is guided by actin-cable bundles generated by the formin mDia1

Type: Lecture
Date: Jun 10 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerErez Geron

Contact cherill.banks@weizmann.ac.il

An engineering approach to aging in C. elegans

Type: Lecture
Date: Jun 07 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Dror Sagi

Contact cherill.banks@weizmann.ac.il

Alternative death pathways: Drosophila germ cells got on board

Type: Lecture
Date: Jun 03 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerKeren Yacobi

Contact cherill.banks@weizmann.ac.il

Chromatin Regulators - From noise to function

Type: Lecture
Date: May 06 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYoav Voichek

Contact cherill.banks@weizmann.ac.il

Distinct roles for PTP Eplison and PTP Alpha in osteoclasts

Type: Lecture
Date: Apr 29 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEynat Finkelshtein

Contact cherill.banks@weizmann.ac.il

Selective Mechanisms Operate to Eliminate the Paternal Mitochondria after Fertilization in Drosophila

Type: Lecture
Date: Apr 22 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYoav Politi

Contact cherill.banks@weizmann.ac.il

From Cancer metabolism to glycosylation and back: chemical reporters of O-GlcNAc modification

Type: Lecture
Date: Apr 17 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Matthew Pratt

Contact cherill.banks@weizmann.ac.il

Abstract
O-GlcNAc modification (O-GlcNAcylation) is a highly abundant protein posttranslational modification that is dramatically altered in several human diseases including cancer. We are investigating any links between O-GlcNAcylation, cancer-specific metabolism, and survival in human cancers. To enable our studies, we have developed chemical tools to robustly visualize, identify, and manipulate O-GlcNAcylation in living cells. In this presentation, I will describe the development and characterization of a metabolic chemical reporter of O-GlcNAc modification created in our laboratory, the subsequent identification of 374 potentially O-GlcNAc modified proteins from mammalian cells, and our efforts to understand O-GlcNAc modification of the ubiquitin ligase NEDD4.

mRNA Reprogramming for the Derivation of Integration-free iPS Cell Lines

Type: Lecture
Date: Mar 29 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Kerry P. Mahon

Contact cherill.banks@weizmann.ac.il

Abstract
To date, the translation of induced pluripotent stem (iPS) cell technology from research labs to regenerative medicine and drug screening applications has been limited by the inability to derive clinically relevant human iPS cell lines. Existing methods are either inefficient and cannot be considered for widespread application or yield iPS cells that contain genomic integrations or viral contaminants resulting from the derivation methods. However, advances in mRNA reprogramming methods have recently enabled the efficient generation of integration-free iPS lines in a wide variety of patient fibroblasts. Here, these advances will be discussed in detail and ongoing efforts to move towards fully defined xeno-free conditions for mRNA reprogramming will be addressed.

Bovine serum aminoxidase and polyamines induce cytotoxic effects on human cancer cells: A new approach in antineoplastic therapy

Type: Lecture
Date: Mar 26 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Enzo Agostinelli

Contact cherill.banks@weizmann.ac.il

Runx3-mediates immunity through impact on dendritic cell development and function

Type: Lecture
Date: Mar 25 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYosef Dicken

Contact cherill.banks@weizmann.ac.il

"Function of Rabs and tethering factors at the maturing late endosome"

Type: Lecture
Date: Mar 12 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Christian Ungermann

Contact cherill.banks@weizmann.ac.il

Systems Biology of Viral Pathogenesis and Immunity: Where are Google and IBM?

Type: Lecture
Date: Mar 12 2012

Time12:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMichael G. Katze, Ph.D.

Contact Rotem.Sorek@weizmann.ac.il

A new link between palmitoylation and the neurodegenerative disease; iNCL

Type: Lecture
Date: Mar 11 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMichal Segal

Contact cherill.banks@weizmann.ac.il

Uncovering the elements that regulate splicing using a novel synthetic intron library

Type: Lecture
Date: Feb 26 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerIdo Yofe

Contact cherill.banks@weizmann.ac.il

Grand unification of non-coding RNA genes

Type: Lecture
Date: Feb 19 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerFrida Belinky

Contact cherill.banks@weizmann.ac.il

Releasing the brakes after DNA damage - c-Abl and the G2-M checkpoint

Type: Lecture
Date: Feb 12 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerVicky Meltser

Contact cherill.banks@weizmann.ac.il

Protein import into peroxisomes

Type: Lecture
Date: Feb 07 2012

Time13:30 - 13:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ralf Erdmann

Contact cherill.banks@weizmann.ac.il

The transcriptional network driving t(8;21) leukemia the most common subtype of human AML (Acute Myeloid Leukemia)

Type: Lecture
Date: Feb 05 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOren Ben-Ami

Contact cherill.banks@weizmann.ac.il

S1P1 inhibits sprouting angiogenesis during vascular development

Type: Lecture
Date: Jan 29 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAdi Shiloah

Contact cherill.banks@weizmann.ac.il

&#8220;T-tubules organization in muscles: functional interaction between MSP-300 and a2&#948; proteins&#8221;

Type: Lecture
Date: Jan 22 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMiri Shnayder

Contact cherill.banks@weizmann.ac.il

Self-organized shuttling: Generating a sharp dorso-ventral polarity in the early Drosophila embryo

Type: Lecture
Date: Jan 15 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMichal Haskel

Contact cherill.banks@weizmann.ac.il

Functions of a hematopoietic-specific microRNA

Type: Lecture
Date: Jan 08 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Elik Chapnik

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Jan 01 2012

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerIlya Soifer

Contact cherill.banks@weizmann.ac.il

Regulation of endosomal protein trafficking by starvation and its link to Batten disease

Type: Lecture
Date: Dec 18 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNiv Dobzinski

Contact cherill.banks@weizmann.ac.il

Pancreatic miRNA-7 controls endocrine cell differentiation by regulating Pax6

Type: Lecture
Date: Dec 11 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerSharon Kredo-Russo

Contact cherill.banks@weizmann.ac.il

The strange case of Dr. Jekyll and Mr. Hyde: The Autophagy Protein Atg12 Reveals its Apoptotic Side

Type: Lecture
Date: Dec 04 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAssaf Rubinstein

Contact cherill.banks@weizmann.ac.il

Lipid Justice: Selection and Evolution in an RNA/DNA Free World

Type: Lecture
Date: Nov 27 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOmer Markovitch

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Nov 20 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOmri Wrutzel

Contact cherill.banks@weizmann.ac.il

Anti-bacterial genetic elements hidden within the genomes of bacteria and human

Type: Lecture
Date: Nov 13 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAsaf Levy

Contact cherill.banks@weizmann.ac.il

The Sesamoids: Old bones, new perspective

Type: Lecture
Date: Oct 30 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShai Hershko

Contact cherill.banks@weizmann.ac.il

Life and Death of a Microbial Community

Type: Lecture
Date: Sep 18 2011

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ilana Kolodkin

Contact cherill.banks@weizmann.ac.il

Cell Cycle Dynamics

Type: Lecture
Date: Sep 14 2011

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Jan Skotheim

Contact cherill.banks@weizmann.ac.il

Presenting TIGM: The largest collection of mutant mouse ES cell resources for the scientific community

Type: Lecture
Date: Jul 21 2011

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ben Morpurgo

Contact cherill.banks@weizmann.ac.il

Uncovering the early biogenesis steps of glycophosphatidylinositol (GPI) anchored proteins

Type: Lecture
Date: Jun 26 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Tslil Ast

Contact cherill.banks@weizmann.ac.il

How to be in good shape? Lessons from migrating neurons

Type: Lecture
Date: Jun 19 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Anna Gorelik

Contact cherill.banks@weizmann.ac.il

The long and winding road: from NDEL1 to PPT1

Type: Lecture
Date: Jun 12 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMichal Segal

Contact cherill.banks@weizmann.ac.il

Compartmentalized Activation of Caspases During Spermatogenesis

Type: Lecture
Date: Jun 05 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Lior Aram

Contact cherill.banks@weizmann.ac.il

Stress Induced Population Splitting in Budding Yeast

Type: Lecture
Date: May 29 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Nurit Avraham

Contact cherill.banks@weizmann.ac.il

The effect of musculature contraction on skeletal morphogenesis

Type: Lecture
Date: May 15 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYulia Shwartz

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: May 08 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEfrat Dvash

Contact cherill.banks@weizmann.ac.il

Systematic measurement of protein dynamics in yeast reveals novel stress response arsenal

Type: Lecture
Date: May 01 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMichal Breker

Contact cherill.banks@weizmann.ac.il

Lost in Translation-the mysteries of the tRNA pool

Type: Lecture
Date: Apr 10 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerZohar Bloom

Contact cherill.banks@weizmann.ac.il

New Insights Into How HIV Kills CD4 T Cells in Human Lymphoid Tissues

Type: Lecture
Date: Apr 06 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Gilad Doitsh

Contact cherill.banks@weizmann.ac.il

DAP5 controls the translation of a specific p53 isoform

Type: Lecture
Date: Apr 03 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShira Gabbay

Contact cherill.banks@weizmann.ac.il

Design, Logic and Collective Behavior in DNA nanorobots

Type: Lecture
Date: Mar 29 2011

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ido Bachelet

Contact cherill.banks@weizmann.ac.il

Notch- mediated cross talk between migrating myoblasts antagonizes fusion

Type: Lecture
Date: Mar 27 2011

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerBoaz Gildor

Contact cherill.banks@weizmann.ac.il

Regulation of neural stem cell & neuron numbers in the developing Drosophila brain

Type: Lecture
Date: Mar 16 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. C&#233;dric Maurange

Contact cherill.banks@weizmann.ac.il

Abstract
Two main phases condition the growth of the developing brain. First, neural stem cells divide symmetrically to undergo a proliferative phase until they reach the adequate number. Then, neural stem cells start to divide asymmetrically to undergo a neurogenic phase. The final number of neural progeny -neurons and glia- will depend on the length of both phases. I will describe how during the last years, using Drosophila as a model system, we have uncovered mechanisms that limit these periods. First, I will show how pulses of a steroid hormone limit the proliferative phase by promoting a switch to the asymmetric mode of division. Second, I will present how, in asymmetrically dividing neural stem cells, a series of sequentially expressed transcription factors schedules the end of their divisions to limit neuronal production.

