Publications

Giannoulis A., Feintuch A., Barak Y., Mazal H., Albeck S., Unger T., Yang F., Su X. & Goldfarb D. (2020). Two closed ATP- and ADP-dependent conformations in yeast Hsp90 chaperone detected by Mn(II) EPR spectroscopic techniques. Proceedings of the National Academy of Sciences of the United States of America. 117:(1)395-404.

Suzumoto Y., Dym O., Roviello G. N., Worek F., Sussman J. L. & Manco G. (2020). Structural and functional characterization of new ssopox variant points to the dimer interface as a driver for the increase in promiscuous paraoxonase activity. International Journal of Molecular Sciences. 21:(5)

Prabahar V., Afriat-Jurnou L., Paluy I., Peleg Y. & Noy D. (2020). New homologues of Brassicaceae water-soluble chlorophyll proteins shed light on chlorophyll binding, spectral tuning, and molecular evolution. FEBS Journal. 287:(5)991-1004.

Lahav-Mankovski N., Prasad P. K., Oppenheimer-Low N., Raviv G., Dadosh T., Unger T., Salame T. M., Motiei L. & Margulies D. (2020). Decorating bacteria with self-assembled synthetic receptors. Nature Communications. 11:(1)

Rosenthal M., Metzl-Raz E., Buergi J., Yifrach E., Drwesh L., Fadel A., Peleg Y., Rapaport D., Wilmanns M., Barkai N., Schuldiner M. & Zalckvar E. (2020). Uncovering targeting priority to yeast peroxisomes using an in-cell competition assay. Proceedings of the National Academy of Sciences of the United States of America. 117:(35)21432-21440.

Warszawski S., Katz A. B., Lipsh R., Khmelnitsky L., Ben Nissan G., Javitt G., Dym O., Unger T., Knop O., Albeck S., Diskin R., Fass D., Sharon M. & Fleishman S. J. (2019). Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces. PLoS Computational Biology. 15:(8)

Dalaloyan A., Martorana A., Barak Y., Gataulin D., Reuveny E., Howe A., Elbaum M., Albeck S., Unger T., Frydman V., Abdelkader E. H., Otting G. & Goldfarb D. (2019). Tracking Conformational Changes in Calmodulin in vitro, in Cell Extract, and in Cells by Electron Paramagnetic Resonance Distance Measurements. ChemPhysChem. 20:(14)1860-1868.

Zahradnik J., Kolarova L., Peleg Y., Kolenko P., Svidenska S., Charnavets T., Unger T., Sussman J. L. & Schneider B. (2019). Flexible regions govern promiscuous binding of IL-24 to receptors IL-20R1 and IL-22R1. FEBS Journal. 286:(19)3858-3873.

Novichkova D. A., Lushchekina S., Dym O., Masson P., Silman I. & Sussman J. L. (2019). The four-helix bundle in cholinesterase dimers: Structural and energetic determinants of stability. Chemico-Biological Interactions. 309.

Arafeh R., Di Pizio A., Elkahloun A. G., Dym O., Niv M. Y. & Samuels Y. (2019). RASA2 and NF1; two-negative regulators of Ras with complementary functions in melanoma. Oncogene. 38:(13)2432-2434.

Karbat I., Altman-Gueta H., Fine S., Szanto T., Hamer-Rogotner S., Dym O., Frolow F., Gordon D., Panyi G., Gurevitz M. & Reuveny E. (2019). Pore-modulating toxins exploit inherent slow inactivation to block K+ channels. Proceedings of the National Academy of Sciences of the United States of America. 116:(37)18700-18709.

Netzer R., Listov D., Lipsh R., Dym O., Albeck S., Knop O., Kleanthous C. & Fleishman S. J. (2018). Ultrahigh specificity in a network of computationally designed protein-interaction pairs. Nature Communications. 9:(1)

Kantaev R., Riven I., Goldenzweig A., Barak Y., Dym O., Peleg Y., Albeck S., Fleishman S. J. & Haran G. (2018). Manipulating the Folding Landscape of a Multi-Domain Protein. Journal of Physical Chemistry B. 122:(49)11030-11038.

Elad N., Baron S., Peleg Y., Albeck S., Grunwald J., Raviv G., Shakked Z., Zimhony O. & Diskin R. (2018). Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 angstrom resolution. Nature Communications. 9:(1)

Karniel A., Mrusek D., Steinchen W., Dym O., Bange G. & Bibi E. (2018). Co-translational folding intermediate dictates membrane targeting of the signal recognition particle-receptor. Journal of Molecular Biology. 430:(11)1607-1620.

Bandyopadhyay B. & Peleg Y. (2018). Facilitating circular permutation using Restriction Free (RF) cloning. Protein Engineering Design & Selection. 31:(3)65-68.

Ben-Nissan G., Vimer S., Warszawski S., Katz A., Yona M., Unger T., Peleg Y., Morgenstern D., Cohen-Dvashi H., Diskin R., Fleishman S. J. & Sharon M. (2018). Rapid characterization of secreted recombinant proteins by native mass spectrometry. Communications Biology. 1:(1)

Sonawane P. D., Pollier J., Panda S., Szymanski J., Massalha H., Yona M., Unger T., Malitsky S., Arendt P., Pauwels L., Almekias-Siegl E., Rogachev I., Meir S., Cardenas P. D., Masri A., Petrikov M., Schaller H., Schaffer A. A., Kamble A., Giri A. P., Goossens A. & Aharoni A. (2017). Correction: Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism (vol 3, 16205, 2016). Nature Plants. 3.

Bandyopadhyay B., Goldenzweig A., Unger T., Adato O., Fleishman S. J., Unger R. & Horovitz A. (2017). Local energetic frustration affects the dependence of green fluorescent protein folding on the chaperonin GroEL. Journal of Biological Chemistry. 292:(50)20583-20591.

Cohen-Khait R., Dym O., Hamer-Rogotner S. & Schreiber G. (2017). Promiscuous Protein Binding as a Function of Protein Stability. Structure (London, England : 1993). 25:(12)1867-1874.e3.

Milrot E., Shimoni E., Dadosh T., Rechav K., Unger T., Van Etten E. J. L. & Minsky A. (2017). Structural studies demonstrating a bacteriophage-like replication cycle of the eukaryote-infecting Paramecium bursaria chlorella virus-1. PLoS Pathogens. 13:(8)

Sun L., Xiong Y., Bashan A., Zimmerman E., Daube S. S., Peleg Y., Albeck S., Unger T., Yonath H., Krupkin M., Matzov D. & Yonath A. (2015). A Recombinant Collagen-mRNA Platform for Controllable Protein Synthesis. ChemBioChem. 16:(10)1415-1419.

Nissinkorn Y., Lahav-Mankovski N., Rabinkov A., Albeck S., Motiei L. & Margulies D. (2015). [Cover Profile] Sensing Protein Surfaces with Targeted Fluorescent Receptors. Chemistry (Weinheim an der Bergstrasse, Germany). 21:(45)15873-15873.

