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More information Time10:15 - 12:30 LocationDolfi and Lola Ebner Auditorium LecturerProf. Mina Bissell and Prof. Nieng Yan OrganizerLife Sciences
Advancing Women in Science Office
Homepage Contact Details Show full text description of Prof. Mina Bissell lecture: "Architecture is dominant ...»Prof. Mina Bissell lecture:
"Architecture is dominant over genotype in both normal and malignant cells: Studies with breast cells in 3D"
Prof. Nieng Yan lecture:
"Targeting Sodium Channels for the Treatment of Pain"
More information Time11:00 TitleSingle-Molecule Spectroscopy with Catalysts, Conductive Polymers, and Optical Microresonators LocationPerlman Chemical Sciences Building
LecturerProf. Randall Goldsmith
University of Wisconsin
OrganizerDepartment of Chemical and Biological Physics Contact
More information Time14:00 - 15:30 LocationNella and Leon Benoziyo Building for Biological Sciences LecturerProf. Anne S. Meyer
The University of Rochester NY, United States of America
Contact Details Show full text description of room 591C...»room 591C
More information Time14:30 - 16:00 LocationMax and Lillian Candiotty Building
LecturerProf. Mina Bissell and Prof. Nieng Yan
Winners of the Weizmann Women and Science 2019 Award
Homepage Contact Details Show full text description of Panel moderated by winners of this year's National Post...»Panel moderated by winners of this year's National Postdoctoral Award Program for Advancing Women in Science:
Dr. Daphna Rothschild, Department of Computer Science and Applied Mathematics And Dr. Dana Rubi Levy,Department of Neurobiology
More information Time10:00 LocationNella and Leon Benoziyo Building for Biological Sciences
LecturerDr. Daphna Nachmani
Department of Medicine and Pathology, Harvard Medical School, USA.
OrganizerDepartment of Molecular Cell Biology Contact
Date:17TuesdaySeptember 201919ThursdaySeptember 2019Academic Events
More information TimeAll day Homepage Contact
Date:17TuesdaySeptember 201919ThursdaySeptember 2019Conference
More information Time08:00 - 08:00 ChairpersonIgal Nevo Contact
More information Time11:00 LocationSussman Family Building for Environmental Sciences
M. Magaritz Seminar Room
LecturerGeorge N. Kiladis
Physical Sciences Division, Earth System Research Laboratory National Oceanic and Atmospheric Administration Boulder, Colorado
OrganizerDepartment of Earth and Planetary Sciences Contact Abstract Show full text abstract about Equatorially trapped waves account for a large portion of th...»Equatorially trapped waves account for a large portion of the perturbations within the tropical atmosphere and ocean. In the atmosphere, these disturbances are coupled to convection and determine a significant amount of rainfall variability on synoptic to intraseasonal time scales. Numerical models used for both weather and climate forecasting universally still have great difficulty simulating these convectively coupled disturbances. We assess the quantitative precipitation forecasts (QPF) skill of NOAA's Global Forecast System (GFS) and the European Centre for Medium Range Weather Forecasting Integrated Forecast System (IFS) operational models used for short term forecasts out to 10 days. Forecast skill was assessed by comparison with virtually independent GPM and CMORPH satellite precipitation estimates. Skill was quantified using a variety of metrics including pattern correlations for various latitude bands, temporal correlation at individual grid points, and space-time spectra of forecast precipitation over the global tropics and extratropics. Results reveal that, in general, initial conditions are reasonably well estimated in both forecast systems, as indicated by relatively good scores for the 6-12 hour forecasts. Since precipitation estimates are not directly assimilated into these systems, this indicates that the initialization of dynamical and thermodynamical fields is able to produce a reasonable QPF field, at least for the larger scales. We present evidence that the specification of the mass circulation rather than the moisture field is the primary source of this initial skill. Model skill is substantially better overall in the extratropics, however, tropical QPF in both systems is not considered useful by typical metrics much beyond a few days. A portion of this lack of tropical skill in can be traced back to inadequate treatment of equatorial wave activity coupled to convection. It is also demonstrated that extratropical forecast skill is positively correlated to preceding tropical skill, strongly suggesting that improvements in the treatment of tropics will lead to improved extratropical forecasts on the weekly and longer timescale.
