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Date:02SundayMarch 2025Lecture
The Clore Center for Biological Physics
More information Time 12:45 - 14:30Title Emergent Disorder and Mechanical Memory in Periodic MetamaterialsLocation Nella and Leon Benoziyo Physics LibraryLecturer Prof. Yair Shokef
Lunch at 12:45Contact Abstract Show full text abstract about <p>Ordered mechanical systems typically have one or on...» <p>Ordered mechanical systems typically have one or only a few stable rest configurations, and hence are not considered useful for encoding memory. Multistable and history-dependent responses usually emerge from quenched disorder, for example in amorphous solids or crumpled sheets. Inspired by the topological structure of frustrated artificial spin ices, we introduce an approach to design ordered, periodic mechanical metamaterials that exhibit an extensive set of spatially disordered states. We show how such systems exhibit non-Abelian and history-dependent responses, as their state can depend on the order in which external manipulations were applied. We demonstrate how this richness of the dynamics enables to recognize, from a static measurement of the final state, the sequence of operations that an extended system underwent. Thus, multistability and potential to perform computation emerge from geometric frustration in ordered mechanical lattices that create their own disorder.</p> -
Date:03MondayMarch 2025Colloquia
Exploring RNA and protein folding with Single-Molecule Force Spectroscopy
More information Time 11:00 - 12:15Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Matthias Rief Homepage Abstract Show full text abstract about <p>Single-molecule force spectroscopy (SMFS) enables h...» <p>Single-molecule force spectroscopy (SMFS) enables high-resolution insights into the kinetics and mechanisms of biomolecular interactions. In this talk, I will present how SMFS, helps uncover key principles in nucleic acid and protein folding. Examples discussed will include the microsecond invasion kinetics of toehold-mediated strand displacement (TMSD) of DNA and RNA as well as mRNA-Roquin interactions, which regulate mRNA degradation via specific 3’UTR hairpin structures. Finally, we study chaperone-mediated unfolding of the glucocorticoid receptor (GR), demonstrating how Hsp70/Hsp40 unfolds GR in discrete ATP-driven steps, stabilizing novel intermediates and acting as an unfoldase. These studies showcase SMFS as a powerful tool to resolve biomolecular dynamics providing new insights into RNA structure-function relationships and chaperone-mediated protein regulation.</p> -
Date:04TuesdayMarch 2025Conference
The 4th International Day of Women in Science
More information Time 08:30 - 16:00Title The 4th International Day of Women in ScienceLocation The David Lopatie Conference CentreChairperson Idit ShacharHomepage Contact -
Date:04TuesdayMarch 2025Lecture
"Cut it Out" – Lytic Cell Death and Inflammation Mediated by the “NINJA” Protein – NINJ1
More information Time 14:00 - 15:00Location Gerhard M.J. Schmidt Lecture HallLecturer Dr. Liron David Organizer Department of Chemical and Structural Biology -
Date:05WednesdayMarch 2025Lecture
students seminar series- Azrieli
More information Time 10:30 - 12:30Location Camelia Botnar BuildingContact -
Date:05WednesdayMarch 2025Lecture
students seminar series- Azrieli
More information Time 10:30 - 12:30Location Camelia Botnar BuildingContact -
Date:06ThursdayMarch 2025Lecture
LSCF departmental seminar by Dr. Yoav Peleg & Prof. Moran Shalev-Benami
More information Time 09:00 - 10:00Location Candiotty AuditoriumLecturer Dr. Yoav Peleg, Prof. Moran Shalev-Benami -
Date:09SundayMarch 2025Lecture
On Light Propagation in Clouds and Light Flashes Above Clouds: Two Crazy Ideas, Two New Models
More information Time 11:00 - 12:00Location Sussman Family Building for Environmental Sciences
M. Magaritz roomLecturer Carynelisa Haspel Contact Abstract Show full text abstract about <p>In this seminar, two new models will be presented. ...» <p>In this seminar, two new models will be presented. The first new model is a first-principles description of the propagation of light in a cloud, based on a classical solution to Maxwell's equations rather than radiative transfer theory. The second new model is a fully three-dimensional, time-dependent model of the regions of possible sprite inception in the mesosphere, based on the classical method of images from electrostatics rather than finite differencing in space. The reason why each model is unique, the problems each model can solve, and the kinds of results each model can produce will be discussed</p> -