Multiplexin promotes heart lumen formation

Type: Lecture
Date: Mar 13 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNofar Harpaz

Contact cherill.banks@weizmann.ac.il

Runx1-mediated transcriptional regulation during muscle stress response and regeneration

Type: Lecture
Date: Mar 06 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerKfir Umansky

Contact cherill.banks@weizmann.ac.il

The emerging role of chromatin structure in cell migration

Type: Lecture
Date: Feb 27 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerGabi Gerlitz

Contact cherill.banks@weizmann.ac.il

N-Wasp- muscle fusion and beyond

Type: Lecture
Date: Feb 20 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYael Gruenbaum-Cohen

Contact cherill.banks@weizmann.ac.il

Bones are getting back on the straight path

Type: Lecture
Date: Feb 13 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerChagai Rot

Contact cherill.banks@weizmann.ac.il

Possible modulation of the tumor suppressor Hippo pathway by the Src proto-oncoprotein

Type: Lecture
Date: Feb 06 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMatan Shanzer

Contact cherill.banks@weizmann.ac.il

The secret behind the secretion: how do cartilage cells function as secretory cells in the hypoxic growth plate?

Type: Lecture
Date: Jan 30 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLital Wiznitzer

Contact cherill.banks@weizmann.ac.il

Efficient coding and the perception of texture

Type: Lecture
Date: Jan 26 2011

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Vijay Balasubramanian

Contact naomi.moses@weizmann.ac.il

Abstract
The principle of efficient coding in sensory processing states in broad terms that the brain should invest computational resources in relation to the expected gain in information from natural visual scenes. In this talk I will discuss how this principle explains two surprising aspects of visual perception in humans: (a) Greater sensitivity to dark spots and regions in images, and (b) the perceptual salience of certain kinds of artificial visual textures.

Non-coding RNA Club

Type: Lecture
Date: Jan 19 2011

Time13:00 - 13:00

LecturerProf. Chaim Cedar

Contact Eran.horenstein@weizmann.ac.il

To be announced

Type: Lecture
Date: Jan 16 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerBen Gradus

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Jan 09 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerItay Koren

Contact cherill.banks@weizmann.ac.il

Intrinsic properties and expression levels determine the execution potencies of effector caspases

Type: Lecture
Date: Jan 02 2011

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAnat Florentin

Contact cherill.banks@weizmann.ac.il

A switch mechanism from transformation to tumor suppression in the Hippo pathway

Type: Lecture
Date: Dec 26 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRom Keshet

Contact cherill.banks@weizmann.ac.il

Molecular chaperones, ER quality control, and protein conformational disease

Type: Lecture
Date: Dec 20 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Jeffrey Brodsky

Contact cherill.banks@weizmann.ac.il

Direct and indirect coordination of transcriptional and post transcriptional control

Type: Lecture
Date: Dec 12 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOphir Shalem

Contact cherill.banks@weizmann.ac.il

Timer, sizer or both: how budding yeast control their size

Type: Lecture
Date: Nov 28 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerIlya Soifer

Contact cherill.banks@weizmann.ac.il

The GAIT system: A gatekeeper of inflammatory gene expression

Type: Lecture
Date: Nov 23 2010

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Paul L. Fox

Contact cherill.banks@weizmann.ac.il

Growth regulation by polyamines: studies at the transcriptional and translational levels

Type: Lecture
Date: Nov 21 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerGuy Landau

Contact cherill.banks@weizmann.ac.il

NADH as a regulatory molecule in protein degradation

Type: Lecture
Date: Nov 14 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerPeter Tsvetkov

Contact cherill.banks@weizmann.ac.il

Gradients of a Ubiquitin E3 Ligase Inhibitor and a Caspase Inhibitor Determine Differentiation or Death in Spermatids

Type: Lecture
Date: Nov 07 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYosef Kaplan

Contact cherill.banks@weizmann.ac.il

The peptidoglycan: a fascinating macromolecule

Type: Lecture
Date: Nov 02 2010

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ivo Gomperts Boneca

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Oct 31 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerIfat Keydar

Contact cherill.banks@weizmann.ac.il

Megakaryopoiesis is regulated by dynamic combinatorial interactions of RUNX1 and cooperating partners: Implications to trisomy 21 leukemia

Type: Lecture
Date: Oct 24 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNiv Pencovich

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Oct 18 2010

Time10:00 - 10:00

LocationUllmann Building of Life Sciences

LecturerProf. david cooke

Contact cherill.banks@weizmann.ac.il

The war between phages and the bacterial CRISPR immune system

Type: Lecture
Date: Oct 17 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAdi Stern

Contact cherill.banks@weizmann.ac.il

Tuning of synaptic growth by endocytic membrane traffic; a tale of two endosomes

Type: Lecture
Date: Oct 12 2010

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Avital Rodal

Contact cherill.banks@weizmann.ac.il

Rise of the Actin Machines

Type: Lecture
Date: Oct 06 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Bruce Goode

Contact cherill.banks@weizmann.ac.il

Targeted Epigenetic Therapy of Breast Cancer

Type: Lecture
Date: Aug 31 2010

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Samuel Waxman

Contact cherill.banks@weizmann.ac.il

mRNA processing and its multiple links to human disease

Type: Lecture
Date: Aug 30 2010

Time11:30 - 11:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. James Manley

Contact cherill.banks@weizmann.ac.il

A surprising new finding about the p53 tumor suppressor protein

Type: Lecture
Date: Aug 30 2010

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Carol Prives

Contact cherill.banks@weizmann.ac.il

Mechanical regulation of bone shape during development

Type: Lecture
Date: Jun 27 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAmnon Sharir

Contact cherill.banks@weizmann.ac.il

Dissecting the epigenetic "in"stability of the pluripotent and somatic cell states

Type: Lecture
Date: Jun 23 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yaqub Hanna

Contact cherill.banks@weizmann.ac.il

A deadly double agent exposed by RNAi screen: The autophagy protein Atg12 plays a second role in apoptosis

Type: Lecture
Date: Jun 13 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAssaf Rubinstein

Contact cherill.banks@weizmann.ac.il

The evolution of signaling pathways controlling dorsoventral patterning and gastrulation in insects

Type: Lecture
Date: Jun 13 2010

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Siegfried Roth

Contact cherill.banks@weizmann.ac.il

DGCR8 role in DiGeorge syndrome

Type: Lecture
Date: Jun 06 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Elik Chapnik

Contact cherill.banks@weizmann.ac.il

Promoter Paso Doble: Insights into the paradigm of alternative promoter usage

Type: Lecture
Date: May 23 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerKaren Rae Bone

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: May 16 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerGil Hornung

Contact cherill.banks@weizmann.ac.il

Transcriptional Regulation in the Liver: From Organogenesis to Cancer

Type: Lecture
Date: May 12 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Klaus Kaestner

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: May 09 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Vasudheva Reddy Akepati

Contact cherill.banks@weizmann.ac.il

PAF-AH catalytic subunits modulate the Wnt pathway in developing GABAergic neurons

Type: Lecture
Date: Apr 25 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerIdit Livnat

Contact cherill.banks@weizmann.ac.il

How to sculpt a bone? The Mechanism that Regulates Skeletal 3D Structure

Type: Lecture
Date: Apr 18 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEinat Blitz

Contact cherill.banks@weizmann.ac.il

Metabolic networks in disease states

Type: Lecture
Date: Apr 18 2010

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Zoltan Oltvai

Contact cherill.banks@weizmann.ac.il

Insights into the mechanism of cell-type specific transcription regulation

Type: Lecture
Date: Apr 11 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yehuda Salzberg

Contact cherill.banks@weizmann.ac.il

Seminar

Type: Lecture
Date: Mar 22 2010

Time14:30 - 16:00

Contact Benny.Shilo@weizmann.ac.il

The mechanism underlying nuclei positioning during muscle development

Type: Lecture
Date: Mar 21 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerHadas Elhanany-Tamir

Contact cherill.banks@weizmann.ac.il

Functional genomic screen of breast epithelial-to-mesenchymal polarity and breast stem cell renewal

Type: Lecture
Date: Mar 17 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Izhak Haviv

Contact cherill.banks@weizmann.ac.il

Advances in Lab Based MicroCT with Applications in Life science and Materials research

Type: Lecture
Date: Mar 17 2010

Time15:00 - 16:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerS H Lau

Contact Vlad.Brumfeld@weizmann.ac.il

Abstract
Leveraging on detector technology currently used in synchrotron radiation tomography, we describe a novel microXCT capable of scanning sample sizes of several cm to mm dimensions with a variable resolution from mm to submicron resolution. The system overcomes the traditional disadvantage of conventional MicroCTs based on geometric magnification- where imaging resolution is limited to spot size of x-ray source, sample size and the sample-source distance. Furthermore, with the unique PhaseEnhanced detector, soft materials such as biological tissue, polymers, composites may be imaged with significantly higher contrast than traditional Flat Panel detectors. Small density variation in materials, such as mineral phases in geomaterials or fossils embedded within rocks may be imaged and be segmented for quantitative measurements. Characterization of porosity, particle shapes, cracks, defects, bonding thickness for porous composites, ceramics, fibers, geomaterials, tissue engineering and biological specimens will be presented. Results will be contrasted with those obtained from synchrotron, SEMs, histology and MRI.

