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  • Date:02SundayMarch 2025

    The Clore Center for Biological Physics

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    Time
    12:45 - 14:30
    Title
    Emergent Disorder and Mechanical Memory in Periodic Metamaterials
    Location
    Nella and Leon Benoziyo Physics Library
    LecturerProf. Yair Shokef
    Lunch at 12:45
    Contact
    AbstractShow full text abstract about <p>Ordered mechanical systems typically have one or on...»
    <p>Ordered mechanical systems typically have one or only a few stable rest configurations, and hence are not considered useful for encoding memory. Multistable and history-dependent responses usually emerge from quenched disorder, for example in amorphous solids or crumpled sheets. Inspired by the topological structure of frustrated artificial spin ices, we introduce an approach to design ordered, periodic mechanical metamaterials that exhibit an extensive set of spatially disordered states. We show how such systems exhibit non-Abelian and history-dependent responses, as their state can depend on the order in which external manipulations were applied. We demonstrate how this richness of the dynamics enables to recognize, from a static measurement of the final state, the sequence of operations that an extended system underwent. Thus, multistability and potential to perform computation emerge from geometric frustration in ordered mechanical lattices that create their own disorder.</p>
    Lecture
  • Date:03MondayMarch 2025

    Exploring RNA and protein folding with Single-Molecule Force Spectroscopy

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    Time
    11:00 - 12:15
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Matthias Rief
    Homepage
    AbstractShow full text abstract about <p>Single-molecule force spectroscopy (SMFS) enables h...»
    <p>Single-molecule force spectroscopy (SMFS) enables high-resolution insights into the kinetics and mechanisms of biomolecular interactions. In this talk, I will present how SMFS, helps uncover key principles in nucleic acid and protein folding. Examples discussed will include the microsecond invasion kinetics of toehold-mediated strand displacement (TMSD) of DNA and RNA as well as mRNA-Roquin interactions, which regulate mRNA degradation via specific 3’UTR hairpin structures.&nbsp;Finally, we study chaperone-mediated unfolding of the glucocorticoid receptor (GR), demonstrating how Hsp70/Hsp40 unfolds GR in discrete ATP-driven steps, stabilizing novel intermediates and acting as an unfoldase. These studies showcase SMFS as a powerful tool to resolve biomolecular dynamics providing new insights into RNA structure-function relationships and chaperone-mediated protein regulation.</p>
    Colloquia
  • Date:04TuesdayMarch 2025

    The 4th International Day of Women in Science

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    Time
    08:30 - 16:00
    Title
    The 4th International Day of Women in Science
    Location
    The David Lopatie Conference Centre
    Chairperson
    Idit Shachar
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    Contact
    Conference
  • Date:04TuesdayMarch 2025

    "Cut it Out" – Lytic Cell Death and Inflammation Mediated by the “NINJA” Protein – NINJ1

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    Time
    14:00 - 15:00
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerDr. Liron David
    Organizer
    Department of Chemical and Structural Biology
    Lecture
  • Date:05WednesdayMarch 2025

    students seminar series- Azrieli

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    Time
    10:30 - 12:30
    Location
    Camelia Botnar Building
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    Lecture
  • Date:05WednesdayMarch 2025

    students seminar series- Azrieli

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    Time
    10:30 - 12:30
    Location
    Camelia Botnar Building
    Contact
    Lecture
  • Date:06ThursdayMarch 2025

    LSCF departmental seminar by Dr. Yoav Peleg & Prof. Moran Shalev-Benami

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    Time
    09:00 - 10:00
    Location
    Candiotty Auditorium
    LecturerDr. Yoav Peleg, Prof. Moran Shalev-Benami
    Lecture
  • Date:09SundayMarch 2025

    On Light Propagation in Clouds and Light Flashes Above Clouds: Two Crazy Ideas, Two New Models