Carlessi R., Levin-Salomon V., Ciprut S., Bialik S., Berissi H., Albeck S., Peleg Y. & Kimchi A. (2011). GTP binding to the ROC domain of DAP-kinase regulates its function through intramolecular signalling. EMBO Reports. 12:(9)917-923.

Karanicolas J., Com J. E., Chen I., Joachimiak L. A., Dym O., Peck S. H., Albeck S., Unger T., Hu W., Liu G., Delbecq S., Montelione G. T., Spiegel C. P., Liu D. R. & Baker D. (2011). A De Novo Protein Binding Pair By Computational Design and Directed Evolution. Molecular Cell. 42:(2)250-260.

Dym O., Albeck S., Peleg Y., Schwarz A., Shakked Z., Burstein Y. & Zimhony O. (2009). Structure-Function Analysis of the Acyl Carrier Protein Synthase (AcpS) from Mycobacterium tuberculosis. Journal of Molecular Biology. 393:(4)937-950.

Levin K. B., Dym O., Albeck S., Magdassi S., Keeble A. H., Kleanthous C. & Tawfik D. (2009). Following evolutionary paths to protein-protein interactions with high affinity and selectivity. Nature Structural & Molecular Biology. 16:(10)1049-U67.

Sharabi O., Peleg Y., Mashiach E., Vardy E., Ashani Y., Simian I., Sussman J. L. & Shifman J. M. (2009). Design, expression and characterization of mutants of fasciculin optimized for interaction with its target, acetylcholinesterase. Protein Engineering Design & Selection. 22:(10)641-648.

Liberman N., Dym O., Unger T., Albeck S., Peleg Y., Jacobovitch Y., Branzburg A., Eisenstein M., Marash L. & Kimchi A. (2008). The Crystal Structure of the C-Terminal DAP5/p97 Domain Sheds Light on the Molecular Basis for Its Processing by Caspase Cleavage. Journal of Molecular Biology. 383:(3)539-548.

Dym O., Albeck S., Unger T., Jacobovitch J., Branzburg A., Michael Y., Frenkiel-Krispin D., Wolf S. G. & Elbaum M. (2008). Crystal structure of the Agrobacterium virulence complex VirE1-VirE2 reveals a flexible protein that can accommodate different partners. Proceedings of the National Academy of Sciences of the United States of America. 105:(32)11170-11175.

Albeck S., Dym O., Unger T., Snapir Z., Bercovich Z. & Kahana C. (2008). Crystallographic and biochemical studies revealing the structural basis for antizyme inhibitor function. Protein Science. 17:(5)793-802.

Goihberg E., Dym O., Tel-Or S., Shimon L., Frolow F., Peretz M. & Burstein Y. (2008). Thermal stabilization of the protozoan Entamoeba histolytica alcohol dehydrogenase by a single proline substitution. Proteins-Structure Function And Bioinformatics. 72:(2)711-719.

Peleg Y. & Unger T. (2008). Application of High-Throughput Methodologies to the Expression of Recombinant Proteins in E. coli. . 197-208.

Fogg M. J., Alzari P., Bahar M., Bertini I., Betton J. -., Burmeister W. P., Cambillau C., Canard B., Carrondo M., Coll M., Daenke S., Dym O., Egloff M. -., Enguita F. J., Geerlof A., Haouz A., Jones T. A., Ma Q. & Manicka S. N. (2006). Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens. Acta Crystallographica Section D: Biological Crystallography. 62:(10)1196-1207.

Unger T., Oren Z. & Shai Y. (2001). The effect of cyclization of magainin 2 and melittin analogues on structure, function, and model membrane interactions: Implication to their mode of action. Biochemistry. 40:(21)6388-6397.

Unger T., Juven-Gershon T., Moallem E., Berger M., Sionov R., Lozano G., Oren M. & Haupt Y. (1999). Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2. EMBO Journal. 18:(7)1805-1814.

Unger T., Sionov R., Moallem E., Yee C., Howley P., Oren M. & Haupt Y. (1999). Mutations in serines 15 and 20 of human p53 impair its apoptotic activity. Oncogene. 18:(21)3205-3212.

Mietz J. A., Unger T., Huibregtse J. M. & Howley P. M. (1992). The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein. EMBO Journal. 11:(13)5013-20.

Unger T., Nau M. M., Segal S. & Minna J. D. (1992). p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer. EMBO Journal. 11:(4)1383-90.

Shpilka T., Welter E., Borovsky N., Amar N., Shimron F., Peleg Y. & Elazar Z. (). Fatty acid synthase is preferentially degraded by autophagy upon nitrogen starvation in yeast. Proceedings of the National Academy of Sciences of the United States of America. 112:(5)1434-1439.

Baron S., Peleg Y., Grunwald J., Morgenstern D., Elad N., Peretz M., Albeck S., Levin Y., Welch J. T., Deweerd K. A., Schwarz A., Burstein Y., Diskin R., Shakked Z. & Zimhony O. (). Expression of a recombinant, 4'-Phosphopantetheinylated, active M. tuberculosis fatty acid synthase I in E. coli. PLoS ONE. (9)

Romier C., Ben Jelloul M., Albeck S., Buchwald G., Busso D., Celie P. H., Christodoulou E., De Marco V., Van Gerwen S., Knipscheer P., Lebbink J. H., Notenboom V., Poterszman A., Rochel N., Cohen S. X., Unger T., Sussman J. L., Moras D., Sixma T. K. & Perrakis A. (). Co-expression of protein complexes in prokaryotic and eukaryotic hosts: Experimental procedures, database tracking and case studies. Acta Crystallographica Section D: Biological Crystallography. 62:(10)1232-1242.

Vitu E., Kim S., Sevier C. S., Lutzky O., Heldman N., Bentzur M., Unger T., Yona M., Kaiser C. A. & Fass D. (). Oxidative activity of yeast Ero1p on protein disulfide isomerase and related oxidoreductases of the endoplasmic reticulum. Journal of Biological Chemistry. 285:(24)18155-18165.

Cardenas P. D., Sonawane P. D., Heinig U., Jozwiak A., Panda S., Abebie B., Kazachkova Y., Pliner M., Unger T., Wolf D., Ofner I., Vilaprinyo E., Meir S., Davydov O., Gal-On A., Burdman S., Giri A., Zamir D., Scherf T., Szymanski J., Rogachev I. & Aharoni A. (). Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases. Nature Communications. 10.

Goldsmith M., Barad S., Knafo M., Savidor A., Ben-Dor S., Brandis A., Mehlman T., Peleg Y., Albeck S., Dym O., Ben-Zeev E., Barbole R. S., Aharoni A. & Reich Z. (). Identification and characterization of the key enzyme in the biosynthesis of the neurotoxin β-ODAP in grass pea. The journal of Biological chemistry. 298:(5)

Mishra N. K., Peleg Y., Cirri E., Belogus T., Lifshitz Y., Voelker D. R., Apell H., Garty H. & Karlish S. J. (). FXYD proteins stabilize Na,K-ATpase: Amplification of specific phosphatidylserine-protein interactions. Journal of Biological Chemistry. 286:(11)9699-9712.