More information Time15:00 - 16:15 LocationNancy and Stephen Grand Israel National Center for Personalized Medicine
LecturerProf. Govert Somsen
University of Amsterdam
OrganizerDepartment of Life Sciences Core Facilities Contact Abstract Show full text abstract about Emerging requirements in biopharmaceutical quality control a...»Emerging requirements in biopharmaceutical quality control and top-down proteomics, have led to a growing interest in intact protein analysis. Detailed characterization of intact protein heterogeneity, e.g. resulting from post-translational modifications, is a challenging task. Separation prior to mass spectrometric (MS) detection commonly is essential to achieve reliable and sensitive assignment of intact protein variants. Conventional liquid chromatographic (LC) protein separation methods often show poor compatibility with MS and/or lack the selectivity to resolve proteoforms. Moreover, LC conditions may be denaturing, precluding assessment of protein conformers and proteoform affinity. This lecture presents the design and application of new LC-MS and capillary electrophoresis (CE)-MS methods allowing detailed determination of the heterogeneity of intact proteins. Performance will be illustrated by characterization of pharmaceutical proteins, such as interferon-beta, erythropoietin, and monoclonal antibodies (mAbs), as well as cell-lysate proteins and IgGs in human plasma.
More information Time14:00 LocationMax and Lillian Candiotty Building
LecturerProf. Menachem Katz OrganizerDepartment of Biological Regulation Contact
Date:22SundaySeptember 201925WednesdaySeptember 2019Conference
More information Time08:00 - 08:00 ChairpersonEli Arama Contact
More information Time11:00 TitleTrick with Bricks: Complex self-assembly comes of age LocationGerhard M.J. Schmidt Lecture Hall LecturerProf Daan Frenkel
University of Cambridge
OrganizerDepartment of Chemical and Biological Physics Contact Abstract Show full text abstract about A holy grail of nano-technology is to create truly complex, ...»A holy grail of nano-technology is to create truly complex, multi-component structures by self-assembly. Most self-assembly has focused on the creation of "structural complexity". In my talk, I will discuss "Addressable Complexity": the creation of structures that contain hundreds or thousands of distinct building blocks that all have to find their place in a 3D structure. Experiments on “DNA bricks” have demonstrated the feasibility of making such structures. Simulation and theory yield surprising insights that suggest design principles for brick structures. Interestingly, the design principles are different for DNA origami.
More information Time14:00 - 15:00 LocationGerhard M.J. Schmidt Lecture Hall LecturerProf. Eddy Arnold
Board of Governors Professor and Distinguished Professor of Chemistry and Chemical Biology, Rutgers University
OrganizerDepartment of Structural Biology Contact
More information Time19:30 - 21:00 LocationGerhard M.J. Schmidt Lecture Hall LecturerProfessor Daniel H. Wagner
Prof. Daniel Wagner has been researching his Polish roots since 1995. He is the author of 35 genealogical papers and the editor of a book about scientific tools in genealogy. He is a member of IGRA, and a member of the Management Committee of the International Institute for Jewish Genealogy and the Paul Jacobi Center.
OrganizerDepartment of Materials and Interfaces Contact Abstract Show full text abstract about In the history of many families, all that remains about the ...»In the history of many families, all that remains about the fate of an ancestor for whom all traces were lost are rumors, often in conflicting versions. One of the most gratifying pleasures of a genealogical quest is to unveil the true story. Two examples taken from the lecturer’s personal history will demonstrate this.
