Cohen IR, Stollerman G. "Non-type specific resistance to Group A streptococci in germ-free and conventional mice." Proc. Soc. Exp. Biol. Med. 1963; 114:202-205.
Stollerman GH, Ekstedt RD, Cohen IR. "Natural resistance of germ-free mice and colostrum-deprived piglets to group A streptococci." J. Immunol. 1963; 95:131-140.
1966
Cohen IR, Norins LC. "Natural human antibodies to gram-negative bacteria: immunoglobulins G, A, and M." Science 1966; 152:1257-9.
1967
Cohen IR. "Natural and immune human antibodies reactive with antigens of virulent Neisseria gonorrhoeae: immunoglobulins G, M, and A." J Bacteriol 1967; 94(1):141-8.
Cohen IR, Norins LC, Julian AJ. "Competition between, and effectiveness of, IgG and IgM antibodies in indirect fluorescent antibody and other tests." J Immunol 1967; 98(1):143-9.
1968
Kellogg DS Jr, Cohen IR, Norins LC, Schroeter AL, Reising G. "Neisseria gonorrhoeae. II. Colonial variation and pathogenicity during 35 months in vitro." J Bacteriol 1968; 96(3):596-605.
Cohen IR, Norins LC. "Antibiodies of the IgG, IgM, and IgA classes in newborn and adult sera reactive with gram-negative bacteria." J Clin Invest 1968; 47(5):1053-62.
Julian AJ, Logan LC, Norins LC, Cohen IR. "Immunoglobulin class of natural human antibodies reactive with Treponema pallidum." Infect. Immunity. 1970; 1:555-558.
Cohen IR, Stavy L, Feldman M. "Glucocotricoids and cellular immunity in vitro: Facilitation of the sensitization phase and inhibition of the effector phase of a lymphocyte anti-fibroblast reaction." J. Exp. Med. 1970; 132:1055-1070.
1971
Cohen IR, Feldman M. "The lysis of fibroblasts by lymphocytes sensitized in vitro: Specific antigen activates a nonspecific effect." Cell Immunol. 1971; 1:521-535.
Cohen IR, Feldman M. "Cellular immunity in vitro: Specific antigen induces sensitization and activates a nonspecific cytolytic effect." in Morphological and Fundamental Aspects of Immunity, eds. Lindahl-Kiessling K, Hanna MG, Alm GV, Plenum Publ Corp Inc, New York. 1971; 371-378.
Cohen IR, Globerson A, Feldman M. "Lymphoid cells sensitized in vitro against allogeneic or syngeneic fibroblasts produce immune effects in vitro and in vivo." Transpl. Proc. 1971; 3:891-894.
Cohen IR, Globerson A, Feldman M. "Rejection of tumor allografts by mouse spleen cells sensitized in vitro." J. Exp. Med. 1971; 133: 821-833.
Cohen IR, Globerson A, Feldman M. "Stimulation of tumor growth by autosensitized spleen cells." Israel J. Med. Sciences. 1971; 7: (4).
1972
Cohen IR, Wekerle H. "Autosensitization of lymphocytes against thymus reticulum cells." Science 1972; 176(41):1324-5. 17b. Feldman M, Cohen IR, Wekerle H. T-cell mediated immunity in vitro: an analysis of antigen recognition and target cell lysis. Transplant Rev 1972; 12:57-90.
Segal S, Cohen IR, Feldman M. "Thymus-derived lymphocytes: humoral and cellular reactions distinguished by hydrocortisone." Science 1972; 175(26):1126-8.
Feldman M, Cohen IR, Wekerle H. "T-cell mediated immunity in vitro: an analysis of antigen recognition and target cell lysis." Transplant Rev 1972;12:57-90.
1973
Cohen IR, Wekerle H. "The induction of a cellular immune reaction against self-antigens present in the thymus." In Microenvironmental Aspects of Immunity, eds. Jankovic BD, Isakovic K, Plenum Publ Corp Inc, New York. 1973 pp. 589-595. J Immunol 1973; 3(12):745-8.
Treves AJ, Cohen IR. "Recruitment of effector T lymphocytes against a tumor allograft by T lymphocytes sensitized in vitro." J Natl Cancer Inst 1973;51(6):1919-25.
Cohen IR. "Difference between the lymph node response to injection of autosensitized T lymphocytes and that in a graft-versus-host reaction."Eur J Immunol 1973; 3(12):829-33.
Cohen IR. "The recruitment of specific effector lymphocytes by antigen-reactive lymphocytes in cell-mediated autosensitization and allosensitization reactions". Cell Immunol 1973; 8(2):209-20.
Ilfeld D, Carnaud C, Cohen IR, Trainin N. "In vitro cytotoxicity and in vivo tumor enhancement induced by mouse spleen cells autosensitized in vitro." Int J Cancer 1973; 12(1):213-22.
Wekerle H, Cohen IR, Feldman M. "The regulation of self tolerance: Implications for immune surveillance against tumor cells." Isr. J. Med. Sci. 1973; 10:1024-1032.
Stavy L, Cohen IR, Feldman M. "The effect of hydrocortisone on lymphocyte-mediated cytolysis." Cell Immunol 1973; 7(2):302-12.
Altman A, Cohen IR, Feldman M. "Normal T-cell receptors for alloantigens." Cell Immunol 1973; 7(1):134-42.
Cohen IR. "Cell-mediated autoimmunity: antigen reactive lymphocytes recruit specific effector lymphocytes." Nat New Biol 1973; 242(115):60-1.
Cohen IR, Wekerle H. "Regulation of T-lymphocyte autosensitization." Transplant Proc 1973; 5(1):83-5.
Cohen IR, Wekerle H. "Regulation of autosensitization. The immune activation and specific inhibition of self-recognizing thymus-derived lymphocytes." J Exp Med 1973; 137(2):224-38.
Wekerle H, Cohen IR, Feldman M. "Lymphocyte receptors for autoantigens, autologous serum inhibits self-recognition." Nat New Biol 1973; 241(105):25-6.
Cohen IR, Wekerle H. "The induction of a cellular immune reaction against self-antigens present in the thymus." Adv Exp Med Biol 1973; 29(0):589-95.
1974
Cohen IR, Treves AJ. "Recruitment of effector lymphocytes in autosensitization and transplantation reactions." in Lymphocyte Recognition and Effector Mechanisms, eds. Lindahl-Kiessling K, Osoba D, Academic Press Inc, New York. 1974;pp.633-638.
Treves AJ, Carnaud C, Trainin N, Feldman M, Cohen IR. "Enhancing T lymphocytes from Tumor-bearing mice suppress host resistance to a syngeneic tumor." Eur J Immunol 1974; 4(11):722-7.
Wekerle H, Cohen IR, Feldman M. "Self-tolerance and autoimmunity. A new concept and its significance". Dtsch Med Wochenschr 1974;99(35):1734-9.
Altman A, Cohen IR. "The nonspecific helper effect of mixed lymphocyte reactions on the induction of T cell-mediated immunity in vitro". Eur J Immunol 1974; 4(8):577-80.
Levo Y, Carnaud C, Cohen IR, Trainin N. "Increased incidence of urethane induced lung adenomata by autosensitized lymphocytes." Br J Cancer 1974; 29(4):312-7.
Orgad S, Cohen IR. "Autoimmune encephalomyelitis: activation of thymus lymphocytes against syngeneic brain antigens in vitro." Science 1974;183(129):1083-5
Stavy L, Cohen IR, Feldman M. "Stimulation of rat lymphocyte proliferation by hydrocortisone during the induction of cell-mediated immunity in vitro." Transplantation 1974; 17(2):173-9.
Cohen IR, Wekerle H. "Autoimmunity and self-recognizing T lymphocytes". in Progress in Immunology II, Vol. 5 (Brent L, Holborrow J, eds.), North Holland, Amsterdam, 1974 pp.5-14.
1975
Altman A, Cohen IR. "The helper effect of mixed lymphocyte culture supernatants on an in vitro T cell-mediated mouse transplantation reaction." Isr J Med Sci 1975; 11(12):1384.
Treves AJ, Cohen IR, Feldman M. "Immunotherapy of tumor metastases by in vitro-sensitized lymphocytes." Transpl. Proc. 1975; 7:529-530.
Livnat S, Cohen IR. "Cell interactions in the recruitment of effector lymphocytes." Transpl. Proc. 1975; 7:251-253.
Livnat S, Cohen IR. "Migration of in vitro sensitized initiator T lymphocytes in recruitment." Isr J Med Sci 1975; 11(12):1386-7.
Altman A, Cohen IR. "Heterogeneity in the development of cytotoxic T lymphocytes in vitro revealed by sensitivity to hydrocortisone." J Exp Med 1975; 142(3):790-5.
Livnat S, Cohen IR. "Recruitment of effector lymphocytes by initiator lymphocytes: role of a trypsin-sensitive membrane component." Eur J Immunol 1975; 5(5):357-60.
Treves AJ, Cohen IR, Feldman M. "Immunotherapy of lethal metastases by lymphocytes sensitized against tumor cells in vitro." J Natl Cancer Inst 1975; 54(3):777-80.
Altman A, Cohen IR. "Cell-free media of mixedlymphocytic cultures augment the sensitization in vitro of mouse T lymphocytes against allogeneic fibroblasts." Eur J Immunol 1975; 5:437--444.
Waksal SD, Cohen IR, Waksal HW, Wekerle H, St Pierre RL, Feldman M. "Induction of T-cell differentiation in vitro by thymus epithelial cells." Ann N Y Acad Sci 1975; 249:492-8.
Cohen IR, Feldman M. "Cellular interactions controlling the immune reactivity of T- lymphocytes." Ann N Y Acad Sci 1975; 249:106-15.
Cohen IR, Livnat S, Livnat D, Steiner E, Waksal H. "Molecular events in the induction of autosensitization of initiator T lymphocytes". in Immune Recognition, ed. Rosenthal A, Academic Press, New York. 1975; pp.201-217.
Treves AJ, Cohen IR, Feldman M. "In vivo effect of lymphocytes sensitized in vitro against tumor cells". in Corynebacterium Parvum, ed. Halpern B, Plenum Publ Corp Inc, New York. 1975, pp.107-111.
1976
Shustik C, Cohen IR, Schwartz RS, Latham-Griffin E, Waksal SD. "T lymphocytes with promiscuous cytotoxicity." Nature 1976; 263(5579):699-701.
Waksal SD, Smolinsky S, Cohen IR, Feldman M. "Transformation of thymocytes by thymus epithelium derived from AKR mice." Nature 1976;263(5577):512-4.
Cohen IR, Livnat S. "The cell-mediated immune response: Interactions of initiator and recruited T lymphocytes." Transpl. Rev. 1976; 29:24-58.
Cohen IR, Livnat S. "Interaction of initiator and recruited T lymphocytes in cell-mediated immunity." in Leukocyte Membrane Determinants Regulating Immune Reactivity, eds. Eijsvoogel VP, Roos D, Zeilemaker WP, Academic Press Inc, New York. 1976, pp.587-597.
Livnat S, Cohen IR. "Recruitment of effector lymphocytes by initiator lymphocytes: Recruited lymphocytes are immunospecific". in Immune Reactivity of Lymphocytes , eds. Feldman M, Globerson A, Plenum Publ Corp Inc, New York.1976; pp.307-311.
Altman A, Cohen IR. "Differentiation of cytotoxic T lymphocytes enhanced by T cell factors produced during mixed lymphocyte interactions." in Immune Reactivity of Lymphocytes, eds. Feldman M, Globerson A, Plenum Publ Corp, Inc, New York. 1976; pp.289-294.
Waksal SD, Smolinsky S, Cohen IR, St Pierre RL, Feldman M. "Thymocyte maturation in AKR leukemia." in Immune Reactivity of Lymphocytes, eds. Feldman M, Globerson A, Plenum Publ Corp, Inc, New York. 1976; pp.141-146.
Manor Y, Treves AJ, Cohen IR, Feldman M. "Transition from T cell protection to T cell enhancement during tumor growth in an allogeneic host." Transplantation 1976; 22(4):360-6.
Cohen IR, Livnat S. "GVH-reactive lymphocytes are recruited by sensitized syngeneic initiator T-lymphocytes." Transplant Proc 1976; 8(3):393-7.
Treves AJ, Cohen IR, Feldman M. "Suppressor factor secreted by T-lymphocytes from tumor-bearing mice."J Natl Cancer Inst 1976; 57(2):409-14.
Livnat S, Cohen IR. Recruitment of effector lymphocytes by initiator lymphocytes. Circulating lymphocytes are trapped in the reacting lymph node. J Immunol 1976; 117(2):608-13.
Livnat S, Cohen IR. "Recruitment of effector lymphocytes by initiator lymphocytes. Recruited lymphocytes are immunospecific and include graft-versus-host-reactive lymphocytes." J Immunol 1976; 117(2):614-9.
Altman A, Cohen IR. "Cell-free media of mixed lymphocyte cultures augmenting sensitization in vitro of mouse T lymphocytes against allogeneic fibroblasts." Eur J Immunol 1976; 5(7):437-44.
Livnat S, Cohen IR. "Recruitment of effector lymphocytes by initiator lymphocytes. In vivo migration of in vitro sensitized initiator T lymphocytes." Eur J Immunol 1976; 5(6):389-94.
Treves AJ, Cohen IR, Feldman M. "A syngeneic metastatic tumor model in mice: the natural immune response of the host and its manipulation." Isr J Med Sci 1976; 12(4-5):369-84.
Treves AJ, Schechter B, Cohen IR, Feldman M. "Sensitization of T lymphocytes in vitro by syngeneic macrophages fed with tumor antigens." J Immunol 1976; 116(4):1059-64.
Treves AJ, Cohen IR, Feldman M, Weiss DW. "Effect of treatment with the methanol extraction residue fraction of killed tubercle bacilli (MER) on the development of spontaneous pulmonary metastases from syngeneic implants of tumor 3LL in C57BL mice." Isr J Med Sci 1976; 12(4-5):384-7.
Treves AJ, Cohen IR, Schechter B, Feldman M. "In vivo effects of lymphocytes sensitized in vitro against tumor cells." Ann N Y Acad Sci 1976; 276:165-75.
Altman A, Cohen IR. "Differentiation of cytotoxic T lymphocytes enhanced by T cell factors produced during mixed lymphocyte interactions." Adv Exp Med Biol 1976; 66:289-94.