Tarayrah-Ibraheim L., Maurice E. C., Hadary G., Ben-Hur S., Kolpakova A., Braun T., Peleg Y., Yacobi-Sharon K. & Arama E. (). DNase II mediates a parthanatos-like developmental cell death pathway in Drosophila primordial germ cells. Nature Communications. 12:(1)

Zeev-Ben-Mordehai T., Paz A., Peleg Y., Toker L., Wolf S. G., Rydberg E. H., Sussman J. & Silman I. (). Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: Over-expression, purification and biophysical characterization. Protein Expression and Purification. 63:(2)147-157.

Goldenzweig A., Goldsmith M., Hill S. E., Gertman O., Laurino P., Ashani Y., Dym O., Unger T., Albeck S., Prilusky J., Lieberman R. L., Aharoni A., Silman I., Sussman J., Tawfik D. & Fleishman S. J. (). Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability. Molecular Cell. 63:(2)337-346.

Peleg Y. & Unger T. (). Application of the Restriction-Free (RF) cloning for multicomponents assembly. . 73-87.

Berry I. M., Dym O., Esnouf R. M., Harlos K., Meged R., Perrakis A., Sussman J., Walter T. S., Wilson J. & Messerschmidt A. (). SPINE high-throughput crystallization, crystal imaging and recognition techniques: Current state, performance analysis, new technologies and future aspects. Acta Crystallographica Section D: Biological Crystallography. 62:(10)1137-1149.

Gould N. L., Scherer G. R., Carvalho S., Shurrush K., Kayyal H., Edry E., Elkobi A., David O., Foqara M., Thakar D., Pavesi T., Sharma V., Walker M., Maitland M., Dym O., Albeck S., Peleg Y., Germain N., Babaev I., Sharir H., Lalzar M., Shklyar B., Hazut N., Khamaisy M., LéVesque M., Lajoie G., Avoli M., Amitai G., Lefker B., Subramanyam C., Shilton B., Barr H. & Rosenblum K. (). Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimers disease phenotype in mice. Journal of Clinical Investigation. 133:(19)

Graslund S., Peleg Y., Albeck S., Unger T., Dym O., Prilusky J. & Sussman J. L. (). Protein production and purification. Nature Methods. 5:(2)135-146.

Rozenberg A., Kaczmarczyk I., Matzov D., Vierock J., Nagata T., Sugiura M., Katayama K., Kawasaki Y., Konno M., Nagasaka Y., Aoyama M., Das I., Pahima E., Church J., Adam S., Borin V. A., Chazan A., Augustin S., Wietek J., Dine J., Peleg Y., Kawanabe A., Fujiwara Y., Yizhar O., Sheves M., Schapiro I., Furutani Y., Kandori H., Inoue K., Hegemann P., Beja O. & Shalev-Benami M. (). Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels. Nature Structural and Molecular Biology. 29:(6)592-603.

Albeck S. & Schreiber G. (). Biophysical characterization of the interaction of the β-lactamase TEM- 1 with its protein inhibitor BLIP. Biochemistry. 38:(1)11-21.

Cohen S., Dym O., Albeck S., Ben-Dov E., Cahan R., Firer M. & Zaritsky A. (). High-Resolution Crystal Structure of Activated Cyt2Ba Monomer from Bacillus thuringiensis subsp. israelensis. Journal of Molecular Biology. 380:(5)820-827.

Sonawane P. D., Pollier J., Panda S., Szymanski J., Massalha H., Yona M., Unger T., Malitsky S., Arendt P., Pauwels L., Almekias-Siegl E., Rogachev I., Meir S., Cardenas P. D., Masri A., Petrikov M., Schaller H., Schaffer A. A., Kamble A., Giri A. P., Goossens A. & Aharoni A. (). Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism. Nature Plants. 3.

RöThlisberger D., Khersonsky O., Wollacott A. M., Jiang L., Dechancie J., Betker J., Gallaher J. L., Althoff E. A., Zanghellini A., Dym O., Albeck S., Houk K. N., Tawfik D. S. & Baker D. (). Kemp elimination catalysts by computational enzyme design. Nature. 453:(7192)190-195.

Aizenberg J., Albeck S., Weiner S. & Addadi L. (). Crystal-protein interactions studied by overgrowth of calcite on biogenic skeletal elements. Journal of Crystal Growth. 142:(1-2)156-164.

Busso D., Peleg Y., Heidebrecht T., Romier C., Jacobovitch Y., Dantes A., Salim L., Troesch E., Schuetz A., Heinemann U., Folkers G. E., Geerlof A., Wilmanns M., Polewacz A., Quedenau C., Buessow K., Adamson R., Blagova E., Walton J., Cartwright J. L., Bird L. E., Owens R. J., Berrow N. S., Wilson K. S., Sussman J., Perrakis A. & Celie P. H. N. (). Expression of protein complexes using multiple Escherichia coli protein co-expression systems: A benchmarking study. Journal of Structural Biology. 175:(2)159-170.

Adams E. M., Pezzotti S., Ahlers J., RüTtermann M., Levin M., Goldenzweig A., Peleg Y., Fleishman S. J., Sagi I. & Havenith M. (). Local Mutations Can Serve as a Game Changer for Global Protein Solvent Interaction. JACS Au. 1:(7)1076-1085.

Xu Y., Li M., Greenblatt H., Chen W., Paz A., Dym O., Peleg Y., Chen T., Shen X., He J., Jiang H., Silman I. & Sussman J. (). Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations. Acta Crystallographica Section D: Biological Crystallography. 68:(1)13-25.

Bose T., Fridkin G., Davidovich C., Krupkin M., Dinger N., Falkovich A. H., Peleg Y., Agmon I., Bashan A. & Yonath A. (). Origin of life: protoribosome forms peptide bonds and links RNA and protein dominated worlds. Nucleic Acids Research. 50:(4)1815-1828.

Itkin M., Heinig U., Tzfadia O., Bhide A. J., Shinde B. A., Cardenas P. D., Bocobza S. E., Unger T., Malitsky S., Finkers R., Tikunov Y., Bovy A., Chikate Y. R., Singh P., Rogachev I., Beekwilder J., Giri A. P. & Aharoni A. (). Biosynthesis of antinutritional alkaloids in solanaceous crops is mediated by clustered genes. Science. 341:(6142)175-179.

Peleg Y., Vincentelli R., Collins B. M., Chen K., Livingstone E. K., Weeratunga S., Leneva N., Guo Q., Remans K., Perez K., Bjerga G. E., Larsen Ø., VaněK O., SkořEpa O., Jacquemin S., Poterszman A., Kjaer S., Christodoulou E., Albeck S., Dym O., Ainbinder E., Unger T., Schuetz A., Matthes S., Bader M., De Marco A., Storici P., Semrau M. S., Stolt-Bergner P., Aigner C., Suppmann S., Goldenzweig A. & Fleishman S. J. (). Community-Wide Experimental Evaluation of the PROSS Stability-Design Method. Journal of Molecular Biology. 433:(13)

Gabizon R., Shraga A., Gehrtz P., Livnah E., Shorer Y., Gurwicz N., Avram L., Unger T., Aharoni H., Albeck S., Brandis A., Shulman Z., Katz B., Herishanu Y. & London N. (). Efficient targeted degradation via reversible and irreversible covalent PROTACs. Journal of the American Chemical Society. 142:(27)11734-11742.