LDL Receptor &#8211; A Virus Portal to the Cell

Type: Lecture
Date: Mar 14 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDanit Finkelshtein

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Mar 07 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNoa Liberman

Contact cherill.banks@weizmann.ac.il

A unified genetic theory of autism

Type: Lecture
Date: Feb 23 2010

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Michael Wigler

Contact cherill.banks@weizmann.ac.il

PGC-1-alpha level is regulated by a unique proteasomal degradation pathway linked to the nutritional status of the cell

Type: Lecture
Date: Feb 21 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yaarit Adamovich

Contact cherill.banks@weizmann.ac.il

"HOW" is it regulated? The activity of the RNA-binding protein HOW is controlled by MAPK

Type: Lecture
Date: Feb 14 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ronit Nir

Contact cherill.banks@weizmann.ac.il

The metabolic regulation of the 26S/20S proteasomal ration: implication in aging and cancer

Type: Lecture
Date: Jan 31 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerPeter Tsvetkov

Contact cherill.banks@weizmann.ac.il

DAP-kinase and glycolytic regulation: an unexpected connection

Type: Lecture
Date: Jan 24 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Inbal Mor

Contact cherill.banks@weizmann.ac.il

Mechanisms of Proteasome Function: From Protein Degradation to Cancer Therapy

Type: Lecture
Date: Jan 20 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Alfred Goldberg

Contact cherill.banks@weizmann.ac.il

Connective tissues in embryonic patterning

Type: Lecture
Date: Jan 13 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Peleg Hasson

Contact cherill.banks@weizmann.ac.il

The competitive advantage of a dual-transporters system

Type: Lecture
Date: Jan 10 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerSagi Levy

Contact cherill.banks@weizmann.ac.il

The roles of WASp in spermatogenesis in flies and mice

Type: Lecture
Date: Jan 03 2010

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShay Rotkopf

Contact cherill.banks@weizmann.ac.il

December 24, Non Coding club

Type: Lecture
Date: Dec 24 2009

Time13:00 - 14:00

LecturerProf. Shula Michaeli

Contact eran.hornstein@weizmann.ac.il

To be announced

Type: Lecture
Date: Dec 20 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOmri Wurtzel

Contact cherill.banks@weizmann.ac.il

To send or receive but not both: From a Notch signaling switch to developmental patterning

Type: Lecture
Date: Dec 09 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. David Sprinzak

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Nov 29 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAnat Florentin

Contact cherill.banks@weizmann.ac.il

The world of non-coding RNAs in Cyanobacteria and beyond

Type: Lecture
Date: Nov 24 2009

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Wolfgang Hess

Contact cherill.banks@weizmann.ac.il

Abstract
Abstract Regulatory RNA has been discovered in all three domains of life. However, transcriptional units that give rise to non-coding RNAs (ncRNAs) or cis-acting antisense RNAs (asRNAs) are not identified during normal genome annotation, and in phototrophic bacteria only a small number of such RNAs have been described so far. We have used 5 different methods for the identification of novel non-coding and antisense RNAs in various cyanobacteria, with a focus on model cyanobacteria. The reliability of computational predictions for the detection of ncRNAs and asRNAs in Synechocystis sp. PCC 6803 and for marine Synechococcus species was scrutinized in microarrays, complemented by deep sequencing of the small RNA population and validated by extensive Northern and 5' RACE analyses (1-4). The total number of classical trans-acting ncRNAs in Synechocystis sp. PCC 6803 reaches several hundred different transcripts, the number of antisense RNAs is even more than 1000. Thus, non-coding RNAs play a much more important role in this model organism and probably also in most other bacteria. Although clear-cut functions have been established only for very few of these RNAs so far (5), there isl evidence for cyanobacterial ncRNAs acting against invading phages, controlling the expression of key photosynthetic genes, or serving as signals for RNA maturation, processing and degradation. (1) Axmann et al. (2005), Genome Biol. 6, R73: 1-16. (2) Steglich et al. (2008), PLoS Genetics 4 (8) e10000173. (3) Voss et al. (2009), BMC Genomics 10, 123. (4) Georg et al. (2009), Mol. Sys. Biol. 5, 305. (5) Duehring et al. (2006) Proc. Natl. Acad. Sci. USA 103, 7054-7058

Computational Skeletogenesis - A Novel Approach to the Study of Bone Development

Type: Lecture
Date: Nov 22 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerTomer Stern

Contact cherill.banks@weizmann.ac.il

Natural variation in a neuroglobin reconfigures O2 responses in wild C. elegans

Type: Lecture
Date: Nov 22 2009

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Einav Gross

Contact cherill.banks@weizmann.ac.il

The impostor syndrome

Type: Lecture
Date: Nov 15 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Maya Schuldiner

Contact cherill.banks@weizmann.ac.il

The interdependent development of the limb and blood vessels

Type: Lecture
Date: Nov 08 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerIdit Eshkar Oren

Contact cherill.banks@weizmann.ac.il

How many viral proteins are needed for poxvirus entry into cells?

Type: Lecture
Date: Nov 02 2009

Time11:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Bernard Moss

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Nov 01 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYehudit Hasin

Contact cherill.banks@weizmann.ac.il

dHtrA2/dOmi is involved in a noncanonical cell death program during normal elimination of spermatogonial cells in Drosophila

Type: Lecture
Date: Oct 25 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Keren Yacobi-Sharon

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Oct 18 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShaul Yogev

Contact cherill.banks@weizmann.ac.il

Coupling of transcription and post-transcriptional regulation and its role in control of cell fate

Type: Lecture
Date: Oct 11 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerReut Shalgi

Contact cherill.banks@weizmann.ac.il

"Imaris: from basic to advanced image visualization and analysis"

Type: Lecture
Date: Sep 23 2009

Time09:30 - 11:00

LecturerLuciano A G Lucas

Contact mosheg@eisenbros.co.il

Abstract
Imaris, launched by Bitplane AG in 1992, is a leading 2D, 3D and 4D microscopy image analysis and visualization software package for scientific and biomedical applications. Imaris&#8217; functions can be tailored to your specific requirements and are designed to allow researchers to visualize, quantify, and track objects over time. Imaris can also analyze filamentous structures (e.g. dendrites, blood vessels, cytoskeletal fibres), classify dendritic spines and determine objective colocalization. Today, Imaris is used worldwide by scientists in a wide range of research fields (see our publication list here: http://www.bitplane.com/go/applications/publication-list ).

"Authentication of forensic DNA samples"

Type: Lecture
Date: Sep 15 2009

Time10:00 - 11:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Dan Frumkin

Contact rotem.sorek@weizmann.ac.il

Abstract
Abstract Over the past twenty years, DNA analysis has revolutionized forensic science, and has become a dominant tool in law enforcement. Today, DNA evidence is key to the conviction or exoneration of suspects of various types of crime, from theft to rape and murder. However, the disturbing possibility that DNA evidence can be faked has been overlooked. It turns out that standard molecular biology techniques such as PCR, molecular cloning, and recently developed whole genome amplification (WGA), enable anyone with basic equipment and know-how to produce practically unlimited amounts of in vitro synthesized (artificial) DNA with any desired genetic profile. This artificial DNA can then be applied to surfaces of objects or incorporated into genuine human tissues and planted in crime scenes. Here we show that the current forensic procedure fails to distinguish between such samples of blood, saliva, and touched surfaces with artificial DNA, and corresponding samples with in vivo generated (natural) DNA. Furthermore, genotyping of both artificial and natural samples with Profiler Plus1 yielded full profiles with no anomalies. In order to effectively deal with this problem, we developed an authentication assay, which distinguishes between natural and artificial DNA based on methylation analysis of a set of genomic loci: in natural DNA, some loci are methylated and others are unmethylated, while in artificial DNA all loci are unmethylated. The assay was tested on natural and artificial samples of blood, saliva, and touched surfaces, with complete success. Adopting an authentication assay for casework samples as part of the forensic procedure is necessary for maintaining the high credibility of DNA evidence in the judiciary system.