1977
Steinman L, Cohen IR, Teitelbaum D, Glickman E, Arnon R. "Regulation of autoimmunity by the mode of presentation of autoantigen to lymphocytes." in Regulatory Mechanisms in Lymphocyte Activation Academic Press, New York. 1977; pp.728-729.
Steinman L, Cohen IR, Teitelbaum D, Arnon R. "Regulation of autosensitisation to encephalitogenic myelin basic protein by macrophage-associated and soluble antigen." Nature. 1977; 265:173-175.
Cohen IR, Wekerle H. "Autoimmunity, self-recognition, and blocking factors." in Autoimmunity. Genetic, Immunologic, Virologic, and Clinical Aspects. ed Talal NAcademic Press, New York. 1977; pp.231-265.
1978
Cohen IR, Livnat S, Waksal SD. "Initiator and recruited T lymphocytes are distinct subclasses of T lymphocytes." Eur J Immunol 1978;8(1):35-41.
Steinman L, Tzehoval E, Cohen IR, Segal S, Glickman E. "Sequential interaction of macrophages, initiator T lymphocytes and recruited T lymphocytes in a cell-mediated immune response to soluble antigen." Eur J Immunol1978; 8(1):29-34.
Ben-Nun A, Cohen IR. "Interaction between lymphocytes and macrophages in genetic control of experimental autoimmune encephalomyelitis." in Genetic Control of Autoimmune Disease , eds. Rose N, Bigazzi L, Warner N, Elsevier, North Holland, Amsterdam.1978; pp.381-386.
1979
Belldegrun A, Cohen IR. "Immunospecific depletion of graft-versus-host-reactive lymphocytes using sensitized syngeneic initiator T lymphocytes." Transplantation 1979; 28(5):382-6.
Cohen IR, Talmon J, Lev-Ram V, Ben-Nun A. "Immune response genes have a variable influence on the selection of antigenic foreign and self determinants of insulin." Proc Natl Acad Sci U S A 1979; 76(8):4066-70.
Maron R, Cohen IR. "Mutation at H-2K locus influences susceptibility to autoimmune thyroiditis." Nature 1979; 279(5715):715-6.
Cohen IR, Ben-Nun A. "The interactions between initiator and recruited T lymphocytes. in Cell Biology and Biochemistry of Leukocyte Function." ed Quastel MR. Academic Press, New York. 1979; pp.363-369.
1980
Ben-Nun A, Ron Y, Cohen IR. " Spontaneous remission of autoimmune encephalomyelitis is inhibited by splenectomy, thymectomy or ageing." Nature 1980; 288(5789):389-90.
Maron R, Cohen IR. "H-2K mutation controls immune response phenotype of autoimmune thyroiditis. Critical expression of mutant gene product in both thymus and thyroid glands." J Exp Med 1980; 152(4):1115-20.
Grossman Z, Cohen IR. "A theoretical analysis of the phenotypic expression of immune response genes." Eur J Immunol 1980; 10(8):633-40.
Belldegrun A, Cohen IR. "Immunospecific depletion of lymphocytes rejecting skin allografts using sensitized syngeneic initiator T lymphocytes." Transplantation 1980; 30(1):40-2.
Cohen IR, Talmon J. "H-2 genetic control of the response of T lymphocytes to insulins. Priming of nonresponder mice by forbidden variants of specific antigenic determinants." Eur J Immunol 1980; 10(4):284-9.
Ben-Nun A, Maron R, Ron Y, Cohen IR. "H-2 gene products influence susceptibility of target thyroid gland to damage in experimental autoimmune thyroiditis." Eur J Immunol 1980; 10(2):156-9.
Steinman L, Cohen IR, Teitelbaum D. "Natural occurrence of thymocytes that react with myelin basic protein." Neurology 1980; 30:755-759.
Berlatzky Y, Cohen IR. "Immunospecific depletion of effector lymphocytes and graft-versus-host reactive lymphocytes using a recruitment model of cell- mediated immunity." in Biology of Bone Marrow Transplantation, Vol. XVII, eds. Gale RP, Fox CF, Acad Press, New York. 1980; pp.247-25.
1981
Ben-Nun A, Cohen IR. "Vaccination against autoimmune encephalomyelitis (EAE): attenuated autoimmune T lymphocytes confer resistance to induction of active EAE but not to EAE mediated by the intact T lymphocyte line." Eur J Immunol 1981; 11(11):949-52.
Cohen O, Sela BA, Schwartz M, Eshhar N, Cohen IR. "Multiple sclerosis-like disease induced in rabbits by immunization with brain gangliosides." Isr J Med Sci 1981; 17(8):711-4.
Ben-Nun A, Wekerle H, Cohen IR. "Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein." Nature 1981; 292(5818):60-1.
Ben-Nun A, Ron Y, Cohen IR. "Spontaneous remission of autoimmune encephalomyelitis is inhibited by splenectomy, thymectomy or aging." Nature 1981; 288:389-390.
Jakobovits A, Frenkel A, Sharon N, Cohen IR. "Inserted H-2 gene membrane products mediate immune response phenotype of antigen-presenting cell." Nature 1981; 291(5817):666-8.
Belldegrun A, Cohen IR, Frenkel A, Servadio C, Zor U. "Hydrocortisone and inhibitors of prostaglandin synthesis. Potentiation of allograft survival in mice." Transplantation 1981; 31(6):407-8.
Ben-Nun A, Otmy H, Cohen IR. "Genetic control of autoimmune encephalomyelitis and recognition of the critical nonapeptide moiety of myelin basic protein in guinea pigs are exerted through interaction of lymphocytes and macrophages." Eur J Immunol 1981; 11(4):311-6.
Cohen IR, Belldegrun A, Ben-Nun A, Hazan R. "Recruitment of effector T lymphocytes by initiator T lymphocytes: application for specific immunosuppression." Transplant Proc 1981; 13(1 Pt 1):623-5.
Ben-Nun A, Wekerle H, Cohen IR. "The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis." Eur J Immunol 1981; 11(3):195-9.
Ranghino G, Talmon J, Yonath A, Cohen IR. "The conformation of antigenic determinants of insulin and H-2 gene control of the immune response of T lymphocytes." in Structural Aspects of Recognition and Assembly in Biological Macromolecules, eds. Balaban M, Sussman JL, Traub W, Yonath A, Balaban ISS, Philadelphia. 1981; pp.263-279.
Ben-Nun A, Wekerle H, Cohen IR. "A line of T lymphocytes specifically reactive against myelin basic protein is functionally active in mediating or modifying autoimmune encephalomyelitis (EAE)." in Mechanisms of Lymphocyte Activation, eds. Resch K, Kirchner H. Elsevier/North Holland Press, Amsterdam. 1981; pp.343-346.
Talmon J, Maron R, Gotlib E, Cohen IR. "Analysis of H-2 gene regulation of the response of T lymphocytes to insulin using synthetic antigenic determinants and antiidiotypes." in Basic and Clinical Aspects of Immunity to Insulin, eds. Keck K, Erb P, eds. De Gruyter, Berlin. 1981; pp.59-69.
Prujansky-Jakobovitz A, Frenkel A, Sharon N, Cohen IR. "Immune response phenotype of insulin-presenting cells modified by insertion of H-2 gene products into cell membranes." in Basic and Clinical Aspects of Immunity to Insulin, eds. Keck K, Erb P, De Gruyter, Berlin.1981; pp.157-162.
1982
Naparstek Y, Holoshitz J, Eisenstein S, Reshef T, Raaport S, Chemke J, Ben-Nun A, Cohen IR. "Effector T lymphocyte line cells migrate to the thymus and persist there." Nature 1982; 300(5889):262-4.
Konat G, Offner H, Lev-Ram V, Cohen O, Schwartz M, Cohen IR, Sela BA. "Abnormalities in brain myelin or rabbits with experimental autoimmune multiple sclerosis-like disease induced by immunization to gangliosides." Acta Neurol Scand 1982; 66(5):568-74.
Ben-Nun A, Eisenstein S, Cohen IR. "Experimental autoimmune (EAE) in genetically resistant rats: PVG rats resist active induction of EAE but are susceptible to and can generate EAE effector T cell lines." J Immunol 1982; 129(3):918-9.
Ben-Nun A, Cohen IR. "Genetic control of experimental autoimmune encephalomyelitis at the level of cytotoxic lymphocytes in guinea pigs" Eur J Immunol 1982; 12(9):709-13.
Ben-Nun A, Cohen IR. "Experimental autoimmune (EAE) mediated by T cell lines: process of selection of lines and characterization of the cells." J Immunol 1982; 129(1):303-8.
Shechter Y, Maron R, Elias D, Cohen IR. "Autoantibodies to insulin spontaneously develop as anti- idiotypes in mice immunized with insulin." Science 1982; 216(4545):542-5.
Ben-Nun A, Cohen IR. "Spontaneous remission and acquired resistance to autoimmune encephalomyelitis (EAE) are associated with suppression of T cell reactivity: suppressed EAE effector T cells recovered as T cell lines." J Immunol 1982; 128(3):1450-7.
Margalit M, Belldegrun A, Berlatzky Y, Frenkel A, Cohen IR. "Experimental animal skin grafting simplified." J Immunol Methods 1982; 51(1):125-7.
Maron R, Klein J, Cohen IR. "Mutations at H-2K or H-2D alter immune response phenotype of autoimmune thyroiditis." Immunogenetics 1982;15(6):625-7.
Ben-Nun A, Cohen IR. "Genes of the major histocompatibility complex control transmission of information between initiator and recruited T lymphocyte." Adv Exp Med Biol 1982; 149:635-41.
Ben-Nun A, Cohen IR. "Genetic control of experimental autoimmune encephalomyelitis (EAE) at the level of cytotoxic T lymphocytes in guinea pigs." Eur. J. Immunol. 1982; 12:709-713.
Talmon J, Cohen IR. "Variable mapping of H-2 genes controlling the T-cell response to antigenic determinants of insulin." Immunogenetics 1982; 16:495-500.
Ben-Nun A, Eisenstein S, Cohen IR. "Experimental autoimmune encephalomyelitis (EAE) in genetically resistant rats: PVG rats resist active induction of EAE but are susceptible to and can generate EAE effector T cell lines." J. Immunol 1982; 129:918-919.
1983
Holoshitz J, Frenkel A, Ben-Nun A, Cohen IR. "Autoimmune encephalomyelitis (EAE) mediated or prevented by T lymphocyte lines directed against diverse antigenic determinants of myelin basic protein. Vaccination is determinant specific." J Immunol 1983; 131(6):2810-3.
Maron R, Zerubavel R, Friedman A, Cohen IR. "T lymphocyte line specific for thyroglobulin produces or vaccinates against autoimmune thyroiditis in mice." J Immunol 1983; 131(5):2316-22.
Maron R, Elias D, de Jongh BM, Bruining GJ, van Rood JJ, Shechter Y, Cohen IR. "Autoantibodies to the insulin receptor in juvenile onset insulin- dependent diabetes." Nature 1983; 303(5920):817-8.
Yarom Y, Naparstek Y, Lev-Ram V, Holoshitz J, Ben-Nun A, Cohen IR. "Immunospecific inhibition of nerve conduction by T lymphocytes reactive to basic protein of myelin." Nature 1983; 303(5914):246-7.
Naparstek Y, Ben-Nun A, Holoshitz J, Reshef T, Frenkel A, Rosenberg M, Cohen IR. "T lymphocyte lines producing or vaccinating against autoimmune encephalomyelitis (EAE). Functional activation induces peanut agglutinin receptors and accumulation in the brain and thymus of line cells." Eur J Immunol 1983; 13(5):418-23.
Holoshitz J, Naparstek Y, Ben-Nun A, Cohen IR. "Lines of T lymphocytes induce or vaccinate against autoimmune arthritis." Science 1983; 219(4580):56-8.
Friedman A, Cohen IR. "Molecular events in the processing of avidin by antigen-presenting cells (APC). I. The immune response of T lymphocytes to avidin is regulated by H-2-linked Ir genes." Immunogenetics 1983; 18(3):267-75.
Friedman A, Zerubavel R, Gitler C, Cohen IR. "Molecular events in the processing of avidin by antigen-presenting cells (APC). II. Identical processing by APC of H-2 high- and low- responder mouse strains." Immunogenetics 1983; 18(3):277-90.
Friedman A, Zerubavel R, Gitler C, Cohen IR. "Molecular events in the processing of avidin by antigen-presenting cells (APC). III. Activation of T-lymphocyte lines and H-2 restriction are mediated by processed avidin associated with I-region gene products." Immunogenetics 1983; 18(3):291-302.
Maron R, Cohen IR. "Thymic reconstitution of H-2-linked T-cell responses to thyroglobulin or insulin." Immunogenetics 1983; 17(1):95-100.
Shechter Y, Elias D, Maron R, Cohen IR. "Mice immunized to insulin develop antibody to the insulin receptor." J Cell Biochem 1983; 21(2):179-85.
Talmon J, Ranghino G, Yonath A, Cohen IR. "Structural analysis of insulin determinants seen by T cells directed by H-2 genes." Immunogenetics 1983; 18(1):79-89.
Friedman A, Gitler C, Cohen IR. "Molecular aspects of the processing and presentation of avidin by macrophages to T lymphocytes." in Ir Gene: Past, Present and Future, eds. Pierce CW, Cullen SE, Ka, JA, Schwartz BD and Shreffler DC. Humana Press, Clifton, NJ, 1983; pp.289-293.
Cohen IR, Ben-Nun A, Holoshitz J, Maron R, Zerubavel R. "Vaccination against autoimmune disease using lines of autoimmune T lymphocytes." Immunology Today 1983; 4:227-230.
1984
Holoshitz J, Naparstek Y, Ben-Nun A, Marquardt P, Cohen IR. "T lymphocyte lines induce autoimmune encephalomyelitis, delayed hypersensitivity and bystander encephalitis or arthritis." Eur J Immunol 1984; 14(8):729-34.
Naparstek Y, Cohen IR, Fuks Z, Vlodavsky I. "Activated T lymphocytes produce a matrix-degrading heparan sulphate endoglycosidase." Nature 1984; 310(5974):241-4.
Shechter Y, Elias D, Maron R, Cohen IR. "Mouse antibodies to the insulin receptor developing spontaneously as anti-idiotypes. I. Characterization of the antibodies." J Biol Chem 1984; 259(10):6411-5.