Franz F., Tapia-Rojo R., Winograd-Katz S., Boujemaa-Paterski R., Li W., Unger T., Albeck S., Aponte-Santamaria C., Garcia-Manyes S., Medalia O., Geiger B. & GräTer F. (). Allosteric activation of vinculin by talin. Nature Communications. 14:(1)

Zeev-Ben-Mordehai T., Mylonas E., Paz A., Peleg Y., Toker L., Silman I., Svergun D. I. & Sussman J. (). The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties. Biophysical Journal. 97:(8)2316-2326.

Quinn S., Zhang N., Fenton T. A., Brusel M., Muruganandam P., Peleg Y., Giladi M., Haitin Y., Lerche H., Bassan H., Liu Y., Ben-Shalom R. & Rubinstein M. (). Complex biophysical changes and reduced neuronal firing in an SCN8A variant associated with developmental delay and epilepsy. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1870:(5)

Reichmann D., Rahat O., Albeck S., Meged R., Dym O. & Schreiber G. (). The modular architecture of protein-protein binding interfaces. Proceedings of the National Academy of Sciences of the United States of America. 102:(1)57-62.

Khersonsky O., Kiss G., RöThlisberger D., Dym O., Albeck S., Houk K. N., Baker D. & Tawfik D. S. (). Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59. Proceedings of the National Academy of Sciences of the United States of America. 109:(26)10358-10363.

Peleg Y. & Unger T. (). Resolving bottlenecks for recombinant protein expression in E. coli. . 173-186.

Yagound B., Dogantzis K. A., Zayed A., Lim J., Broekhuyse P., Remnant E. J., Beekman M., Allsopp M. H., Aamidor S. E., Dim O., Buchmann G. & Oldroyd B. P. (). A Single Gene Causes Thelytokous Parthenogenesis, the Defining Feature of the Cape Honeybee Apis mellifera capensis. Current Biology. 30:(12)2248-2259.

Zimhony O., Schwarz A., Raitses-Gurevich M., Peleg Y., Dym O., Albeck S., Burstein Y. & Shakked Z. (). AcpM, the meromycolate extension Acyl carrier protein of mycobacterium tuberculosis, is activated by the 4-phosphopantetheinyl transferase PptT, a potential target of the multistep mycolic acid biosynthesis. Biochemistry. 54:(14)2360-2371.

Davidi D., Shamshoum M., Guo Z., Baron Y. M., Prywes N., Oz A., Jablonska J., Flamholz A., Wernick D. G., Antonovsky N., Pins B., Shachar L., Hochhauser D., Peleg Y., Albeck S., Sharon I., Muellercajar O. & Milo R. (). Highly active rubiscos discovered by systematic interrogation of natural sequence diversity. The EMBO Journal. 39:(18)

Scheerer D., Adkar B. V., Bhattacharyya S., Levy D., Iljina M., Riven I., Dym O., Haran G. & Shakhnovich E. I. (). Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase. Proceedings of the National Academy of Sciences - PNAS. 120:(18)

Nissinkorn Y., Lahav-Mankovski N., Rabinkov A., Albeck S., Motiei L. & Margulies D. (). Sensing Protein Surfaces with Targeted Fluorescent Receptors. Chemistry (Weinheim an der Bergstrasse, Germany). 21:(45)15981-15987.

Albeck S., Addadi L. & Weiner S. (). Regulation of calcite crystal morphology by intracrystalline acidic proteins and glycoproteins. Connective Tissue Research. 35:(1-4)365-370.

Sonawane P. D., Heinig U., Panda S., Gilboa N. S., Yona M., Kumar S. P., Alkan N., Unger T., Bocobza S., Pliner M., Malitsky S., Tkachev M., Meir S., Rogachev I. & Aharoni A. (). Short-chain dehydrogenase/reductase governs steroidal specialized metabolites structural diversity and toxicity in the genus Solanum. Proceedings of the National Academy of Sciences of the United States of America. 115:(23)E5419-E5428.

Arfi Y., Shamshoum M., Rogachev I., Peleg Y. & Bayer E. (). Integration of bacterial lytic polysaccharide monooxygenases into designer cellulosomes promotes enhanced cellulose degradation. Proceedings of the National Academy of Sciences of the United States of America. 111:(25)9109-9114.

Sen S., Bhowmik P., Tiwari S., Peleg Y. & Bandyopadhyay B. (). Versatility of reverse transcriptase loop-mediated isothermal amplification (RT-LAMP) from diagnosis of early pathological infection to mutation detection in organisms. Molecular Biology Reports. 51:(1)

Goihberg E., Peretz M., Tel-Or S., Dym O., Shimon L., Frolow F. & Burstein Y. (). Biochemical and structural properties of chimeras constructed by exchange of cofactor-binding domains in alcohol dehydrogenases from thermophilic and mesophilic microorganisms. Biochemistry. 49:(9)1943-1953.

KolářOvá L., ZahradníK J., HuličIak M., Mikulecký P., Peleg Y., Shemesh M., Schreiber G. & Schneider B. (). De novo developed protein binders mimicking Interferon lambda signaling. The FEBS journal. 289:(9)2672-2684.

Smock R. G., Yadid I., Dym O., Clarke J. & Tawfik D. (). De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints. Cell. 164:(3)476-486.

Sonawane P. D., Jozwiak A., Barbole R., Panda S., Abebie B., Kazachkova Y., Gharat S. A., Ramot O., Unger T., Wizler G., Meir S., Rogachev I., Doron-Faigenboim A., Petreikov M., Schaffer A., Giri A. P., Scherf T. & Aharoni A. (). 2-Oxoglutarate-Dependent Dioxygenases Drive Expansion of Steroidal Alkaloid Structural Diversity in the Genus Solanum. The New Phytologist. 234:(4)1394-1410.

Jiang W., Wang X. W., Unger T., Forgues M., Kim J. W., Hussain S. P., Bowman E., Spillare E. A., Lipsky M. M., Meck J. M., Cavalli L. R., Haddad B. R. & Harris C. C. (). Cooperation of tumor-derived HBx mutants and p53-249^ser mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized normal human hepatocyte-derived cell line. International Journal of Cancer. 127:(5)1011-1020.

Cohen J., Unger T., Rechavi G., Canaani E. & Givol D. (). Rearrangement of the oncogene c-mos in mouse myeloma NSI and hybridomas. Nature. 306:(5945)797-799.

Lapidoth G., Khersonsky O., Lipsh R., Dym O., Albeck S., Rogotner S. & Fleishman S. J. (). Highly active enzymes by automated combinatorial backbone assembly and sequence design. Nature Communications. 9.