&#8220;Protein schizophrenia&#8221;: Dual and eclipsed distribution of proteins in eukaryotes

Type: Lecture
Date: Jun 24 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ophry Pines

Contact cherill.banks@weizmann.ac.il

The Spatial Organization of Protein Folding Quality Control

Type: Lecture
Date: Jun 22 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Daniel Kaganovich

Contact cherill.banks@weizmann.ac.il

Human RNase P: a new type of transcription factor that is made of ribonucleoprotein

Type: Lecture
Date: Jun 10 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Nayef Jarrous

Contact cherill.banks@weizmann.ac.il

Cytoskeletal control of cell shape and tissue patterning

Type: Lecture
Date: Jun 03 2009

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Buzz Baum

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: May 31 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMerav Arieli and Michal Haskal

Contact cherill.banks@weizmann.ac.il

Neural Extoderm Secreted-FGF Initiates the Expression of Nkx2.5 in Cardiac Progenitors

Type: Lecture
Date: May 27 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Eyal Bengal

Contact cherill.banks@weizmann.ac.il

DCDC5, a "sweet" member of the Doublecortin family, tells its story for the 1st time

Type: Lecture
Date: May 24 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAna Kaplan

Contact cherill.banks@weizmann.ac.il

Cardiac and Skeletal Muscle Developmental Programs during Embryogenesis and Adulthood

Type: Lecture
Date: May 20 2009

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eldad Tzahor

Contact cherill.banks@weizmann.ac.il

miRNAs role in endocrine pancreas development

Type: Lecture
Date: May 17 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerSharon Kredo

Contact cherill.banks@weizmann.ac.il

Phosphorylation of the Groucho/TLE co-repressor by MAPK: implications for EGFR signalling

Type: Lecture
Date: May 13 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ze'ev Paroush

Contact cherill.banks@weizmann.ac.il

Postponed to next Sunday

Type: Lecture
Date: May 10 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerSharon Kredo

Contact cherill.banks@weizmann.ac.il

Molecular Mechanisms of Neuronal Morphogenesis in the Vertebrate Retina

Type: Lecture
Date: May 06 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Flavio R. Zolessi

Contact cherill.banks@weizmann.ac.il

The role of multiple mRNA-3&#8217;UTRs in translation regulation by micro-RNA

Type: Lecture
Date: May 03 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOren Ben-Ami

Contact cherill.banks@weizmann.ac.il

Mechanisms of axonal degeneration

Type: Lecture
Date: Apr 30 2009

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Avraham Yaron

Contact cherill.banks@weizmann.ac.il

A Novel Regulator of Robo Activity in Drosophila Embryonic Muscle Development

Type: Lecture
Date: Apr 26 2009

Time13:00 - 13:00

LecturerBess Wayburn

Contact cherill.banks@weizmann.ac.il

Transcription factor/microRNA interplay paradigm: The Runx1/miR-27a regulatory loop

Type: Lecture
Date: Apr 23 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOren Ben-Ami

Contact cherill.banks@weizmann.ac.il

Together, two ubiquitin-binding proteins can serve as a polyubiquitin chain-length sensor

Type: Lecture
Date: Apr 22 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Michael Glickman

Contact cherill.banks@weizmann.ac.il

A new C. elegans cell death pathway

Type: Lecture
Date: Apr 20 2009

Time13:00 - 13:00

LecturerDr. Shai Shaham

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Apr 19 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Apr 05 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYaara Azaria

Contact cherill.banks@weizmann.ac.il

Yeast tubulin cochaperone E: analysis of a UbL domain protein

Type: Lecture
Date: Apr 01 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Dina Raveh

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Mar 29 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerIlya Venger

Contact cherill.banks@weizmann.ac.il

HBV activates dNTP synthesis in quiescent cells

Type: Lecture
Date: Mar 22 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDorit Cohen

Contact cherill.banks@weizmann.ac.il

Scientific Publishing & The Editorial Process at The EMBO Journal

Type: Lecture
Date: Mar 19 2009

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Karen Dumstrei

Contact cherill.banks@weizmann.ac.il

14-3-3 proteins in the cell surface transport of membrane proteins

Type: Lecture
Date: Mar 16 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Blanche Schwappach

Contact cherill.banks@weizmann.ac.il

Growth regulation by polyamines: studies at transcriptional and translational levels

Type: Lecture
Date: Mar 15 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerGuy Landau

Contact cherill.banks@weizmann.ac.il

Fatal attraction: Two interconnected kinases regulate cell death

Type: Lecture
Date: Mar 08 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAvital Eisenberg-Lerner

Contact cherill.banks@weizmann.ac.il

VICKZ RNA binding proteins as interior designers during development and disease

Type: Lecture
Date: Mar 04 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Joel Yisraeli

Contact cherill.banks@weizmann.ac.il

Tyrosine phosphatase Epsilon regulates leptin signaling and body mass

Type: Lecture
Date: Mar 01 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLiat Rousso-Noori

Contact cherill.banks@weizmann.ac.il

Two ubiquitin related mystery plots

Type: Lecture
Date: Feb 25 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Michael Brandeis

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Feb 22 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerSagi Levy

Contact cherill.banks@weizmann.ac.il

The Yeast model for Batten Disease: BTN1, BTN2 and BTN3 and their critical role in endosome-Golgi protein retrieval

Type: Lecture
Date: Feb 15 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr Vydehi Kanneganti

Contact cherill.banks@weizmann.ac.il

Mechanisms and compartmentalization in glycoprotein ER quality control

Type: Lecture
Date: Feb 11 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Gerardo Lederkremer

Contact cherill.banks@weizmann.ac.il

S1P1 controls blood vessel diameter by negatively regulating VEGF signaling (Adi Shiloah); A minimilastic EGFR ligand processing machinery in the flour beetle (Tal Rousso)

Type: Lecture
Date: Feb 08 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerTal Rousso & Adi Shiloah

Contact cherill.banks@weizmann.ac.il

Off the beaten track: alternative pathways for mRNA transport to cellular compartments

Type: Lecture
Date: Feb 04 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yoav Arava

Contact cherill.banks@weizmann.ac.il

Genome - the edited version: RNA and DNA editing in human

Type: Lecture
Date: Jan 28 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Erez Levanon

Contact cherill.banks@weizmann.ac.il

Evolution of gene expression:divergence between related yeast species and rewiring in their hybrid

Type: Lecture
Date: Jan 25 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Itay Tirosh

Contact cherill.banks@weizmann.ac.il

miRNA loss of function causes ALS-like motor neuron disease

Type: Lecture
Date: Jan 22 2009

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eran Hornstein

Contact cherill.banks@weizmann.ac.il

Cancelled

Type: Lecture
Date: Jan 18 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAmnon Sharir

Contact cherill.banks@weizmann.ac.il

The in vivo dynamics of mRNA processing and transport

Type: Lecture
Date: Jan 14 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yaron Shav-Tal

Contact cherill.banks@weizmann.ac.il

Molecular regulation of tendon induction and differentiation

Type: Lecture
Date: Jan 14 2009

Time15:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ronen Schweitzer

Contact cherill.banks@weizmann.ac.il

Mimivirus: Distinct DNA Exit and Packaging Portals

Type: Lecture
Date: Jan 11 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNathan Zauberman

Contact cherill.banks@weizmann.ac.il

miRNAs in osteoclast differentiation and function

Type: Lecture
Date: Jan 04 2009

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerMati Mann

Contact cherill.banks@weizmann.ac.il

Cancelled

Type: Lecture
Date: Dec 31 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ophry Pines

Contact cherill.banks@weizmann.ac.il

Struggling for harmony - skeletal development as part of the musculoskeletal system

Type: Lecture
Date: Dec 31 2008

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Elazar Zelzer

Contact cherill.banks@weizmann.ac.il

Evolutionary conserved biogenesis of mitochondrial outer membrane proteins

Type: Lecture
Date: Dec 24 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Doron Rapaport

Contact cherill.banks@weizmann.ac.il

Slowdown: A novel regulator of Muscle/Tendon junction formation in Drosophila melanogaster

Type: Lecture
Date: Dec 21 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEli Gilsohn

Contact cherill.banks@weizmann.ac.il

Noise Facilitates the Evolution of Novel Morphologies in Bacteria

Type: Lecture
Date: Dec 18 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Avigdor Eldar

Contact cherill.banks@weizmann.ac.il

Control of Kidney Development by BMPs, SHH and beta-catenin

Type: Lecture
Date: Dec 17 2008

Time09:45 - 09:45

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Norman Rosenblum

Contact cherill.banks@weizmann.ac.il

Stop codon mediated suppression of splicing - A story without translation

Type: Lecture
Date: Dec 14 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEyal Kamhi

Contact cherill.banks@weizmann.ac.il

miRNAs in midbrain dopamine neuron development and function

Type: Lecture
Date: Dec 11 2008

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Asa Abeliovich

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Dec 07 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLiat Ravid

Contact cherill.banks@weizmann.ac.il

Dissecting the role of trafficking regulators by a membrane reporter fusion approach

Type: Lecture
Date: Dec 03 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Dan Cassel

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Nov 30 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Maya Schuldiner

Contact cherill.banks@weizmann.ac.il

Proteasome Power and Processivity: Designer Substrates that Test the Limits

Type: Lecture
Date: Nov 26 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Philip Coffino

Contact cherill.banks@weizmann.ac.il

Regulation of Caspase Activation during Drosophila Spermatogenesis

Type: Lecture
Date: Nov 26 2008

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eli Arama

Contact cherill.banks@weizmann.ac.il

Nuclear lamin regulation of chromosome organization, mitosis and aging

Type: Lecture
Date: Nov 19 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Yosef Gruenbaum

Contact cherill.banks@weizmann.ac.il

Role of microRNA-21 in gliomagenesis

Type: Lecture
Date: Nov 17 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Galina Gabriely