Cohen IR. "Prospects for treatment of immunological diseases." in Clinics in Immunology and Allergy. Vol. 4, No. 3, eds. van Rood JJ, . de Vries RRP, Saunders WB. London.1984; pp.593-605.
Elias D, Maron R, Cohen IR, Schechter Y. "Mouse antibodies to the insulin receptor developing spontaneously as anti-idiotypes. II. Effects on glucose homeostasis and the insulin receptor." J Biol Chem 1984; 259(10):6416-9.
Cohen IR. "The interactions between antigen-presenting cells (APC) and T lymphocytes." Ann Immunol (Paris) 1984; 135C(3):400-2.
Sela BA, Offner H, Konat G, Lev-Ram V, Cohen O, Cohen IR. "Immunological expression of gangliosides in multiple sclerosis and in a demyelinating model disease in rabbits." Adv Exp Med Biol 1984; 174:441-53.
Friedman A, Cohen IR. "T cell Ir phenotype modified by excising primary antigen deposit." Immunogenetics 1984; 19(5):449-54.
Holoshitz J, Matitiau A, Cohen IR. "Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II." J Clin Invest 1984; 73(1):211-5.
Cohen IR, Elias D, Maron R, Shechter Y. "Immunization to insulin generates antiidiotypes that behave as antibodies to the insulin hormone receptor and cause diabetes mellitus." in Idiotypy, eds. Kohler H, Urbain J, Cazenave PA, Academic Press, New York, 1984; Vol. 20 pp.385-400.
Cohen IR. "Autoimmune T lymphocyte lines." in Progress in Immunology, V, ed. T. Tada, Academic Press, Japan. 1984; Vol. 5 pp.1129-1137.
Schalke BCG, Hohlfeld R, Kalies I, Ben-Nun A, Cohen IR and Wekerle H. "Permanent lines of T lymphocytes specific for acetylcholine receptors: A clonal aroach to study the pathogenesis of myasthenia gravis." in Recent Advances in Immunology, (ed. A.Y. Muftuoglu and N. Barlas) Plenum Publ. Co. N.Y. 1984; pp.205-209.
1985
Cohen IR. "Manipulation of autoimmune diseases using autoimmune T lymphocytes." in Human T Cell Clones, eds. Feldmann M, Lamb, JR, Woody, J.N. New Jersey, Humana Press Inc. 1985; pp.229-237.
van Eden W, Holoshitz J, Nevo Z, Frenkel A, Klajman A, Cohen IR. "Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans." Proc Natl Acad Sci U S A 1985; 82(15):5117-20.
Cohen IR, Holoshitz J, van Eden W, Frenkel A. "T lymphocyte clones illuminate pathogenesis and affect therapy of experimental arthritis." Arthritis Rheum 1985; 28(8):841-5.
Cohen IR. "The study and manipulation of experimental autoimmune disease using T lymphocyte lines." J Invest Dermatol 1985; 85(1 Sul):34s-38s.
Vandenbark AA, Offner H, Reshef T, Fritz R, Chou CH, Cohen IR. "Specificity of T lymphocyte lines for peptides of myelin basic protein." J Immunol 1985; 135(1):229-33.
Holoshitz J, Matitiau A, Cohen IR. "Role of the thymus in induction and transfer of vaccination against adjuvant arthritis with a T lymphocyte line in rats." J Clin Invest 1985; 75(2):472-7.
Cohen IR, Friedman A. "Processed antigen and MHC molecules." Prog Allergy 1985; 36:190-202.
Kolb H, Ben-Nun A, Cohen IR, Barberena I, Kiesel U. "Autoimmune T-lymphocytes with specificity for pancreatic islet antigens." Immunol Lett 1985; 9(1):29-32.
Cohen IR. "Manipulation of autoimmune diseases using autoimmune T lymphocytes." in Human T Cell Clones, eds. Feldmann, M., Lamb, J.R. and Woody, J.N. New Jersey, Humana Press Inc. 1985; pp.229-237.
Cohen IR. "Experimental autoimmune encephalomyelitis: Pathogenesis and prevention." in Immunoregulatory Processes in Multiple Sclerosis and Experimental Allergic Encephalomyelitis, eds. Vandenbark AA, Raus JCM, Elsevier Biomedical Press, Amsterdam.1985; pp.7:91-125.
Vlodavsky I, Fuks Z, Bar-Ner M, Yahalom J, Eldor A, Naphtali S, Naparstek Y, Cohen IR. "Degradation of heparan sulfate in the subendothelial basement membrane by normal and malignant blood-borne cells." in Extracellular Matrix: Structure and Function, Alan R. Liss.1985; pp.283-308.
1986
Cohen IR. "Regulation of autoimmune disease: physiological and therapeutic." Immunol Rev 1986; 94:5-21.
Holoshitz J, Klajman A, Drucker I, Lapidot Z, Yaretzky A, Frenkel A, van Eden W, Cohen IR. "T lymphocytes of rheumatoid arthritis patients show augmented reactivity to a fraction of mycobacteria cross-reactive with cartilage." Lancet 1986; 2(8502):305-9.
Grossman Z, Greenblatt CL, Cohen IR. "Parasite immunology and lymphocyte population dynamics." J Theor Biol 1986; 121(2):129-39.
Baharav E, Lider O, Margalit M, Cohen IR. "A modified technique for experimental skin grafting." J Immunol Methods 1986; 90(1):143-4.
Livneh A, Avraham H, Elias D, Sack J, Cohen IR, Eshhar Z. "A human monoclonal antibody to insulin." Diabetes 1986; 35(1):68-73.
Lider O, Shinitzky M, Cohen IR. "Vaccination against experimental autoimmune diseases using T lymphocytes treated with hydrostatic pressure." Ann N Y Acad Sci 1986; 475:267-73.
Beraud E, Reshef T, Vandenbark AA, Offner H, Friz R, Chou CH, Bernard D, Cohen IR. "Experimental autoimmune encephalomyelitis mediated by T lymphocyte lines: genotype of antigen-presenting cells influences immunodominant epitope of basic protein." J Immunol 1986; 136(2):511-5.
Elias D, Maron R, Golander A, Shechter Y, Cohen, IR. "Anti-idiotypic network generates antibodies to the insulin receptor and to insulin." Pediat Adolesc Endocr 1986; 15.
Van Eden W, Holoshitz J, Cohen IR. "Autoimmunity and the host parasite relationship." Clin. Immunol. Allerg. 1986; 6:113-126.
Cohen IR, Shpigel N. "Autoimmune processes and prospects for therapy of insulin dependent diabetes mellitus." in The Immunology of Diabetes Mellitus, eds. Jaworski,M.A. Amsterdam, Elsevier. 1986; pp.359-365.
Cohen IR. "Resistance to experimental autoimmunity using T lymphocyte vaccines." in Progress in Immunology VI, eds. Cinader B, Miller RG. New York, Academic Press. 1986; pp.491-499.
Cohen IR, Lider O, Baharav E, Hardan I, Miller T, Bar-Ner M, Fridman R, Naparstek Y, Vlodavsky I. "Regulation of experimental autoimmunity and allograft rejection by heparins that inhibit T lymphocyte heparanase." Proceedings 1st IUIS Conference on Clinical Immunology, Toronto. Elsevier Science Publications. 1986.
Grossman Z, Greenblatt CL, Cohen IR. "Parasite immunology and lymphocyte population dynamics." J. Theoret. Biol. 1986; 121:129-139.
1987
Altmann DM, Lider O, Douek DC, Cohen IR. "Activation of specific T cell lines by the antigens avidin and myelin basic protein in the absence of antigen-presenting cells." Eur J Immunol 1987; 17(11):1635-40.
Vlodavsky I, Eldor A, Bar-Ner M, Fridman R, Cohen IR, Klagsbrun M. "Heparan sulfate degradation in tumor cell invasion and angiogenesis." in Cancer Metastasis, eds. Hellman K, Liotta LA, Brodi G. Plenum Publ. 1987.
Westarp ME, Wekerle H, Ben-Nun A, Cohen IR, Vohl ML, Przuntek H. "T lymphocyte line-mediated experimental allergic encephalomyelitis--a pharmacologic model for testing of immunosuressive agents for the treatment of autoimmune central nervous system disease." J Pharmacol Exp Ther 1987;242(2):614-20.
Bar-Ner M, Eldor A, Wasserman L, Matzner Y, Cohen IR, Fuks Z, Cohen IR, Vlodavsky I. "Inhibition of heparanase-mediated degradation of extracellular matrix heparan sulfate by non-anticoagulant heparin species." Blood 1987; 70(2):551-7.
Lider O, Karin N, Shinitzky M, Cohen IR. "Therapeutic vaccination against adjuvant arthritis using autoimmune T cells treated with hydrostatic pressure." Proc Natl Acad Sci U S A 1987; 84(13):4577-80.
Stanescu R, Lider O, van Eden W, Holoshitz J, Cohen IR. "Histopathology of arthritis induced in rats by active immunization to mycobacterial antigens or by systemic transfer of T lymphocyte lines. A light and electron microscopic study of the articular surface using cationized ferritin." Arthritis Rheum 1987; 30(7):779-92.
Elias D, Cohen IR, Schechter Y, Spirer Z, Golander A. "Antibodies to insulin receptor followed by anti-idiotype. Antibodies to insulin in child with hypoglycemia." Diabetes 1987; 36(3):348-54.
Fridman R, Lider O, Naparstek Y, Fuks Z, Vlodavsky I, Cohen IR. "Soluble antigen induces T lymphocytes to secrete an endoglycosidase that degrades the heparan sulfate moiety of subendothelial extracellular matrix." J Cell Physiol 1987; 130(1):85-92.
Van Eden W, Holoshitz J, Cohen IR. " Antigenic mimicry between mycobacteria and cartilage proteoglycans: The model of adjuvant arthritis, in Autoimmunoregulation and Autoimmune Disease. Concepts in Immunopathology, JM. Cruse RE. Lewis, Jr. eds. Basel, Karger. 1987; 4:144-170.
Shoenfeld Y, Cohen IR. "Infection and autoimmunity." in The Antigens ed. Sela, M. Academic Press. San Diego. 1987; pp.307-325.
Bar-Ner M, Eldor A, Wasserman L, Matzner Y, Fuks Z, Cohen IR, Vlodavsky I. "Inhibition of heparanase mediated degradation of extracellular matrix heparan sulfate by non- anticoagulant heparin species." Blood 1987; 70:551-557.
1988
Cohen IR. "Vaccination against experimental autoimmune disease using autoimmune T- lymphocytes." Isr J Med Sci 1988; 24(12):734-6.
Cohen IR, Weiner HL. "T-cell vaccination." Immunol Today 1988; 9(11):332-5.
Res PC, Schaar CG, Breedveld FC, van Eden W, van Embden JD, Cohen IR, de Vries RRP. "Synovial fluid T cell reactivity against 65 kD heat shock protein of mycobacteria in early chronic arthritis." Lancet 1988; 2(8609):478-80.
Wise PM, Cohen IR, Weiland NG, London ED. "Aging alters the circadian rhythm of glucose utilization in the suprachiasmatic nucleus." Proc Natl Acad Sci U S A 1988; 85(14):5305-9.
Elias D, Rapoport M, Cohen IR, Shechter Y. "Desensitization of the insulin receptor by anti-receptor antibodies in vivo is blocked by treatment of mice with beta-adrenergic agonists." J Clin Invest 1988; 81(6):1979-85.
van Eden W, Thole JE, van der Zee R, Noordzij A, van Embden JD, Hensen EJ, Cohen IR. "Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis." Nature 1988; 331(6152):171-3.
Lider O, Reshef T, Beraud E, Ben-Nun A, Cohen IR. "Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis." Science 1988; 239(4836):181-3.
Vlodavsky I, Eldor A, Bar-Ner M, Fridman R, Cohen IR, Klagsbrun M. "Heparan sulfate degradation in tumor cell invasion and angiogenesis." Adv Exp Med Biol 1988; 233:201-10.
Cohen IR . "T lymphocyte vaccination against autoimmune diseases." in Perspectives on Autoimmunity. IR Cohen, ed. CRC Press, Boca Raton Florida. 1988; pp.210-217.
Holoshitz.J, Van Eden W, Frenkel A, Cohen IR. " Autoimmune arthritis induced by immunization to mycobacterial antigens." in Perspectives on Autoimmunity, Cohen IR ed. CRC Press, Boca Raton, Florida. 1988; pp.155-165.
Cohen IR ed. Perspectives on Autoimmunity, CRC Press, Boca Raton, Florida. 1988; pp.1-225.
Shechter Y, Elias D, Bruck R, Maron R, Cohen IR. "Mice immunized to insulin develop anti-idiotypic antibody to the insulin receptor." in Anti-idiotypes, receptors and molecular mimicry, Scott Linthicum D, Farid NR. eds. Springer-Verlag. 1988; pp.73-91.
Cohen IR, Elias D, Shecter Y. "The DM idiotypic network: antibodies that mimic insulin and its receptor." in Molecular Mimicry in Health and Disease, Interactions of Biological substances with neural endocrine and immune cells, eds. Lernmark A , Dyrberg,T, Terenius L, Hokfelt B, Excerpta Medica. 1988; pp.267-271.
1989
Cohen IR. "An eclectic summary of the symposium on autoimmunity." Immunol Today 1989; 10(12):394-6. Cohen IR.
Cohen IR."Autoimmunity to receptors." Isr J Med Sci 1989; 25(12):695-7.
Friedman A, Lider O, Beraud E, Cohen IR. "Absence of major histocompatibility complex restriction in the interaction between processed basic protein and IA of two rat strains." Scand J Immunol 1989; 29(6):747-50.
Lohse A, Cohen IR. "Mechanisms of Resistance to Autoimmune Disease Induced by T-Cell Vaccination in The Proceedings of Molecular Biology of Autoimmune Diseases," Athens, Greece.
Lohse AW, Mor F, Karin N, Cohen IR. "Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells." Science 1989; 244(4906):820-2.
Lohse A, Cohen IR. "Therapy of Autoimmune Disease: Future Aspects." in Proceedings of The XIVth Congress of the European Academy of Allergology and Clinical Immunology, Berlin, W. Germany.
Lider O, Baharav E, Mekori YA, Miller T, Naparstek Y, Vlodavsky I, Cohen IR. "Suppression of experimental autoimmune diseases and prolongation of allograft survival by treatment of animals with low doses of heparins." J Clin Invest 1989; 83(3):752-6.
