Research

The role of DSIF in inherent neurodegenerative diseases

Spt4/Spt5 (DSIF) is a transcription elongation factor involved in stress responses. We are interested in its regulation as a prime target for inherited neurodegenerative diseases.

Transcription-translation and transcription-mRNA fates links

What is the mRNA fate? Will it be degraded or translated? We are identifying mammalian and viral translation regulatory elements and their potential use in RNA therapeutics.

Translation initiation regulatory mechanisms

How is translation initiation regulated? We have interests in: (i) the role of translation initiation factors (eIFs); (ii) specialized translation driven by ribosome intrinsic mRNA binding; (iii) cellular and viral ribosome binding proteins; (iv) stress and mitogenic signals