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Nov 09 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Maya Schuldiner

Contact cherill.banks@weizmann.ac.il

MAPK signaling in equations and embryos

Type: Lecture
Date: Nov 06 2008

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Stanislav Shvartsman

Contact cherill.banks@weizmann.ac.il

Reductionism and Systems Biology in Studying the COP9 Signalosome

Type: Lecture
Date: Nov 05 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Danny Chamovitz

Contact cherill.banks@weizmann.ac.il

Microbial biology with high throughput sequencing

Type: Lecture
Date: Nov 02 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Rotem Sorek

Contact cherill.banks@weizmann.ac.il

Ovary formation and stem cell establishment in Drosophila melanogaster

Type: Lecture
Date: Oct 29 2008

Time09:45 - 09:45

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLilach Gilboa

Contact cherill.banks@weizmann.ac.il

Cancelled

Type: Lecture
Date: Oct 29 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Michael Glickman

Contact cherill.banks@weizmann.ac.il

Post-transcriptional gene regulation in the Drosophila germ line

Type: Lecture
Date: Oct 28 2008

Time14:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Paul Lasko

Contact cherill.banks@weizmann.ac.il

"Unwinding the structure and function of the MCM helicase"

Type: Lecture
Date: Aug 06 2008

Time11:00 - 12:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Zvi Kelman

Contact shmuel.pietrokovski@weizmann.ac.il

To be announced

Type: Lecture
Date: Jun 29 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerRoy Amariglio

Contact cherill.banks@weizmann.ac.il

miRNAs of the inner ear

Type: Lecture
Date: Jun 26 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLilach Fridman

Contact cherill.banks@weizmann.ac.il

Translational control in cancer and innate immunity

Type: Lecture
Date: Jun 25 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Nahum Sonenberg

Contact cherill.banks@weizmann.ac.il

Cancelled

Type: Lecture
Date: Jun 22 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAmir Mitchel

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Jun 15 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerLiat Ravid

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Jun 11 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Elior Peles

Contact cherill.banks@weizmann.ac.il

Ranning Long Distance In Injured Nerve

Type: Lecture
Date: Jun 04 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Michael Fainzilber

Contact cherill.banks@weizmann.ac.il

Direct Reprogramming of Somatic Cells to Pluripotent ES-like Cells

Type: Lecture
Date: Jun 03 2008

Time12:00 - 12:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yaqub Hanna

Contact cherill.banks@weizmann.ac.il

System level studies of the Programmed Cell Death (PCD) network

Type: Lecture
Date: Jun 01 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Einat Zalckvar

Contact cherill.banks@weizmann.ac.il

Adult stem cells regulation by miRNA

Type: Lecture
Date: May 29 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerSharon Kredo

Contact cherill.banks@weizmann.ac.il

Fragile homeostasis control of the gut evident in knockout mice

Type: Lecture
Date: May 28 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Yinon Ben-Neriah

Contact cherill.banks@weizmann.ac.il

LIS1 - More or Less

Type: Lecture
Date: May 28 2008

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Tamar Sapir

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: May 25 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerPeter Tsvetkov

Contact cherill.banks@weizmann.ac.il

Focusing on miRNA involvement in WNT signaling and in gut development

Type: Lecture
Date: May 15 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Moshe Biton

Contact cherill.banks@weizmann.ac.il

Translational Control during Mitosis

Type: Lecture
Date: May 14 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Orna Elroy Stein

Contact cherill.banks@weizmann.ac.il

"The role of PTPalpha in bone" & "Catch a message by the tail - mRNA localization in yeast and mammalian cells"

Type: Lecture
Date: May 11 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEynat Finkelshtein & Boris Slobodin

Contact cherill.banks@weizmann.ac.il

The actin nucleator SCAR/WAVE mediates myoblast fusion

Type: Lecture
Date: May 04 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerBoaz Gildor

Contact cherill.banks@weizmann.ac.il

Ribosomal protein S6 phosphorylation: From TOP mRNAs to cell size

Type: Lecture
Date: Apr 30 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Oded Meyuhas

Contact cherill.banks@weizmann.ac.il

Mechanisms directing the arrest of muscle migration and the formation of the myotendinous junction

Type: Lecture
Date: Apr 30 2008

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Talila Volk

Contact cherill.banks@weizmann.ac.il

MicroRNAs Regulate Brain to Body Anti-Inflammatory Signaling

Type: Lecture
Date: Apr 17 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Mona Soreq

Contact cherill.banks@weizmann.ac.il

SIRT1: a possible link between metabolism and the circadian clock

Type: Lecture
Date: Apr 16 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Gad Asher

Contact cherill.banks@weizmann.ac.il

DAP1: regulation and function in autophagy

Type: Lecture
Date: Apr 13 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerItay Koren

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Apr 06 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerZohar Snapir

Contact cherill.banks@weizmann.ac.il

A multistep epigenetic mechanism for the inactivation of embryonic-specific genes

Type: Lecture
Date: Apr 02 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Yehudit Bergman

Contact cherill.banks@weizmann.ac.il

Phagocytosis of apoptotic cells: learning from the fly

Type: Lecture
Date: Mar 26 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Estee Kurant

Contact cherill.banks@weizmann.ac.il

Taking a bite out of life: The role of PTP epsilon in bone resorption

Type: Lecture
Date: Mar 23 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerShira Granot-Attas

Contact cherill.banks@weizmann.ac.il

Structural insights into the nuclear envelope by cryo-electron tomography

Type: Lecture
Date: Mar 19 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ohad Medalia

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Mar 16 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yaarit Adamovich

Contact cherill.banks@weizmann.ac.il

Molecular Genetics, Dept. Retreat

Type:
Date: Mar 11 2008 - Mar 13 2008

Cell biology and evolution of dorsoventral axis formation

Type: Lecture
Date: Mar 09 2008

Time15:00 - 15:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Siegfried Roth

Contact cherill.banks@weizmann.ac.il

Robust lateral inhibition selection process

Type: Lecture
Date: Mar 09 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOmer Barad

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Mar 02 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOren Ben-Ami

Contact cherill.banks@weizmann.ac.il

Induction and suppression of RNA silencing: insights from viral infections

Type: Lecture
Date: Feb 28 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerTamar Yifhar

Contact cherill.banks@weizmann.ac.il

Abstract
In eukaryotes, small RNA molecules engage in sequence-specific interactions to inhibit gene expression by RNA silencing. This process fulfills fundamental regulatory roles, as well as antiviral functions, through the activities of microRNAs and small interfering RNAs. As a counter-defense mechanism, viruses have evolved various anti-silencing strategies that are being progressively unraveled. These studies have not only highlighted our basic understanding of host-parasite interactions, but also provide key insights into the diversity, regulation and evolution of RNA-silencing pathways.

Modulation of axon responsiveness to guidance cues

Type: Lecture
Date: Feb 27 2008

Time10:00 - 10:00

LecturerProf. Avraham Yaron

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Feb 27 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Karina Yaniv

Contact cherill.banks@weizmann.ac.il

Genetic Analysis of Dopaminergic Differentiation in Zebrafish &#8211; From Neuronal Specification to Behavior

Type: Lecture
Date: Feb 25 2008

Time11:30 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Wolfgang Driever

Contact Gil.Levkowitz@weizmann.ac.il

ZIP kinase - a unique case of murine evolutionary divergence

Type: Lecture
Date: Feb 24 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYishay Shoval

Contact cherill.banks@weizmann.ac.il

Adventures at the sensory synapse

Type: Lecture
Date: Feb 20 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Shai Shaham

Contact cherill.banks@weizmann.ac.il

Ndel1 Palmitoylation: a Novel Mean to Regulate Cytoplasmic Dynein Activity

Type: Lecture
Date: Feb 17 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAnat Shmueli

Contact cherill.banks@weizmann.ac.il

Functional interactions between sterols and sphingolipids in yeast

Type: Lecture
Date: Feb 13 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Howard Riezman

Contact cherill.banks@weizmann.ac.il

Scaling of the BMP gradient in Xenopus

Type: Lecture
Date: Feb 10 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDanny Ben-Zvi

Contact cherill.banks@weizmann.ac.il

Mechanisms of genetic control of telomere length

Type: Lecture
Date: Feb 06 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Martin Kupiec

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Feb 03 2008

Time13:00 - 13:00

LecturerYehudit Hasin

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Jan 27 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDanny Levy

Contact cherill.banks@weizmann.ac.il

Enzymes-in-pieces: evolution and activity of split-inteins

Type: Lecture
Date: Jan 20 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Bareket Dassa

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Jan 13 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEinat Blitz

Contact cherill.banks@weizmann.ac.il

The neuronal circuitry underlying olfactory perception

Type: Lecture
Date: Jan 10 2008

Time11:30 - 11:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Gilad Barnea

Contact cherill.banks@weizmann.ac.il

The amazing ribosome

Type: Lecture
Date: Jan 09 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ada Yonath

Contact cherill.banks@weizmann.ac.il

To be announced

Type: Lecture
Date: Jan 06 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerTal Sines

Contact cherill.banks@weizmann.ac.il

Viruses and the cellular DNA damage machinery

Type: Lecture
Date: Jan 03 2008

Time13:00 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Matthew Weitzman

Contact karni.hertz@weizmann.ac.il

Exploring the Molecular Mechanism of Axon Pruning

Type: Lecture
Date: Jan 02 2008

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Oren Schuldiner

Contact cherill.banks@weizmann.ac.il

Osteopaenia (Bone Deficit) and Runx3: The Skeletons in Runx3 Closet

Type: Lecture
Date: Dec 30 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOmri Bauer

Contact cherill.banks@weizmann.ac.il

Global and local architecture of the mammalian microRNA-transcription factor regulatory network

Type: Lecture
Date: Dec 23 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerReut Shalgi

Contact cherill.banks@weizmann.ac.il

Hepatitis C virus replication is mediated by a Rab1 GTPase-activating protein

Type: Lecture
Date: Dec 19 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ella Sklan

Contact cherill.banks@weizmann.ac.il

ER stress in atherosclerosis: the unfortunate "survival of the fattest"?

