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תוצאות חיפוש לאירועים
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Date:03שנימרץ 2025סימפוזיונים
Exploring RNA and protein folding with Single-Molecule Force Spectroscopy
More information שעה 11:00 - 12:15מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Matthias Rief דף בית תקציר Show full text abstract about <p>Single-molecule force spectroscopy (SMFS) enables h...» <p>Single-molecule force spectroscopy (SMFS) enables high-resolution insights into the kinetics and mechanisms of biomolecular interactions. In this talk, I will present how SMFS, helps uncover key principles in nucleic acid and protein folding. Examples discussed will include the microsecond invasion kinetics of toehold-mediated strand displacement (TMSD) of DNA and RNA as well as mRNA-Roquin interactions, which regulate mRNA degradation via specific 3’UTR hairpin structures. Finally, we study chaperone-mediated unfolding of the glucocorticoid receptor (GR), demonstrating how Hsp70/Hsp40 unfolds GR in discrete ATP-driven steps, stabilizing novel intermediates and acting as an unfoldase. These studies showcase SMFS as a powerful tool to resolve biomolecular dynamics providing new insights into RNA structure-function relationships and chaperone-mediated protein regulation.</p> -
Date:04שלישימרץ 2025כנסים
The 4th International Day of Women in Science
More information שעה 08:30 - 16:00כותרת The 4th International Day of Women in Scienceמיקום מרכז כנסים על-שם דויד לופאטייושב ראש Idit Shacharדף בית צרו קשר -
Date:04שלישימרץ 2025הרצאה
"Cut it Out" – Lytic Cell Death and Inflammation Mediated by the “NINJA” Protein – NINJ1
More information שעה 14:00 - 15:00מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Liron David מארגן המחלקה לביולוגיה מבנית וכימית -
Date:05רביעימרץ 2025הרצאה
students seminar series- Azrieli
More information שעה 10:30 - 12:30מיקום בניין קמיליה בוטנארצרו קשר -
Date:05רביעימרץ 2025הרצאה
students seminar series- Azrieli
More information שעה 10:30 - 12:30מיקום בניין קמיליה בוטנארצרו קשר -
Date:06חמישימרץ 2025הרצאה
LSCF departmental seminar by Dr. Yoav Peleg & Prof. Moran Shalev-Benami
More information שעה 09:00 - 10:00מיקום Candiotty Auditoriumמרצה Dr. Yoav Peleg, Prof. Moran Shalev-Benami מארגן המחלקה לתשתיות מחקר מדעי החיים -
Date:09ראשוןמרץ 2025הרצאה
On Light Propagation in Clouds and Light Flashes Above Clouds: Two Crazy Ideas, Two New Models
More information שעה 11:00 - 12:00מיקום בניין משפחת זוסמן
M. Magaritz roomמרצה Carynelisa Haspel צרו קשר תקציר Show full text abstract about <p>In this seminar, two new models will be presented. ...» <p>In this seminar, two new models will be presented. The first new model is a first-principles description of the propagation of light in a cloud, based on a classical solution to Maxwell's equations rather than radiative transfer theory. The second new model is a fully three-dimensional, time-dependent model of the regions of possible sprite inception in the mesosphere, based on the classical method of images from electrostatics rather than finite differencing in space. The reason why each model is unique, the problems each model can solve, and the kinds of results each model can produce will be discussed</p> -
Date:09ראשוןמרץ 2025הרצאה
On Light Propagation in Clouds and Light Flashes Above Clouds: Two Crazy Ideas, Two New Models
More information שעה 11:00 - 12:00מיקום בניין משפחת זוסמן
M. Magaritz seminar roomמרצה Carynelisa Haspel צרו קשר תקציר Show full text abstract about <p>In this seminar, two new models will be presented. ...» <p>In this seminar, two new models will be presented. The first new model is a first-principles description of the propagation of light in a cloud, based on a classical solution to Maxwell's equations rather than radiative transfer theory. The second new model is a fully three-dimensional, time-dependent model of the regions of possible sprite inception in the mesosphere, based on the classical method of images from electrostatics rather than finite differencing in space. The reason why each model is unique, the problems each model can solve, and the kinds of results each model can produce will be discussed. </p> -
Date:11שלישימרץ 2025הרצאה
A Vascular-Centered View on Aging, Regeneration and Rejuvenation
More information שעה 12:30 - 13:30מיקום בניין ע"ש מקס ולילאן קנדיוטי
Auditoriumמרצה Prof. Eli Keshet מארגן המחלקה לאימונולוגיה ורגנרציה ביולוגיתצרו קשר -
Date:11שלישימרץ 2025הרצאה
What is special about activity in the basal ganglia?