Beraud E, Lider O, Baharav E, Reshef T, Cohen IR. "Vaccination against experimental autoimmune encephalomyelitis using a subencephalitogenic dose of autoimmune effector cells (1). Characteristics of vaccination." J Autoimmun 1989; 2(1):75-86.
Lider O, Beraud E, Reshef T, Friedman A, Cohen IR. "Vaccination against experimental autoimmune encephalomyelitis using a subencephalitogenic dose of autoimmune effector T cells. (2). Induction of a protective anti-idiotypic response." J Autoimmun 1989; 2(1):87-99.
van Eden W, Hogervorst EJ, Hensen EJ, van der Zee R, van Embden JD, Cohen IR. "A cartilage-mimicking T-cell epitope on a 65K mycobacterial heat-shock protein adjuvant arthritis as a model for human rheumatoid arthritis." Curr Top Microbiol Immunol 1989; 145:27-43.
Cohen IR, Elias D, Rapoport M, Shechter Y. "Production and properties of anti-idiotypic antibodies that recognize insulin receptor." Methods Enzymol 1989; 178:300-8.
van Eden W, Hogervorst EJ, van der Zee R, van Embden JD, Hensen EJ, Cohen IR. "The mycobacterial 65 kD heat-shock protein and autoimmune arthritis." Rheumatol Int 1989; 9(3-5):187-91.
Atlan, H., Cohen, I.R. "Introduction to immune networks in Theories of Immune Networks," eds. Atlan H, Cohen IR. Springer-Verlag. (Berlin), 1989; pp.1-3.
Cohen IR. "T cell vaccination and suppression of autoimmune," in Progress in Immunology VII, Proceedings of the 7th International Congress of Immunology, Berlin, eds. Melchers F, et al, Springer-Verlag Berlin, 1989; 867-873.
Karin N, Cohen IR. "Autoimmune arthritis and immunity to a heat shock protein lessons from adjuvant arthritis." in Septieme Symposia international D’immuno-rhumatologie, Montpellier eds. Clot J, Sany J, Brochier J, 1989; pp.167-171.
Lohse A, Cohen IR. "Mechanisms of Resistance to Autoimmune Disease Induced by T-Cell Vaccination," in The Proceedings of Molecular Biology of Autoimmune Diseases, Athens, Greece.
Lohse A., Cohen, IR. "Therapy of Autoimmune Disease: Future Aspects" in The Proceedings of The XIVth Congress of the European Academy of Allergology and Clinical Immunology, Berlin, W. Germany.
1990
Elias D, Bone AJ, Baird JD, Cooke A, Cohen IR. "Insulin-mimicking anti-idiotypic antibodies in development of spontaneous autoimmune diabetes in BB/E rats." Diabetes 1990; 39(12):1467-71.
Lohse AW, Mor E, Reshef T, Meyer zum Buschenfelde KH, Cohen IR. "Inhibition of the mixed lymphocyte reaction by T cell vaccination." Eur J Immunol 1990; 20(11):2521-4.
Naparstek Y, Ben-Yehuda A, Cohen IR, Bar-Tana R. "Crossreactivity of anti-DNA antibodies." Immunol Today 1990; 11(11):388-9.
Naparstek Y, Ben-Yehuda A, Madaio MP, Bar-Tana R, Schuger L, Pizov G. "Binding of anti-DNA antibodies and inhibition of glomerulonephritis in MRL-lpr/lpr mice by heparin." Arthritis Rheum 1990; 33(10):1554-9.
Mekori YA, Karin N, Gottesman G, Cohen IR. "Tolerance to experimental contact sensitivity induced by T cell vaccination." Eur J Immunol 1990;20(9):2083-7.
Mor F, Lohse AW, Karin N, Cohen IR. "Clinical modeling of T cell vaccination against autoimmune diseases in rats. Selection of antigen-specific T cells using a mitogen." J Clin Invest 1990; 85(5):1594-8.
Lider O, Mekori YA, Miller T, Bar-Tana R, Vlodavsky I, Baharav E, Cohen IR, Naparstek Y. "Inhibition of T lymphocyte heparanase by heparin prevents T cell migration and T cell-mediated immunity." Eur J Immunol 1990; 20(3):493-9.
Elias D, Markovits D, Reshef T, van der Zee R, Cohen IR. "Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein." Proc Natl Acad Sci U S A 1990; 87(4):1576-80.
Lohse AW, Manns M, Dienes HP, Meyer zum Buschenfelde KH, Cohen IR. "Experimental autoimmune hepatitis: disease induction, time course and T- cell reactivity." Hepatology 1990; 11(1):24-30.
Cohen IR. "A heat shock protein, molecular mimicry and autoimmunity." in The Role of Micro-organisms in Non-infectious Diseases. R.R.P. de Vries, I.R. Cohen, J.J. van Rood, eds. Proceedings of Argenteuil Symposia, Springer-Verlag, London. 1990; pp.167-173 and Isr J Med Sci 1990; 26(12):673-6.
Lohse AW, Cohen IR. "T cell vaccines." in Autoimmunity and Molecular Biology, ed. Brahn E, ,Little Brown & Co. 1990.
Cohen IR. "One microbial heat shock protein and two autoimmune diseases." in Frontiers of Infectious Diseases. New Antibacterial Strategies, ed. Neu HC, Churchill Livingston, Edinburgh. 1990; pp.263-268.
1991
Cohen IR. "T-cell vaccination in immunological disease." J Intern Med 1991; 230(6):471-7.
Cohen IR, Lohse AW. "Physiology and pathophysiology of autoimmunity." Semin Liver Dis 1991; 11(3):183-6.
Elias D, Reshef T, Birk OS, van der Zee R, Walker MD, Cohen IR. "Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein." Proc Natl Acad Sci U S A 1991; 88(8):3088-91.
Cohen IR. "Unresolved questions in clinical T cell vaccination." Br J Rheumatol 1991; 30 Sul 2:17-9.
Lohse AW, Cohen IR. "Mechanisms of resistance to autoimmune disease induced by T-cell vaccination." Autoimmunity 1991; 9(2):119-21.
Feige U, Cohen IR. "The 65-kDa heat-shock protein in the pathogenesis, prevention and therapy of autoimmune arthritis and diabetes mellitus in rats and mice." Springer Semin Immunopathol 1991; 13(1):99-113.
Ekre H.-P, Naparstek Y, Lider O, Hyden P., Hagermark O, Nilsson T, Vlodavsky I., Cohen IR. "Anti-inflammatory effects of heparin and its derivatives. Inhibition of complement and of lymphocyte migration. in Heparin and Related Polysaccharadies," ed. Lane D, Lindahl U. Plenum Publishing Corp., London.1991.
Cohen IR. Critique on “The Aging Paradox and Autoimmune Disease”, hypothesis by Talor and Rose. Autoimmunity 1991 8:253.
Markman O, Elias D, Addadi L, Cohen IR., Berkovitch-Yellin Z. "Monoclonal antibodies to insulin and to the insulin receptor (anti-ID) modify the morphologies of the insulin crystals." J Crystal Growth 1992; 122:344-350.
Cohen IR. "Weigert M. Autoimmunity Editorial Overview," Current Opinion in Immunol. 1992; 3:887.
Mor F, Cohen IR. "T cells in the lesion of experimental autoimmune encephalomyelitis. Enrichment for reactivities to myelin basic protein and to heat shock proteins." J Clin Invest 1992; 90(6):2447-55.
Zerubavel-Weiss R, Markovits D, Cohen IR. "Autoimmune thyroiditis (EAT) in genetically resistant mice mediated by a T cell line." J Autoimmun 1992;5(5):617-27.
Danieli MG, Markovits D, Gabrielli A, Corvetta A, Giorgi PL, van der Zee R, van Embden JD, Danieli G, Cohen IR. "Juvenile rheumatoid arthritis patients manifest immune reactivity to the mycobacterial 65-kDa heat shock protein, to its 180-188 peptide, and to a partially homologous peptide of the proteoglycan link protein." Clin Immunol Immunopathol 1992; 64(2):121-8.
Danieli MG, Candela M, Ricciatti AM, Reginelli R, Danieli G, Cohen IR, Gabrielli A. "Antibodies to mycobacterial 65 kDa heat shock protein in systemic sclerosis (scleroderma)." J Autoimmun 1992; 5(4):443-52.
Cohen IR. "Immunologically specific treatment of spontaneous insulin-dependent diabetes mellitus of NOD mice." J Autoimmun 1992; 5 Sul A:227-30.
Hershkoviz R, Mor F, Gilat D, Cohen IR, Lider O. "T cells in the spinal cord in experimental autoimmune encephalomyelitis are matrix adherent and secrete tumor necrosis factor alpha." J Neuroimmunol 1992; 37(1-2):161-6.
Mor F, Cohen IR. "Analysis of the autoimmune infiltrate in experimental encephalomyelitis." Isr J Med Sci 1992; 28(2):139-40.
Hershkoviz R, Miron S, Cohen IR, Miller A, Lider O. "T lymphocyte adhesion to the fibronectin and laminin components of the extracellular matrix is regulated by the CD4 molecule." Eur J Immunol 1992; 22(1):7-13.
Lohse AW, Cohen IR. "Immunoregulation: studies of physiological and therapeutic autoreactivity by T cell vaccination." Springer Semin Immunopathol 1992; 14(2):179-86.
Vlodavsky I, Eldor A, Haimovitz-Friedman A, Matzner Y, Ishai-Michaeli R, Lider O, Naparstek Y, Cohen IR, Fuks Z. "Expression of heparanase by platelets and circulating cells of the immune system: possible involvement in diapedesis and extravasation." Invasion Metastasis 1992; 12(2):112-27.
Friedman A, Reshef T, Cohen IR. "Induction of experimental autoimmune encephalomyelitis by native myelin basic protein-activated T lymphocyte lines." Eur J Immunol 1992; 22(1):279-82.
Ekre H.-P, Naparstek Y, Lider O, Hyden P, Hagermark O, Nilsson T. Vlodavsky I, Cohen IR. "Anti-inflammatory effects of heparin and its derivates: inhibition of complement and of lymphocyte migration." Adv. Exp. Med. Biol. 1992; 313:329-340.
Hershkoviz R, Miron S, Cohen IR, Miller A, Lider O. "The CD4 molecule is involved in regulating T lymphocyte adhesion to the fibronectin and laminin components of the extracellular matrix." Eur J Immunol 1992 22:7-13.
Mor F, Cohen IR. "Towards idiotype specific therapy in autoimmune disease." in Frontiers in Pharmacology and Therapeutics T Cell Directed Immunointervention, eds. Bach JF. Blackwell Publications.1992 Chapter 12, pp.259-269.
Atlan A, Cohen IR. "Paradoxical effects of suppressor T cells in adjuvant arthritis: Neural network analysis." in Theoretical and Experimental Insights into Immunology. eds. A.S. Perelson and G. Weisbuch, NATO ASI Series, Vol. H66, Springer-Verlag Berlin 1992; pp.379-395.
Hafler DA, Cohen I, Benjamin DS, Weiner HL. "T cell vaccination in multiple sclerosis: A preliminary report." Clinical Immunology and Immunopathology 1992 62:307-313.
1993
Birk OS, Cohen IR. "T-cell autoimmunity in type 1 diabetes mellitus." Curr Opin Immunol 1993; 5(6):903-9.
Yagev H, Frenkel A, Cohen IR, Friedman A. "Adjuvant arthritis is associated with changes in the glycosylation of serum IgG1 and IgG2b." Clin Exp Immunol 1993; 94(3):452-8.
Mor F, Cohen IR. "Shifts in the epitopes of myelin basic protein recognized by Lewis rat T cells before, during, and after the induction of experimental autoimmune encephalomyelitis." J Clin Invest 1993; 92(5):2199-206.
Alon R, Hershkoviz R, Bayer EA, Cohen IR, Wilchek M, Lider O. "Streptavidin blocks immune reactions mediated by fibronectin-VLA-5 recognition through an RGD mimicking site." Eur. J. Immunol. 1993; 23:893-898.
Naparstek E, Slavin S, Weiss L, Sidi H, Ohana M, Reich S, Vlodavsky I, Cohen IR, Naparstek Y. "Low-dose heparin inhibits acute graft versus host disease in mice." Bone Marrow Transplant 1993; 12(3):185-9.
Mor F, Cohen IR. "T cell vaccines for autoimmune diseases." Ann N Y Acad Sci 1993; 685:784-7.
Lohse AW, Spahn TW, Wolfel T, Herkel J, Cohen IR, Meyer zum Buschenfelde KH. "Induction of the anti-ergotypic response." Int Immunol 1993; 5(5):533-9.
van Laar JM, Miltenburg AM, Verdonk MJ, Leow A, Elferink BG, Daha MR, Cohen IR, De Vries RRP,. Breedveld FC. "Effects of inoculation with attenuated autologous T cells in patients with rheumatoid arthritis." J Autoimmun 1993; 6(2):159-67.
Mor F, Cohen IR. "Experimental aspects of T cell vaccination." Clin Exp Rheumatol 1993; 11:S55-7.
Shapira OM, Mor E, Reshef T, Pfeffermann RA, Cohen IR. "Prolongation of survival of rat cardiac allografts by T cell vaccination." J Clin Invest 1993; 91(2):388-90.
Cohen IR. "The meaning of the immunological homunculus." Isr J Med Sci 1993; 29(2-3):173-4.
Hershkoviz R, Gilat D, Miron S, Mekori YA, Aderka D, Wallach D. Vlodavsky I, Cohen IR, LIder O. "Extracellular matrix induces tumour necrosis factor-alpha secretion by an interaction between resting rat CD4+ T cells and macrophages." Immunology 1993; 78(1):50-7.
Cohen IR, Mor F. "On the regulation of EAE." Int Rev Immunol 1993; 9(4):243-9.
1994
Achiron A, Gilad R, Margalit R, Gabbay U, Sarova-Pinhas I, Cohen IR,. Melamed E, Lider O, Noy S, Ziv I. "Intravenous gammaglobulin treatment in multiple sclerosis and experimental autoimmune encephalomyelitis: delineation of usage and mode of action." J Neurol Neurosurg Psychiatry 1994; 57 Sul:57-61.