Type: Lecture
Date: Dec 16 2007

Time13:00 - 13:00

LecturerDr. Tali Garin

Contact cherill.banks@weizmann.ac.il

A molecular stent mediates substrate reception and translocation through the proteasome

Type: Lecture
Date: Dec 12 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Michael Glickman

Contact cherill.banks@weizmann.ac.il

GETting from High-Throughput Biology to Mechanism - The Role of the Yeast GET Complex in Tail Anchored Protein Biogenesis

Type: Lecture
Date: Dec 11 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Maya Schuldiner

Contact cherill.banks@weizmann.ac.il

miRNA role in Diabetes and pancreas development

Type: Lecture
Date: Nov 28 2007

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eran Hornstein

Contact cherill.banks@weizmann.ac.il

Determinants of the DNA replication timing program of the yeast genome

Type: Lecture
Date: Nov 18 2007

Time13:00 - 13:00

LecturerAmnon Koren

Contact cherill.banks@weizmann.ac.il

A Decade of GeneCards

Type: Lecture
Date: Nov 15 2007

Time09:00 - 18:00

LocationDolfi and Lola Ebner Auditorium

Contact marilyn.safran@weizmann.ac.il

The evolution of RNA polyadenylation; different tails tell different tales

Type: Lecture
Date: Nov 14 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Gadi Schuster

Contact cherill.banks@weizmann.ac.il

Stop codon mediated suppression of splicing - a story without translation

Type: Lecture
Date: Nov 08 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEyal Kamhi

Contact cherill.banks@weizmann.ac.il

A metabolic circuit regulates protein stability of a key factor in glucose homeostasis

Type: Lecture
Date: Nov 04 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Amir Shlomai

Contact cherill.banks@weizmann.ac.il

What's in the Net(work)? Signaling Pathways Underlying Neuronal Differentiation of the Zebrafish Forebrain

Type: Lecture
Date: Oct 31 2007

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Gil Levkowitz

Contact cherill.banks@weizmann.ac.il

Memories: What keeps them going, if at all

Type: Lecture
Date: Oct 31 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Yadin Dudai

Contact cherill.banks@weizmann.ac.il

MicroRNAs Play an Essential Role in Craniofacial Development

Type: Lecture
Date: Oct 28 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ayelet Schlesinger

Contact cherill.banks@weizmann.ac.il

The repertoire of human miRNA genes

Type: Lecture
Date: Oct 25 2007

Time13:00 - 14:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOmer Barad

Contact cherill.banks@weizmann.ac.il

The Search for Biological Networks of Hearing

Type: Lecture
Date: Oct 17 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Karen Avraham

Contact cherill.banks@weizmann.ac.il

Copy number variation in human olfactory receptors

Type: Lecture
Date: Jul 29 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYehudit Hasin

Contact cherill.banks@weizmann.ac.il

Student seminar

Type: Lecture
Date: Jul 22 2007

Time13:00 - 13:00

LecturerSagi Levy

Contact cherill.banks@weizmann.ac.il

Student Seminar

Type: Lecture
Date: Jul 15 2007

Time13:00 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDima Lukatsky

Contact karni.hertz@weizmann.ac.il

Student Seminar

Type: Lecture
Date: Jul 08 2007

Time13:00 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerViki Meltzer

Contact karni.hertz@weizmann.ac.il

Design Principles from Viral Genetic Circuits: Complexity, Feedback, and Transcriptional Noise

Type: Lecture
Date: Jul 03 2007

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Leor S. Weinberger

Contact cherill.banks@weizmann.ac.il

Student Seminar

Type: Lecture
Date: Jul 01 2007

Time13:00 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerTal Garin & Yehudit Hasin

Contact karni.hertz@weizmann.ac.il

microRNAs in beta cell biology and Diabetes

Type: Lecture
Date: Jun 24 2007

Time13:00 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Tal Melkman

Contact karni.hertz@weizmann.ac.il

Cross-talk between the nucleus and the cytoplasm: identifying general and specific coordinators of mRNA synthesis, transport, translation and degredation

Type: Lecture
Date: Jun 20 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Mordechai (Motti) Choder

Contact cherill.banks@weizmann.ac.il

Abstract
Gene expression is traditionally divided into distinct stages (e.g., transcription, translation). We have identified a heredodimer, Rpb4/7, that functions in all major stages of gene expression, while shuttling between the nucleus and the cytoplasm. Rpb4/7-interacts with Pol II and stimulates transcription. During transcription, Rpb4/7 interacts with the transcript and later escorts the transcripts during its life cycle &#8211; thus mediating the various post-transcriptional steps. At some stage during the mRNA decay pathway, the heterodimer returns to the nucleus to initiate a new round of transcription. Our preliminary observations suggest that upon returning to the nucleus, Rpb4/7 delivers information about the mRNA level in the cytoplasm. In addition to Rpb4/7 that seems to play a general role, we have found class-specific factors that interact with Rpb4 and probably shuttle together with Rpb4/7 and function similarly to Rpb4/7. We found that the post-transcriptional functions of Rpb4/7 are mechanistically coupled to its transcriptional role. Thus, recruitment of Rpb4/7 to Pol II is a prerequisite to its roles in the cytoplasm. Based on these and other results, we propose that gene expression can be regarded as one continuous process. We hypothesize that coupling between all stages is made possible by general and class-specific coordinators whose main role is to make sure that all steps are carried out at appropriate pace. Rpb4/7 might function as a platform on which class-specific coordinators are assembled.

The role of the musculature in joint formation

Type: Lecture
Date: Jun 17 2007

Time13:00 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerJoy Kahn

Contact karni.hertz@weizmann.ac.il

Adenosine to Inosine editing in the human genome

Type: Lecture
Date: Jun 13 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Gideon Rechavi

Contact cherill.banks@weizmann.ac.il

Abstract
RNA editing by members of the ADAR (adenosine deaminases acting on RNA) family leads to site-specific conversion of adenosine to inosine (A-to-I) in precursor messenger RNAs. Editing by ADARs is believed to occur in all metazoa, and is essential for mammalian development. Until recently, only a limited number of human ADAR substrates were known, including the glutamate and serotonin receptors. Several diseases were associated with altered editing including depression associated suicide and amyotrophic lateral sclerosis. We conducted a computational search for ADAR editing sites in the human transcriptome, using millions of available expressed sequences. We mapped 12,723 A-to-I editing sites in 1,637 different genes, with an estimated accuracy of 95%, raising the number of known editing sites by two orders of magnitude. We experimentally validated our method by verifying the occurrence of editing in 26 novel substrates. A-to-I editing in humans primarily occurs in noncoding regions of the RNA, typically in Alu repeats. Analysis of the large set of editing sites indicates the role of editing in controlling dsRNA stability. Widespread editing could be relevant to various disease states.

Student Seminar

Type: Lecture
Date: Jun 10 2007

Time13:00 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOren Ben-Ami

Contact karni.hertz@weizmann.ac.il

Tracking the progression of hepatocellular carcinoma in mouse models

Type: Lecture
Date: Jun 06 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Yinon Ben-Neriah

Contact cherill.banks@weizmann.ac.il

Abstract
Hepatocellular carcinoma (HCC) commonly develops on the background of chronic hepatitis. We have recently shown that nuclear factor-kappaB (NF-kappaB), a molecular hallmark of inflammatory responses that is frequently detected in human tumors, links between inflammation and cancer. We ratified this hypothesis by studying Mdr2-knockout (Mdr2-/-) mice, which spontaneously develops cholestatic hepatitis followed by HCC. NF-kappaB inhibition in this model markedly slows tumor progression, yet surprisingly has an opposite effect in a carcinogen-induced liver cancer model where it facilitates tumorigenesis. Furthermore, as time elapses, tumor incidence is significantly elevated despite NF-kappaB inhibition even in the inflammation-HCC model. As NF-kappaB is considered an important target for anti-inflammatory and anti-cancer therapy, understanding its contrasting effects in liver cancer progression is of significant importance. Our studies aim to resolve the NF-kappaB paradox and identify other relevant mechanisms in inflammation-induced cancer.

Embryonic stem cells as a cellular model for normal and pathological skin development

Type: Lecture
Date: Jun 04 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Daniel Aberdam

Contact cherill.banks@weizmann.ac.il

Chromatin reassembly - it's all in the timing

Type: Lecture
Date: May 30 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Chaim Cedar

Contact cherill.banks@weizmann.ac.il

Student Seminar

Type: Lecture
Date: May 27 2007

Time13:00 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Itay Tirosh

Contact karni.hertz@weizmann.ac.il

Transcription Regulation: How are the regulators regulated?