More information Time11:00 - 12:15 LocationGerhard M.J. Schmidt Lecture Hall LecturerProf. Eric Westhof
Institut de Biologie Moléculaire et Cellulaire Centre National de la Recherche Scientifique
OrganizerFaculty of Chemistry Contact Abstract Show full text abstract about Decoding during ribosomal translation occurs through complex...»Decoding during ribosomal translation occurs through complex and interdependent molecular recognition networks between mRNA, tRNA, and rRNA. Among those, the stability of codon-anticodon triplets, the fold of the tRNA anticodon hairpin, the modified nucleotides, and the interactions with rRNA bases at the decoding site cosntitute key contributors. On the basis of biochemical and genetic data in the literature, coupled with many crystal structures of fully active ribosomes, nucleotide modifications at positions 34 and 37 of the anticodon loop are now understood molecularly. Both pre-organize the anticodon loop for efficient mRNA binding. The modifications at 37 stabilize AU-rich codon-anticodon pairs and maintain the coding frame. The modifications at 34 help to avoid miscoding and allow to decode purine-ending codons in split codon boxes by promoting base pairing that can be accommodated within the structural constraints of the ribosomal grip at the decoding site.
Depending on the codon box, the tRNA modifications allow for diversity in codon usage depending on genomic GC content as well as on the number and types of isoacceptor tRNAs. Although universal, the genetic code is not translated identically and differences exist not only between organisms in the three kingdoms of life but also between cellular types. To decipher diversely but efficiently the genetic code, cells developed sophisticated arrays between tRNA pools and tRNA modifications, anchored in the cellular metabolic enzymatic pathways and guaranteeing protein homeostasis. Examples of mutations leading to specific human diseases in some of those enzymes will be described.
More information Time14:00 - 15:00 LocationNella and Leon Benoziyo Building for Brain Research LecturerProf. Alexey Semyanov
Head, Dept of Molecular Neurobiology, Institute of BioOrganic Chemistry, Moscow
OrganizerDepartment of Neurobiology Contact Details Show full text description of Benoziyo Brain Research Building Room 113 Host: Prof. M...»Benoziyo Brain Research Building Room 113
Host: Prof. Menahem Segal email@example.com tel: 2553
For assistance with accessibility issues, please contact firstname.lastname@example.org
Abstract Show full text abstract about GABAA receptors mediate two forms of signaling in the brain:...»GABAA receptors mediate two forms of signaling in the brain: phasic and tonic. Phasic signaling (e.g., IPSCs) is mediated by synaptic GABAA receptors, while tonic signaling (e.g., tonic current or tonic conductance) is mediated by extrasynaptic GABAA receptors. Tonic current is expressed in a cell-type specific manner and is mediated by heterogeneous and plastic GABAA receptors. These receptors are activated by ambient GABA that originates from vesicular and non-vesicular sources and is regulated by different GABA transporter systems.
Tonic GABAA conductance is commonly referred as tonic inhibition. We found that ambient GABA can actually excite adult hippocampal interneurons. In these cells, the GABAA reversal potential is depolarizing, making baseline tonic GABAA conductance excitatory. Increasing the tonic conductance enhances shunting-mediated inhibition, which eventually overpowers the excitation. Because hippocampal interneurons are the key to setting the network rhythms this mechanism allows bidirectional control of network synchronization by tonic GABAA receptor-mediated signaling.
We also show that tonic GABAA conductance decreases the membrane time constant (τm) and improves the temporal fidelity of EPSP-spike coupling. Long-term potentiation (LTP) induced by different stimulation patterns is differently affected by tonic GABAA conductance.
Our findings thus point to an important role of extrasynaptic signaling mediated by GABAA receptors in brain computations.
More information Time09:00 - 10:00 TitleStem Cells, Regeneration and Aging Breakfast Seminar LocationMax and Lillian Candiotty Building
OrganizerDepartment of Biological Regulation Contact
More information Time10:00 - 11:00 LocationNella and Leon Benoziyo Building for Biological Sciences
LecturerProf. Peter Bozhkov
Professor of Biochemistry, Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, SWEDEN
OrganizerDepartment of Plant and Environmental Sciences Contact Details Show full text description of Host: Dr. Hadas Zehavi...»Host: Dr. Hadas Zehavi
More information Time11:00 - 12:00 LocationWolfson Building for Biological Research
LecturerProf.Mark Dawson OrganizerDepartment of Immunology Contact
Date:24TuesdaySeptember 2019Academic Events
More information Time14:00 - 16:00 LocationDavid Lopatie Conference Centre