Cohen IR. Review of The Molecular Pathology of Autoimmune Diseases. eds. Bona CA,. Siminovitch KA, Zanetti M, Theofilopoulos. AN. The Lancet, 1994.
Ingber A, Trattner A, Cohen IR, Mekori YA. "Low doses of low molecular weight heparin in vivo inhibits the elicitation of contact hypersensitivity." Acta Derm Venereol 1994; 74(6):454-6.
Reizis B, Schramm C, Cohen IR, Mor F. "Expression of major histocompatibility complex class II molecules in rat T cells." Eur J Immunol 1994; 24(11):2796-802.
Elias D, Prigozin H, Polak N, Rapoport M, Lohse AW, Cohen IR. "Autoimmune diabetes induced by the β-cell toxin STZ. Immunity to the 60-kDa heat shock protein and to insulin." Diabetes 1994; 43(8):992-8.
Verhagen C, Mor F, Cohen IR. "T cell immunity to myelin basic protein induces anterior uveitis in Lewis rats." J Neuroimmunol 1994; 53(1):65-71.
Achiron A, Margalit R, Hershkoviz R, Markovits D, Reshef T, Melamed E, Cohen IR, Lider O. "Intravenous immunoglobulin treatment of experimental T cell-mediated autoimmune disease. Upregulation of T cell proliferation and downregulation of tumor necrosis factor alpha secretion." J Clin Invest 1994; 93(2):600-5.
Levy L, Enk CD, Zipris D, Cohen IR. "Protection of mice against mycobacterial infection by lymphoid cell vaccination." Isr J Med Sci 1994; 30(1):22-5.
van Laar JM, Miltenburg AM, Breedveld FC, Cohen IR, de Vries RR. "Towards T cell vaccination in rheumatoid arthritis." Chem Immunol 1994; 58:206-35.
Cohen IR. "Antigen receptors as targets for therapy in autoimmune diseases" in Autoimmune Diseases Aetiopathogenesis, Diagnosis and Treatment, Essays in honour of the retirement of Prof. Ivan Roitt FRS, ed. Lydyard PM, Brostoff J. Blackwell Science, UK, 1994; pp.157-163.
Cohen IR, Miller A., eds. Autoimmune Disease Models. A Guidebook. Academic Press. 1994; pp.1-329
1995
Mor F, Cohen IR. "Vaccines to prevent and treat autoimmune diseases." Int Arch Allergy Immunol 1995; 108(4):345-9.
Elias D, Marcus H, Reshef T, Ablamunits V, Cohen IR. "Induction of diabetes in standard mice by immunization with the p277 peptide of a 60-kDa heat shock protein." Eur J Immunol 1995; 25(10):2851-7.
Mor F, Cohen IR. "Pathogenicity of T cells responsive to diverse cryptic epitopes of myelin basic protein in the Lewis rat." J Immunol 1995; 155(7):3693-9.
Elias D, Cohen IR. "Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock protein 60 peptide p277." Diabetes 1995; 44(9):1132-8.
Reizis B, Mor F, Cohen IR. "Functional activation of encephalitogenic T cells in the absence of antigen-presenting cells." Int Immunol 1995; 7(8):1375-9.
Konen-Waisman S, Fridkin M, Cohen IR. "Self and foreign 60-kilodalton heat shock protein T cell epitope peptides serve as immunogenic carriers for a T cell-independent sugar antigen." J Immunol 1995; 154(11):5977-85.
Lider O, Cahalon L, Gilat D, Hershkoviz R, Siegel D, Margalit R, Shoseyov O, Cohen IR. "A disaccharide that inhibits tumor necrosis factor α is formed from the extracellular matrix by the enzyme heparanase." Proc Natl Acad Sci U S A 1995; 92(11):5037-41.
Segel LA, Jager E, Elias D, Cohen IR. "A quantitative model of autoimmune disease and T-cell vaccination: does more mean less?" Immunol Today 1995; 16(2):80-4.
Mor F, Cohen, IR. "IL2 rescues antigen-specific T cells from radiation or dexamethasone-induced apoptosis: correlation with induction Bcl-2." J. Immunol 1995; 156(2):512:22.
1996
Reizis B, Mor F, Eisenstein M, Schild H, Stefanovic S, Rammensee HG, Cohen IR. "The peptide binding specificity of the MHC class II I-A molecule of the Lewis rat, RT1.BI." Int Immunol 1996; 8(12):1825-32.
Atlan H, Cohen IR. "T-cell vaccination for HIV-seropositive patients." in Immunology of HIV Infection. ed. Gupta S. Plenum Press, New York,1996, pp.535-559.
Cohen IR, Elias.D. "Immunity to 60 kDa heat shock protein in autoimmune diabetes." Diab. Nutr. Metab. 1996; 9:229-232.
Mor F, Reizis B, Cohen IR, Steinman L. "IL-2 and TNF receptors as targets of regulatory T-T interactions: isolation and characterization of cytokine receptor-reactive T cell lines in the Lewis rat." J Immunol 1996; 157(11):4855-61.
Yamamura T, Geng TC, Kozovska MF, Yokoyama K, Cohen IR, Tabira T. "An alpha-chain TCR CDR3 peptide can enhance EAE induced by myelin basic protein or proteolipid protein." J Neurosci Res 1996; 45(6):706-13.
Mor F, Kantorowitz M, Cohen IR. "The dominant and the cryptic T cell repertoire to myelin basic protein in the Lewis rat." J Neurosci Res 1996; 45(6):670-9.
Elias D, Cohen IR. "The hsp60 peptide p277 arrests the autoimmune diabetes induced by the toxin streptozotocin." Diabetes 1996; 45(9):1168-72.
Waisman A, Ruiz PJ, Hirschberg DL, Gelman A, Oksenberg JR, Brocke S, Mor F, Cohen IR, Steinman L. "Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity." Nat Med 1996; 2(8):899-905.
Ben-Yehuda A, Bar-Tana R, Livoff A, Ron N, Cohen IR, Naparstek Y. "Lymph node cell vaccination against the lupus syndrome of MRL/lpr/lpr mice." Lupus 1996; 5(3):232-6.
Birk OS, Elias D, Weiss AS, Rosen A, van der Zee R, Walker MD, Cohen IR. "NOD mouse diabetes: the ubiquitous mouse hsp60 is a beta-cell target antigen of autoimmune T cells." J Autoimmun 1996; 9(2):159-66.
Birk OS, Douek DC, Elias D, Takacs K, Dewchand H, Gur SL, Walker MD, van der Zee R, Cohen IR, Altmann DM. "A role of Hsp60 in autoimmune diabetes: analysis in a transgenic model." Proc Natl Acad Sci U S A 1996; 93(3):1032-7.
Mor F, Cohen IR. "IL-2 rescues antigen-specific T cells from radiation or dexamethasone-induced apoptosis. Correlation with induction of Bcl-2." J Immunol 1996; 156(2):515-22.
Cohen IR. "Heat shock protein 60 and the regulation of autoimmunity." in Stress Proteins in Medicine, eds. van Eden W, Young DB. Marcel Dekker, Inc., New York, 1996, pp.93-102.
Cohen IR. Mor F. "Vaccination therapy against autoimmune diseases" in Concepts in Vaccine Development ed. Kaufmann SHE, 1996.
1997
Reizis B, Altmann DM, Cohen IR. "Biochemical characterization of the human diabetes-associated HLA-DQ8 allelic product: similarity to the major histocompatibility complex class II I-A(g)7 protein of non-obese diabetic mice." Eur J Immunol 1997; 27(10):2478-83.
Cahalon L, Lider O, Schor H, Avron A, Gilat D, Hershkoviz R, Margalit R, Eshel A, Shoseyev O, Cohen IR. "Heparin disaccharides inhibit tumor necrosis factor-α production by macrophages and arrest immune inflammation in rodents." Int Immunol 1997; 9(10):1517-22.
Bockova J, Elias D, Cohen IR. "Treatment of NOD diabetes with a novel peptide of the hsp60 molecule induces Th2-type antibodies." J Autoimmun 1997; 10(4):323-9.
Cohen IR, Steinman L. "Exploring the potential of DNA vaccination." Hosp Pract (Off Ed) 1997; 32(5):169-71, 176-8.
Elias D, Meilin A, Ablamunits V, Birk OS, Carmi P, Konen-Waisman S, Cohen IR. "Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various beta-cell antigens." Diabetes 1997; 46(5):758-64.
Reizis B, Eisenstein M, Bockova J, Konen-Waisman S, Mor F, Elias D, Cohen IR. "Molecular characterization of the diabetes-associated mouse MHC class II protein, I-Ag7." Int Immunol 1997; 9(1):43-51.
Reizis B, Schild H, Stefanovic S, Mor F, Rammensee H, Cohen IR. "Peptide binding motifs of the MHC class I molecules (RT1.Al) of the Lewis rat." Immunogenetics 1997; 45(4):278-9.
1998
Erez-Alon N, Herkel J, Wolkowicz R, Ruiz PJ, Waisman A, Rotter V, Cohen IR. "Immunity to p53 induced by an idiotypic network of anti-p53 antibodies: generation of sequence-specific anti-DNA antibodies and protection from tumor metastasis." Cancer Res 1998; 58(23):5447-52.
Shpigel E, Elias D, Cohen IR, Shoseyov O. "Production and purification of a recombinant human hsp60 epitope using the cellulose-binding domain in Escherichia coli." Protein Expr Purif 1998; 14(2):185-91.
Hirschberg DL, Moalem G, He J, Mor F, Cohen IR, Schwartz M. "Accumulation of passively transferred primed T cells independently of their antigen specificity following central nervous system trauma." J Neuroimmunol 1998; 89(1-2):88-96.
Ruiz PJ, Wolkowicz R, Waisman A, Hirschberg DL, Carmi P, Erez N, Garren H, Herkel J, Karpuj M, Steinman L, Rotter V, Cohen I. " Idiotypic immunization induces immunity to mutated p53 and tumor rejection." Nat Med 1998; 4(6):710-2.
Reizis B, Eisenstein M, Mor F, Cohen IR. "The peptide-binding strategy of the MHC class II I-A molecules." Immunol Today 1998; 19(5):212-6.
Hodak E, Yosipovitch G, David M, Ingber A, Chorev L, Lider O, Cahalon L, Cohen IR. "Low-dose low-molecular-weight heparin (enoxaparin) is beneficial in lichen planus: a preliminary report." J Am Acad Dermatol 1998; 38(4):564-8.
Ablamunits V, Elias D, Reshef T, Cohen IR. "Islet T cells secreting IFN-g in NOD mouse diabetes: arrest by p277 peptide treatment." J Autoimmun 1998; 11(1):73-81.
Ablamunits V, Quintana F, Reshef T, Elias D, Cohen IR. "Acceleration of autoimmune diabetes by cyclophosphamide is associated with an enhanced IFN-g secretion pathway." J Autoimmun 1999; 13(4):383-92.
Verhagen C, Mor F, Ki JB, de Vos AF, van der Gaag R, Cohen IR. "Experimental autoimmune keratitis induced in rats by anti-cornea T-cell lines." Invest Ophthalmol Vis Sci 1999; 40(10):2191-8.
Krause I, Tomer Y, Elias D, Blank M, Gilburd B, Cohen IR, Schoenfeld Y. "Inhibition of diabetes in NOD mice by idiotypic induction of SLE." J Autoimmun 1999; 13(1):49-55.
Moalem G, Monsonego A, Shani Y, Cohen IR, Schwartz M. "Differential T cell response in central and peripheral nerve injury: connection with immune privilege."FASEB J 1999; 13(10):1207-17.
Shapira OM, Rene H, Lider O, Pfeffermann RA, Shemin RJ, Cohen IR. "Prolongation of rat skin and cardiac allograft survival by low molecular weight heparin." J Surg Res 1999; 85(1):83-7.
Schwartz M, Moalem G, Leibowitz-Amit R, Cohen IR. "Innate and adaptive immune responses can be beneficial for CNS repair." Trends Neurosci 1999; 22(7):295-9.
Elias D, Tikochinski Y, Frankel G, Cohen IR. "Regulation of NOD mouse autoimmune diabetes by T cells that recognize a TCR CDR3 peptide." Int Immunol 1999; 11(6):957-66.
Tikochinski Y, Elias D, Steeg C, Marcus H, Kantorowitz M, Reshef T, Ablumunits V, Cohen IR, Friedman A. "A shared TCR CDR3 sequence in NOD mouse autoimmune diabetes." Int Immunol 1999; 11(6):951-6.
Birk OS, Gur SL, Elias D, Margalit R, Mor F, Carmi P, Bockova J, Altmann DM, Cohen IR. "The 60-kDa heat shock protein modulates allograft rejection." Proc Natl Acad Sci U S A 1999; 96(9):5159-63.
Rechter M, Lider O, Cahalon L, Baharav E, Dekel M, Seigel D, Vlodavsky I,Aingorn H, Cohen IR, Shoseyov O. "A cellulose-binding domain-fused recombinant human T cell connective tissue-activating peptide-III manifests heparanase activity." Biochem Biophys Res Commun 1999; 255(3):657-62.
Abulafia-Lapid R, Elias D, Raz I, Keren-Zur Y, Atlan H, Cohen IR. "T Cell Proliferative Responses of Type 1 Diabetes Patients and Healthy Individuals to Human hsp60 and its Peptides." J Autoimmun 1999; 12(2):121-9.
Figueiredo AC, Cohen IR, Mor F. "Diversity of the B cell repertoire to myelin basic protein in rat strains susceptible and resistant to EAE." J Autoimmun 1999; 12(1):13-25.
Ablamunits V, Elias D, Cohen IR. "The pathogenicity of islet-infiltrating lymphocytes in the non-obese diabetic (NOD) mouse." Clin Exp Immunol 1999; 115(2):260-7.
Moalem G, Leibowitz-Amit R, Yoles E, Mor F, Cohen IR, Schwartz M. "Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy." Nat Med 1999; 5(1):49-55.
Konen-Waisman S, Cohen A, Fridkin M, Cohen IR. "Self heat-shock protein (hsp60) peptide serves in a conjugate vaccine against a lethal pneumococcal infection." J Infect Dis 1999; 179(2):403-13.
2000
Hauben E, Nevo U, Yoles E, Moalem G, Agranov E, Mor F Akselrod S, Neeman M, Cohen IR, Schwartz M. "Autoimmune T cells as potential neuroprotective therapy for spinal cord injury." Lancet 2000; 355(9200):286-7.
