Investigating the health effects of urban pollution
The World Health Organization and the Global Burden of Disease Assessment concluded recently that exposure to ambient particulate pollution is the most important environmental health risk to people globally. Mechanistic understanding of the effect of particulate matter on lung inflammation is lacking. Today, all particulate pollution is assumed to have the same risk, although they are produced from different sources and chemical composition. The goal of this study is to reach an in-depth mechanistic understanding of how PM, and its chemical composition, affect human health through a combination of detailed chemical speciation and controlled laboratory PM exposure experiments. Overall, this study is expected to provide an essential link between exposure to particulate air pollution and increase in the onset of oxidative stress and inflammation, thereby providing a mechanistic quantitative link between environmental exposure to the increased risk of diseases. The combination of state of the science atmospheric chemistry with most advanced biological investigation presents a unique multidisciplinary new approach to address this important challenge.
Knowledge in biochemistry or chemistry is an andvantage