Type: Lecture
Date: May 20 2007

Time13:00 - 14:30

LecturerSarit Weissmann

Contact karni.hertz@weizmann.ac.il

Nuclear gate-keepers and flying cargoes: reconstituting nuclear transport in the test-tube

Type: Lecture
Date: May 16 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Amnon Harel

Contact cherill.banks@weizmann.ac.il

Novel Roles for the Polarity Kinase MARK2/Par1 during Neuronal Migration

Type: Lecture
Date: May 13 2007

Time13:00 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerSivan Sapoznik

Contact karni.hertz@weizmann.ac.il

Human Embryonic Stem Cells in Genetic Research

Type: Lecture
Date: May 09 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Nissim Benvenisty

Contact cherill.banks@weizmann.ac.il

Abstract
Human embryonic stem cells (HESCs) have been suggested to play a major role in transplantation medicine and to further our knowledge in human embryology. We propose that these cells should also play a vital role in the creation of models for human disorders. Here we demonstrate three different methodologies to isolate HESCs carrying genetic disorders: 1. We have targeted the HPRT1 gene in HESCs by homologous recombination. Mutation in this gene triggers an overproduction of uric acid and leads to Lesch-Nyhan disease. The HPRT1- cells show a higher rate of uric acid accumulation compared to wild-type cells. Therefore, these cells recapitulate to some extent the characteristics of Lesch-Nyhan syndrome, and can help to further investigate this genetic disease. 2. By searching for spontaneous chromosomal aberrations that occur in culture, we have isolated several HESC clones with 45,X0 karyotype. These clones may enable us to identify genetic factors that could explain the fact that 99% of XO pregnancies terminate during the first trimester, in addition to the variable manifestations in Turner syndrome. 3. We have isolated ES cell lines from blastocysts harboring a preexisting mutation for Fragile X syndrome identified by preimplantation genetic diagnosis (PGD). Most Fragile X patients do not express the FMR1 protein as a result of a CGG triplet repeat expansion at the 5&#8217; UTR of the gene. Currently, it is unclear at what stage in development and by what mechanism FMR1 is being silenced. Since the CGG expansion cannot be modeled in mice, we aimed to study the developmental inactivation of FMR1 expression using HESCs. Our strategies emphasize the role of HESCs in studying human genetic disorders, especially where the mouse models fail to recapitulate the phenotype observed in patients.

DAP5 controls cell survival by promoting cap-independent translation of Cdc2 and Bcl-2

Type: Lecture
Date: May 06 2007

Time13:00 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerNoa Liberman

Contact karni.hertz@weizmann.ac.il

On the Turning Away: Axon Guidance at a Choice Point

Type: Lecture
Date: May 02 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Avihu Klar

Contact cherill.banks@weizmann.ac.il

The involvement of translation regulation in species divergence

Type: Lecture
Date: Apr 29 2007

Time13:00 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOrna Man

Contact karni.hertz@weizmann.ac.il

Ataxia-Telangiectasia: Closer to Unraveling the Mystery?

Type: Lecture
Date: Apr 25 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Yosef Shiloh

Contact cherill.banks@weizmann.ac.il

slow-motion: A novel regulator of the myotendinous junction adhesion

Type: Lecture
Date: Apr 22 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEli Gilsohn

Contact cherill.banks@weizmann.ac.il

Dynamics of pancreatic beta cells: cellular origins and regenerative potential

Type: Lecture
Date: Apr 18 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Yuval Dor

Contact cherill.banks@weizmann.ac.il

Student Seminar

Type: Lecture
Date: Apr 15 2007

Time13:00 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDorit Cohen

Contact karni.hertz@weizmann.ac.il

slow-motion: A novel regulator of the myotendinous junction adhesion

Type: Lecture
Date: Apr 14 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerEli Gilsohn

Contact cherill.banks@weizmann.ac.il

The c-Jun dimerization protein 2, JDP2, a tumor suppressor or an oncogene?

Type: Lecture
Date: Apr 11 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ami Aronheim

Contact cherill.banks@weizmann.ac.il

Abstract
The AP-1 transcription factor is a dimeric complex composed between members of the basic leucine zipper (bZIP) proteins. The c-Jun dimerization protein 2, JDP2, is a relatively novel member of the bZIP family that was isolated initially based on its ability to bind c-Jun. JDP2 is able to strongly repress AP-1 dependent transcription by multiple mechanisms. JDP2 is involved in differentiation of skeletal muscle and osteoclast cells. In addition, JDP2 over-expression results in inhibition of cell proliferation and cellular transformation both in vitro and in vivo. However, other studies suggested that JDP2 may function as an oncogene. We have generated transgenic mice over-expressing JDP2 specifically in the liver under the control of the tetracycline regulated promoter. This model can functionally inhibit AP-1 transcription in a reversible and regulated manner and therefore has several advantages over the current available conditional knockout mice of single components of the AP-1 transcription factor. Hepatocellular carcinoma is the fifth most frequent cancer in the world and the third leading cause of cancer death. To reveal the role of JDP2 in oncogenesis, we are using two distinct mice models for liver cancer resembling the etiology of heptocellular carcinoma in human. The first is a chemically induced liver cancer model that includes a single injection of diethylnitrosamine (DEN) that results in liver cancer within 10-12 months of age. The second liver cancer model is: an inflammation dependent genetic model in which the multi drug resistance 2 gene (Mdr2) is disrupted. In this model, liver cancer spontaneously develops at 12 months of age. By using these two models we obtained different consequences in the development of hepatocellular carcinoma as a result of JDP2 over-expression. The possible mechanisms involved in the differential effects exerted by JDP2 will be discussed.

Genetic dissection of Pax6 dosage requirements in the developing iris

Type: Lecture
Date: Mar 28 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ruth Ashery Padan

Contact cherill.banks@weizmann.ac.il

Physical constraints and limits to precision in early embryonic development

Type: Lecture
Date: Mar 22 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Thomas Gregor

Contact cherill.banks@weizmann.ac.il

FF, a new family of type I plasma membrane proteins that mediate developmental cell fusion

Type: Lecture
Date: Mar 21 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Benjamin Podbilewicz

Contact cherill.banks@weizmann.ac.il

Student Seminar

Type: Lecture
Date: Mar 18 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerYaron Gruper

Contact karni.hertz@weizmann.ac.il

Role of Nuclear Factor-kappaB in pancreatic beta cell death

Type: Lecture
Date: Mar 14 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Danielle Melloul

Contact cherill.banks@weizmann.ac.il

DAP-kinase is a Novel Regulator of JNK Signaling Acting Upstream of Protein Kinase D

Type: Lecture
Date: Mar 11 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAvital Eisenberg

Contact karni.hertz@weizmann.ac.il

Inherited skin disorders in genetically homogeneous populations

Type: Lecture
Date: Mar 07 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Eli Sprecher

Contact cherill.banks@weizmann.ac.il

miRNA that makes siRNAs that make asymmetric leaves

Type: Lecture
Date: Feb 28 2007

Time10:00 - 10:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ira Pekker

Contact cherill.banks@weizmann.ac.il

In vivo Localization of mRNAs Encoding Peroxisomal and Mitochondrial Genes

Type: Lecture
Date: Feb 25 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerGadi Zipor

Contact karni.hertz@weizmann.ac.il

The role of glia in Drosophila nervous system development

Type: Lecture
Date: Feb 21 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Ulrike Gaul

Contact cherill.banks@weizmann.ac.il

Abstract
Glia play crucial and diverse roles in nervous system development and function, but the underlying molecular and cellular mechanisms are not well characterized. We have established the transcription profile of Drosophila embryonic glia using FACS and Affymetrix microarray analysis, identified ~250 genes with differential glial expression, and examined the function of interesting candidates using RNAi and gene knockout. In my talk, I will discuss a novel GPCR pathway with a role in glial blood-brain barrier formation, a novel secreted factor involved in axon tract formation, and a novel scavenger receptor required for the phagocytosis of apoptotic neurons.

Student Seminar

Type: Lecture
Date: Feb 18 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Julia Adler

Contact karni.hertz@weizmann.ac.il

Mitochondrial VDAC: The gatekeeper of cell life and death

Type: Lecture
Date: Feb 14 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Varda Shoshan-Barmatz

Contact cherill.banks@weizmann.ac.il

Abstract
Mitochondria are not only central to basic life functions as the generators of cellular energy, but also act as the point for cellular decisions leading to apoptosis. In mitochondria-mediated apoptosis, pro-apoptotic proteins, normally located in the mitochondrial intermembranal space, are released to the cytosol. In this process, the voltage-dependent anion channel (VDAC) plays a central role. VDAC, located at the outer mitochondrial membrane, provides the passage for nucleotides, Ca2+ and other metabolites into and out of mitochondria while serving as a site for apoptotic signalling. The role of VDAC in regulating cell life and death was investigated by silencing endogenous human VDAC1 (hVDAC1) expression using shRNA, controlling native and mutated murine VDAC1 expression levels, over-expressing anti-apoptotic proteins such as hexokinase-I (HK-I) and Bcl2, and using VDAC1-based peptides. We found that down-expression of hVDAC1 led to an inhibition of cell proliferation due to disrupted energy production in the cell. On the other hand, over-expression of native or mutated VDAC1 resulted in apoptotic cell death. We demonstrate that over-expression of HK-I and Bcl2 protects against apoptosis and that a single mutation in VDAC1 prevents this effect, suggesting that such protections relies on binding to VDAC1. In addition, our results indicate that oligomeric VDAC1 forms a protein-conducting channel for the passage of cytochrome c. Moreover, the VDAC1 N-terminus is required for the induction of apoptosis since cells expressing truncated VDAC1 were resistance to mitochondria-mediated apoptosis as induced by starusporine, curcumin or As2O3. Furthermore, using a SPR-based approach, a synthetic peptide representing the VDAC1 N-terminus was shown to specifically binds to HK-I and Bcl2. When expressed in cells overexpressing these proteins, the peptide prevented the protective effects of HK-I and Bcl2 in the face of staurosporine-induced apoptotic cell death. These results suggest that VDAC1 is a component of the apoptotic machinery, with its N-terminal region mediating this role regulating, pointing to VDAC1 as a checkpoint for cell life and death.

