<p>Living systems from individual cells to entire tissues adopt diverse curved shapes, appearing on many length scales and commonly driven by active contractile stresses generated in the cell cytoskeleton. Yet, how these forces generate specific 3D forms remains unclear. By recreating the cell cytoskeleton from basic components, with precisely controlled composition and initial geometry, we demonstrate that the spontaneous buildup of stress gradients generated by these molecular motors drive shape deformation. We identify the shape selection rules that determine the final adopted configurations. These are encoded in the initial radius to thickness aspect ratio, likely indicating shaping scalability. These results provide insights on the mechanically induced spontaneous shape transitions in contractile active matter, revealing potential shared mechanisms with living systems across scales.</p><p> </p><p> </p><p><strong>FOR THE LATEST UPDATES AND CONTENT ON SOFT MATTER AND BIOLOGICAL PHYSICS AT THE WEIZMANN, VISIT OUR WEBSITE: https://www.biosoftweizmann.com/</strong></p>
