Antigen microarray chip for profiling antibody repertoires
In collaboration with Prof. Eytan Domany of the Department of Physics of Complex Systems, we developed an antigen chip that allows the global analysis of antibody reactivities to an array of various molecules including self-molecules.
The antigen chip provides patterns of reactivities that can be analyzed by various informatic technologies as a means to detect the state of the individual immune system in health and disease: autoimmune diseases, cancer, transplantation, degenerative diseases and infections.
This information is being used for early diagnosis, disease monitoring, stratification of patients, individualized medical care, prediction of incipient disease, prediction of response to treatment, and study of the evolution from birth of the healthy antibody and autoantibody repertoires.