Unger T., Jacobovitch Y., Dantes A., Bernheim R. & Peleg Y. (). Applications of the Restriction Free (RF) cloning procedure for molecular manipulations and protein expression. Journal of Structural Biology. 172:(1)34-44.

Shemi A., Ben-Dor S., Rotkopf R., Dym O. & Vardi A. (). Phylogeny and biogeography of the algal DMS-releasing enzyme in the global ocean. ISME Communications. 3.

Erijman A., Shifman J. M. & Peleg Y. (). A single-tube assembly of DNA using the transfer-PCR (TPCR) platform. . 89-101.

Berman P., De Haro L. A., Cavaco A. R., Panda S., Dong Y., Kuzmich N., Lichtenstein G., Peleg Y., Harat H., Jozwiak A., Cai J., Heinig U., Meir S., Rogachev I. & Aharoni A. (). The biosynthetic pathway of the hallucinogen mescaline and its heterologous reconstruction. Molecular Plant. 17:(7)1129-1150.

Sberro H., Leavitt A., Kiro R., Koh E., Peleg Y., Qimron U. & Sorek R. (). Discovery of Functional Toxin/Antitoxin Systems in Bacteria by Shotgun Cloning. Molecular Cell. 50:(1)136-148.

Falini G., Albeck S., Weiner S. & Addadi L. (). Control of aragonite or calcite polymorphism by mollusk shell macromolecules. Science. 271:(5245)67-69.

Unger T. & Peleg Y. (). Recombinant protein expression in the baculovirus-infected insect cell system. . 187-199.

Mohan V., Gaffney J. P., Solomonov I., Levin M., Klepfish M., Akbareian S., GrüNwald B., Dym O., Eisenstein M., Yu K. H., Kelsen D. P., KrüGer A., Edwards D. R. & Sagi I. (). Conformation-specific inhibitory anti-mmp-7 monoclonal antibody sensitizes pancreatic ductal adenocarcinoma cells to chemotherapeutic cell kill. Cancers. 13:(7)

Meged R., Dym O. & Sussman J. L. (). High throughput pH optimization of protein crystallization. Methods in molecular biology (Clifton, N.J.). 426:411-418.

Erijman A., Dantes A., Bernheim R., Shifman J. M. & Peleg Y. (). Transfer-PCR (TPCR): A highway for DNA cloning and protein engineering. Journal of Structural Biology. 175:(2)171-177.

Rezenman S., Knafo M., Tsigalnitski I., Barad S., Jona G., Levi D., Dym O., Reich Z. & Kapon R. (). gUMI-BEAR, a modular, unsupervised population barcoding method to track variants and evolution at high resolution. PLoS ONE. 18:(6)e0286696.

Bab-Dinitz E., Albeck S., Peleg Y., Brumfeld V., Gottschalk K. E. & Karlish S. J. (). A C-terminal lobe of the β subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules. Biochemistry. 48:(36)8684-8691.

Addadi L., Aizenberg J., Albeck S., Falini G. & Weiner S. (). Structural control over the formation of calcium carbonate mineral phases in biomineralization. Supramolecular Stereochemistry. 473:127-139.

Wong E., Cohen T., Romi E., Levin M., Peleg Y., Arad U., Yaron A., Milla M. E. & Sagi I. (). Harnessing the natural inhibitory domain to control TNF alpha Converting Enzyme (TACE) activity in vivo. Scientific Reports. 6.

Bednarczyk D., Dym O., Prabahar V., Peleg Y., Pike D. H. & Noy D. (). Fine Tuning of Chlorophyll Spectra by Protein-Induced Ring Deformation. Angewandte Chemie-International Edition. 55:(24)6901-6905.

Chaturvedi A. K., Dym O., Levin Y. & Fluhr R. (). PGR5-LIKE PHOTOSYNTHETIC PHENOTYPE1A redox states alleviate photoinhibition during changes in light intensity. Plant Physiology. 194:(2)1059-1074.

Dym O., Mevarech M. & Sussman J. L. (). Structural features that stabilize halophilic malate dehydrogenase from an archaebacterium. Science. 267:(5202)1344-1346.

Saikia C., Dym O., Altman-Gueta H., Gordon D., Reuveny E. & Karbat I. (). A Molecular Lid Mechanism of K+ Channel Blocker Action Revealed by a Cone Peptide. Journal of Molecular Biology. 433:(17)

Yadid I., Kirshenbaum N., Sharon M., Dym O. & Tawfik D. (). Metamorphic proteins mediate evolutionary transitions of structure. Proceedings of the National Academy of Sciences of the United States of America. 107:(16)7287-7292.

Saikia C., Altman-Gueta H., Dym O., Karbat I. & Reuveny E. (). Conkunitzin-C2 from Conus consors induces an incomplete block of the Shaker K+ channel using a unique mode of action. Biophysical Journal. 121:(3(1))500a-500a.

Katzir N., Rechavi G., Cohen J., Unger T., Simoni F., Segal S., Cohen D. & Givol D. (). 'Retroposon' insertion into the cellular oncogene c-myc in canine transmissible venereal tumor. Proceedings of the National Academy of Sciences of the United States of America. 82:(4)1054-1058.

Seal M., Jash C., Jacob R., Feintuch A., Harel Y., Albeck S., Unger T. & Goldfarb D. (). Evolution of CPEB4 Dynamics across its Liquid-Liquid Phase Separation Transition. Journal Of Physical Chemistry B. 125:(47)12947-12957.

Ganor Y., Besser M., Ben-Zakay N., Unger T. & Levite M. (). Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration. Journal of Immunology. 170:(8)4362-4372.

Pode Z., Peri-Naor R., Georgeson J. M., Ilani T., Kiss V., Unger T., Markus B., Barr H. M., Motiei L. & Margulies D. (). Protein recognition by a pattern-generating fluorescent molecular probe. Nature Nanotechnology. 12:(12)1161-1168.

Khmelnitsky L., Milo A., Dym O. & Fass D. (). Diversity of CysD domains in gel-forming mucins. FEBS Journal.

Wong E., Maretzky T., Peleg Y., Blobel C. P. & Sagi I. (). The functional maturation of a disintegrin and metalloproteinase (ADAM) 9, 10, and 17 requires processing at a newly identified proprotein convertase (PC) cleavage site. The journal of Biological chemistry. 290:(19)12135-12146.

Ofir-Birin Y., Ben Ami Pilo H., Camacho A. C., Rudik A., Rivkin A., Revach O., Nir N., Tamin T. B., Karam P. A., Kiper E., Peleg Y., Nevo R., Solomon A., Havkin-Solomon T., Rojas A., Rotkopf R., Porat Z., Avni D., Schwartz E., Zillinger T., Hartmann G., Di Pizio A., Ben Quashie N., Dikstein R., Gerlic M., Torrecilhas A. C., Levy C., Hoen E. N. M. N., Bowie A. G. & Regev-Rudzki N. (). Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration. Nature Communications. 12:(1)

Selzer T., Albeck S. & Schreiber G. (). Rational design of faster associating and tighter binding protein complexes. Nature Structural Biology. 7:(7)537-541.