Date:09SundayMarch 2025Lecture
On Light Propagation in Clouds and Light Flashes Above Clouds: Two Crazy Ideas, Two New Models
More information Time 11:00 - 12:00Location Sussman Family Building for Environmental Sciences
M. Magaritz seminar roomLecturer Carynelisa Haspel Contact Abstract Show full text abstract about <p>In this seminar, two new models will be presented. ...» <p>In this seminar, two new models will be presented. The first new model is a first-principles description of the propagation of light in a cloud, based on a classical solution to Maxwell's equations rather than radiative transfer theory. The second new model is a fully three-dimensional, time-dependent model of the regions of possible sprite inception in the mesosphere, based on the classical method of images from electrostatics rather than finite differencing in space. The reason why each model is unique, the problems each model can solve, and the kinds of results each model can produce will be discussed. </p> -
Date:11TuesdayMarch 2025Lecture
A Vascular-Centered View on Aging, Regeneration and Rejuvenation
More information Time 12:30 - 13:30Location Max and Lillian Candiotty Building
AuditoriumLecturer Prof. Eli Keshet Organizer Department of Immunology and Regenerative BiologyContact -
Date:11TuesdayMarch 2025Lecture
What is special about activity in the basal ganglia?
More information Time 12:30 - 14:00Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Mati Joshua Organizer Department of Brain SciencesContact Abstract Show full text abstract about <p>There are two major classes of theories about the b...» <p>There are two major classes of theories about the basal ganglia. The first class hypothesizes</p><p>that the basal ganglia are the site where cortical sensorimotor and dopaminergic reward</p><p>information interact to potentiate and select actions. These theories predict that content</p><p>specificity of information emerges from within the basal ganglia. The second class of</p><p>theories posits that information is manipulated within the basal ganglia through processes</p><p>such as dimensionality reduction. These theories are primarily based on the fact that there</p><p>is a large reduction in the number of neurons from the input to the output stages of the basal</p><p>ganglia. These theories posit that there are changes in the coding properties of neurons</p><p>rather than the emergence of content specificity.</p><p>In this talk, I will present a set of studies where we analyzed the eye movement system of</p><p>monkeys to compare single-neuron activity in the basal ganglia with activity in the</p><p>cerebellum and the frontal cortex. We used tasks that manipulated both eye movements</p><p>and expected rewards. We found that rather than coding specific sensorimotor or reward</p><p>parameters, the basal ganglia were unique in how they coded these parameters, both in</p><p>terms of the signal-to-noise ratio of responses and in the variety of their temporal patterns.</p><p>These results strongly suggest that the basal ganglia play a role in manipulating rather than</p><p>generating reward and sensorimotor signals.</p> -
Date:12WednesdayMarch 2025Lecture
Birthday hormone: the neuroendocrine control of hatching in fish
More information Time 10:00 - 11:00Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Dr. Matan Golan Contact -
Date:13ThursdayMarch 2025Lecture
To be announced
More information Time 15:00 - 16:00Location Leon Benoziyo for Biological Sciences
Auditorium Rm.191Lecturer Dr. Lior Nissim
(HUJI) -
Date:16SundayMarch 2025Conference
EPScon 2025 - The 14th Students' Conference for Earth and Planetary Sciences
More information Time 08:00 - 08:00Location The David Lopatie Conference CentreChairperson Adam Chaikin Lifshitz -
Date:18TuesdayMarch 2025Lecture
Vascular Aging:
More information Time 11:00 - 12:00Title The Hidden Driver of Age-Related Organ DysfunctionLocation Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Dr. Myriam Grunewald Organizer Sagol Institute for Longevity ResearchContact Abstract Show full text abstract about <p>As life expectancy increases, age-related diseases ...» <p>As life expectancy increases, age-related diseases are becoming more prevalent. While these conditions are traditionally studied in isolation, mounting evidence points to shared, systemic mechanisms underlying these conditions. Our research highlights the vasculature as a key player in organ homeostasis and repair, and a system shared across all organs—making its dysfunction potential driver of age-related pathologies.</p><p>We demonstrate that manipulating <strong>VEGF signaling</strong> to counteract age-related microvascular rarefaction promotes <strong>comprehensive geroprotection</strong>, preserving organ function and delaying disease onset. Our findings also reveal a link between vascular rarefaction and altered RNA splicing. While hypoxia-driven and age-related changes in alternative RNA splicing have been studied independently, we propose a unifying mechanism that links the two. To explore this further, we also employ patient-derived organoids, which retain their biological age in culture, providing a robust in vitro platform to test anti-aging interventions.</p><p>Our findings support a <strong>vascular theory of aging</strong>, identifying vascular health as a promising target to mitigate age-related diseases and promote healthier aging.</p> -
Date:18TuesdayMarch 2025Lecture
Proteome-wide prediction of protein-protein interaction networks and protein compound interactions and their integration for biological discovery
More information Time 14:00 - 15:00Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Barry Honig Organizer Department of Chemical and Structural Biology -
Date:20ThursdayMarch 2025Lecture
Spotlight on Science Lecture by Dr. Osnat Bartok
More information Time 12:30 - 14:00Location Gerhard M.J. Schmidt Lecture HallLecturer Dr. Osnat Bartok
Spotlight on Science lecture sponsored by the Staff Scientists CouncilContact -
Date:20ThursdayMarch 2025Lecture
Spatial transcriptomics of pancreatic cancer development and immune cells targeting to restrict tumor growth
More information Time 14:00 - 15:00Location Max and Lillian Candiotty Building
AuditoriumLecturer Dr. Oren Parnas Organizer Dwek Institute for Cancer Therapy Research -
Date:24MondayMarch 2025Lecture
Foundations of Computer Science Seminar
More information Time 11:15 - 12:15Title Privacy amplification by random allocation (is approximately Poisson subsampling)Location Jacob Ziskind Building
Room 1 - 1 חדרLecturer Moshe Shenfeld
Hebrew University of JerusalemOrganizer Department of Computer Science and Applied MathematicsContact Abstract Show full text abstract about Given two distributions P, Q and an integer t, we analyze tw...» Given two distributions P, Q and an integer t, we analyze two sampling processes. In "random allocation," we first sample an index i uniformly from [t], then draw r_{i} ~ P and r_{j} ~ Q for all other j in [t]. In "Poisson sampling," we independently draw r_{i} ~ 1/t*P + (1-1/t)*Q for each i in [t]. We bound the difference between these processes' output distributions and the baseline of sampling r_{i} ~ Q for all i.
This theoretical result provides key insights for analyzing DP-SGD, a privacy-preserving variant of stochastic gradient descent. While Poisson subsampling has well-understood privacy guarantees, common implementations use element shuffling, which was recently shown to have larger privacy losses in certain regimes. Random allocation offers a middle ground, and we prove its privacy analysis reduces to comparing the distributions described above.
We show that these variants' privacy guarantees are within a constant factor of each other across all parameter regimes and converge asymptotically in t. Our proof has two key components: decomposing Poisson sampling into a mixture of random allocation processes, and showing that random allocation can be viewed as a modified Poisson process where sampling probabilities depend on previous outputs.
Joint work with Vitaly Feldman -
Date:27ThursdayMarch 2025Lecture
Regulation of immune cell function in tumor microenvironment of triple-negative breast cancer
More information Time 14:00 - 15:00Location Max and Lillian Candiotty Building
AuditoriumLecturer Prof. Idit Shachar Organizer Dwek Institute for Cancer Therapy Research