Hershkoviz R, Schor H, Ariel A, Hecht I, Cohen IR, Lider O Cahalon L. "Disaccharides generated from heparan sulphate or heparin modulate chemokine-induced T-cell adhesion to extracellular matrix." Immunology 2000; 99(1):87-93.
Van Eden W, Cohen IR. "Autoimmunity and Microbial Infection," in Effects of Microbes on the Immune System, eds. Cunningham MW, Fujinami R, Lippincott, Williams & Williams, Philadelphia.2000; Chapter 1 pp.1-8.
Quintana FJ, Rotem A, Carmi P, Cohen IR. "Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in nonobese diabetic mice: modulation of spontaneous 60-kDa heat shock protein autoimmunity." J Immunol 2000; 165(11):6148-55.
Moalem G, Gdalyahu A, Shani Y, Otten U, Lazarovici P, Cohen IR, Schwartz M. "Production of neurotrophins by activated T cells: implications for neuroprotective autoimmunity." J Immunol 2000; 15(3):331-45.
Achiron A, Mor F, Margalit R, Cohen IR, Lider O, Miron S. "Suppression of experimental autoimmune encephalomyelitis by intravenously administered polyclonal immunoglobulins." J Immunol 2000; 15(3):323-30.
Hauben E, Butovsky O, Nevo U, Yoles E, Moalem G, Agranov E, , Mor F, Leibowitz-Amit R, Pevsner E, Akselrod S, Neeman M, Cohen IR, Schwartz M. "Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion." J Neurosci 2000; 20(17):6421-30.
Kipnis J, Yoles E, Porat Z, Cohen A, Mor F, Sela M. " T cell to copolymer 1 confers neuroprotection on the damaged optic nerve: possible therapy for optic neuropathies." Proc Natl Acad Sci U S A 2000; 97(13):7446-51.
Moalem G, Yoles E, Leibowitz-Amit R, Muller-Gilor S, Mor F, Cohen IR, Schwartz M. "Autoimmune T cells retard the loss of function in injured rat optic nerves." J Neuroimmunol 2000; 106(1-2):189-97.
Mor F, Kantorowitz M, Cohen IR. "Selection of anti-myelin basic protein T-cell lines in the lewis rat: V-b 8.2 dominance and complementarity-determining-region-3 motifs are dependent on serine at position 78 of myelin basic protein." J Neuroimmunol 2000; 106(1-2):154-64.
Herkel J, Erez-Alon N, Mimran A, Wolkowicz R, Harmelin A, Ruiz P, Rotter V. Cohen IR. "Systemic lupus erythematosus in mice, spontaneous and induced, is associated with autoimmunity to the C-terminal domain of p53 that recognizes damaged DNA." Eur J Immunol 2000; 30(4):977-84.
Moalem G, Gdalyahu A, Shani Y, Otten U, Lazarovici P, Cohen IR, Schwartz M. "Production of neurotrophins by activated T cells: Implications for neuroprotective autoimmunity." J Autoimmun 2000; 15;(3):331-45.
Hauben E, Nevo U, Yoles E, Moalem G, Agranov E, Mor F, Akselrod S, Neeman M, Cohen IR, Schwartz M. "Autoimmune T cells as potential neuroprotective therapy for spinal cord injury." Lancet 2000; 22;355(9200):286-7.
Hershkoviz R, Schor H, Ariel A, Hecht I, Cohen IR, Lider O, Cahalon L. "Disaccharides generated from heparan sulphate or heparin modulate chemokine-induced T-cell adhesion to extracellular matrix." Immunology 2000; 99(1):87-93.
Cohen IR. "Principles of molecular mimicry and autoimmune disease." In Molecular Mimicry, eds. Cunningham M. Fujinami. R. ASM Press, Washington, DC. 2000, pp.17-26.
Cohen IR. "Disease The Idiotypic Network in Autoimmunity." In The Molecular Pathology of Autoimmune Diseases, 2nd Edition. Bona CA Siminovitch KA, Zanetti M, Theofilopoulos AN. eds., 2000.
Abulafia-Lapid R, Bentwich Z, Keren-Zur Y, Cohen I, Atlan H. "Autologous T-cell vaccination for HIV-seropositive patients: a phase I clinical trial." The Fifth European Conference on Experimental AIDS Reaseach. Madrid, Monduzzi Proceeding Division, 2000.
Cohen IR, Tending Adam’s Garden: Evolving the Cognitive Immune Self. Academic Press, London, UK. 2000.
2001
Louzoun Y, Atlan H, Cohen IR. "Modeling the Influence of TH1- and TH2-type Cells in Autoimmune Diseases." J Autoimmun 2001; 17(4):311-21.
Louzoun Y, Solomon S, Atlan H, Cohen IR. "Modeling complexity in biology." Physica A 2001; 297: 242-252.
Souan L, Margalit R, Brenner O, Cohen IR, Mor F. "Self prion protein peptides are immunogenic in Lewis Rats." J Autoimmun 2001; 17(4):303-10.
Raz I, Elias D, Avron A, Tamir M, Metzger M, Cohen IR. "b-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double- blind, phase II trial." Lancet 2001; 358(9295):1749-53.
Quintana FJ, Cohen IR. "Autoantibody patterns in diabetes-prone NOD mice and in standard C57BL/6 mice." J Autoimmun 2001; 17(3):191-7.
Jensen P, Johansen HK, Carmi P, Hoiby N, Cohen IR. "Autoantibodies to pancreatic hsp60 precede the development of glucose intolerance in patients with cystic fibrosis." J Autoimmun 2001; 17(2):165-72.
Segel LA, Cohen IR eds. Design Principles for the Immune System and Other Distributed Autonomous Systems. Santa Fe Institute Studies in the Sciences of Complexity. Oxford University Press; Oxford. 2001.
Herkel J, Mimran A, Erez N, Kam N, Lohse AW, Marker-Hermann E, Rotter V, Cohen IR. "Autoimmunity to the p53 protein is a feature of systemic lupus erythematosus (SLE) related to anti-DNA antibodies." J Autoimmun 2001; 17(1):63-9.
Souan L, Tal Y, Felling Y, Cohen IR, Taraboulos A, Mor F. "Modulation of proteinase-K resistant prion protein by prion peptide immunization." Eur J Immunol 2001; 31(8):2338-46.
Yoles E, Hauben E, Palgi O, Agranov E, Gothilf A, Cohen A, Kuchroo V, Cohen IR, Weiner H, Schwartz M. "Protective autoimmunity is a physiological response to CNS trauma." J Neurosci 2001; 21(11):3740-8.
Chowers Y, Lider O, Schor H, Barshack I, Tal R, Ariel A, Bar-Meir S, Cohen IR, Cahalon L. "Disaccharides derived from heparin or heparan sulfate regulate IL-8 and IL-1 beta secretion by intestinal epithelial cells." Gastroenterology 2001; 120(2):449-59.
Kam N, Cohen IR, Harel D. "The immune system as a reactive system: modeling T cell activation with Statecharts." Proc. Visual Languages and Formal Methods (VLFM), IEEE 2001.
Mor F, Cohen IR. "Propagation of lewis rat encephalitogenic T cell lines: T-cell-growth- factor is superior to recombinant IL-2." J Neuroimmunol 2002; 123(1-2):76-82.
Mor F, Weinberger A, Cohen IR. "Identification of alpha-tropomyosin as a target self-antigen in Behçet's syndrome." Eur J Immunol 2002; 32(2):356-65.
Cohen IR, Atlan H. "Limits to genetic explanations impose limits on the human genome project". In Encyclopedia of the Human Genome, Nature Publishing Group, Macmillan, 2002.
Cohen IR, Efroni S. "Inflammation and Vaccination: Cause and Cure for Type 1 Diabetes." In Diabetes: From Research to Diagnosis and Treatment. Edited by I. Raz, J. Skyler & E. Shafrir. Martin Dunitz Publishers.
Cohen IR. "Vaccine Therapy for Autoimmune Diabetes." In New Generation Vaccines, 3rd Edition Eds Levine MM, Kaper JB, Rappuoli R, Liu M, Good MD Marcel Dekker, Inc. New York.
Efroni S, Cohen IR. "Simplicity belies a complex system: a response to the minimal model of immunity of Langman and Cohen." Cellular Immunology 2002,216:22-30.
Quintana FJ, Carmi P, Mor F, Cohen IR. "Inhibition of Adjuvant Arthritis by a DNA Vaccine Encoding Human HSP60." J Immunol 2002 Sep 15;169(6):3422-8.
Cohen IR. "Peptide therapy for Type I diabetes: the immunological homunculus and the rationale for vaccination." Diabetologia 2002 Oct;45(10):1468-74.
Quintana FJ, Carmi P, Cohen IR. "DNA vaccination with heat shock protein 60 inhibits cyclophosphamide-accelerated diabetes." J Immunol 2002 Nov 15;169(10):6030-5.
Mor F, Quintana FJ, Mimran A, Cohen IR. "Autoimmune encephalomyelitis and uveitis induced by T cell immunity to self b-synuclein." J Immunol 2002 170:628-634.
Herkel J, Modrow JP, Bamberger S, Kanzler S, Rotter V, Cohen IR, Lohse AW. "Prevalence of autoantibodies to the p53 protein in autoimmune hepatitis." Autoimmunity 2002 35(8):493-6.
Gonzalez G, Montero E, Leon K, Cohen IR, Lage A. "Autoimmunization to epidermal growth factor, a component of the immunological homunculus." Autoimmun Rev. 2002 Feb;1(1-2):89-95.
2003
Tal Y, Souan L, Cohen IR, Meiner Z, Taraboulos A, Mor F. "Complete Freund's adjuvant immunization prolongs survival in experimental prion disease in mice." J Neurosci Res. 2003 Jan15;71(2):286-90.
Quintana FJ, Pitashny M, Cohen IR. "Experimental autoimmune myasthenia gravis in naive non-obese diabetic (NOD/LtJ) mice: susceptibility associated with natural IgG antibodies to the acetylcholine receptor." Int Immunol. 2003 Jan;15(1):11-6.
Mor F, Quintana F, Mimran A, Cohen IR. "Autoimmune encephalomyelitis and uveitis induced by T cell immunity to self β-synuclein." J Immunol. 2003 Jan 1;170(1):628-34.
Louzoun Y, Solomon S, Atlan H, Cohen IR. "Proliferation and competition in discrete biological systems." Bull Math Biol. 2003 May;65(3):375-96.
Amir-Kroll H, Nussbaum G, Cohen IR. "Proteins and their derived peptides as carriers in a conjugate vaccine for streptococcus pneumoniae: Self-heat shock protein 60 and tetanus toxoid." J Immunol. 2003 Jun 15;170(12):6165-71.
Abulafia-Lapid R, Gillis D, Yosef O, Atlan H, Cohen IR. "T Cells and autoantibodies to human HSP70 in Type 1 diabetes in children." J Autoimmun. 2003 Jun;20(4):313-21.
Zanin-Zhorov A, Nussbaum G, Franitza S, Cohen IR, Lider O. "T cells respond to heat shock protein 60 via TLR2: activation of adhesion and inhibition of chemokine receptors." FASEB J. 2003 Aug;17(11):1567-9. Epub 2003 Jun 17.
Quintana FJ, Getz G, Hed G, Domany E, Cohen IR. "Cluster analysis of human autoantibody reactivities in health and in type 1 diabetes mellitus: a bio-informatic approach to immune complexity." J Autoimmun. 2003 Aug;21(1):65-75.
Efroni S, Cohen IR. "The heuristics of biologic theory: the case of self–nonself discrimination." Cell Immunol. 2003; 223(1): 87-89.
Quintana FJ, Carmi P, Mor F, Cohen IR. "DNA fragments of the human 60-kDa heat shock protein (HSP60) vaccinate against adjuvant arthritis: identification of a regulatory HSP60 peptide." J Immunol. 2003 Oct 1;171(7):3533-41.
Efroni S, Harel D, Cohen IR. "Toward rigorous comprehension of biological complexity: modeling, execution, and visualization of thymic T-cell maturation." Genome Res. 2003 Nov;13(11):2485-97.
Hecht I, Hershkoviz R, Shivtiel S, Lapidot T, Cohen IR, Lider O, Cahalon L. "Heparin-disaccharide affects T cells: inhibition of NF-KB activation, cell migration, and modulation of intracellular signaling." J Leukoc Biol. 2004 Mar 12.
Mor F, Quintana FJ, Cohen IR. "Angiogenesis-inflammation cross-talk: vascular endothelial growth factor is secreted by activated T cells and induces Th1 polarization." J Immunol. 2004 Apr 1;172(7):4618-23.
Mimran A, Mor F, Carmi P, Quintana FJ, Rotter V, Cohen IR. "DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response." J Clin Invest. 2004 Mar;113(6):924-32.
Quintana FJ, Buzas E, Prohászka Z, Bíró A, Kocsis J, Füst G, Falus A, Cohen IR. "Knock-out of the histidine decarboxylase gene modifies the repertoire of natural autoantibodies." J Autoimmun. 2004 June;22(4):297-305.
Cohen IR. "Thoughts on the pathogenesis of type 1 diabetes and on the arrest of autoimmune beta-cell destruction by peptide p277 vaccination." Isr Med Assoc J. 2004 May;6(5):260-1.
Montero E, Nussbaum G, Kaye JF, Perez R, Lage A, Ben-Nun A, Cohen IR. "Regulation of experimental autoimmune encephalomyelitis by CD4+, CD25+ and CD8+ T cells: analysis using depleting antibodies." J Autoimmun. 2004;23: 1-7.
Achiron A, Lavie G, Kishner I, Stern Y, Sarova-Pinhas I, Ben-Aharon T, Barak Y, Raz H, Lavie M, Barliya T, Faibel M, Cohen IR, Mandel M. "T cell vaccination in multiple sclerosis relapsing–remittin nonresponders patients." Clin. Immunol 2004:113,155– 160.
Herkel J, Kam N, Erez N, Mimran A, Heifetz A, Eisenstein M, Rotter V, Cohen IR. "Monoclonal antibody to a DNA-binding domain of p53 mimics charge structure of DNA: anti-idiotypes to the anti-p53 antibody are anti-DNA." Eur J Immunol. 2004 Dec;34(12):3623-32.