Shaaltiel Y., Bartfeld D., Hashmueli S., Baum G., Brill-Almon E., Galili G., Dym O., Boldin-Adamsky S. A., Silman I., Sussman J. L., Futerman A. H. & Aviezer D. (). Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system. Plant Biotechnology Journal. 5:(5)579-590.

Albeck S., Alzari P., Andreini C., Banci L., Berry I. M., Bertini I., Cambillau C., Canard B., Carter L., Cohen S. X., Diprose J. M., Dym O., Esnouf R. M., Felder C., Ferron F., Guillemot F., Hamer R., Ben Jelloul J. M., Laskowski R. A., Laurent T., Longhi S., Lopez R., Luchinat C., Malet H., Mochel T., Morris R. J., Moulinier L., Oinn T., Pajon A., Peleg Y., Perrakis A., Poch O., Prilusky J., Rachedi A., Ripp R., Rosato A., Silman I., Stuart D. I., Sussman J., Thierry J. -., Thompson J. D., Thornton J. M., Unger T., Vaughan B., Vranken W., Watson J. D., Whamond G. & Henrick K. (). SPINE bioinformatics and data-management aspects of high-throughput structural biology. Acta Crystallographica Section D-Structural Biology. 62:(10)1184-1195.

Warszawski S., Katz A. B., Lipsh R., Khmelnitsky L., Nissan G. B., Javitt G., Dym O., Unger T., Knop O., Albeck S., Diskin R., Fass D., Sharon M. & Fleishman S. J. (). Erratum: Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces (PLoS Computational Biology(2019)15: 8(e1007207)Doi: 10.1371/journal.pcbi.1007207). PLoS Computational Biology. 16:(10)

Albeck S., Nordlund P. & Sussman J. L. (). New trends in protein expression. Journal of Structural Biology. 172:(1)1-2.

Kahlon S., Shreibman D., Unger T., Ben-Yehuda D. & Elias S. (). The oncogenic fusion protein CBFB-SMMHC downregulates CD48 to evade NK cell recognition. Blood Cancer Journal. 8:(5)

Khersonsky O., Goldsmith M., Zaretsky I., Hamer-Rogotner S., Dym O., Unger T., Yona M., Fridmann-Sirkis Y. & Fleishman S. J. (). Stable Mammalian Serum Albumins Designed for Bacterial Expression. Journal of Molecular Biology. 435:(17)

Khersonsky O., RöThlisberger D., Dym O., Albeck S., Jackson C. J., Baker D. & Tawfik D. S. (). Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the ke07 series. Journal of Molecular Biology. 396:(4)1025-1042.

Addadi L., Aizenberg J., Albeck S., Berman A., Leiserowitz L. & Weiner S. (). Controlled occlusion of proteins: A tool for modulating the properties of skeletal elements. Molecular Crystals and Liquid Crystals. 248:(1)185-198.

Mishra N. K., Habeck M., Kirchner C., Haviv H., Peleg Y., Eisenstein M., Apell H. J. & Karlish S. J. D. (). Molecular Mechanisms and Kinetic Effects of FXYD1 and Phosphomimetic Mutants on Purified Human Na,K-ATPase. Journal of Biological Chemistry. 290:(48)28746-28759.

Baran D., Pszolla M. G., Lapidoth G. D., Norn C., Dym O., Unger T., Albeck S., Tyka M. D. & Fleishman S. J. (). Principles for computational design of binding antibodies. Proceedings of the National Academy of Sciences of the United States of America. 114:(41)10900-10905.

Yeshaya N., Gupta P. K., Dym O., Morgenstern D., Major D. T. & Fass D. (). VWD domain stabilization by autocatalytic Asp-Pro cleavage. Protein Science. 33:(3)

Grossman M., Tworowski D., Dym O., Lee M., Levy Y., Murphy G. & Sagi I. (). The intrinsic protein flexibility of endogenous protease inhibitor TIMP-1 controls its binding interface and affects its function. Biochemistry. 49:(29)6184-6192.

ZahradníK J., Marciano S., Shemesh M., Zoler E., Harari D., Chiaravalli J., Meyer B., Rudich Y., Li C., Marton I., Dym O., Elad N., Lewis M., Andersen H., Gagne M., Seder R., Douek D. & Schreiber G. (). SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution. Nature Microbiology. 6:(9)1188-1198.

Krieg E., Albeck S., Weissman H., Shimoni E. & Rybtchinski B. (). Separation, Immobilization, and Biocatalytic Utilization of Proteins by a Supramolecular Membrane. PLoS ONE. 8:(5)

Goldsmith M., Barad S., Peleg Y., Albeck S., Dym O., Brandis A., Mehlman T. & Reich Z. (). The identification and characterization of an oxalyl-CoA synthetase from grass pea ( Lathyrus sativus L.). RSC Chemical Biology. 3:(3)320-333.

Siton O., Ideses Y., Albeck S., Unger T., Bershadsky A. D., Gov N. S. & Bernheim-Groswasser A. (). Cortactin releases the brakes in actin- based motility by enhancing WASP-VCA detachment from Arp2/3 branches. Current Biology. 21:(24)2092-2097.

Halfin O., Avram L., Albeck S., Unger T., Motiei L. & Margulies D. (). Unnatural enzyme activation by a metal-responsive regulatory protein. Chemical Science. 15:(35)14209-14217.

Levi Y., Albeck S., Brack A., Weiner S. & Addadi L. (). Control over aragonite crystal nucleation and growth: An in vitro study of biomineralization. Chemistry-A European Journal. 4:(3)389-396.

Shraga A., Olshvang E., Davidzohn N., Khoshkenar P., Germain N., Shurrush K., Carvalho S., Avram L., Albeck S., Unger T., Lefker B., Subramanyam C., Hudkins R. L., Mitchell A., Shulman Z., Kinoshita T. & London N. (). Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor. Cell Chemical Biology. 26:(1)98 - 108.

Dym O., Aggarwal N., Ashani Y., Leader H., Albeck S., Unger T., Hamer-Rogotner S., Silman I., Tawfik D. S. & Sussman J. L. (). The impact of molecular variants, crystallization conditions and the space group on ligand-protein complexes: a case study on bacterial phosphotriesterase. Acta Crystallographica Section D: Structural Biology. 79:(Pt 11)992-1009.

Aricescu A. R., Assenberg R., Bill R. M., Busso D., Chang V. T., Davis S. J., Dubrovsky A., Gustafsson L., Hedfalk K., Heinemann U., Jones I. M., Ksiazek D., Lang C., Maskos K., Messerschmidt A., Macieira S., Peleg Y., Perrakis A., Poterszman A., Schneider G., Sixma T. K., Sussman J., Sutton G., Tarboureich N., Zeev-Ben-Mordehai T. & Jones E. Y. (). Eukaryotic expression: Developments for structural proteomics. Acta Crystallographica Section D: Biological Crystallography. 62:(10)1114-1124.

