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  • Date:05WednesdayMarch 2025

    students seminar series- Azrieli

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    Time
    10:30 - 12:30
    Location
    Camelia Botnar Building
    Contact
    Lecture
  • Date:05WednesdayMarch 2025

    students seminar series- Azrieli

    More information
    Time
    10:30 - 12:30
    Location
    Camelia Botnar Building
    Contact
    Lecture
  • Date:06ThursdayMarch 2025

    LSCF departmental seminar by Dr. Yoav Peleg & Prof. Moran Shalev-Benami

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    Time
    09:00 - 10:00
    Location
    Candiotty Auditorium
    LecturerDr. Yoav Peleg, Prof. Moran Shalev-Benami
    Organizer
    Department of Life Sciences Core Facilities
    Lecture
  • Date:09SundayMarch 2025

    On Light Propagation in Clouds and Light Flashes Above Clouds: Two Crazy Ideas, Two New Models

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    Time
    11:00 - 12:00
    Location
    Sussman Family Building for Environmental Sciences
    M. Magaritz room
    LecturerCarynelisa Haspel
    Contact
    AbstractShow full text abstract about <p>In this seminar, two new models will be presented. ...»
    <p>In this seminar, two new models will be presented. The first new model is a first-principles description of the propagation of light in a cloud, based on a classical solution to Maxwell's equations rather than radiative transfer theory. The second new model is a fully three-dimensional, time-dependent model of the regions of possible sprite inception in the mesosphere, based on the classical method of images from electrostatics rather than finite differencing in space. The reason why each model is unique, the problems each model can solve, and the kinds of results each model can produce will be discussed</p>
    Lecture
  • Date:09SundayMarch 2025

    On Light Propagation in Clouds and Light Flashes Above Clouds: Two Crazy Ideas, Two New Models

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    Time
    11:00 - 12:00
    Location
    Sussman Family Building for Environmental Sciences
    M. Magaritz seminar room
    LecturerCarynelisa Haspel
    Contact
    AbstractShow full text abstract about <p>In this seminar, two new models will be presented. ...»
    <p>In this seminar, two new models will be presented. The first new model is a first-principles description of the propagation of light in a cloud, based on a classical solution to Maxwell's equations rather than radiative transfer theory. The second new model is a fully three-dimensional, time-dependent model of the regions of possible sprite inception in the mesosphere, based on the classical method of images from electrostatics rather than finite differencing in space. The reason why each model is unique, the problems each model can solve, and the kinds of results each model can produce will be discussed.&nbsp;&nbsp;</p>
    Lecture
  • Date:09SundayMarch 2025

    The Clore Center for Biological Physics

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    Time
    12:45 - 14:30
    Title
    Mechanical communication in cardiac cell beating
    Location
    Nella and Leon Benoziyo Physics Library
    LecturerProf. Shelly Tzlil
    Lunch at 12:45
    Contact
    AbstractShow full text abstract about <p>Cell-cell communication is essential for growth, de...»
    <p>Cell-cell communication is essential for growth, development and function. Cells can communicate mechanically by responding to mechanical deformations generated by their neighbors in the extracellular matrix (ECM).</p><p>We use a 2D cardiac tissue model to study the role of mechanical communication between cardiac cells in the normal conduction wave. We quantify the mechanical coupling between cells in a monolayer and use this to identify a critical threshold of mechanical coupling, below which spiral waves are induced in the tissue. We demonstrate that normal conduction wave can be recovered only using mechanical stimulation. We further show that mechanical coupling reduces the sensitivity to geometrical defects in the tissue.</p><p>We show that due to the dynamic viscoelastic properties of collagen hydrogels (a major component of the cardiac ECM), the shape of the mechanical signal changes in a frequency dependent manner as it propagates through the gel, leading to a frequency dependent mechanical communication. Moreover, we show that the sensitivity of cardiac cell response to the shape of the mechanical signal results from its sensitivity to the loading rate. We also show that an optimal loading rate exists for mechanical communication, implying that there are ideal viscoelastic properties for effective mechanical communication.</p><p></p><p><strong>FOR THE LATEST UPDATES AND CONTENT ON SOFT MATTER AND BIOLOGICAL PHYSICS AT THE WEIZMANN, VISIT OUR&nbsp;WEBSITE:&nbsp;https://www.biosoftweizmann.com/</strong></p>
    Lecture
  • Date:11TuesdayMarch 2025

    A Vascular-Centered View on Aging, Regeneration and Rejuvenation

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    Time
    12:30 - 13:30
    Location
    Max and Lillian Candiotty Building
    Auditorium
    LecturerProf. Eli Keshet
    Organizer
    Department of Immunology and Regenerative Biology
    Contact
    Lecture
  • Date:11TuesdayMarch 2025

    What is special about activity in the basal ganglia?

