Systems Medicine 2019

Lecture Notes and exercises

  • Lecture 1 - The lnsulin-glucose circuit. (Notes)

     

     

  • Lecture 2 - Beta-cell tissue size control has fragilities that lead to type-2 diabetes: Dynamical compensation and mutant resistance in tissues (Notes)

  • Exercise 1

  • Lecture 3 - Autoimmune disease as a fragility of surveillance against hypersecreting mutants (Notes)

     

  • Lecture 4 - Two-gland feedback in the stress-hormone axis generates seasonal clocks and explains clinical phenomena with a timescale of months (Notes)

  • Exercise 2

  • Lecture 5 - The basic facts of ageing (Notes)

     

  • Lecture 6 - Aging and the saturation of damage removal (Notes)

  • Exercise 3

  • Lecture 7 - Aging-related diseases and their exponentially rising incidence with age (Notes)

     

  • Lecture 8 - Inflammation and fibrosis as a bistable system (Notes)

  • Exercise 4

  • Lecture 9 - Evolutionary tradeoffs, division of labor in tissues, and Universal cancer tasks (Notes)

     

  • Lecture 10 - The growth axis, catch-up growth and mini growth spurts (Notes) 

     

  • Lecture 11 - Major depression and the slow timescale of treatment (Notes)

     

  • Exercise 5

  • Lecture 12 - Addiction (Notes)