More information שעה 12:30 - 14:00מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Mati Joshua מארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about <p>There are two major classes of theories about the b...» <p>There are two major classes of theories about the basal ganglia. The first class hypothesizes</p><p>that the basal ganglia are the site where cortical sensorimotor and dopaminergic reward</p><p>information interact to potentiate and select actions. These theories predict that content</p><p>specificity of information emerges from within the basal ganglia. The second class of</p><p>theories posits that information is manipulated within the basal ganglia through processes</p><p>such as dimensionality reduction. These theories are primarily based on the fact that there</p><p>is a large reduction in the number of neurons from the input to the output stages of the basal</p><p>ganglia. These theories posit that there are changes in the coding properties of neurons</p><p>rather than the emergence of content specificity.</p><p>In this talk, I will present a set of studies where we analyzed the eye movement system of</p><p>monkeys to compare single-neuron activity in the basal ganglia with activity in the</p><p>cerebellum and the frontal cortex. We used tasks that manipulated both eye movements</p><p>and expected rewards. We found that rather than coding specific sensorimotor or reward</p><p>parameters, the basal ganglia were unique in how they coded these parameters, both in</p><p>terms of the signal-to-noise ratio of responses and in the variety of their temporal patterns.</p><p>These results strongly suggest that the basal ganglia play a role in manipulating rather than</p><p>generating reward and sensorimotor signals.</p> -
Date:12רביעימרץ 2025הרצאה
Birthday hormone: the neuroendocrine control of hatching in fish
More information שעה 10:00 - 11:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואי
Botnar Auditoriumמרצה Dr. Matan Golan צרו קשר -
Date:13חמישימרץ 2025הרצאה
Synthetic biology platforms for biomedical applicationsnnounced
More information שעה 15:00 - 16:00מיקום Leon Benoziyo for Biological Sciences
Auditorium Rm.191מרצה Dr. Lior Nissim
The Faculty of Medicine - Hebrew University of Jerusalem -
Date:16ראשוןמרץ 2025כנסים
EPScon 2025 - The 14th Students' Conference for Earth and Planetary Sciences
More information שעה 08:00 - 08:00מיקום מרכז כנסים על-שם דויד לופאטייושב ראש Adam Chaikin Lifshitz -
Date:18שלישימרץ 2025הרצאה
Vascular Aging:
More information שעה 11:00 - 12:00כותרת The Hidden Driver of Age-Related Organ Dysfunctionמיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Dr. Myriam Grunewald מארגן מכון סגול לאריכות ימיםצרו קשר תקציר Show full text abstract about <p>As life expectancy increases, age-related diseases ...» <p>As life expectancy increases, age-related diseases are becoming more prevalent. While these conditions are traditionally studied in isolation, mounting evidence points to shared, systemic mechanisms underlying these conditions. Our research highlights the vasculature as a key player in organ homeostasis and repair, and a system shared across all organs—making its dysfunction potential driver of age-related pathologies.</p><p>We demonstrate that manipulating <strong>VEGF signaling</strong> to counteract age-related microvascular rarefaction promotes <strong>comprehensive geroprotection</strong>, preserving organ function and delaying disease onset. Our findings also reveal a link between vascular rarefaction and altered RNA splicing. While hypoxia-driven and age-related changes in alternative RNA splicing have been studied independently, we propose a unifying mechanism that links the two. To explore this further, we also employ patient-derived organoids, which retain their biological age in culture, providing a robust in vitro platform to test anti-aging interventions.</p><p>Our findings support a <strong>vascular theory of aging</strong>, identifying vascular health as a promising target to mitigate age-related diseases and promote healthier aging.</p> -
