The Center for Magnetic Resonance Research (CMRR) has been at the forefront of magnetic resonance imaging (MRI) innovation, pioneering ultra-high field (7 Tesla and above) technologies that are revolutionizing brain research and clinical care. This presentation will explore CMRR's groundbreaking journey, from the first functional MRI study to development of high-resolution fMRI capabilities revealing cortical columns within the human cortex. The presentation will also explore the translation of these technologies into clinical practice, with a focus on the unique visualization capabilities of 7T MRI, particularly for enhancing the precision of Deep Brain Stimulation (DBS) procedures.By exploring the progression from the 7T system to the world’s first 10.5T human MRI, this presentation will illustrate how these transformative technologies have pushed the limits of imaging science, uncovering new insights into brain function and advancing personalized clinical care at the intersection of technology, research, and medicine.