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    Time
    12:30 - 14:00
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Mati Joshua
    Organizer
    Department of Brain Sciences
    Contact
    AbstractShow full text abstract about <p>There are two major classes of theories about the b...»
    <p>There are two major classes of theories about the basal ganglia. The first class hypothesizes</p><p>that the basal ganglia are the site where cortical sensorimotor and dopaminergic reward</p><p>information interact to potentiate and select actions. These theories predict that content</p><p>specificity of information emerges from within the basal ganglia. The second class of</p><p>theories posits that information is manipulated within the basal ganglia through processes</p><p>such as dimensionality reduction. These theories are primarily based on the fact that there</p><p>is a large reduction in the number of neurons from the input to the output stages of the basal</p><p>ganglia. These theories posit that there are changes in the coding properties of neurons</p><p>rather than the emergence of content specificity.</p><p>In this talk, I will present a set of studies where we analyzed the eye movement system of</p><p>monkeys to compare single-neuron activity in the basal ganglia with activity in the</p><p>cerebellum and the frontal cortex. We used tasks that manipulated both eye movements</p><p>and expected rewards. We found that rather than coding specific sensorimotor or reward</p><p>parameters, the basal ganglia were unique in how they coded these parameters, both in</p><p>terms of the signal-to-noise ratio of responses and in the variety of their temporal patterns.</p><p>These results strongly suggest that the basal ganglia play a role in manipulating rather than</p><p>generating reward and sensorimotor signals.</p>
    Lecture
  • Date:12WednesdayMarch 2025

    Birthday hormone: the neuroendocrine control of hatching in fish

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    Time
    10:00 - 11:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    LecturerDr. Matan Golan
    Contact
    Lecture
  • Date:13ThursdayMarch 2025

    Synthetic biology platforms for biomedical applicationsnnounced

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    Time
    15:00 - 16:00
    Location
    Leon Benoziyo for Biological Sciences
    Auditorium Rm.191
    LecturerDr. Lior Nissim
    The Faculty of Medicine - Hebrew University of Jerusalem
    Lecture
  • Date:16SundayMarch 2025

    EPScon 2025 - The 14th Students' Conference for Earth and Planetary Sciences

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    Time
    08:00 - 08:00
    Location
    The David Lopatie Conference Centre
    Chairperson
    Adam Chaikin Lifshitz
    Conference
  • Date:18TuesdayMarch 2025

    Vascular Aging:

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    Time
    11:00 - 12:00
    Title
    The Hidden Driver of Age-Related Organ Dysfunction
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerDr. Myriam Grunewald
    Organizer
    Sagol Institute for Longevity Research
    Contact
    AbstractShow full text abstract about <p>As life expectancy increases, age-related diseases ...»
    <p>As life expectancy increases, age-related diseases are becoming more prevalent. While these conditions are traditionally studied in isolation, mounting evidence points to shared, systemic mechanisms underlying these conditions. Our research highlights the vasculature as &nbsp;a key player in organ homeostasis and repair, and a system shared across all organs—making its dysfunction potential driver of age-related pathologies.</p><p>We demonstrate that manipulating <strong>VEGF signaling</strong> to counteract age-related microvascular rarefaction promotes <strong>comprehensive geroprotection</strong>, preserving organ function and delaying disease onset. Our findings also reveal a link between vascular rarefaction and altered RNA splicing. While hypoxia-driven and age-related changes in alternative RNA splicing have been studied independently, we propose a unifying mechanism that links the two. To explore this further, we also employ patient-derived organoids, which retain their biological age in culture, providing a robust in vitro platform to test anti-aging interventions.</p><p>Our findings support a <strong>vascular theory of aging</strong>, identifying vascular health as a promising target to mitigate age-related diseases and promote healthier aging.</p>
    Lecture
  • Date:18TuesdayMarch 2025

    Proteome-wide prediction of protein-protein interaction networks and protein compound interactions and their integration for biological discovery

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    Time
    14:00 - 15:00
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Barry Honig
    Organizer
    Department of Chemical and Structural Biology
    Lecture
  • Date:20ThursdayMarch 2025