" The Role of Antizyme Inhibitor (AzI) in Regulation of Cellular Growth

Type: Lecture
Date: Feb 11 2007

Time13:00 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerAlona Keren-Paz

Contact karni.hertz@weizmann.ac.il

Cell Death, Compensatory Proliferation and Cancer

Type: Lecture
Date: Feb 07 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Hermann Steller

Contact cherill.banks@weizmann.ac.il

A multidisciplinary study of intein-like domains specific to predatory

Type: Lecture
Date: Feb 04 2007

Time13:00 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Bareket Dassa

Contact karni.hertz@weizmann.ac.il

Neurogenesis of Cerebellar Granule Cells is regulated by Notch and BMP signaling

Type: Lecture
Date: Jan 31 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Nissim Ben-Arie

Contact cherill.banks@weizmann.ac.il

Abstract
Cerebellar granule cells (CGC) are the most abundant neurons in the mammalian brain, and an important tool for unraveling molecular mechanisms underlying neurogenesis. Math1 is a bHLH transcription activator that is essential for the genesis of CGC. To delineate the effects of Math1 on CGC differentiation, we generated and studied primary cultures of CGC progenitors from Math1/lacZ knockout mice. We found that that CGC differentiation, but not specification, depends on Math1, which acts by regulating the level of multiple components of the Notch signaling pathway. Cerebellar granule cells arise in the rhombic lip located at the roof of the brain's fourth ventricle. Bordering the rhombic lip is the choroid plexus, a non-neuronal structure, composed of blood vessels enveloped by epithelial cells. We discovered a striking decrease in neural differentiation of rhombic lip-derived cells, which failed to extend neuritic processes and attenuate Math1 promoter activity, when co-cultured with choroid plexus cells. Our data indicate that besides its secretory and barrier functions, the choroid plexus has a novel role in attenuating the differentiation of adjacent neural progenitors via the BMP signaling pathway.

The repertoire of human miRNA genes

Type: Lecture
Date: Jan 25 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerOmer Barad

Contact cherill.banks@weizmann.ac.il

Neuronal fate determined by microtubule reorientation and vesicle targeting: the case of regeneration after injury and experimental tauopathy

Type: Lecture
Date: Jan 24 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Micha Spira

Contact cherill.banks@weizmann.ac.il

Production of recombinant spider silk protein fibers and analysis of their properties towards their utilization as novel biomaterials

Type: Lecture
Date: Jan 17 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Uri Gat

Contact cherill.banks@weizmann.ac.il

Abstract
The spider web fibers are made from a fascinating material that has attracted the interest of man for thousands of years. Among the different types of spider silks, from which the web fibers are composed, the &#8220;dragline silk&#8221; is the most intensely studied due to its extreme toughness that is higher than that of most other known materials whether natural or man made. Utilizing the powerful baculovirus expression system in insect cells we have employed the garden-cross (A. Diadematus) spider dragline silk partial cDNA clones and produced high levels of the two encoded proteins, which are the main components of the spider&#8217;s dragline silk fibers. Surprisingly, analysis of the insect cells expressing one of the proteins showed the spontaneous self-assembly of long and intricate silk fibers. These artificial spider silk fibers could be easily isolated and purified from the cells due to their resilience, which was similar to that of natural silk fibers, and indeed recapitulated the extraordinary chemical resistance properties of the later. By genetically engineering the spider silk protein domains, this system opens the way for structure-function analysis of spider silk fiber formation, which has been long considered one of natures&#8217; greatest mysteries. For example we have recently shown that the non-repetitive C-terminal domain of ADF4 is essential for producing oriented spider silk fibers, demonstrating how we can utilize this system to learn about the assembly properties of these unique proteins. Our future research goal is to be able to synthesize spider silk-based fibers that constitute novel biomaterials, which may then be exploited for various industrial applications

Mechanisms underlying the generation of Neural Crest migration

Type: Lecture
Date: Jan 10 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerProf. Chaya Kalcheim

Contact cherill.banks@weizmann.ac.il

Abstract
The Neural Crest is a transient embryonic structure that generates a rich variety of derivatives such as peripheral neurons and glia, Schwann cells, melanocytes, endocrine cells and mesectoderm of the head and face. During neural crest ontogeny, an epithelial to mesenchymal transition is necessary for cell emigration from the dorsal neural tube. This process is likely to involve a network of gene activites which remain largely unexplored. I will discuss our studies implying a pivotal role for a BMP/noggin balance that in turn stimulates canonical Wnt signaling and cell cycle properties required for generating cell movement. In addition, we show that N-cadherin inhibits the onset of crest delamination both by a cell adhesion-dependent mechanism as well as by repressing canonical Wnt signaling. N-cadherin protein is normally downregulated along the dorsal tube in association with the onset of crest delamination, and we find that this process is triggered by BMP4. BMP4 stimulates cleavage of N-cadherin into a soluble cytoplasmic fragment via an ADAM10-dependent mechanism. The resulting cytoplasmic N-cadherin fragment translocates into the nucleus, stimulates cyclinD1 transcription and crest delamination, while enhancing transcription of b-catenin. Hence, by promoting its cleavage, BMP4 converts N-cadherin inhibition into an activity likely to participate, along with canonical Wnt signaling, in the stimulation of neural crest emigration.

Metabolists, Geneticists, Compartmentalists, Unite!!!

Type: Lecture
Date: Jan 04 2007

Time10:30 - 11:30

Website http://www.colbud.hu/fellows/szathmary.shtml

LecturerE&ouml;rs Szathm&aacute;ry

Contact doron.lancet@weizmann.ac.il

Abstract
METABOLISTS, GENETICISTS, COMPARTMENTALISTS, UNITE!! E&ouml;rs Szathm&aacute;ry Collegium Budapest (Institute for Advanced Study) szathmary@colbud.hu I shall give my perspective on the origin of life research. In my view structural studies must be complemented by dynamical ones, and a systems chemical approach is inevitable. I shall discuss the main difficulties in the (re)construction of various (infra) biological chemical systems, and shall attempt to outline some tasks for the future.

Genomic incursions into the unconquered terrains of human genetic disease

Type: Lecture
Date: Jan 03 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Nadav Ahituv

Contact cherill.banks@weizmann.ac.il

Abstract
At present, within the post human genomic era, it is estimated that over 1,200 genes have been characterized to cause human Mendelian disease. However, many common human diseases, such as obesity, are on the greater part not Mendelian but complex, whose etiology is both genetic and environmental. To identify potential genetic contributors to obesity, we resequenced the coding exons and splice junctions of 58 genes in 379 obese and 378 lean individuals. Our 96Mb survey included 21 genes associated with monogenic forms of obesity in humans or mice, as well as 37 genes that function in body weight-related pathways. We found that the monogenic obesity-associated gene group was enriched for rare deleterious nonsynonymous variants unique to the obese versus lean population. Taken together, these data suggest that multiple rare alleles contribute to obesity in the population and provide a deep medical sequencing-based approach to detect them. In addition, human disease may be caused by cis-regulatory mutations, a terrain that remains largely unexplored mainly due to the unavailability of a known regulatory code. Using comparative genomics we have characterized evolutionary conserved non-coding regions on a whole-genome scale and are using the mouse as a tool to generate a whole-genome enhancer database (http://enhancer.lbl.gov). Having a comprehensive list of mammalian enhancers will give researchers a training set to develop a regulatory code for these elements, thus allowing to comprehend the effects of nucleotide changes within these elements and their contribution to human disease. The use of rigorous mouse manipulations such as knockouts to further characterize the regulatory function of some of these elements will also be described.

Hepatitis C virus replication is mediated by a Rab1 GTPase-activating protein

Type: Lecture
Date: Jan 01 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDr. Ella Sklan

Contact cherill.banks@weizmann.ac.il

What's in the Net(work)?

Type: Lecture
Date: Jan 01 2007

Student Seminar

Type: Lecture
Date: Jan 01 2007

Time13:00 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerDorit Cohen

Contact karni.hertz@weizmann.ac.il

Student Seminar

Type: Lecture
Date: Jan 01 2007

Time13:00 - 14:30

LocationArthur and Rochelle Belfer Building for Biomedical Research

Contact karni.hertz@weizmann.ac.il

To be announced

Type: Lecture
Date: Jan 01 2007

Time13:00 - 13:00

LocationArthur and Rochelle Belfer Building for Biomedical Research

LecturerReut Shalgi

Contact cherill.banks@weizmann.ac.il