Quintana FJ, Carmi P, Mor F, Cohen IR. "Inhibition of Adjuvant-Induced Arthritis by DNA Vaccination With the 70-kd or the 90-kd Human Heat-Shock Protein Immune Cross-Regulation With the 60-kd Heat-Shock Protein." Arthritis & Rheumatism 2004 Nov; 50(11):3712–3720.
Abulafia-Lapid R, Bentwich Z, Keren-Zur Y, Cohen IR, Atlan H. "T-cell vaccination against anti-CD4 autoimmunity in HIV-1 infected patients." J Clin Virol. 2004 Dec;31 Suppl 1:S48-54..
Quintana FJ, Carmi P, Mor F, Cohen IR. "Network cross-reactivity: DNA vaccination with HSP70 or HSP90 modulates immunity to HSP60 and inhibits adjuvant arthritis." Immunology 2004, Medimond Srl, Italy. 2004 pp.207-213.
2005
Zanin-Zhorov A, Bruck R, Tal G, Oren S, Aeed H, Hershkoviz R, Cohen IR, Lider O. "Heat Shock Protein 60 Inhibits Th1-Mediated Hepatitis Model via Innate Regulation of Th1/Th2 Transcription Factors and Cytokines." J Immunol. 2005 Mar 15;174(6):3227-36.
Abulafia-Lapid R, Mayan S, Bentwich Z, Keren-Zur Y, Avbramovitz Y, Cohen IR, Atlan H. "T-cell vaccination against anti-CD4 autoimmunity in HIV-1 subtypes B and C-infected patients - An extended open trial." Vaccine 2005 Mar 18;23(17-18):2149-53.
Rouvio O, Dvorkin T, Amir-Kroll H, Atias D, Cohen IR, Rager-Zisman B, Porgador A. "Self HSP60 peptide serves as an immunogenic carrier for a CTL epitope against persistence of murine cytomegalovirus in the salivary gland." Vaccine 2005;23:3508-18.
Quintana FJ, Cohen IR. "DNA vaccines coding for heat-shock proteins (HSPs): tools for the activation of HSP-specific regulatory T cells." Expert Opinion 2005;5(4):545-554.
Gerber D, Quintana FJ, Bloch I, Cohen IR, Shai Y. "D-enantiomer peptide of the TCRα transmembrane domain inhibits T-cell activation in vitro and in vivo." The FASEB Journal 2005; 19(9):1190-2.
Zanin-Zhorov A, Tal G, Shivtiel S, Cohen M, Lapidot T, Nussbaum G, Margalit R, Cohen IR, Lider O. "Heat shock protein 60 activates cytokine-associated negative regulator suppressor of cytokine signaling 3 in T cells: effects on signaling, chemotaxis, and inflammation." J Immunol. 2005;Jul 1;175(1):276-285.
Quintana FJ, Gerber D, Kent SC, Cohen IR, Shai Y. "HIV-1 fusion peptide targets the TCR and inhibits antigen-specific T cell activation." J Clin Invest. 2005;Jul 7;115(8):2149-58.
Cohen-Sfady M, Nussbaum G, Pevsner-Fischer M, Mor F, Carmi P, Zanin-Zhorov A, Lider O, Cohen IR. "Heat Shock Protein 60 Activates B Cells via the TLR4-MyD88 Pathway. " J Immunol. 2005 15; 175(6):3594-602.
Mandel M, Gurevich M, Lavie G, Cohen IR, Achiron A. "Unique gene expression patterns in human T-cell lines generated from multiple sclerosis patients by stimulation with a synthetic MOG peptide. " Clinical & Developmental Immunology September 2005; 12(3):203-209.
Cohen IR. "Regen und Auferstehung: Talmud und Naturwissenschaft im Dialog mit der Welt. " Vandenhoek & Ruprecht.Göttingen, Germany. 2005.
Eldor R, Cohen IR, Raz I. "Innovative immune-based therapeutic approaches for the treatment of Type 1 diabetes mellitus." Int Rev Immunol. 2005 Sep-Dec; 24(5):327-39.
Snir O, Lavie G, Achiron A, Bank I, Benn-Aharon T, Sredni B, Cohen IR, Mandel M. "G-CSF enhances the adhesion of encephalitogenic T cells to extracellular matrix components: a possible mechanism for exacerbation of multiple sclerosis." J Neuroimmunol. 2006 Mar;172(1-2):145-55.
Mor F, Cohen IR. "How special is a pathogenic CNS autoantigen? Immunization to many CNS self-antigens does not induce autoimmune disease." J Neuroimmunol. 2006 May;174(1-2):3-11.
(See Editorial Quintana FJ, Weiner HL. Understanding natural and pathological autoimmunity, J Neuroimmunol. 2006 May; 174(1-2): 1-2.)
Zanin-Zhorov A, Cahalon L, Tal G, Margalit R, Lider O, Cohen IR. "Heat shock protein 60 enhances CD4+CD25+ regulatory T cell function via innate TLR2 signaling." J Clin Invest. 2006 Jul; 116(7):2022-32.
Amir-Kroll H, Riveron L, Sarmiento ME, Sierra G, Acosta A, Cohen IR. "A conjugate vaccine composed of a heat shock protein 60 T-cell epitope peptide (p458) and Neisseria meningitidis type B capsular polysaccharide." Vaccine. 2006 Oct 30;24(42-43):6555-63.
Quintana FJ, Zaltzman R, Fernandez-Montesinos R, Herrera JL, Gozes I, Cohen IR, Pozo D. "NAP, a Peptide Derived from the Activity-Dependent Neuroprotective Protein, Modulates Macrophage Function." Ann N Y Acad Sci.. 2006 Jul; 1070:500-6. [E-pub ahead of print].
Nussbaum G, Zanin-Zhorov A, Quintana F, Lider O, Cohen IR. "Peptide p277 of HSP60 signals T cells: inhibition of inflammatory chemotaxis." Int Immunol., 2006 Oct;18(10):1413-9. [Epub 2006 Aug 7].
Quintana JF, Merbl Y, Sahar E, Domany E, Cohen IR. "Antigen-chip technology for accessing global information about the state of the body." Lupus, 2006; 15: 428-430.
Huurman VA, Decochez K, Mathieu C, Cohen IR, Roep BO. "Therapy with the hsp60 peptide DiaPep277(trade mark) in C-peptide positive type 1 diabetes patients." Diabetes Metab Res Rev., 2006; Oct 6.
Frankenstein Z, Alon U, Cohen IR. "The immune-body cytokine network defines a social architecture of cell interactions." Biol. Direct, 2006; Oct 24;1(1):32 [Epub ahead of print].
Raz I, Avron A, Tamir M, Metzger M, Symer L, Eldor R, Cohen IR, Elias D. "Treatment of new-onset type 1 diabetes with peptide DiaPep277((R)) is safe and associated with preserved beta-cell function: extension of a randomized, double-blind, phase II trial." Diabetes Metab Res Rev., 2006; Nov 24.
2007
Pevsner-Fischer M, Morad V, Cohen-Sfady M, Rousso-Noori L, Zanin-Zhorov A, Cohen S, Cohen IR, Zipori D. "Toll-like receptors and their ligands control mesenchymal stem cell functions." Blood, 2007 Feb 15;109(4):1422-32. [Epub 2006 Oct 12].
Bloch I, Quintana FJ, Gerber D, Cohen T, Cohen IR, Shai Y. "T-Cell inactivation and immunosuppressive activity induced by HIV gp41 via novel interacting motif. " FASEB J., 2007 Feb;21(2):393-401 [Epub 2006 Dec 21].
Brent L, Cohen IR, Doherty PC, Feldmann M, Matzinger P, Holgate ST, Lachmann P, Mitchison NA, Nossal G, Rose NR, Zinkernagel R. "Crystal-ball gazing - the future of immunological research viewed from the cutting edge." Clin Exp Immunol., 2007 Jan;147(1):1-10.
Efroni S, Harel D, Cohen IR. (2007) "Emergent Dynamics of Thymocyte Development and Lineage Determination." PLoS Comput Biol.,2007 Jan 26;3(1):e13. [Epub 2006 Dec 11].
Quintana FJ, Gerber D, Bloch I, Cohen IR, Shai Y. (2007) "A Structurally Altered d,l-Amino Acid TCRα Transmembrane Peptide Interacts with the TCRα and Inhibits T-Cell Activation in Vitro and in an Animal Model." Biochemistry, 2007 Mar 6;46(9):2317-25. Epub 2007 Feb 9.
Merbl Y, Zucker-Toledano M, Quintana FJ, Cohen IR. (2007) "Newborn humans manifest autoantibodies to defined self molecules detected by antigen microarray informatics." J Clin Invest., 2007 Mar;117(3):712-8.
Shternhall-Ron K, Quintana FJ, Perl S, Meivar-Levy I, Barshack I, Cohen IR, Ferber S. (2007) "Ectopic PDX-1 expression in liver ameliorates type 1 diabetes." J Autoimmun.,2007 Mar 22; [Epub ahead of print].
Wucherpfennig KW, Allen PM, Celada F, Cohen IR, De Boer R, Garcia KC, Goldstein B, Greenspan R, Hafler D, Hodgkin P, Huseby ES, Krakauer DC, Nemazee D, Perelson AS, Pinilla C, Strong RK, Sercarz EE. (2007) "Polyspecificity of T cell and B cell receptor recognition." Semin Immunol.,2007 Mar 28; [Epub ahead of print].
Quintana FJ, Gerber D, Bloch I, Cohen IR, Shai Y. (2007) Response to "Interaction between HIV gp41 fusion peptide and T cell receptor: putting the puzzle pieces back together." FASEB J.,2007 Jun;21(8):1635.
Zanin-Zhorov A, Tal-Lapidot G, Cahalon L, Cohen-Sfady M, Pevsner-Fischer M, Lider O, Cohen IR. (2007) "Cutting Edge: T Cells Respond to Lipopolysaccharide Innately via TLR4 Signaling." J. Immunol.,2007 Jul 1;179(1):41-44.
Cohen N, Stolarsky-Bennun M, Amir-Kroll H, Margalit R, Nussbaum G, Cohen-Sfady M, Pevsner-Fischer M, Fridkin M, Bercovier H, Eisenbach L, Jung S, Cohen IR. "Pneumococcal Capsular Polysaccharide Is Immunogenic When Present on the Surface of Macrophages and Dendritic Cells: TLR4 Signaling Induced by a Conjugate Vaccine or by Lipopolysaccharide Is Conducive." J. Immunol. 2008 Feb 15;180(4):2409-2418.
Cohen T, Pevsner-Fischer M, Cohen N, Cohen IR, Shai Y. "Characterization of the interacting domain of the HIV-1 fusion peptide with the transmembrane domain of the T-cell receptor." Biochemistry 2008;Apr 22;47(16):4826-33.
Huurman VA, van der Meide PE, Duinkerken G, Willemen S, Cohen IR, Elias D, Roep BO. "Immunological efficacy of heat shock protein 60 peptide DiaPep277™ therapy in clinical type I diabetes." Clin. Exp. Immunol. 2008;Jun;152(3):488-97.
Quintana FJ, Cohen IR. "HSP60 speaks to the immune system in many voices." Novartis Found Symp. 2008;291:101-11; discussion 111-4, 137-40.
Quintana FJ, Solomon A, Cohen IR, Nussbaum G. "Induction of IgG3 to LPS via toll-like receptor 4 co-stimulation." PLoS One. 2008; 3(10): e3509.
Quintana FJ, Farez MF, Viglietta V, Iglesias AH, Merbl Y, Izquierdo G, Lucas M, Basso AS, Khoury SJ, Lucchinetti CF, Cohen IR, Weiner HL. "Antigen microarrays identify unique serum autoantibody signatures associated with different clinical forms and pathologic subtypes of multiple sclerosis." Proc Natl Acad Sci U S A. 2008;Dec 2;105(48):18889-94.
Setty Y., Cohen IR., Dor Y., Harel D. "Four-dimensional realistic modelling of pancreatic organogenesis." Proc Natl Acad Sci U S A. 2008; Dec 17. [Epub ahead of print]
Zhang J, Cohen IR. Eds, "T-Cell Vaccination". 2008. Nova Biomedical Books, New York. pp. 1-171.
Quintana FJ, Cohen IR. "Anti-ergotypic regulatory T cells". In T-Cell Vaccination, Eds Zhang J and Cohen IR. 2008. Chapter 1. pp 1-9, Nova Biomedical Books, New York.
Quintana FJ, Mimran A, Carmi P, Mor F, Cohen IR. "HSP60 as a target of anti-ergotypic regulatory T cells." PLoS ONE, 2008;3(12):e4026. [Epub 2008 Dec 24]
2009
Merbl Y, Itzchak R, Vider-Shalit T, Louzoun Y, Quintana FJ, Vadai E, Eisenbach L, Cohen IR. "A systems immunology approach to the host-tumor interaction: large-scale patterns of natural autoantibodies distinguish healthy and tumor-bearing mice." PLoS One, 2009 Jun 25;4(6):e6053.
Cohen-Sfady M, Pevsner-Fischer M, Margalit R, Cohen IR. "Heat shock protein 60, via MyD88 innate signaling, protects B cells from apoptosis, spontaneous and induced." J Immunol. 2009 Jul 15;183(2):890-6.
Volovitz I, Mor F, Machlenkin A, Goldberger O, Marmor Y, Eisenbach L, Cohen IR. "T-cell seeding: Neonatal transfer of anti-myelin basic protein T-cell lines renders Fischer rats susceptible later in life to the active induction of EAE." Immunology 2009; 128: 92-102.
Madi A, Hecht I, Bransburg-Zabary S, Merbl Y, Pick A, Zucker-Toledano M, Quintana FJ, Tauber AI, Cohen IR, Ben-Jacob E. "Organization of the autoantibody repertoire in healthy newborns and adults revealed by system level informatics of antigen microarray data." Proc Natl Acad Sci U S A. 2009; Aug 25;106(34):14484-9. Epub 2009 Aug 10.
Cohen, Irun R; Atlan, Henri; and Efroni, Sol (December 2009) "Genetics as Explanation: Limits to the Human Genome Project." In Encyclopedia of Life Sciences (ELS). John Wiley & Sons, Ltd: Chichester.
DOI: 10.1002/9780470015902.a0005881.pub2
2010
Cohen SJ, Cohen IR, Nussbaum G. "IL-10 mediates resistance to adoptive transfer experimental autoimmune encephalomyelitis in MyD88(-/-) mice." J Immunol. 2010 Jan 1;184(1):212-221. Epub 2009 Nov 30.