    Harnessing Mistakes to Expose Cancer’s Vulnerability

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    Time
    12:30 - 14:00
    Title
    Spotlight on Science lecture sponsored by the Staff Scientists Council
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerIlana Eyal
    Spotlight on Science lecture sponsored by the Staff Scientists Council
    Contact
    AbstractShow full text abstract about <p>Over the past few decades, immunotherapy has revolu...»
    <p>Over the past few decades, immunotherapy has revolutionized cancer treatment with great success in treating cancer patients and preventing tumor recurrence after surgery. Harnessing the immune system to fight cancer largely relies on the ability of T lymphocytes to distinguish&nbsp;between “self” and “non-self” to specifically identify and eliminate malignant cells.&nbsp;This is achieved through the recognition of neoantigens, tumor-specific proteins resulting from genetic mutations.</p><p>The Samuels’ lab is exploring the immune-tumor interactions, with specific focus on the mechanisms underlying cancer-cell recognition, and developing novel strategies to increase antitumor immune responses.</p><p>In this talk, I will present results from our recent studies investigating the link between mRNA mistranslation in cancer cells and immunological tumor control.</p>
    Lecture
  • Date:20ThursdayMarch 2025

    Spatial transcriptomics of pancreatic cancer development and immune cells targeting to restrict tumor growth

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    Time
    14:00 - 15:00
    Location
    Max and Lillian Candiotty Building
    Auditorium
    LecturerDr. Oren Parnas
    Organizer
    Dwek Institute for Cancer Therapy Research
    Lecture
  • Date:24MondayMarch 2025

    Foundations of Computer Science Seminar

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    Time
    11:15 - 12:15
    Title
    Privacy amplification by random allocation (is approximately Poisson subsampling)
    Location
    Jacob Ziskind Building
    Room 1 - 1 חדר
    LecturerMoshe Shenfeld
    Hebrew University of Jerusalem
    Organizer
    Department of Computer Science and Applied Mathematics
    Contact
    AbstractShow full text abstract about Given two distributions P, Q and an integer t, we analyze tw...»
    Given two distributions P, Q and an integer t, we analyze two sampling processes. In "random allocation," we first sample an index i uniformly from [t], then draw r_{i} ~ P and r_{j} ~ Q for all other j in [t]. In "Poisson sampling," we independently draw r_{i} ~ 1/t*P + (1-1/t)*Q for each i in [t]. We bound the difference between these processes' output distributions and the baseline of sampling r_{i} ~ Q for all i.

    This theoretical result provides key insights for analyzing DP-SGD, a privacy-preserving variant of stochastic gradient descent. While Poisson subsampling has well-understood privacy guarantees, common implementations use element shuffling, which was recently shown to have larger privacy losses in certain regimes. Random allocation offers a middle ground, and we prove its privacy analysis reduces to comparing the distributions described above.

    We show that these variants' privacy guarantees are within a constant factor of each other across all parameter regimes and converge asymptotically in t. Our proof has two key components: decomposing Poisson sampling into a mixture of random allocation processes, and showing that random allocation can be viewed as a modified Poisson process where sampling probabilities depend on previous outputs.

    Joint work with Vitaly Feldman
    Lecture
  • Date:27ThursdayMarch 2025

    Regulation of immune cell function in tumor microenvironment of triple-negative breast cancer

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    Time
    14:00 - 15:00
    Location
    Max and Lillian Candiotty Building
    Auditorium
    LecturerProf. Idit Shachar
    Organizer
    Dwek Institute for Cancer Therapy Research
    Lecture
  • Date:27ThursdayMarch 2025

    To be announced

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    Time
    15:00 - 16:00
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    Auditorium Rm. 191
    LecturerKeren Yizhak
    (Technion)
    Lecture
  • Date:30SundayMarch 2025

    Special Guest Seminar - Dr. Thierry Nordmann

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    Time
    11:15 - 12:15
    Title
    Unraveling the Molecular Architecture of the Skin for Personalized Medicine
    Location
    Wolfson Auditorium
    LecturerDr. Thierry Nordmann
    Organizer
    Department of Molecular Cell Biology
    Contact
    Lecture
  • Date:31MondayMarch 2025

    Decoding the molecular mechanism of histone modification

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    Time
    11:00 - 12:15
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Cynthia Wolberger
    Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University
    Organizer
    Department of Chemical and Structural Biology
    Homepage
    Contact
    AbstractShow full text abstract about <p>Post-translational modifications of histones play a...»
    <p>Post-translational modifications of histones play a central role in regulating all cellular processes requiring access to DNA. Monoubiquitinated histone H2B-K120 is a hallmark of actively transcribed genes that plays multiple roles in activating transcription, while monoubiquitinated histone H2A-K119 is abundant in heterochromatin, which is transcriptionally silent. Our structural studies have revealed how histone H2B is specifically ubiquitinated and deubiquitinated, and ubiquitinated H2B stimulates histone methylation. We have also shown how ubiquitin can regulate access to the nucleosome acidic patch, a hotspot for interactions with other chromatin-modifying enzymes. I will also discuss recent studies of a histone kinase that has an unusual mode of binding nucleosomes.</p>
    Colloquia

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