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    Time
    11:00 - 12:00
    Location
    Sussman Family Building for Environmental Sciences
    M. Magaritz room
    LecturerCarynelisa Haspel
    Contact
    AbstractShow full text abstract about <p>In this seminar, two new models will be presented. ...»
    <p>In this seminar, two new models will be presented. The first new model is a first-principles description of the propagation of light in a cloud, based on a classical solution to Maxwell's equations rather than radiative transfer theory. The second new model is a fully three-dimensional, time-dependent model of the regions of possible sprite inception in the mesosphere, based on the classical method of images from electrostatics rather than finite differencing in space. The reason why each model is unique, the problems each model can solve, and the kinds of results each model can produce will be discussed</p>
    Lecture
  • Date:09SundayMarch 2025

    On Light Propagation in Clouds and Light Flashes Above Clouds: Two Crazy Ideas, Two New Models

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    Time
    11:00 - 12:00
    Location
    Sussman Family Building for Environmental Sciences
    M. Magaritz seminar room
    LecturerCarynelisa Haspel
    Contact
    AbstractShow full text abstract about <p>In this seminar, two new models will be presented. ...»
    <p>In this seminar, two new models will be presented. The first new model is a first-principles description of the propagation of light in a cloud, based on a classical solution to Maxwell's equations rather than radiative transfer theory. The second new model is a fully three-dimensional, time-dependent model of the regions of possible sprite inception in the mesosphere, based on the classical method of images from electrostatics rather than finite differencing in space. The reason why each model is unique, the problems each model can solve, and the kinds of results each model can produce will be discussed.&nbsp;&nbsp;</p>
    Lecture
  • Date:11TuesdayMarch 2025

    A Vascular-Centered View on Aging, Regeneration and Rejuvenation

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    Time
    12:30 - 13:30
    Location
    Max and Lillian Candiotty Building
    Auditorium
    LecturerProf. Eli Keshet
    Organizer
    Department of Immunology and Regenerative Biology
    Contact
    Lecture
  • Date:11TuesdayMarch 2025

    What is special about activity in the basal ganglia?

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    Time
    12:30 - 14:00
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Mati Joshua
    Organizer
    Department of Brain Sciences
    Contact
    AbstractShow full text abstract about <p>There are two major classes of theories about the b...»
    <p>There are two major classes of theories about the basal ganglia. The first class hypothesizes</p><p>that the basal ganglia are the site where cortical sensorimotor and dopaminergic reward</p><p>information interact to potentiate and select actions. These theories predict that content</p><p>specificity of information emerges from within the basal ganglia. The second class of</p><p>theories posits that information is manipulated within the basal ganglia through processes</p><p>such as dimensionality reduction. These theories are primarily based on the fact that there</p><p>is a large reduction in the number of neurons from the input to the output stages of the basal</p><p>ganglia. These theories posit that there are changes in the coding properties of neurons</p><p>rather than the emergence of content specificity.</p><p>In this talk, I will present a set of studies where we analyzed the eye movement system of</p><p>monkeys to compare single-neuron activity in the basal ganglia with activity in the</p><p>cerebellum and the frontal cortex. We used tasks that manipulated both eye movements</p><p>and expected rewards. We found that rather than coding specific sensorimotor or reward</p><p>parameters, the basal ganglia were unique in how they coded these parameters, both in</p><p>terms of the signal-to-noise ratio of responses and in the variety of their temporal patterns.</p><p>These results strongly suggest that the basal ganglia play a role in manipulating rather than</p><p>generating reward and sensorimotor signals.</p>
    Lecture
  • Date:12WednesdayMarch 2025

    Birthday hormone: the neuroendocrine control of hatching in fish

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    Time
    10:00 - 11:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    LecturerDr. Matan Golan
    Contact
    Lecture
  • Date:13ThursdayMarch 2025

    To be announced

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    Time
    15:00 - 16:00
    Location
    Leon Benoziyo for Biological Sciences
    Auditorium Rm.191
    LecturerDr. Lior Nissim
    (HUJI)
    Lecture
  • Date:16SundayMarch 2025

    EPScon 2025 - The 14th Students' Conference for Earth and Planetary Sciences

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    Time
    08:00 - 08:00
    Location
    The David Lopatie Conference Centre
    Chairperson
    Adam Chaikin Lifshitz
    Conference
  • Date:18TuesdayMarch 2025

    Vascular Aging:

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    Time
    11:00 - 12:00
    Title
    The Hidden Driver of Age-Related Organ Dysfunction
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerDr. Myriam Grunewald
    Organizer
    Sagol Institute for Longevity Research
    Contact
    AbstractShow full text abstract about <p>As life expectancy increases, age-related diseases ...»
    <p>As life expectancy increases, age-related diseases are becoming more prevalent. While these conditions are traditionally studied in isolation, mounting evidence points to shared, systemic mechanisms underlying these conditions. Our research highlights the vasculature as &nbsp;a key player in organ homeostasis and repair, and a system shared across all organs—making its dysfunction potential driver of age-related pathologies.</p><p>We demonstrate that manipulating <strong>VEGF signaling</strong> to counteract age-related microvascular rarefaction promotes <strong>comprehensive geroprotection</strong>, preserving organ function and delaying disease onset. Our findings also reveal a link between vascular rarefaction and altered RNA splicing. While hypoxia-driven and age-related changes in alternative RNA splicing have been studied independently, we propose a unifying mechanism that links the two. To explore this further, we also employ patient-derived organoids, which retain their biological age in culture, providing a robust in vitro platform to test anti-aging interventions.</p><p>Our findings support a <strong>vascular theory of aging</strong>, identifying vascular health as a promising target to mitigate age-related diseases and promote healthier aging.</p>
    Lecture
  • Date:18TuesdayMarch 2025

    Proteome-wide prediction of protein-protein interaction networks and protein compound interactions and their integration for biological discovery

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    Time
    14:00 - 15:00
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Barry Honig
    Organizer
    Department of Chemical and Structural Biology
    Lecture
  • Date:20ThursdayMarch 2025

    Spotlight on Science Lecture by Dr. Osnat Bartok

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    Time
    12:30 - 14:00
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerDr. Osnat Bartok
    Spotlight on Science lecture sponsored by the Staff Scientists Council
    Contact
    Lecture
  • Date:20ThursdayMarch 2025

    Spatial transcriptomics of pancreatic cancer development and immune cells targeting to restrict tumor growth

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    Time
    14:00 - 15:00
    Location
    Max and Lillian Candiotty Building
    Auditorium
    LecturerDr. Oren Parnas
    Organizer
    Dwek Institute for Cancer Therapy Research
    Lecture
  • Date:24MondayMarch 2025

    Foundations of Computer Science Seminar

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    Time
    11:15 - 12:15
    Title
    Privacy amplification by random allocation (is approximately Poisson subsampling)
    Location
    Jacob Ziskind Building
    Room 1 - 1 חדר
    LecturerMoshe Shenfeld
    Hebrew University of Jerusalem
    Organizer
    Department of Computer Science and Applied Mathematics
    Contact
    AbstractShow full text abstract about Given two distributions P, Q and an integer t, we analyze tw...»
    Given two distributions P, Q and an integer t, we analyze two sampling processes. In "random allocation," we first sample an index i uniformly from [t], then draw r_{i} ~ P and r_{j} ~ Q for all other j in [t]. In "Poisson sampling," we independently draw r_{i} ~ 1/t*P + (1-1/t)*Q for each i in [t]. We bound the difference between these processes' output distributions and the baseline of sampling r_{i} ~ Q for all i.

    This theoretical result provides key insights for analyzing DP-SGD, a privacy-preserving variant of stochastic gradient descent. While Poisson subsampling has well-understood privacy guarantees, common implementations use element shuffling, which was recently shown to have larger privacy losses in certain regimes. Random allocation offers a middle ground, and we prove its privacy analysis reduces to comparing the distributions described above.

    We show that these variants' privacy guarantees are within a constant factor of each other across all parameter regimes and converge asymptotically in t. Our proof has two key components: decomposing Poisson sampling into a mixture of random allocation processes, and showing that random allocation can be viewed as a modified Poisson process where sampling probabilities depend on previous outputs.

    Joint work with Vitaly Feldman
    Lecture
  • Date:27ThursdayMarch 2025

    Regulation of immune cell function in tumor microenvironment of triple-negative breast cancer

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    Time
    14:00 - 15:00
    Location
    Max and Lillian Candiotty Building
    Auditorium
    LecturerProf. Idit Shachar
    Organizer
    Dwek Institute for Cancer Therapy Research
    Lecture

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