Group

2021-current: Lab Manager of the Shoshani lab
2019-2021: Lab Technician, Protein engineering, lab of Prof. S. Fleishman
2006-2019: Senior Researcher, Development of Biosimilars, Teva Pharmaceutical Industries
1999-2006: Research Assistant and Laboratory Supervisor, Development of treatments for spinal cord injury, Proneuron Biotechnologies
1995-1998: MSc student, lab of Prof. A. Hochberg, Research of the imprinted oncofetal long non-coding RNA H19, Department of Biochemistry, The Hebrew University of Jerusalem 

I am a cancer researcher with the aim to gain deeper understanding of cancer genomic evolution and therapeutic resistance mechanisms. I have extensive experience with establishing and genetically manipulating patient derived organoids. Currently, I am working on developing patient derived organoid models to study gene amplification as a cancer mechanism to resist therapy.

Education:
PhD in Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.  Supervisor: Prof. Varda Rotter. Thesis topic: The role of mutant p53 in the tumorigenesis of bone-marrow mesenchymal stem cells   and Metabolism
Postdoctoral fellow, The Institute of Cancer Research and the Francis Crick institute, London, UK. Supervisor: Prof. Axel Behrens. Research topic: Pancreatic cancer cell of origin, heterogeneity and stemness.
 

Ph.D., Bar Ilan University (Advisor: Prof. Michael Blank)
Studying the role of nuclear membrane integrity in the evolution of gene amplification. Through this work, I aim to uncover the underlying mechanisms driving complex genome rearrangements in cancer.

B.Sc., Ben-Gurion University
M.Sc., Weizmann Institute of Science (Advisor: Prof. Ronen Alon)
I am studying the role of DNA damage in the formation of chromosome catastrophes in cancer

B.Sc., Université Paul Sabatier, Toulouse, France
M.Sc., Université Paul Sabatier, Toulouse, France (Advisor: Dr. Pierre Billon)
Studying how chromosome catastrophes drive cellular transformation

B.Sc., The Hebrew University Of Jerusalem
M.Sc., Weizmann Institute Of Science Advisor: Dr. Ofer Shoshani)
Studying the spatiotemporal dynamics of ecDNA within cells. Additionally, I am enthusiastic about exploring the potential of manipulating ecDNA localization in various cancers as a novel therapeutic strategy.
 

B.Sc., Bar Ilan University
M.Sc., Weizmann Institute of Science (Advisor: Dr. Ofer Shoshani)
Studying the mechanisms underlying the inheritance of extrachromosomal DNA

B.Sc., Hebrew University of Jerusalem
M.Sc., Weizmann Institute of Science (Advisor: Prof. Nir London)
Studying the impact of gene amplification on cellular physiology. I am also interested in the spatial localization of gene amplifications in tumors.
 

B.Sc., Tel Aviv University
Studying the interplay between chromosome catastrophes and the tumor microenvironment

B.Sc., Bar-Ilan University
Studying the role of DNA double strand breaks in cancer genome evolution