Fattal I, et al. "An antibody profile of systemic lupus erythematosus detected by antigen microarray." Immunology, 2010 Jul;130(3):337-343. Epub 2010 Feb 26.
Hagedorn PH, Burton CM, Carlsen J, Steinbruechel D, Andersen CB, Sahar E, Domany E, Cohen IR, Flyvberg H, Iversen M. "Chronic rejection of a lung transplant is marked by a profile of specific autoantibodies." Immunology, 2010 Jul;130(3):427-435. Epub 2010 Feb 26.
Gershoni-Yahalom O, Landes S, Kleiman-Shoval S, Ben-Nathan D, Kam M, Lachmi BE, Khinich Y, Simanov M, Samina I, Eitan A, Cohen IR, Rager-Zisman B, Porgador A. "Chimeric vaccine composed of viral peptide and mammalian heat-shock protein 60 peptide protects against West Nile virus challenge." Immunology, 2010 Aug;130(4):527-535. Epub 2010 Mar 16.
Volovitz I, Marmor Y, Mor F, Flügel A, Odoardi F, Eisenbach L, Cohen IR. "T cell vaccination induces the elimination of EAE effector T cells: Analysis using GFP-transduced, encephalitogenic T cells." J Autoimmun. 2010 Sep;35(2):135-144. Epub 2010 Jun 26.
Cohen T, Cohen SJ, Antonovsky N, Cohen IR, Shai Y. "HIV-1 gp41 and TCRalpha trans-membrane domains share a motif exploited by the HIV virus to modulate T-cell proliferation." PLoS Pathog. 2010 Sep 2;6(9):e1001085.
Henderson B, Calderwood SK, Coates AR, Cohen I, van Eden W, Lehner T, Pockley AG. "Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminants." Cell Stress Chaperones. 2010 Mar;15(2):123-141.
Cohen IR, Ziv A, eds. Medical Education in the 21st Century. The New Medical School in the Galilee. New Paradigms, Innovations and Challenges. The National Institute for Health Policy Research. 2010. pp 1-277.
Hagedorn PH, Burton CM, Sahar E, Domany E, Cohen IR, Flyvbjerg H, Iversen M. "Integrative analysis correlates donor transcripts to recipient autoantibodies in primary graft dysfunction after lung transplantation." Immunology. 2010 Nov 11. doi: 10.1111/j.1365-2567.2010.03373.x. [Epub ahead of print]
Margel D, Pesvner-Fischer M, Baniel J, Yossepowitch O, Cohen IR. "Stress Proteins and Cytokines are Urinary Biomarkers for Diagnosis and Staging of Bladder Cancer." European Urology 2011; 59:113-119.
Quintana FJ, Cohen IR. "The HSP60 immune system network." Trends Immunol.. 2010 Dec 8. [Epub ahead of print]
Vainas O, Harel D, Cohen IR, Efron S. "Reactive animation: From piecemeal experimentation to reactive biological systems." Autoimmunity Jun;44(4):271-281. Epub 2011 Jan 19.PMID: 21244340
Nemirovsky A, Fisher Y, Baron R, Cohen IR, Monsonego A. "Amyloid beta-HSP60 peptide conjugate vaccine treats a mouse model of Alzheimer's disease." Vaccine 2011 Apr 5. [Epub ahead of print] PMID: 21473952
Cohen IR. " Infections, Biomarkers, and Vaccines." in The Art & Science of Tuberculosis Vaccine Development, Eds. N.M. Nor, A. Acosta, and Sarmiento, M.E. Oxford University Press, 2010. pp. 36-45.
Madi A, Kenett DY, Bransburg-Zabary S, Merbl Y, Quintana FJ, Tauber AI, Cohen IR, Ben-Jacob E. "Network theory analysis of antibody-antigen reactivity data: the immune trees at birth and adulthood." PLoS One2011 Mar 8;6(3):e17445. PMID: 21408156
Madi A, Kenett DY, Bransburg-Zabary S, Merbl Y, Quintana FJ, Boccaletti S, Tauber AI, Cohen IR, Ben-Jacob E. "Analyses of antigen dependency networks unveil immune system reorganization between birth and adulthood." Chaos 2011 Mar;21(1):016109. PMID: 21456851
Volovitz I, Marmor Y, Azulay M, Machlenkin A, Goldberger O, Mor F, Slavin S, Ram Z, Cohen IR, Eisenbach L. "Split immunity: immune inhibition of rat gliomas by subcutaneous exposure to unmodified live tumor cells." J Immunol. 2011 Nov 15;187(10):5452-62.
Pevsner-Fischer M, Levin S, Hammer-Topaz T, Cohen Y, Mor F, Wagemaker G, Nagler A, Cohen IR, Zipori D. "Stable Changes in Mesenchymal Stromal Cells from Multiple Myeloma Patients Revealed through their Responses to Toll-Like Receptor Ligands and Epidermal Growth Factor." Stem Cell Rev. 2011 Sep 1. [Epub ahead of print]
2012
Madi A, Bransburg-Zabary S, Kenett DY, Ben-Jacob E, Cohen IR. "The natural autoantibody repertoire in newborns and adults: a current overview." Adv Exp Med Biol. 2012;750:198-212. Review.
Buzzetti R, Cernea S, Petrone A, Capizzi M, Spoletini M, Zampetti S, Guglielmi C, Venditti C, Pozzilli P, DiaPep Trialists Group. "C-peptide response and HLA genotypes in subjects with recent-onset type 1 diabetes after immunotherapy with DiaPep277: an exploratory study." Diabetes. 2011 Nov;60(11):3067-72.
Quintana FJ, Farez MF, Izquierdo G, Lucas M, Cohen IR, Weiner HL. "Antigen microarrays identify CNS-produced autoantibodies in RRMS." Neurology. 2012 Feb 21;78(8):532-9.
Cohen N, Margalit R, Pevsner-Fischer M, Yona S, Jung S, Eisenbach L, Cohen IR. "Mouse dendritic cells pulsed with capsular polysaccharide induce resistance to lethal pneumococcal challenge: roles of T cells and B cells." PLoS One. 2012;7(6):e39193. Epub 2012 Jun 18.PMID: 22723962
Karussis D, Shor H, Yachnin J, Lanxner N, Amiel M, Baruch K, Keren-Zur Y, Haviv O, Filippi M, Petrou P, Hajag S, Vourka-Karussis U, Vaknin-Dembinsky A, Khoury S, Abramsky O, Atlan H, Cohen IR, Abulafia-Lapid R. "T cell vaccination benefits relapsing progressive multiple sclerosis patients: a randomized, double-blind clinical trial." PLoS One. 2012;7(12):e50478. doi: 10.1371/journal.pone.0050478. Epub 2012 Dec 14.
2013
Mor F, Cohen IR. "Beta-lactam antibiotics modulate T-cell functions and gene expression via covalent binding to cellular albumin." Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2981-6. doi: 10.1073/pnas.1215722110. Epub 2013 Feb 4.
Bransburg-Zabary S, Kenett DY, Dar G, Madi A, Merbl Y, Quintana FJ, Tauber AI, Cohen IR, Ben-Jacob E. "Individual and meta-immune networks." Phys Biol. 2013 Mar 15;10(2):025003. [PDF]
Zanin-Zhorov A, Cohen IR. "Signaling via TLR2 and TLR4 Directly Down-Regulates T Cell Effector Functions: The Regulatory Face of Danger Signals." Front Immunol. 2013 Jul 25;4:211. doi: 10.3389/fimmu.2013.00211. Print 2013.
Schloot NC, Cohen IR. "DiaPep277 and Immune Intervention for Treatment of Type 1 Diabetes." Clin. Immunol. 2013 Dec;149(3):307-16. doi: 10.1016/j.clim.2013.09.001.
2014
Raz I, Zieglar AG, Linn T, Schernthaner G, Bonnici F, Distiller LA, Giordano C, Giorgino F, de Vries L, Mauricio D, Prochazka V, Wainstein J, Elias D, Avron A, Tamir M, Eren R, Peled D, Dagan S, Cohen IR, Pozzilli P. "Treatment of Recent Onset Type 1 Diabetes Patients with DiaPep277: Results of a Double-Blind, Placebo-Controlled, Randomized Phase 3 Trial."Diabetes Care, 2014 May;37(5):1392-400,[PDF], [suppl data] .
Pozzilli P, Raz I, Peled D, Elias D, Avron A, Tamir M, Eren R, Dagan S, Cohen IR. "Evaluation of Long-Term Treatment Effect in a Type 1 Diabetes Intervention Trial: Differences after Stimulation with Glucagon or a Mixed Meal."Diabetes Care, 2014 May;37(5):1384-91, [PDF] ,[suppl data].
Fattal I, Shental N, Molad Y, Gabrielli A, Shapira E, Oren S, Livneh A, Langevitz P, Pauzner R, Sarig O, Gafter U, Domany E, Cohen IR. "EBV Antibodies Mark SLE and Scleroderma Patients Negative for Anti-DNA." Immunology, 2014 Feb;141(2):276-85. doi: 10.1111/imm.12200.
Cohen IR. Activation of Benign Autoimmunity as Both Tumor and Autoimmune Disease Immunotherapy: A Comprehensive Review. J Autoimmunity. 2014 Jun 9. pii: S0896-8411(14)00091-2. doi: 10.1016/j.jaut.2014.05.002. [Epub ahead of print]
Madi A, Bransburg-Zabary S, Maayan-Metzger A, Dar G, Ben-Jacob E Cohen IR. Tumor-associated and disease-associated autoantibody repertoires in healthy colostrum and maternal and newborn cord sera. J Immunol. 2015 Jun 1;194(11):5272-81.
Fattal I, Shental N, Ben-Dor S, Molad Y, Gabrielli A, Pokroy-Shapira E, Oren S, Livneh A, Langevitz P, Zandman-Goddard G, Sarig O, Margalit R, Gafter U, Domany E, Cohen IR. Guanine polynucleotides are self-antigens for human natural autoantibodies and are significantly reduced in the human genome. Immunology. 2015 Nov;146(3):401-10. doi: 10.1111/imm.12514.
Swiatczak B, Cohen IR. Gut feelings of safety: tolerance to the microbiota mediated by innate immune receptors. Microbiol Immunol. 2015 Oct;59(10):573-85. doi: 10.1111/1348-0421.12318.
2016
Putterman C, Wu A, Reiner-Benaim A, Batty DS Jr, Sanz I, Oates J, Jakobi K, Petri M, Safer P, Gerwien R, Sorek R, Blumenstein Y, Cohen IR. SLE-key(®) rule-out serologic test for excluding the diagnosis of systemic lupus erythematosus: Developing the ImmunArray iCHIP(®).J Immunol Methods. 2016;429:1-6. doi: 10.1016/j.jim.2015.12.003. Epub 2015 Dec 8.
Cohen IR, Friedman N, Quintana FJ. T cell vaccination: An insight into T cell regulation. In Translational Neuroimmunology in Multiple Sclerosis: From disease mechanisms to clinical applications. Arnon R and Miller A, eds. Elsevier. In press.
Cohen IR, Atlan H, Efroni S (2016) Genetics as explanation: Limits to the Human Genome Project. In: eLS. JohnWiley & Sons, Ltd: Chichester. DOI: 1002/9780470015902.a0005881.pub3
Cohen IR. Antigen-Microarray Profiling of Antibodies in SLE: A Personal View of Translation from Basic Science to the Clinic. Lupus: Open Access 2016 1:3
Cohen IR. Updating Darwin: Information and entropy drive the evolution of life. F1000Research 2016, 5:2808 (doi: 10 12688/f1000research. 10 289.1)
Dishon S, Cohen SJ, Cohen IR and Nussbaum G (2017) Inhibition of Myeloid Differentiation Factor 88 Reduces Human and Mouse T-Cell Interleukin-17 and IFNγ Production and Ameliorates Experimental Autoimmune Encephalomyelitis Induced in Mice. Front. Immunol. 8:615. doi: 10.3389/fimmu.2017.00615
Asaf Madi, Asaf Poran, Eric Shifrut, Shlomit Reich-Zeliger, Erez Greenstein, Irena Zaretsky, Tomer Arnon, Francois Van Laethem, Alfred Singer, Jinghua Lu, Peter D Sun, Irun R Cohen, Nir Friedman. T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences. eLife 2017;6:e22057. DOI: 10.7554/eLife.22057
Johannes Herkel, Jorg Schrader, Neta Erez, Ansgar W. Lohse and Irun R. Cohen. Activation of the Akt–CREB signalling axis by a proline-rich heptapeptide confers resistance to stress-induced cell death and inflammation. Immunology, 2017; 151, 474–480
Theo van den Broek, Asaf Madi, Eveline M.Delemarre, Alvin W. L. Schadenberg, Kiki Tesselaar, Jos´e A. M. Borghans, Stefan Nierkens, Frank A. Redegeld, Henny G. Otten, Maura Rossetti, Salvatore Albani, Rachel Sorek, Irun R. Cohen, Nicolaas J. G. Jansen and Femke van Wijk. Human neonatal thymectomy induces altered B-cell responses and autoreactivity. Eur. J. Immunol. 2017. 47: 1970–1981
2018
Chaim Putterman, David S. Pisetsky, Michelle Petri, Roberto Caricchio, Alan H. B. Wu, Ignacio Sanz, Jim C. Oates, Steve Wallace, Rachel Sorek, Robert Gerwien, Pennina Safer, Keren Jakobi-Brook and Irun R. Cohen. The SLE-key test serological signature: new insights into the course of lupus. Rheumatology (Oxford). 2018 Sep 1;57(9):1632-1640. doi: 10.1093/rheumatology/key149.
2019
Cohen IR and Efroni S (2019) The Immune System Computes the State of the Body: Crowd Wisdom, Machine Learning, and Immune Cell Reference Repertoires Help Manage Inflammation. Front. Immunol. 10:10. doi: 10.3389/fimmu.2019.00010
Ofer N. Gofrit, Herve Bercovier, Benjamin Y. Klein. Irun R. Cohen, Tamir Ben-Hur, Charles L. Greenblatt. Can immunization with Bacillus Calmette-Guerin (BCG) protect against Alzheimer's disease? Medical Hypotheses 123 (2019) 95-97