Singh A., Erijman A., Noronha A., Kumar H., Peleg Y., Yarden Y. & Shifman J. M. (). Engineered variants of the Ras effector protein RASSF5 (NORE1A) promote anti-cancer activities in lung adenocarcinoma. Journal of Biological Chemistry. 297:(6)

Juven-Gershon T., Shifman O., Unger T., Elkeles A., Haupt Y. & Oren M. (). The Mdm2 oncoprotein interacts with the cell fate regulator numb. Molecular and Cellular Biology. 18:(7)3974-3982.

Daniel E., Maksimainen M. M., Smith N., Ratas V., Biterova E., Murthy S. N., Tanvir Rahman M., Kiema T. R., Sridhar S., Cordara G., Dalwani S., Venkatesan R., Prilusky J., Dym O., Lehtio L., Kristian Koski M., Ashton A. W., Sussman J. L. & Wierenga R. K. (). IceBear: An intuitive and versatile web application for research-data tracking from crystallization experiment to PDB deposition. Acta Crystallographica Section D: Structural Biology. 77:(2)151-163.

Albeck S., Burstein Y., Dym O., Jacobovitch Y., Levi N., Meged R., Michael Y., Peleg Y., Prilusky J., Schreiber G., Silman I., Unger T. & Sussman J. (). Three-dimensional structure determination of proteins related to human health in their functional context at the Israel Structural Proteomics Center (ISPC). Acta Crystallographica Section D: Biological Crystallography. 61:(10)1364-1372.

Yifrach E., Holbrooksmith D., BüRgi J., Othman A., Eisenstein M., Roermund C. W., Visser W., Tirosh A., Rudowitz M., Bibi C., Galor S., Weill U., Fadel A., Peleg Y., Erdmann R., Waterham H. R., Wanders R. J. A., Wilmanns M., Zamboni N., Schuldiner M. & Zalckvar E. (). Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions. Molecular Systems Biology. 18:(9)

Vazana Y., Barak Y., Unger T., Peleg Y., Shamshoum M., Ben-Yehezkel T., Mazor Y., Shapiro E., Lamed R. & Bayer E. (). A synthetic biology approach for evaluating the functional contribution of designer cellulosome components to deconstruction of cellulosic substrates. Biotechnology for Biofuels. 6:(1)

Peleg Y., Prabahar V., Bednarczyk D. & Unger T. (). Harnessing the Profinity eXact™ System for Expression and Purification of Heterologous Proteins in E. coli. . 33-43.

Bharat T. A. M., Zbaida D., Eisenstein M., Frankenstein Z., Mehlman T., Weiner L., Sorzano C. O. S., Barak Y., Albeck S., Briggs J. A. G., Wolf S. G. & Elbaum M. (). Variable internal flexibility characterizes the helical capsid formed by agrobacterium VirE2 protein on single-stranded DNA. Structure. 21:(7)1158-1167.

Allouche-Arnon H., Khersonsky O., Tirukoti N. D., Peleg Y., Dym O., Albeck S., Brandis A., Mehlman T., Avram L., Harris T., Yadav N. N., Fleishman S. J. & Bar-Shir A. (). Computationally designed dual-color MRI reporters for noninvasive imaging of transgene expression. Nature biotechnology. 40:(7)1143-1149.

Albeck S., Unger R. & Schreiber G. (). Evaluation of direct and cooperative contributions towards the strength of buried hydrogen bonds and salt bridges. Journal of Molecular Biology. 298:(3)503-520.

Goihberg E., Dym O., Tel-Or S., Levin I., Peretz M. & Burstein Y. (). A single proline substitution is critical for the thermostabilization of Clostridium beijerinckii alcohol dehydrogenase. Proteins-Structure Function And Bioinformatics. 66:(1)196-204.

Frenkiel-Krispin D., Wolf S. G., Albeck S., Unger T., Peleg Y., Jacobovitch J., Michael Y., Daube S., Sharon M., Robinson C. V., Svergun D. I., Fass D., Tzfira T. & Elbaum M. (). Plant transformation by Agrobacterium tumefaciens: Modulation of single-stranded DNA-VirE2 complex assembly by VirE. Journal of Biological Chemistry. 282:(6)3458-3464.

Udi Y., Grossman M., Solomonov I., Dym O., Rozenberg H., Moreno V., Cuniasse P., Dive V., Arroyo A. G. & Sagi I. (). Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody. Structure. 23:(1)104-115.

Gurfinkel N., Unger T., Givol D. & Mushinski J. F. (). Expression of the bcl2 gene in mouse B lymphocytic cell lines is differentiation stage specific. European Journal of Immunology. 17:(4)567-570.

Unger T., Mietz J. A., Scheffner M., Yee C. L. & Howley P. M. (). Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression. Molecular and Cellular Biology. 13:(9)5186-94.

Bandyopadhyay B. & Peleg Y. (). Application of Restriction Free (RF) Cloning in Circular Permutation. . 149-163.

Manicka S., Peleg Y., Unger T., Albeck S., Dym O., Greenblatt H. A., Bourenkov G., Lamzin V., Krishnaswamy S. & Sussman J. (). Crystal structure of YagE, a putative DHDPS-like protein from Escherichia coli K12. Proteins-Structure Function And Bioinformatics. 71:(4)2102-2108.

Chill J., Nivasch R., Levy R., Albeck S., Schreiber G. & Anglister J. (). The human interferon receptor: NMR-based modeling, mapping of the IFN-α2 binding site, and observed ligand-induced tightening. Biochemistry. 41:(11)3575-3585.

Ben-Nissan G., Belov M. E., Morgenstern D., Levin Y., Dym O., Arkind G., Lipson G., Makarov A. A. & Sharon M. (). Triple-Stage Mass Spectrometry Unravels the Heterogeneity of an Endogenous Protein Complex. Analytical Chemistry. 89:(8)4708-4715.

Erez Z., Steinberger-Levy I., Shamir M., Doron S., Stokar Avihail A. A., Peleg Y., Melamed S., Leavitt A., Savidor A., Albeck S., Amitai G. & Sorek R. (). Communication between viruses guides lysis-lysogeny decisions. Nature. 541:(7638)488-493.

SchüTz A., Bernhard F., Berrow N., Buyel J. F., Ferreira-Da-Silva F., Haustraete J., Van Den Heuvel J., Hoffmann J. E., De Marco A., Peleg Y., Suppmann S., Unger T., Vanhoucke M., Witt S. & Remans K. (). A concise guide to choosing suitable gene expression systems for recombinant protein production. STAR Protocols. 4:(4)

Yosef E., Katz A., Peleg Y., Mehlman T. & Karlish S. J. (). Do Src kinase and caveolin interact directly with Na,K-ATPase?. Journal of Biological Chemistry. 291:(22)11736-11750.

Goldsmith M., Avram L., Brandis A., Mehlman T., Ben-Dor S., Peleg Y., Ben-Zeev E., Barbole R. S. & Reich Z. (). LsBOS utilizes oxalyl-CoA produced by LsAAE3 to synthesize β-ODAP in grass pea. Nature Communications. 15.

Asher G., Dym O., Tsvetkov P., Adler J. & Shaul Y. (). The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol. Biochemistry. 45:(20)6372-6378.