Date:18שלישימרץ 2025הרצאה
Proteome-wide prediction of protein-protein interaction networks and protein compound interactions and their integration for biological discovery
More information שעה 14:00 - 15:00מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Barry Honig מארגן המחלקה לביולוגיה מבנית וכימית -
Date:20חמישימרץ 2025הרצאה
Harnessing Mistakes to Expose Cancer’s Vulnerability
More information שעה 12:30 - 14:00כותרת Spotlight on Science lecture sponsored by the Staff Scientists Councilמיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Ilana Eyal
Spotlight on Science lecture sponsored by the Staff Scientists Councilצרו קשר תקציר Show full text abstract about <p>Over the past few decades, immunotherapy has revolu...» <p>Over the past few decades, immunotherapy has revolutionized cancer treatment with great success in treating cancer patients and preventing tumor recurrence after surgery. Harnessing the immune system to fight cancer largely relies on the ability of T lymphocytes to distinguish between “self” and “non-self” to specifically identify and eliminate malignant cells. This is achieved through the recognition of neoantigens, tumor-specific proteins resulting from genetic mutations.</p><p>The Samuels’ lab is exploring the immune-tumor interactions, with specific focus on the mechanisms underlying cancer-cell recognition, and developing novel strategies to increase antitumor immune responses.</p><p>In this talk, I will present results from our recent studies investigating the link between mRNA mistranslation in cancer cells and immunological tumor control.</p> -
Date:20חמישימרץ 2025הרצאה
Spatial transcriptomics of pancreatic cancer development and immune cells targeting to restrict tumor growth
More information שעה 14:00 - 15:00מיקום בניין ע"ש מקס ולילאן קנדיוטי
Auditoriumמרצה Dr. Oren Parnas מארגן המכון לחקר הטיפול בסרטן עש דואק -
Date:24שנימרץ 2025הרצאה
Foundations of Computer Science Seminar
More information שעה 11:15 - 12:15כותרת Privacy amplification by random allocation (is approximately Poisson subsampling)מיקום בניין יעקב זיסקינד
Room 1 - 1 חדרמרצה Moshe Shenfeld
Hebrew University of Jerusalemמארגן המחלקה למדעי המחשב ומתמטיקה שימושיתצרו קשר תקציר Show full text abstract about Given two distributions P, Q and an integer t, we analyze tw...» Given two distributions P, Q and an integer t, we analyze two sampling processes. In "random allocation," we first sample an index i uniformly from [t], then draw r_{i} ~ P and r_{j} ~ Q for all other j in [t]. In "Poisson sampling," we independently draw r_{i} ~ 1/t*P + (1-1/t)*Q for each i in [t]. We bound the difference between these processes' output distributions and the baseline of sampling r_{i} ~ Q for all i.
This theoretical result provides key insights for analyzing DP-SGD, a privacy-preserving variant of stochastic gradient descent. While Poisson subsampling has well-understood privacy guarantees, common implementations use element shuffling, which was recently shown to have larger privacy losses in certain regimes. Random allocation offers a middle ground, and we prove its privacy analysis reduces to comparing the distributions described above.
We show that these variants' privacy guarantees are within a constant factor of each other across all parameter regimes and converge asymptotically in t. Our proof has two key components: decomposing Poisson sampling into a mixture of random allocation processes, and showing that random allocation can be viewed as a modified Poisson process where sampling probabilities depend on previous outputs.
Joint work with Vitaly Feldman -
Date:27חמישימרץ 2025הרצאה
Regulation of immune cell function in tumor microenvironment of triple-negative breast cancer
More information שעה 14:00 - 15:00מיקום בניין ע"ש מקס ולילאן קנדיוטי
Auditoriumמרצה Prof. Idit Shachar מארגן המכון לחקר הטיפול בסרטן עש דואק -
Date:27חמישימרץ 2025הרצאה
To be announced
More information שעה 15:00 - 16:00מיקום בניין לביוכימיה על שם נלה וליאון בנוזיו
Auditorium Rm. 191מרצה Keren Yizhak
(Technion)