Shoshani Lab

Chromosome Catastrophes in Cancer

Research

Our group aims to understand the plasticity of the cancer genome and how it contributes to disease progression. To study this, we apply chromosome manipulation approaches in cells, combined with live cell imaging, cytogenetics, and multiple sequencing approaches. Our goal is to identify vulnerabilities in mechanisms driving chromosome evolution, in order to design next-generation therapies with reduced resistance in patients.

Learn more about what we study in this 30-minutes seminar 
(from March 8, 2022)

Research page

News

September 10, 2024

Congratulations to Inbar and Ali - the first M.Sc. graduates of the lab!

August 8, 2024

Our new lab website is launched!

All News

Selected Publications

Transient genomic instability drives tumorigenesis through accelerated clonal evolution

Shoshani O., Bakker B., de Haan L., Tijhuis A., Wang Y., Kim D. H., Maldonado M., Demarest M., Artates J., Zhengyu O., Mark A., Wardenaar R., Sasik R., Spierings D., Vitre B., Fisch K., Foijer F. & Cleveland D. W. (2021) Genes and Development. 35, 15-16, p. 1093-1109

Chromothripsis drives the evolution of gene amplification in cancer

Shoshani O., Brunner S. F., Yaeger R., Ly P., Nechemia-Arbely Y., Kim D. H., Fang R., Castillon G. A., Yu M., Li J. S. Z., Sun Y., Ellisman M. H., Ren B., Campbell P. J. & Cleveland D. W. (2021) Nature. 591, 7848, p. 137-141
All Publications