Hatai J., Prasad P. K., Lahav-Mankovski N., Oppenheimer-Low N., Unger T., Sirkis Y. F., Dadosh T., Motiei L. & Margulies D. (). Assessing changes in the expression levels of cell surface proteins with a turn-on fluorescent molecular probe. Chemical Communications. 57:(15)1875-1878.

Alzari P. M., Berglund H., Berrow N. S., Blagova E., Busso D., Cambillau C., Campanacci V., Christodoulou E., Eiler S., Fogg M. J., Folkers G., Geerlof A., Hart D., Haouz A., Herman M. D., Macieira S., Nordlund P., Perrakis A., Quevillon-Cheruel S., Tarandeau F., Van Tilbeurgh H., Unger T., Luna-Vargas M., Velarde M., Willmanns M. & Owens R. J. (). Implementation of semi-automated cloning and prokaryotic expression screening: The impact of SPINE. Acta Crystallographica Section D: Biological Crystallography. 62:(10)1103-1113.

Osher E., Anis Y., Singer-Shapiro R., Urshanski N., Unger T., Albeck S., Bogin O., Weisinger G., Kohen F., Valevski A., Fattal-Valevski A., Sagi L., Weitman M., Shenberger Y., Sagiv N., Navon R., Wilchek M. & Stern N. (). Treating late-onset Tay Sachs disease: Brain delivery with a dual trojan horse protein. Molecular Therapy Methods and Clinical Development. 32:(3)

Khersonsky O., Lipsh R., Avizemer Z., Ashani Y., Goldsmith M., Leader H., Dym O., Rogotner S., Trudeau D. L., Prilusky J., Amengual-Rigo P., Guallar V., Tawfik D. S. & Fleishman S. J. (). Automated Design of Efficient and Functionally Diverse Enzyme Repertoires. Molecular Cell. 72:(1)178-186.e5.

Pokorna S., Khersonsky O., Lipsh-Sokolik R., Goldenzweig A., Nielsen R., Ashani Y., Peleg Y., Unger T., Albeck S., Dym O., Tirosh A., Tarayra R., Hocquemiller M., Laufer R., Ben-Dor S., Silman I., Sussman J. L., Fleishman S. J. & Futerman A. H. (). Design of a stable human acid-β-glucosidase: towards improved Gaucher disease therapy and mutation classification. FEBS Journal. 290:(13)3383-3399.

Li M., Greenblatt H. M., Dym O., Albeck S., Pais A., Gunanathan C., Milstein D., Degani H. & Sussman J. (). Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of selective estrogen receptor modulators. Journal of Medicinal Chemistry. 54:(10)3575-3580.

Israeli H., Degtjarik O., Fierro F., Chunilal V., Gill A. K., Roth N. J., Botta J., Prabahar V., Peleg Y., Chan L. F., Ben-Zvi D., Mccormick P. J., Niv M. Y. & Shalev-Benami M. (). Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling. Science (American Association for the Advancement of Science). 372:(6544)808-814.

Ben-David M., Soskine M., Dubovetskyi A., Cherukuri K., Dym O., Sussman J. L., Liao Q., Szeler K., Kamerlin S. C. L. & Tawfik D. S. (). Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition. Molecular Biology and Evolution. 37:(4)1133-1147.

Albeck S., Weiner S. & Addadi L. (). Polysaccharides of intracrystalline glycoproteins modulate calcite crystal growth in vitro. Chemistry-A European Journal. 2:(3)278-284.

Mock B., Givol D., Dhoostelaere L., Huppi K., Seldin M., Gurfinkel N., Unger T., Potter M. & Mushinski J. (). Mapping of the bcl-2 oncogene on mouse chromosome 1. Cytogenetics and Cell Genetics. 47:(1-2)11-15.

Reichmann D., Cohen M., Abramovich R., Dym O., Lim D., Strynadka N. C. J. & Schreiber G. (). Binding Hot Spots in the TEM1-BLIP Interface in Light of its Modular Architecture. Journal of Molecular Biology. 365:(3)663-679.

Giannoulis A., Feintuch A., Unger T., Amir S. & Goldfarb D. (). Monitoring the Conformation of the Sba1/Hsp90 Complex in the Presence of Nucleotides with Mn(II)-Based Double ElectronElectron Resonance. Journal of Physical Chemistry Letters. 12:(51)12235-12241.

Meltzer H., Marom E., Alyagor I., Mayseless O., Berkun V., Segal-Gilboa N., Unger T., Luginbuhl D. & Schuldiner O. (). Tissue-specific (ts) CRISPR as an efficient strategy for in vivo screening in Drosophila. Nature Communications. 10:(1)

Yifrach E., Rudowitz M., Cruz-Zaragoza L. D., Tirosh A., Gazi Z., Peleg Y., Kunze M., Eisenstein M., Schliebs W., Schuldiner M., Erdmann R. & Zalckvar E. (). Determining the targeting specificity of the selective peroxisomal targeting factor Pex9. Biological Chemistry. 404:(2-3)121-133.

Albeck S., Aizenberg J., Addadi L. & Weiner S. (). Interactions of Various Skeletal Intracrystalline Components with Calcite Crystals. Journal of the American Chemical Society. 115:(25)11691-11697.

Cohen S., Albeck S., Ben-Dov E., Cahan R., Firer M., Zaritsky A. & Dym O. (). Cyt1Aa toxin: Crystal structure reveals implications for its membrane-perforating function. Journal of Molecular Biology. 413:(4)804-814.

Tal L., Friedlander G., Gilboa N. S., Unger T., Gilad S. & Eshed Y. (). Coordination of Meristem Doming and the Floral Transition by Late Termination, a Kelch Repeat Protein. Plant Cell. 29:(4)681-696.

Sela-Passwell N. A., Kikkeri R., Dym O., Rozenberg H., Margalit R., Arad-Yellin R., Eisenstein M., Brenner O., Shoham T., Danon T., Shanzer A. & Sagi I. (). Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential. Nature Medicine. 18:(1)143-147.

Oranges M., Giannoulis A., Vanyushkina A., Sirkis Y. F., Dalaloyan A., Unger T., Su X. C., Sharon M. & Goldfarb D. (). C-terminal domain dimerization in yeast Hsp90 is moderately modulated by the other domains. Biophysical Journal.

Berrow N. S., Buessow K., Coutard B., Diprose J., Ekberg M., Folkers G. E., Levy N., Lieu V., Owens R. J., Peleg Y., Pinaglia C., Quevillon-Cheruel S., Salim L., Scheich C., Vincentelli R. & Busso D. (). Recombinant protein expression and solubility screening in Escherichia coli: A comparative study. Acta Crystallographica Section D: Biological Crystallography. 62:(10)1218-1226.

Heyne M., Shirian J., Cohen I., Peleg Y., Radisky E. S., Papo N. & Shifman J. M. (). Climbing up and down Binding Landscapes through Deep Mutational Scanning of Three Homologous Protein-Protein Complexes. Journal of the American Chemical Society. 143:(41)17261-17275.